AlanLeighGoldinMD

Other MD/DO • Irvine, CA

Professor, Microbiology & Molecular Genetics, University of California, Irvine, School of Medicine

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Office
Univ Ca Irvine Micro Mole
240 Med Sci L Bld B
Irvine, CA 92697
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Education & Training

University of Michigan Medical SchoolClass of 1983

Publications & Presentations

PubMed

7 citations
Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model.
Jennifer C. Wong, Steven F. Grieco, Karoni Dutt, Lujia Chen, Jacquelyn T. Thelin, George Andrew S Inglis, Shangrila Parvin, Sandra M. Garraway, Xiangmin Xu, Alan L. Go...> ;Neuropsychopharmacology. 2021 Mar 3
Molecular charge associated with antiarrhythmic actions in a series of amino-2-cyclohexyl ester derivatives
Michael K. Pugsley, Sandro L. Yong, Alan L. Goldin, Eric S. Hayes, Michael J A Walker> ;European Journal of Pharmacology. 2019 Feb 5
1 citations
Pharmacological and toxicological activity of RSD921, a novel sodium channel blocker.
Michael J A Walker, Eric S. Hayes, David A. Saint, G. Adaikan, Shlomo Abraham, Alan L. Goldin, G.N. Beatch, Bernard A. MacLeod, Richard A. Wall, Michael K. Pugsley> ;Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2018 Oct 1
30 citations
Early-life febrile seizures worsen adult phenotypes in Scn1a mutants.
Stacey B. B. Dutton, Karoni Dutt, Ligia A. Papale, Sandra L. Helmers, Alan L. Goldin, Andrew Escayg> ;Experimental Neurology. 2017 Jul 1
63 citations
Regulation of Thalamic and Cortical Network Synchrony by Scn8a.
Christopher D. Makinson, Brian S. Tanaka, Jordan M. Sorokin, Jennifer C. Wong, Catherine A. Christian, Alan L. Goldin, Andrew Escayg, John R. Huguenard> ;Neuron. 2017 Mar 8
94 citations
SCN8A encephalopathy: Research progress and prospects
Miriam H. Meisler, Guy Helman, Michael F. Hammer, Brandy E. Fureman, William D. Gaillard, Alan L. Goldin, Shinichi Hirose, Atsushi Ishii, Barbara Kroner, Christoph Los...> ;Epilepsia. 2016 Jul 1
17 citations
An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior
Christopher D. Makinson, Karoni Dutt, Frank G. Lin, Ligia A. Papale, Anupama Shankar, Arthur J. Barela, Robert C. Liu, Alan L. Goldin, Andrew Escayg> ;Experimental Neurology. 2016 Jan 1
Complex genetic interactions in a mouse model of absence epilepsy.
Alan L. Goldin, Andrew Escayg> ;Epilepsy Currents. 2015 Jan 1
21 citations
The Riluzole Derivative 2-Amino-6-trifluoromethylthio-benzothiazole (SKA-19), a Mixed KCa2 Activator and NaV Blocker, is a Potent Novel Anticonvulsant
Nichole Coleman, Hai M. Nguyen, Zhengyu Cao, Brandon M. Brown, David Paul Jenkins, Dorota Zolkowska, Yi-Je Chen, Brian S. Tanaka, Alan L. Goldin, Michael A. Rogawski, ...> ;Neurotherapeutics. 2015 Jan 1
3 citations
Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels.
Rong Gao, Yuzhe Du, Lingxin Wang, Yoshiko Nomura, Gul Satar, Dalia Gordon, Michael Gurevitz, Alan L. Goldin, Ke Dong> ;Neuroscience. 2014 May 30
34 citations
Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance
Christopher D. Makinson, Brian S. Tanaka, Tyra Lamar, Alan L. Goldin, Andrew Escayg> ;Neurobiology of Disease. 2014 Aug 1
47 citations
Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics.
Maria I. Lioudyno, A. M. Birch, Brian S. Tanaka, Yuri Sokolov, Alan L. Goldin, K G Chandy, James E. Hall, Michael T. Alkire> ;The Journal of Neuroscience. 2013 Oct 9
51 citations
Modulation of voltage-gated K+ channels by the sodium channel β1 subunit
