AdamDavidDurbinMDPh.D.

PubMed

• 43 citations
  EP300 selectively controls the enhancer landscape of MYCN-amplified neuroblastoma.
  Adam D. Durbin, Tingjian Wang, Virangika K. Wimalasena, Mark W. Zimmerman, Deyao Li, Neekesh V. Dharia, Luca Mariani, Noha A.M Shendy, Stephanie Nance, Anand G. Patel,...> ;Cancer Discovery. 2021 Nov 12
• 18 citations
  Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma
  Mark W. Zimmerman, Adam D. Durbin, Shuning He, Felix Oppel, Hui Shi, Ting Tao, Zhaodong Li, Alla Berezovskaya, Yu Liu, Jinghui Zhang, Richard A. Young, Brian J. Abraha...> ;Science Advances. 2021 Oct 22
• 2 citations
  Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.
  Jasper E Neggers, Brenton R Paolella, Adhana Asfaw, Michael V Rothberg, Thomas A Skipper, Annan Yang, Radha L Kalekar, John M Krill-Burger, Neekesh V Dharia, Guillaume...> ;Cell Reports. 2021 Jul 13
• A Resident-Led Virtual Journal Club to Educate Pediatric Residents About Coronavirus Disease 2019.
  Milad Rezvani, Geoffrey A. Smith, Joseph A. Majzoub, Adam D. Durbin, Ariel S. Winn> ;Academic Pediatrics. 2021 Feb 16
• 14 citations
  Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.
  Jasper E Neggers, Brenton R Paolella, Adhana Asfaw, Michael V Rothberg, Thomas A Skipper, Annan Yang, Radha L Kalekar, John M Krill-Burger, Neekesh V Dharia, Guillaume...> ;Cell Reports. 2020 Dec 15
• 8 citations
  Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors.
  Ting Tao, Hui Shi, Meng Wang, Antonio R. Perez-Atayde, Wendy B. London, Alejandro Gutierrez, Bernardo Lemos, Adam D. Durbin, A. Thomas Look> ;The Journal of Experimental Medicine. 2020 Oct 5
• 30 citations
  LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.
  Ting Tao, Hui Shi, Luca Mariani, Brian J. Abraham, Adam D. Durbin, Mark W. Zimmerman, John T. Powers, Pavlos Missios, Kenneth N. Ross, Antonio R. Perez-Atayde, Martha ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Jul 14
• 40 citations
  ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression
  Hui Shi, Ting Tao, Brian J. Abraham, Adam D. Durbin, Mark W. Zimmerman, Cigall Kadoch, A. Thomas Look> ;Science Advances. 2020 Jul 1
• 36 citations
  Using Chemical Epigenetics to Target Cancer
  Virangika K. Wimalasena, Tingjian Wang, Logan H. Sigua, Adam D. Durbin, Jun Qi> ;Molecular Cell. 2020 May 13
• 59 citations
  Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2
  Ken Morita, Shuning He, Radosław P. Nowak, Jinhua Wang, Mark W. Zimmerman, Cong Fu, Adam D. Durbin, Megan W. Martel, Nicole Prutsch, Nathanael S. Gray, Eric S. Fischer...> ;Cell. 2020 Apr 30
• 49 citations
  ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
  Lu Wang, Tze King Tan, Adam D. Durbin, Mark W. Zimmerman, Brian J. Abraham, Shi Hao Tan, Phuong Cao Thi Ngoc, Nina Weichert-Leahey, Koshi Akahane, Lee N. Lawton, Jo Ly...> ;Nature Communications. 2019 Dec 9
• 13 citations
  Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors.
  Dong Hyuk Ki, Felix Oppel, Adam D. Durbin, A. Thomas Look> ;Oncogene. 2019 Aug 23
• 156 citations
  Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry.
  Adam D. Durbin, Mark W. Zimmerman, Neekesh V. Dharia, Brian J. Abraham, Amanda Balboni Iniguez, Nina Weichert-Leahey, Shuning He, John M. Krill-Burger, David E. Root, ...> ;Nature Genetics. 2018 Aug 20
