AlainThibaultMD

PubMed

• 1 citations
  The NHance ® Mutation-Equipped Anti-MET Antibody ARGX-111 Displays Increased Tissue Penetration and Anti-Tumor Activity in Advanced Cancer Patients.
  Philippe Aftimos, Christian Rolfo, Sylvie Rottey, Philippe Barthélémy, Christophe Borg, Keunchil Park, Do Youn Oh, Sang We Kim, Natalie De Jonge, Valérie Hanssens, Kar...> ;Biomedicines. 2021 Jun 10
• 37 citations
  Phase I Dose-Escalation Study of the Anti-CD70 Antibody ARGX-110 in Advanced Malignancies
  Philippe Aftimos, Christian Rolfo, Sylvie Rottey, Fritz Offner, D. Bron, Marie Maerevoet, Jean-Charles Soria, Mahan Moshir, Torsten Dreier, Luc van Rompaey, Jean-Marie...> ;Clinical Cancer Research. 2017 Jan 1
• 126 citations
  Phase II Study of R115777, a Farnesyl Transferase Inhibitor, in Myelodysplastic Syndrome
  Razelle Kurzrock, M. Albitar, Jorge E. Cortes, Elihu H. Estey, Stefan Faderl, Guillermo Garcia-Manero, D. A. Thomas, Francis Giles, Mary Ellen Ryback, Alain Thibault, ...> ;Journal of Clinical Oncology. 2004 Apr 1
• 38 citations
  A Phase I trial of the farnesyl protein transferase inhibitor R115777 in combination with gemcitabine and cisplatin in patients with advanced cancer.
  Alex A. Adjei, Gary A. Croghan, Charles Erlichman, Randolph S. Marks, Joel M. Reid, Jeff A. Sloan, Henry C. Pitot, Steven R. Alberts, Richard M. Goldberg, Lorelei J. H...> ;Clinical Cancer Research. 2003 Jul 1
• 166 citations
  Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies
  Jorge E. Cortes, Maher Albitar, Deborah A. Thomas, Francis J. Giles, Razelle Kurzrock, Alain Thibault, Wayne R. Rackoff, Charles A. Koller, Susan O'Brien, Guillermo Ga...> ;Blood. 2003 Mar 1
• 98 citations
  Lipid Metabolism as a Target for Brain Cancer Therapy: Synergistic Activity of Lovastatin and Sodium Phenylacetate Against Human Glioma Cells
  Premakala Prasanna, Alain Thibault, Lei Liu, Dvorit Samid> ;Journal of Neurochemistry. 2002 Nov 23
• 364 citations
  Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory corre...
  Judith E. Karp, Jeffrey E. Lancet, Scott H. Kaufmann, David W. End, John J. Wright, Kees Bol, Ivan Horak, Michael L. Tidwell, Jane L. Liesveld, Timothy Kottke, Dawn An...> ;Blood. 2001 Jun 1
• 45 citations
  Peroxisome Proliferator-activated Receptor γ as a Novel Target in Cancer Therapy: Binding and Activation by an Aromatic Fatty Acid with Clinical Antitumor Activity
  Dvorit Samid, Michelle Wells, Marianne E. Greene, Weiyin Shen, Colin N. A. Palmer, Alain Thibault> ;Clinical Cancer Research. 2000 Mar 1
• 18 citations
  Phenylbutyrate Induces Cell Differentiation and Modulates Epstein-Barr Virus Gene Expression in Burkitt’s Lymphoma Cells
  Matia Bar-Ner, Alain Thibault, Maria Tsokos, Ian T. Magrath, Dvorit Samid> ;Clinical Cancer Research. 1999 Jun 1
• 8 citations
  A phase II study of 5-aza-2'deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer.
  A Thibault, W D Figg, R C Bergan, R M Lush, C E Myers, A Tompkins, E Reed, D Samid> ;Tumori. 1998 Jun 10
• 2 citations
  Meeting summary: Workshop conference on endocrine therapy of advanced prostate cancer, airlie house, November 3-4, 1996.
  Richard J. Santen, Alain Thibault, Charles E. Myers, Leland W.K. Chung> ;Urologic Oncology. 1997 Jan 1
• 25 citations
  The differentiating agent phenylacetate increases prostate-specific antigen production by prostate cancer cells
  Ron M. Walls, Alain Thibault, Lei Liu, Christopher G Wood, James M. Kozlowski, William D. Figg, Maureen Sampson, Ronald J. Elin, Dvorit Samid> ;The Prostate. 1996 Sep 1
• 28 citations
  Vulnerability of multidrug-resistant tumor cells to the aromatic fatty acids phenylacetate and phenylbutyrate.
