AdamTylerWhaley-ConnellDO

Professor, Internal Medicine, University of Missouri, Columbia School of Medicine; Associate Chief of Staff Research and Development, Harry S Truman Memorial Veterans' Hospital

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Office
One Hospital Dr
Columbia, MO 65212
Phone+1 573-882-7991

Fax+1 573-884-4820
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Education & Training

University of Missouri-ColumbiaFellowship, Nephrology, 2004 - 2006
University of Missouri-ColumbiaResidency, Internal Medicine, 2001 - 2004
Kansas City University of Medicine and Biosciences College of Osteopathic MedicineClass of 2001

Certifications & Licensure

MO State License 2002 - 2025
American Board of Internal Medicine Nephrology

Awards, Honors, & Recognition

Fellow (ASNF) American Society of Nephrology

Publications & Presentations

PubMed

Hemoadsorption: Consensus report of the 30th Acute Disease Quality Initiative workgroup.
Ghada Ankawi, Sean M Bagshaw, Rinaldo Bellomo, Ian Baldwin, Rajit Basu, Gabriella Bottari, Vincenzo Cantaluppi, William Clark, Silvia De Rosa, Lui G Forni, Dana Fuhrma...> ;Nephrology, Dialysis, Transplantation. 2024 Apr 15
Obesity in Hypertension: The Role of the Expanding Waistline Over the Years and Insights Into the Future.
Guanghong Jia, James R Sowers, Adam T Whaley-Connell> ;Hypertension. 2024 Apr 1
1 citations
Endothelial MRs Mediate Western Diet-Induced Lipid Disorders and Skeletal Muscle Insulin Resistance in Females.
Javad Habibi, Huma Naz, Dongqing Chen, Guido Lastra, Adam Whaley-Connell, James R Sowers, Guanghong Jia, Carlton Homan> ;Endocrinology. 2023 Jun 6
Volume Removal in Heart Failure: Current Concepts and a Look into the Future.
Claudio Ronco, Camila Manrique-Acevedo, Adam Whaley-Connell> ;Cardiorenal Medicine. 2023 Jan 1
1 citations
Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet-induced obese male mice.
Annayya Aroor, Vincent G DeMarco, Adam T Whaley-Connell, Guanghong Jia, Yan Yang, Neekun Sharma, Huma Naz, Chetan Hans, Melvin R Hayden, Michael A Hill, James R Sowers...> ;American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2023 Jan 1
3 citations
Mineralocorticoid Receptors Mediate Diet-Induced Lipid Infiltration of Skeletal Muscle and Insulin Resistance.
Jack L Hulse, Javad Habibi, Aderonke E Igbekele, Bingyue Zhang, Jessie Li, Adam Whaley-Connell, James R Sowers, Guanghong Jia> ;Endocrinology. 2022 Oct 11
6 citations
Inhibition of sphingomyelinase attenuates diet - Induced increases in aortic stiffness.
Javad Habibi, Vincent G DeMarco, Jack L Hulse, Melvin R Hayden, Adam Whaley-Connell, Michael A Hill, James R Sowers, Guanghong Jia> ;Journal of Molecular and Cellular Cardiology. 2022 Jun 1
6 citations
Targeting mineralocorticoid receptors in diet-induced hepatic steatosis and insulin resistance.
Javad Habibi, Dongqing Chen, Jack L Hulse, Adam Whaley-Connell, James R Sowers, Guanghong Jia> ;American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2022 Mar 1
4 citations
Cystamine reduces vascular stiffness in Western diet-fed female mice.
Francisco I Ramirez-Perez, Francisco J Cabral-Amador, Adam T Whaley-Connell, Annayya R Aroor, Mariana Morales-Quinones, Makenzie L Woodford, Thaysa Ghiarone, Larissa F...> ;American Journal of Physiology. Heart and Circulatory Physiology. 2022 Feb 1
2 citations
Mineralocorticoid Receptor in Myeloid Cells Mediates Angiotensin II-Induced Vascular Dysfunction in Female Mice.
Camila Manrique-Acevedo, Jaume Padilla, Huma Naz, Makenzie L Woodford, Thaysa Ghiarone, Annayya R. Aroor, Jack L. Hulse, Francisco J Cabral-Amador, Vanesa Martinez-Dia...> ;Frontiers in Physiology. 2021 Mar 29
6 citations
DPP4 inhibition mitigates ANG II-mediated kidney immune activation and injury in male mice.
Ravi Nistala, Alex Meuth, Cassandra Smith, Jianzhong An, Javad Habibi, Melvin R. Hayden, Megan S. Johnson, Annayya R. Aroor, Adam Whaley-Connell, James R. Sowers, Susa...> ;American Journal of Physiology. Renal Physiology. 2021 Feb 1