• 5 citations
  Diffusion-Weighted Imaging Changes in a Child With Posterior Ischemic Optic Neuropathy
  Dana B. Harrar, Jessica D. Solomon, Ankoor S. Shah, Jennifer Vaughn, Adam D. Durbin, Michael J. Rivkin> ;Pediatric Neurology. 2018 Jul 1
• 42 citations
  The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma
  Myron S. Ignatius, Madeline N. Hayes, Riadh Lobbardi, Eleanor Y. Chen, Karin M. McCarthy, Prethish Sreenivas, Zainab Motala, Adam D. Durbin, Aleksey Molodtsov, Sophia ...> ;Cell Reports. 2017 Jun 13
• 128 citations
  MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification
  Mark W. Zimmerman, Yu Liu, Shuning He, Adam D. Durbin, Brian J. Abraham, John Easton, Ying Shao, Beisi Xu, Shizhen Zhu, Xiaoling Zhang, Zhaodong Li, Nina Weichert-Leah...> ;Cancer Discovery. 2017 Dec 28
• 5 citations
  Vitamin B12 Deficiency Presenting with Neurological Dysfunction in an Adolescent
  Coral M. Stredny, Olivia Frosch, Samata Singhi, Elissa Furutani, Adam D. Durbin, Rachael F. Grace, Nicole J. Ullrich> ;Pediatric Neurology. 2016 Sep 1
• 23 citations
  Malignant Peripheral Nerve Sheath Tumors
  Adam D. Durbin, Dong Hyuk Ki, Shuning He, A. Thomas Look> ;Advances in Experimental Medicine and Biology. 2016 Jan 1
• 219 citations
  Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism
  Derek A. Oldridge, Andrew C. Wood, Nina Weichert-Leahey, Ian Crimmins, Robyn T. Sussman, Cynthia Winter, Lee D. McDaniel, Maura Diamond, Lori S. Hart, Shizhen Zhu, Ada...> ;Nature. 2015 Dec 17
• 523 citations
  An Oncogenic Super-Enhancer Formed Through Somatic Mutation of a Noncoding Intergenic Element
  Marc R. Mansour, Brian J. Abraham, Lars Anders, Alla Berezovskaya, Alejandro Gutierrez, Adam D. Durbin, Julia Etchin, Lee N. Lawton, Stephen E. Sallan, Lewis B. Silver...> ;Science. 2014 Dec 12
• 4 citations
  The oncogenic and growth-suppressive functions of the integrin-linked kinase are distinguished by JNK1 expression in human cancer cells.
  Adam D. Durbin, Ivan Pasic, Dennis Wong, Gregory E. Hannigan, David Malkin> ;Cell Cycle. 2010 May 15
• 130 citations
  Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma.
  Ivan Pasic, Adam Shlien, Adam D. Durbin, Dimitrios J. Stavropoulos, Berivan Baskin, Peter N. Ray, Ana Novokmet, David Malkin> ;Cancer Research. 2010 Jan 1
• 17 citations
  Oncogenic ILK, tumor suppression and all that JNK.
  Adam D. Durbin, Gregory E. Hannigan, David Malkin> ;Cell Cycle. 2009 Dec 15
• 37 citations
  JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma
  Adam D. Durbin, Gino R. Somers, Michael Forrester, Malgorzata Pienkowska, Gregory E. Hannigan, David Malkin> ;The Journal of Clinical Investigation. 2009 Jun 1
• 31 citations
  Expression of insulin-like growth factor pathway proteins in rhabdomyosarcoma: IGF-2 expression is associated with translocation-negative tumors.
  Shalini Makawita, Michael Ho, Adam D. Durbin, Paul S. Thorner, David Malkin, Gino R. Somers> ;Pediatric and Developmental Pathology. 2009 Mar 1
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Journal Articles

• Selective Gene Dependencies in MYCN-Amplified Neuroblastoma Include the Core Transcriptional Regulatory Circuitry  
  William C Hahn, Todd R Golub, A Thomas Look, Adam D Durbin, Neekesh V Dharia, Kimberly Stegmaier, Nature