  Sonsoles Shack, Alexandra C. Miller, Lei Liu, Premakala Prasanna, Alain Thibault, Dvorit Samid> ;Clinical Cancer Research. 1996 May 1
• 314 citations
  Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer
  Alain Thibault, Dvorit Samid, Anne Tompkins, William D. Figg, Michael R. Cooper, Raymond J. Hohl, Jane B. Trepel, Bertrand C. Liang, Nicholas J. Patronas, David Venzon...> ;Clinical Cancer Research. 1996 Mar 1
• 59 citations
  Antitumor activity of suramin in hormone‐refractory prostate cancer controlling for hydrocortisone treatment and flutamide withdrawal as potentially confounding variables
  Nancy A. Dawson, Michael R. Cooper, William D. Figg, Donna Headlee, Alain Thibault, Raymond C. Bergan, Seth M. Steinberg, Edward A. Sausville, Charles E. Myers, Oliver...> ;Cancer. 1995 Aug 1
• 101 citations
  Phase I study of phenylacetate administered twice daily to patients with cancer
  Alain Thibault, Dvorit Samid, Michael R. Cooper, William D. Figg, Anne Tompkins, Nicholas J. Patronas, Donna Headlee, David R. Kohler, David Venzon, Charles E. Myers> ;Cancer. 1995 Jun 15
• 36 citations
  A phase I study of the somatostatin analogue somatuline in patients with metastatic hormone‐refractory prostate cancer
  William D. Figg, Alain Thibault, Michael R. Cooper, Robert L. Reid, Donna Headlee, Nancy A. Dawson, David R. Kohler, Eddie Reed, Oliver Sartor> ;Cancer. 1995 Apr 15
• 47 citations
  Disposition of Phenylbutyrate and Its Metabolites, Phenylacetate and Phenylacetylglutamine
  Stephen C. Piscitelli, Alain Thibault, William D. Figg, Anne Tompkins, Donna Headlee, Ronald Lieberman, Dvorit Samid, Charles E. Myers> ;Journal of Clinical Pharmacology. 1995 Apr 1
• 70 citations
  Prostate specific antigen decline following the discontinuation of flutamide in patients with stage D2 prostate cancer
  William D. Figg, Oliver Sartor, Michael R. Cooper, Alain Thibault, Raymond C. Bergan, Nancy A. Dawson, Eddie Reed, Charles E. Myers> ;The American Journal of Medicine. 1995 Apr 1
• 23 citations
  Acute renal toxicity associated with suramin in the treatment of prostate cancer.
  William D. Figg, Michael R. Cooper, Alain Thibault, Donna Headlee, Jeffrey S. Humphrey, Raymond C. Bergan, Eddie Reed, Oliver Sartor> ;Cancer. 1994 Sep 1
• 10 citations
  In vitro antitumor effect of hydroxyurea on hormone-refractory prostate cancer cells and its potentiation by phenylbutyrate.
  William D. Figg, Ronald G. Walls, Michael R. Cooper, Alain Thibault, Oliver Sartor, Natalie A. McCall, Charles E. Myers, Dvorit Samid> ;Anti-Cancer Drugs. 1994 Jun 1
• 40 citations
  Growth inhibition, tumor maturation, and extended survival in experimental brain tumors in rats treated with phenylacetate.
  Zvi Ram, Dvorit Samid, Stuart Walbridge, Eric M. Oshiro, John J. Viola, Jung-Hwa Tao-Cheng, Sonsoles Shack, Alain Thibault, Charles E. Myers, Edward H. Oldfield> ;Cancer Research. 1994 Jun 1
• 4 citations
  Hypothyroidism associated with aminoglutethimide in patients with prostate cancer.
  William D. Figg, Alain Thibault, A. Oliver Sartor, David A. Mays, Donna Headlee, Karim A. Calis, Michael R. Cooper> ;Archives of Internal Medicine. 1994 May 9
• 135 citations
  A Phase I and Pharmacokinetic Study of Intravenous Phenylacetate in Patients with Cancer
  Alain Thibault, Michael R. Cooper, William D. Figg, David Venzon, A. Oliver Sartor, Anne Tompkins, Maribeth S. Weinberger, Donna Headlee, Natalie A. McCall, Dvorit Sam...> ;Cancer Research. 1994 Apr 1
• 11 citations
  Assay of the antiangiogenic compound TNP-470, and one of its metabolites, AGM-1883, by reversed-phase high-performance liquid chromatography in plasma
  William D. Figg, Herman J.C. Yeh, Alain Thibault, James M. Pluda, Fumio Itoh, Robert Yarchoan, Michael R. Cooper> ;Journal of Chromatography. 1994 Feb 11
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