AdamLernerMD

PubMed

• Primary intracranial extraosseous Ewing's sarcoma of the skull base in an elderly adult: illustrative case.
  Kristine Ravina, Sonora A Windermere, Qing Zhao, Adam Lerner, Michael Dyer, Urvashi Upadhyay, R Tushar Jha> ;Journal of Neurosurgery. Case Lessons. 2022 Oct 17
• 1 citations
  Standard 30-minute Monitoring Time and Less Intensive Pre-medications is Safe in Patients Treated With Subcutaneous Daratumumab for Multiple Myeloma and Light Chain Am...
  David M Hughes, Lynnette Henshaw, Frances Blevins, Camille Edwards, Adam Lerner, John Mark Sloan, Vaishali Sanchorawala> ;Clinical Lymphoma, Myeloma & Leukemia. 2022 Aug 1
• 1 citations
  Underrepresentation of Black participants and adverse events in clinical trials of lenalidomide for myeloma.
  Charles J Milrod, Michael Mann, Frances Blevins, David Hughes, Preya Patel, Katie Y Li, Adam Lerner, Vaishali Sanchorawala, J Mark Sloan> ;Critical Reviews in Oncology/hematology. 2022 Apr 1
• 2 citations
  Incidence of skin hyperpigmentation in Black patients receiving treatment with immunomodulatory drugs.
  Charles J Milrod, Frances Blevins, David Hughes, Adam Lerner, Shayna Sarosiek, Vaishali Sanchorawala, J. Mark Sloan> ;Blood. 2020 Nov 5
• Recognition of hemophagocytic lymphohistiocytosis in sickle cell vasoocclusive crises is a potentially lifesaving diagnosis.
  Leiva, O.,McMahon, L.,Sloan, J. M.,Lee, J.,Lerner, A.> ;Haematologica. 2019 Feb 02
• 9 citations
  Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays.
  Ana Santos de Medeiros, Arlene R. Wyman, Manal A. Alaamery, Christina J. Allain, F. Douglas Ivey, Lili Wang, Hai Le, James P. Morken, Alawi Habara, Cuong Le, Shuaiying...> ;Cellular Signalling. 2017 Dec 1
• 355 citations
  Brentuximab vedotin or physician's choice in CD30-positive cutaneous T-cell lymphoma (ALCANZA): an international, open-label, randomised, phase 3, multicentre trial
  H. Miles Prince, Youn H. Kim, Steven M. Horwitz, Reinhard Dummer, Julia Scarisbrick, Pietro Quaglino, Pier Luigi Zinzani, Pascal Wolter, Jose A Sanches, Pablo L. Ortiz...> ;Lancet. 2017 Aug 5
• 14 citations
  Anti-inflammatory effects of novel barbituric acid derivatives in T lymphocytes.
  Chenjia Xu, Arlene R. Wyman, Manal A. Alaamery, Shannon A. Argueta, F. Douglas Ivey, John A. Meyers, Adam Lerner, Tricia H. Burdo, Timothy Connolly, Charles S. Hoffman...> ;International Immunopharmacology. 2016 Sep 1
• 15 citations
  Epstein-Barr virus-associated diffuse large B-cell lymphoma arising in atrial myxoma: a proposal for a modified therapeutic approach.
  Umit Tapan, J Bruno Pestana, John C. Lee, Adam Lerner> ;Leukemia & Lymphoma. 2015 Feb 1
• 12 citations
  Inhibition of Type 4 Cyclic Nucleotide Phosphodiesterase Blocks Intracellular TLR Signaling in Chronic Lymphocytic Leukemia and Normal Hematopoietic Cells
  Ying Tan, Amanda A. Watkins, Benjamin B. Freeman, John A. Meyers, Ian R. Rifkin, Adam Lerner> ;Journal of Immunology. 2015 Jan 1
• Target DNA detection and quantitation on a single cell with single base resolution.
  Konry, T.,Lerner, A.,Yarmush, M. L.,Smolina, I. V.> ;Technology (Singap). 2014 Jul 01
• Generalized syringotropic mycosis fungoides responsive to extracorporeal photopheresis.
  Jennings, L.,Campbell, S. M.,Yaar, R.,Mahalingam, M.,Sahni, D.,Lerner, A.,Rünger, T. M.> ;Br. J. Dermatol.. 2013 Aug 2
