AgataMariaSmogorzewskaMDPhD

PubMed

• RTF2 controls replication repriming and ribonucleotide excision at the replisome.
  Brooke A Conti, Penelope D Ruiz, Cayla Broton, Nicolas J Blobel, Molly C Kottemann, Sunandini Sridhar, Francis P Lach, Tom F Wiley, Nanda K Sasi, Thomas Carroll, Agata...> ;Nature Communications. 2024 Mar 2
• FANCA c.3624C>T (p.Ser1208=) is a hypomorphic splice variant associated with delayed onset of Fanconi anemia.
  Lach, F., Donovan, F., Maxwell, R., Rosenberg, A., MacMillan, M., Wagner, J., Auerbach, A., Smogorzewska, A., Chandrasekharappa, S., Ramanagoudr-Bhojappa, R., Tryon, R.> ;Blood Advances. 2024 Feb 27
• Temporary HMCES-DNA cross-link prevents permanent DNA damage.
  Penelope D Ruiz, Agata Smogorzewska> ;Cell Reports. 2024 Jan 23
• 22 citations
  Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer.
  Andrew L H Webster, Mathijs A Sanders, Krupa Patel, Ralf Dietrich, Raymond J Noonan, Francis P Lach, Ryan R White, Audrey Goldfarb, Kevin Hadi, Matthew M Edwards, Fran...> ;Nature. 2022 Dec 1
• 5 citations
  Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation.
  Madison Caballero, Tiffany Ge, Ana Rita Rebelo, Seungmae Seo, Sean Kim, Kayla Brooks, Michael Zuccaro, Radhakrishnan Kanagaraj, Dan Vershkov, Dongsung Kim, Agata Smogo...> ;Human Molecular Genetics. 2022 Aug 25
• 8 citations
  The structure-specific endonuclease complex SLX4-XPF regulates Tus-Ter-induced homologous recombination.
  Rajula Elango, Arvind Panday, Francis P Lach, Nicholas A Willis, Kaitlin Nicholson, Erin E Duffey, Agata Smogorzewska, Ralph Scully> ;Nature Structural & Molecular Biology. 2022 Aug 1
• 13 citations
  Treatment of Fanconi Anemia-Associated Head and Neck Cancer: Opportunities to Improve Outcomes.
  Rex H. Lee, Hyunseok Kang, Sue S. Yom, Agata Smogorzewska, Daniel Johnson, Jennifer R. Grandis> ;Clinical Cancer Research. 2021 May 27
• 13 citations
  Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia.
  Zhaolin Yang, Xiaoli S. Wu, Yiliang Wei, Sofya A. Polyanskaya, Shruti V. Iyer, Moonjung Jung, Francis P. Lach, Emmalee R. Adelman, Olaf Klingbeil, Joseph P. Milazzo, M...> ;Cancer Discovery. 2021 Apr 23
• 4 citations
  Endogenous formaldehyde destroys blood stem cells
  Moonjung Jung, Agata Smogorzewska> ;Blood. 2021 Apr 15
• 40 citations
  CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy
  Simona Giunta, Solène Hervé, Ryan R. White, Therese Wilhelm, Marie Dumont, Andrea Scelfo, Riccardo Gamba, Cheng Kit Wong, Giulia Rancati, Agata Smogorzewska, Hironori ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Mar 9
• 7 citations
  Esophageal cancer as initial presentation of Fanconi anemia in patients with a hypomorphic FANCA variant.
  Francis P. Lach, Sonia Singh, Kimberly A. Rickman, Penelope D. Ruiz, Raymond J. Noonan, Kenneth B. Hymes, Mark D. DeLacure, Jennifer A. Kennedy, Settara C. Chandrasekh...> ;Cold Spring Harbor Molecular Case Studies. 2020 Dec 17
• 4 citations
  Comparison of the clinical phenotype and haematological course of siblings with Fanconi anaemia.
  Moonjung Jung, Parinda A. Mehta, Caroline S. Jiang, Rasim Ozgur Rosti, Gabriel Usleaman, Joel Correa da Rosa, Francis P. Lach, Erica Goodridge, Arleen D. Auerbach, Ste...> ;British Journal of Haematology. 2021 Jun 1
• 5 citations
  Suppression of non-homologous end joining does not rescue DNA repair defects in Fanconi anemia patient cells.
  Supawat Thongthip, Brooke A. Conti, Francis P. Lach, Agata Smogorzewska> ;Cell Cycle. 2020 Aug 30
