Adam Crystal MD

Chief Medical Officer, C4 Therapeutics.

C4 Therapeutics, Inc490 Arsenal Way, Suite 100Watertown, MA 02472

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Summary

Medical oncologist (MD-PhD), board certified; Industry experience in early phase oncology drug development including small molecules, IO and CAR-T; Translational research: acquired resistance to targeted therapy in lung cancer.

Education & Training

Mass General Brigham/Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 2009 - 2013
Mass General Brigham/Massachusetts General HospitalInternship, Internal Medicine, 2006 - 2007
Perelman School of Medicine at the University of PennsylvaniaClass of 2006

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Certifications & Licensure

MA State Medical License 2008 - 2027

Publications & Presentations

PubMed

14 citations
Discovery of CFT8634, a Potent, Selective, and Orally Bioavailable Heterobifunctional Degrader of BRD9.
Katrina L Jackson, Ning Yin, Roman V Agafonov, Prasoon Chaturvedi, Kyle Cole
Journal of Medicinal Chemistry. 2025-12-11
27 citations
A Phase I Study of LSZ102, an Oral Selective Estrogen Receptor Degrader, With or Without Ribociclib or Alpelisib, in Patients with Estrogen Receptor-Positive Breast Ca...
Komal Jhaveri, Dejan Juric, Yoon Sim Yap, Sara Cresta, Rachel M. Layman
Clinical Cancer Research. 2021-11-01
729 citations
Prospects for combining targeted and conventional cancer therapy with immunotherapy
Philip Gotwals, Scott Cameron, Daniela Cipolletta, Viviana Cremasco, Adam S. Crystal
Nature Reviews. Cancer. 2017-05-01

Press Mentions

Tango Therapeutics Presents Preclinical Data on Precision Oncology Programs at the American Association of Cancer Research 2023 Annual MeetingApril 18th, 2023
Tango Therapeutics Reports Fourth Quarter and Full Year 2022 Financial Results and Provides Business HighlightsMarch 27th, 2023
AACR: C4's Multiple Myeloma Data Prompts Dosing Switch, Giving Patients a Longer Treatment ReprieveApril 8th, 2022

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Doximity / States / Massachusetts / Watertown / Adam Crystal, MD

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