• 33 citations
  Clinically meaningful reduction in pruritus in patients with cutaneous T-cell lymphoma treated with romidepsin.
  Youn H. Kim, Marie-France Demierre, Ellen J. Kim, Adam Lerner, Alain H. Rook, Madeleine Duvic, Tadeusz Robak, Alexey Samtsov, William McCulloch, Suephy C. Chen, Joel W...> ;Leukemia & Lymphoma. 2013 Feb 1
• 14 citations
  Breast Cancer Anti-estrogen Resistance 3 (BCAR3) Protein Augments Binding of the c-Src SH3 Domain to Crk-associated Substrate (p130cas)
  Anthony Makkinje, Pierre Vanden Borre, Richard I. Near, Prayag S. Patel, Adam Lerner> ;The Journal of Biological Chemistry. 2012 Aug 10
• Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment.
  Lerner A, Beckford A, Ugent S, Goldberg L, Jalisi S, Demierre M> ;Arch Dermatol. 2011-08-01
• 20 citations
  BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas
  Pierre Vanden Borre, Richard I. Near, Anthony Makkinje, Gustavo Mostoslavsky, Adam Lerner> ;Cellular Signalling. 2011 Jun 1
• 476 citations
  Final Results From a Multicenter, International, Pivotal Study of Romidepsin in Refractory Cutaneous T-Cell Lymphoma
  Sean Whittaker, Marie-France Demierre, Ellen J. Kim, Alain H. Rook, Adam Lerner, Madeleine Duvic, Julia Scarisbrick, Sunil Reddy, Tadeusz Robak, Jürgen C. Becker, Alex...> ;Journal of Clinical Oncology. 2010 Oct 10
• 19 citations
  AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern
  Anthony Makkinje, Richard I. Near, Giuseppe Infusini, Pierre Vanden Borre, Alexander B. Bloom, Dongpo Cai, Catherine E. Costello, Adam Lerner> ;Cellular Signalling. 2009 Sep 1
• 24 citations
  Chronic lymphocytic leukemia and B and T cells differ in their response to cyclic nucleotide phosphodiesterase inhibitors.
  John A. Meyers, Derrick W. Su, Adam Lerner> ;Journal of Immunology. 2009 May 1
• 16 citations
  Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens
  Richard I. Near, Richard S. Smith, Paul Toselli, Thomas F. Freddo, Alexander B. Bloom, Pierre Vanden Borre, David C. Seldin, Adam Lerner> ;Molecular Vision. 2009 Apr 3
• 23 citations
  Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading.
  Victoriya A. Rufanova, Anna Alexanian, Tetsuro Wakatsuki, Adam Lerner, Andrey Sorokin> ;Journal of Cellular Physiology. 2009 Apr 1
• 28 citations
  AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology.
  Richard I. Near, Yujun Zhang, Anthony Makkinje, Pierre Vanden Borre, Adam Lerner> ;Journal of Cellular Physiology. 2007 Sep 1
• 25 citations
  Phosphodiesterase 4 Inhibitors Augment Levels of Glucocorticoid Receptor in B Cell Chronic Lymphocytic Leukemia but Not in Normal Circulating Hematopoietic Cells
  John A. Meyers, Josephine A. Taverna, Jorge Chaves, Anthony Makkinje, Adam Lerner> ;Clinical Cancer Research. 2007 Aug 15
• 42 citations
  CD40 Ligand-mediated Activation of the de Novo RelB NF-κB Synthesis Pathway in Transformed B Cells Promotes Rescue from Apoptosis
  Nora D. Mineva, Thomas L. Rothstein, John A. Meyers, Adam Lerner, Gail E. Sonenshein> ;The Journal of Biological Chemistry. 2007 Jun 15
• 50 citations
  Preclinical assessment of curcumin as a potential therapy for B-CLL
  Peter C. Everett, John A. Meyers, Anthony Makkinje, Mohammed Rabbi, Adam Lerner> ;American Journal of Hematology. 2007 Jan 1
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Journal Articles