Hai M. Nguyen, Haruko Miyazaki, Naoto Hoshi, Brian J. Smith, Nobuyuki Nukina, Alan L. Goldin, K. George Chandy> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov 6
19 citations
Substitutions in the Domain III Voltage-sensing Module Enhance the Sensitivity of an Insect Sodium Channel to a Scorpion β-Toxin
Weizhong Song, Yuzhe Du, Zhiqi Liu, Ningguang Luo, Michael Turkov, Dalia Gordon, Michael Gurevitz, Alan L. Goldin, Ke Dong> ;The Journal of Biological Chemistry. 2011 May 6
261 citations
Sodium channel SCN1A and epilepsy: mutations and mechanisms.
Andrew Escayg, Alan L. Goldin> ;Epilepsia. 2010 Sep 1
16 citations
Sodium channel carboxyl-terminal residue regulates fast inactivation.
Hai M. Nguyen, Alan L. Goldin> ;The Journal of Biological Chemistry. 2010 Mar 19
168 citations
Altered Function of the SCN1A Voltage-gated Sodium Channel Leads to γ-Aminobutyric Acid-ergic (GABAergic) Interneuron Abnormalities
Melinda S. Martin, Karoni Dutt, Ligia A. Papale, Céline Dubé, Stacey B. B. Dutton, Georgius de Haan, Anupama Shankar, Sergio Tufik, Miriam H. Meisler, Tallie Z. Baram,...> ;The Journal of Biological Chemistry. 2010 Mar 26
78 citations
A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation
Bin Tang, Karoni Dutt, Ligia A. Papale, Raffaella Rusconi, Anupama Shankar, Jessica Ezzell Hunter, Sergio Tufik, Frank H. Yu, William A. Catterall, Massimo Mantegazza,...> ;Neurobiology of Disease. 2009 Jul 1
12 citations
Role of the terminal domains in sodium channel localization.
Annie Lee, Alan L. Goldin> ;Channels. 2009 Jun 30
13 citations
Role of the amino and carboxy termini in isoform‐specific sodium channel variation
Annie Lee, Alan L. Goldin> ;The Journal of Physiology. 2008 Aug 15
1 citations
Alternative polyadenylation signals in the 3′ non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression
Gwendolyn M. Jang, Brian S. Tanaka, George A. Gutman, Alan L. Goldin, Bert L. Semler> ;Gene. 2008 Jan 31
19 citations
Semliki Forest virus vectors with mutations in the nonstructural protein 2 gene permit extended superinfection of neuronal and non-neuronal cells.
Markus U. Ehrengruber, Alan L. Goldin> ;Journal of Neurovirology. 2007 Jan 1
60 citations
An Epilepsy Mutation in the Sodium Channel SCN1A That Decreases Channel Excitability
Arthur J. Barela, Salina P. Waddy, Jay G. Lickfett, Jessica Ezzell Hunter, Aimee Anido, Sandra L. Helmers, Alan L. Goldin, Andrew Escayg> ;The Journal of Neuroscience. 2006 Aug 1
1308 citations
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.
William A Catterall, Alan L Goldin, Stephen G Waxman> ;Pharmacological Reviews. 2005 Dec 1
169 citations
International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.
William A Catterall, Edward Perez-Reyes, Terrance P Snutch, Joerg Striessnig> ;Pharmacological Reviews. 2005 Dec 1
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Grant Support

SCN8A And Seizure ResistanceNational Institute Of Neurological Disorders And Stroke2009–2012
Sodium Channel Mutations That Cause EpilepsyNational Institute Of Neurological Disorders And Stroke2004–2012
Medical Scientist Training ProgramNational Institute Of General Medical Sciences1999–2011
Molecular Basis Of Sodium Channel DiversityNational Institute Of Neurological Disorders And Stroke1989–2002

AlanLeighGoldinMD

Dr. Goldin is on Doximity

Education & Training

Publications & Presentations

Grant Support

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