AlexanderGozmanMD

PubMed

• Pembrolizumab in patients from China with microsatellite instability-high/mismatch repair deficient tumors: KEYNOTE-158.
  Jianming Xu, Yimin Mao, Nong Xu, Yuxian Bai, Dong Wang, Xiaojun Chen, Xianli Yin, Yanhong Deng, Jianwei Yang, Jieqing Zhang, Jie Tang, Yi Huang, Jiayi Li, Suxia Luo, H...> ;Immunotherapy. 2024 Mar 20
• Clinical outcomes for previously treated patients with advanced biliary tract cancer: a meta-analysis.
  Mayur M Amonkar, Lauren A Abderhalden, Grace E Fox, Andrew M Frederickson, Torkia Grira, Alexander Gozman, Usha Malhotra, William Malbecq, Katherine G Akers> ;Future Oncology. 2024 Apr 1
• Biomarker Testing Journey Among Patients with Advanced Solid Tumors and Treatment Patterns by Homologous Recombination Repair Status: A Clinico-Genomic Database Study.
  Shao, C., Ren, Y., Zhou, H., Lee, L., Chen, C., Dettman, E., Cristescu, R., Jin, F., Zhou, W., Gozman, A.> ;Advances in Therapy. 2024 Feb 1
• Association Between Homologous Recombination Repair Biomarkers and Survival in Patients With Solid Tumors.
  Changxia Shao, Yixin Ren, Heng Zhou, Cai Chen, Elisha J Dettman, Liam C Lee, Razvan Cristescu, Alexander Gozman, Fan Jin, Wei Zhou> ;JCO Precision Oncology. 2023 Sep 1
• 49 citations
  A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species
  Hongliang Zong, Alexander Gozman, Eloisi Caldas-Lopes, Tony Taldone, Eric M. Sturgill, Sarah Brennan, Stefan O. Ochiana, Erica M. Gomes-DaGama, Siddhartha Sen, Anna Ro...> ;Cell Reports. 2015 Dec 15
• 17 citations
  Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer.
  Anna Rodina, Tony Taldone, Yanlong Kang, Pallav D. Patel, John Koren, Pengrong Yan, Erica DaGama Gomes, Chenghua Yang, Maulik R. Patel, Liza Shrestha, Stefan O. Ochian...> ;ACS Chemical Biology. 2014 Aug 15
• 41 citations
  Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein...
  Yanlong Kang, Tony Taldone, Hardik J. Patel, Pallav D. Patel, Anna Rodina, Alexander Gozman, Ronnie Maharaj, Cristina C. Clement, Maulik R. Patel, Jeffrey L. Brodsky, ...> ;Journal of Medicinal Chemistry. 2014 Feb 18
• 34 citations
  Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Bind...
  Tony Taldone, Yanlong Kang, Hardik J. Patel, Maulik R. Patel, Pallav D. Patel, Anna Rodina, Y C Patel, Alexander Gozman, Ronnie Maharaj, Cristina C. Clement, Alvin Lu,...> ;Journal of Medicinal Chemistry. 2014 Feb 18
• 76 citations
  Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein
  Anna Rodina, Pallav D. Patel, Yanlong Kang, Y C Patel, Imad Baaklini, Michael J.H. Wong, Tony Taldone, Pengrong Yan, Chenghua Yang, Ronnie Maharaj, Alexander Gozman, M...> ;Chemistry & Biology. 2013 Dec 19
• 31 citations
  Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.
  Iwona E. Wrona, Alexander Gozman, Tony Taldone, Gabriela Chiosis, James S. Panek> ;The Journal of Organic Chemistry. 2010 May 7
• 243 citations
  Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models
  Eloisi Caldas-Lopes, Leandro Cerchietti, James H. Ahn, Cristina C. Clement, Ana I. Robles, Anna Rodina, Kamalika Moulick, Tony Taldone, Alexander Gozman, Yunke Guo, Ni...> ;Proceedings of the National Academy of Sciences of the United States of America. 2009 May 19
• 235 citations
  Targeting Hsp90: small-molecule inhibitors and their clinical development
  Tony Taldone, Alexander Gozman, Ronnie Maharaj, Gabriela Chiosis> ;Current Opinion in Pharmacology. 2008 Aug 1
• HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.
  Marubayashi, S., Koppikar, P., Taldone, T., Abdel-Wahab, O., West, N., Bhagwat, N., Caldas-Lopes, E., Ross, K. N., Gönen, M., Gozman, A., Ahn, J. H., Rodina, A., Ouerf...> ;J Clin Invest. 2010 Oct
• Hsal 1 is related to kidney and gonad development and is expressed in Wilms tumor.
  Ma, Y., Singer, D. B., Gozman, A., Ford, D., Chai, L., Steinhoff, M. M., Hansen, K., Maizel, A. L.> ;Pediatr Nephrol. 2001 Sep
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