• Primary cutaneous CD56 positive lymphoma: a diagnostic conundrum in an unusual case of lymphoma  
  Schieke SM, Sharaf M, Lerner A, Runger T, Mahalingam M, J. Cutan. Pathol, 1/1/2012
• AND-34/BCAR3 augments the ability of p130Cas to bind the Src SH3 domain in a BCAR3-p130Cas complex-dependent manner  
  Makkinje A, VandenBorre P, Near RI, Patel P and Lerner A, J. Biol. Chem, 1/1/2012
• Chemotherapy as treatment for colocolonic intussusception associated with acquired immunodeficiency-related lymphoma  
  Lerner A, Soto J and Rosen J, Surgery, 1/1/2011
• Complete response of metastatic hidradenocarcinoma to capecitabine  
  Lerner A, Beckford A, Ugent S, Goldberg L, Jalisi S and Demierre MF, Archives of Derm, 1/1/2011
• Structural insights into the association between BCAR3 and Cas family members; an atypical complex implicated in anti-oestrogen resistance  
  Garron ML, Arsenieva D, Zhong J, Bloom A, Lerner A, O’Neill GM and Arold ST, J. Mol. Biol, 1/1/2009
• AND-34/BCAR3 is required for structural integrity of the adult mouse lens  
  Near RI, Smith RS, Toselli PA, Freddo T, Bloom A, Vanden Borre P, Seldin D and Lerner A, Molecular Vision, 1/1/2009
• Infliximab as therapy for idiopathic hypereosinophilic syndrome  
  Taverna JA, Lerner A, Goldberg L, Werth S, Demierre MF, Arch. Dermatol, 1/1/2007
• Successful adjuvant treatment of recalcitrant mucous membrane pemphigoid with anti-CD20 antibody Rituximab  
  Taverna JA, Lerner A, Bhawan J, Demierre MF, J.Drugs Dermatol, 1/1/2007
• Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies  
  Lerner A and Epstein P, Biochemical Journal, 1/1/2006
• Characterization of AND-34 function and signaling  
  Felekkis KN, Quilliam LA and Lerner A, Methods in Enzymology, 1/1/2006
• Vinca alkaloids vs. taxanes as therapy in lymphoid malignancies: Do our experimental models obscure our knowledge of how these drugs really work?  
  Lerner A and Andrea N, Cancer Invest, 1/1/2005
• Immunologic recovery after autologous blood stem cell transplantation in patients with AL-amyloidosis  
  Akpek G, Lenz G, Lee SM, Sancharawala V, Wright DG, Colarusso T, Waraska K, Lerner A, Vosburgh E, Skinner M and Comenzo RL, Bone Marrow Transplantation, 1/1/2001
• P130Cas regulates the activity of AND-34, a novel Ral, Rap1 and R-Ras guanine nucleotide exchange factor  
  Gotoh T, Cai D, Feig L and Lerner A, J. Biol. Chem, 1/1/2000
• The cAMP signaling pathway as a therapeutic target in lymphoid malignancies  
  Lee R, Kim DH and Lerner A, Leukemia and Lymphoma, 1/1/2000
• AND-34, a novel p130Cas-binding thymic stromal cell protein induced by inflammatory cytokines  
  Cai D, Clayton LK, Smolyar A and Lerner A, J. Immunol, 1/1/1999
• Pre-TCR signaling components trigger transcriptional activation of a rearranged TCR alpha gene locus and silencing of the pre-TCR alpha locus: implications for intrath...  
  Koyasu S, Clayton LC, Lerner A, Heiken H, Parkes A, Reinherz EL, Int. Immunol, 1/1/1997
• Cross-linking of T cell receptors on double positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death  
  Lerner A, Clayton LC, Mizoguchi E, Ghendler Y, Koyasu S, Bhan AK and Reinherz EL, EMBO J, 1/1/1996
• Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse  
  Koyasu S, Hussey RE, Clayton LK, Lerner A, Pederson R, Delaney-Heiken P, Chau F and Reinherz EL, EMBO J, 1/1/1994
• CD3 zeta/eta/theta locus is colinear with and transcribed antisense to the gene encoding the transcription factor Oct-1  
  Lerner A, D’Adamio L, Diener AC, Clayton LK and Reinherz EL, J Immunol, 1/1/1993
• Etoposide, doxorubicin, and cisplatin chemotherapy for advanced gastric adenocarcinoma: results of a phase II trail  
  Lerner A, Gonin R, Steele GD, Mayer RJ, J. Clin. Oncol, 1/1/1992
• Human genomic sequences corresponding to murine CD3 eta-related transcripts: lack of expression of homologous human products  
  Lerner A, Diener AC, Reinherz EL, Clayton LK, Eur J Immunol, 1/1/1992
• Differential regulation of T-cell receptor processing and surface expression affected by CD3 theta, an alternatively spliced product of the CD3 zeta/eta gene locus  
  Clayton LK, Diener AC, Lerner A, Tse A, Koyasu S and Reinherz EL, J.Biol.Chem, 1/1/1992
• T cell receptor isoforms  
  Clayton LK, Lerner A, Diener AC, Hussey RE, Koyasu S, and Reinherz EL, Int. J. Cancer, 1/1/1992
• Type 4 cAMP phosphodiesterase as a therapeutic target in chronic lymphocytic leukemia  
  Kim, D.H. and Lerner A, Blood, 1/1/1992
• PGP-1 T lymphocytes accumulate with age in mice and respond poorly to concanavalin A  
  Lerner A, Yamada A, Miller R, Eur J Immunol, 1/1/1989
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Books/Book Chapters

• Goldman’s Cecil Medicine 
  Chapter: Primary and metastatic malignant bone lesions 
  Lerner A and Antman KEdition 24th,2011
• ACP Medicine 
  Chapter: Sarcomas of soft tissue and bone 
  Lerner A and Antman KB C Decker Publishers2011
• Cyclic Nucleotide Phosphodiesterases in Health and Disease 
  Chapter: Role of Phosphodiesterases in apoptosis 
  Page 559 - 582Lerner A, Moon E and Tiwari SEditors: J Beavo, S Francis and M Houslay.CRC Press2006
• Current Practice in Medicine 
  Chapter: Bone and soft tissue sarcomas 
  Lerner A, Elias AChurchill Livingstone Inc., New York, N.Y.Edition 2nd ,1999
• Mol. Basis of Immune Resp. 
  Chapter: T cell receptor isoforms during thymic differentiation 
  Reinherz EL, Lerner A, Diener AC, Hussey R, Koyasu S and Clayton LKEditors: H. Nariuchi.Academic Press1993
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Abstracts/Posters

• Successful Transition from Bortezomib Subcutaneous (SubQ) to Generic Intravenous (IV) Bortezomib: Cost Savings Initiative with Global Economic Impact
  Adam Lerner, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019