• 17 citations
  Mechanisms of direct replication restart at stressed replisomes.
  Brooke A. Conti, Agata Smogorzewska> ;DNA Repair. 2020 Aug 16
• 2 citations
  A homozygous missense variant in UBE2T is associated with a mild Fanconi anemia phenotype.
  Laura Schultz-Rogers, Francis P. Lach, Kimberly A. Rickman, Alejandro Ferrer, Abhishek A. Mangaonkar, Tanya L. Schwab, Christopher T. Schmitz, Karl J. Clark, Nikita R....> ;Haematologica. 2020 Jul 9
• 39 citations
  Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links
  Kimberly A. Rickman, Raymond J. Noonan, Francis P. Lach, Sunandini Sridhar, Anderson T. Wang, Avinash Abhyankar, Athena L. Huang, Michael J. Kelly, Arleen D. Auerbach,...> ;Genes & Development. 2020 Jun 1
• 19 citations
  Association of clinical severity with FANCB variant type in Fanconi anemia.
  Moonjung Jung, Ramanagouda Ramanagoudr-Bhojappa, Sylvie van Twest, Rasim Ozgur Rosti, Vincent J. Murphy, Winnie Tan, Frank X. Donovan, Francis P. Lach, Danielle C. Kim...> ;Blood. 2020 Apr 30
• 56 citations
  Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication.
  Daniel Ardeljan, Jared P. Steranka, Chunhong Liu, Zhi Li, Martin S. Taylor, Lindsay M. Payer, Mikhail Gorbounov, Jacob S. Sarnecki, Vikram Deshpande, Ralph H. Hruban, ...> ;Nature Structural & Molecular Biology. 2020 Feb 1
• 9 citations
  A founder variant in the South Asian population leads to a high prevalence of FANCL Fanconi anemia cases in India
  Frank X. Donovan, Avani Solanki, Minako Mori, Niranjan Chavan, Merin George, Selvaa Kumar C, Yusuke Okuno, Hideki Muramastsu, Kenichi Yoshida, Akira Shimamoto, Akifumi...> ;Human Mutation. 2020 Jan 1
• 101 citations
  Advances in understanding DNA processing and protection at stalled replication forks.
  Kimberly A. Rickman, Agata Smogorzewska> ;The Journal of Cell Biology. 2019 Apr 1
• 96 citations
  Chromosome instability syndromes
  A. Malcolm R. Taylor, Cynthia Rothblum-Oviatt, Nathan A. Ellis, Ian D. Hickson, Stefan Meyer, Thomas O. Crawford, Agata Smogorzewska, Barbara Pietrucha, Corry M.R. Wee...> ;Nature Reviews. Disease Primers. 2018 Feb 1
• 26 citations
  A comprehensive approach to identification of pathogenic FANCA variants in Fanconi anemia patients and their families.
  Danielle C. Kimble, Francis P. Lach, Siobhan Q. Gregg, Frank X. Donovan, Elizabeth K. Flynn, Aparna Kamat, Alice Young, Meghana Vemulapalli, James W. Thomas, James C. ...> ;Human Mutation. 2018 Feb 1
• 23 citations
  Somatic mosaicism of an intragenic FANCB duplication in both fibroblast and peripheral blood cells observed in a Fanconi anemia patient leads to milder phenotype
  Rajalakshmi S. Asur, Danielle C. Kimble, Francis P. Lach, Moonjung Jung, Frank X. Donovan, Aparna Kamat, Raymond J. Noonan, James W. Thomas, Morgan Park, Peter S. Chin...> ;Molecular Genetics & Genomic Medicine. 2018 Jan 1
• 37 citations
  Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.
  Molly C. Kottemann, Brooke A. Conti, Francis P. Lach, Agata Smogorzewska> ;Molecular Cell. 2018 Jan 4
• 1 citations
  Corrigendum: Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program.
  Anna E Mazzucco, Agata Smogorzewska, Chanhee Kang, Ji Luo, Michael R Schlabach, Qikai Xu, Rupesh Patel, Stephen J Elledge> ;Genes & Development. 2017 Nov 15
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Lectures

• Molecular Mechanisms of Bone Marrow Failure 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019