13 citations
Western diet induces renal artery endothelial stiffening that is dependent on the epithelial Na+ channel.
Yuxin Xiong, Annayya R. Aroor, Francisco I. Ramirez-Perez, Guanghong Jia, Javad Habibi, Camila Manrique-Acevedo, Guido Lastra, Donqqing Chen, Vincent G. DeMarco, Luis ...> ;American Journal of Physiology. Renal Physiology. 2020 May 1
13 citations
Endothelial sodium channel activation promotes cardiac stiffness and diastolic dysfunction in Western diet fed female mice.
James R. Sowers, Javad Habibi, Guanghong Jia, Brian Bostick, Camila Manrique-Acevedo, Guido Lastra, Yan Yang, Dongqing Chen, Zhe Sun, Timothy L. Domeier, William Duran...> ;Metabolism. 2020 Aug 1
1 citations
Renal resistive index as a novel biomarker for cardiovascular and kidney risk reduction in type II diabetes
Annayya R. Aroor, Adam Whaley-Connell, James R. Sowers> ;Journal of Clinical Hypertension. 2020 Jan 31
18 citations
Sexual Dimorphism in Obesity-Associated Endothelial ENaC Activity and Stiffening in Mice.
Jaume Padilla, Makenzie L Woodford, Guido Lastra-Gonzalez, Vanesa Martinez-Diaz, Shumpei Fujie, Yan Yang, Alexandre M C Lising, Francisco I. Ramirez-Perez, Annayya R. ...> ;Endocrinology. 2019 Dec 1
7 citations
Utility of obesity and metabolic dyslipidemia (a non-insulin based determinate of the metabolic syndrome and insulin resistance) in predicting arterial stiffness.
Annayya R. Aroor, Adam Whaley-Connell, James R. Sowers> ;Journal of Clinical Hypertension. 2019 Aug 1
34 citations
Epithelial sodium channels in endothelial cells mediate diet-induced endothelium stiffness and impaired vascular relaxation in obese female mice.
James R. Sowers, Javad Habibi, Annayya R. Aroor, Yan Yang, Guido Lastra, Michael A. Hill, Adam Whaley-Connell, Frederic Jaisser, Guanghong Jia> ;Metabolism. 2019 Jul 11
33 citations
Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm.
Neekun Sharma, Rishabh Dev, Anthony M Belenchia, Annayya R. Aroor, Adam Whaley-Connell, Lakshmi Pulakat, Chetan P. Hans> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2019 Feb 1
83 citations
Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management
Yingmei Zhang, Adam Whaley-Connell, James R. Sowers, Jun Ren> ;Pharmacology & Therapeutics. 2018 Nov 1
64 citations
Arterial Stiffness in Hypertension: an Update.
Korshie Dumor, Michael Shoemaker-Moyle, Ravi Nistala, Adam Whaley-Connell> ;Current Hypertension Reports. 2018 Jul 4
10 citations
Diabetes and Hypertension: Clinical Update.
Darshan Khangura, L. Romayne Kurukulasuriya, Adam Whaley-Connell, James R. Sowers> ;American Journal of Hypertension. 2018 Apr 13
5 citations
Treatment of Diabetic Kidney Disease With Hypertension Control and Renin Angiotensin System Inhibition
Vikram Patney, Kunal Chaudhary, Adam Whaley-Connell> ;Advances in Chronic Kidney Disease. 2018 Mar 1
37 citations
Enhanced endothelium epithelial sodium channel signaling prompts left ventricular diastolic dysfunction in obese female mice
Guanghong Jia, Javad Habibi, Annayya R. Aroor, Michael A. Hill, Vincent G. DeMarco, Li E. Lee, Lixin Ma, Brady J. Barron, Adam Whaley-Connell, James R. Sowers> ;Metabolism. 2018 Jan 1
54 citations
Insulin Resistance in Kidney Disease: Is There a Distinct Role Separate from That of Diabetes or Obesity?
Adam Whaley-Connell, James R. Sowers> ;Cardiorenal Medicine. 2018 Jan 1
433 citations
Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease
Guanghong Jia, Adam Whaley-Connell, James R. Sowers> ;Diabetologia. 2018 Jan 1
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Authored Content

Treatment of Diabetic Kidney Disease with Hypertension Control and Renin Angiotensin System InhibitionMarch 2018
Treatment of Diabetic Kidney Disease with Hypertension Control and Renin Angiotensin System InhibitionMarch 2018