AlexanderMarsonMD

PubMed

• 4 citations
  Modular pooled discovery of synthetic knockin sequences to program durable cell therapies.
  Franziska Blaeschke, Yan Yi Chen, Ryan Apathy, Bence Daniel, Andy Y Chen, Peixin Amy Chen, Katalin Sandor, Wenxi Zhang, Zhongmei Li, Cody T Mowery, Tori N Yamamoto, Wi...> ;Cell. 2023 Sep 14
• 7 citations
  CRISPR screens decode cancer cell pathways that trigger γδ T cell detection.
  Murad R Mamedov, Shane Vedova, Jacob W Freimer, Avinash Das Sahu, Amrita Ramesh, Maya M Arce, Angelo D Meringa, Mineto Ota, Peixin Amy Chen, Kristina Hanspers, Vinh Q ...> ;Nature. 2023 Sep 1
• 21 citations
  Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes.
  Dana V Foss, Joseph J Muldoon, David N Nguyen, Daniel Carr, Srishti U Sahu, John M Hunsinger, Stacia K Wyman, Netravathi Krishnappa, Rima Mendonsa, Elaine V Schanzer, ...> ;Nature Biomedical Engineering. 2023 May 1
• 2 citations
  Advancing T cell-based cancer therapy with single-cell technologies.
  Samantha L Bucktrout, Nicholas E Banovich, Lisa H Butterfield, Cansu Cimen-Bozkus, Josephine R Giles, Zinaida Good, Daniel Goodman, Vanessa D Jonsson, Caleb Lareau, Al...> ;Nature Medicine. 2022 Sep 1
• 51 citations
  RASA2 ablation in T cells boosts antigen sensitivity and long-term function.
  Julia Carnevale, Eric Shifrut, Nupura Kale, William A Nyberg, Franziska Blaeschke, Yan Yi Chen, Zhongmei Li, Sagar P Bapat, Morgan E Diolaiti, Patrick O'Leary, Shane V...> ;Nature. 2022 Sep 1
• 53 citations
  High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails.
  Brian R Shy, Vivasvan S Vykunta, Alvin Ha, Alexis Talbot, Theodore L Roth, David N Nguyen, Wolfgang G Pfeifer, Yan Yi Chen, Franziska Blaeschke, Eric Shifrut, Shane Ve...> ;Nature Biotechnology. 2023 Apr 1
• 5 citations
  A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity.
  Christopher P Cook, Mark Taylor, Yale Liu, Ralf Schmidt, Andrew Sedgewick, Esther Kim, Ashley Hailer, Jeffrey P North, Paymann Harirchian, Hao Wang, Sakeen W Kashem, Y...> ;Cell Reports. Medicine. 2022 Aug 16
• 23 citations
  Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks.
  Jacob W Freimer, Oren Shaked, Sahin Naqvi, Nasa Sinnott-Armstrong, Arwa Kathiria, Christian M Garrido, Amy F Chen, Jessica T Cortez, William J Greenleaf, Jonathan K Pr...> ;Nature Genetics. 2022 Aug 1
• 82 citations
  Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence.
  Julia A Belk, Winnie Yao, Nghi Ly, Katherine A Freitas, Yan-Ting Chen, Quanming Shi, Alfredo M Valencia, Eric Shifrut, Nupura Kale, Kathryn E Yost, Connor V Duffy, Ben...> ;Cancer Cell. 2022 Jul 11
• 11 citations
  Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling.
  Jeffrey R Johnson, David C Crosby, Judd F Hultquist, Andrew P Kurland, Prithy Adhikary, Donna Li, John Marlett, Justine Swann, Ruth Hüttenhain, Erik Verschueren, Tasha...> ;Cell Reports. 2022 Apr 12
• 4 citations
  Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression.
  James R Byrnes, Amy M Weeks, Eric Shifrut, Julia Carnevale, Lisa Kirkemo, Alan Ashworth, Alexander Marson, James A Wells> ;Molecular & Cellular Proteomics. 2022 Apr 1
• 73 citations
  Obesity alters pathology and treatment response in inflammatory disease.
  Sagar P Bapat, Caroline Whitty, Cody T Mowery, Yuqiong Liang, Arum Yoo, Zewen Jiang, Michael C Peters, Ling-Juan Zhang, Ian Vogel, Carmen Zhou, Vinh Q Nguyen, Zhongmei...> ;Nature. 2022 Apr 1
• 23 citations
  A functional map of HIV-host interactions in primary human T cells.
  Joseph Hiatt, Judd F Hultquist, Michael J McGregor, Mehdi Bouhaddou, Ryan T Leenay, Lacy M Simons, Janet M Young, Paige Haas, Theodore L Roth, Victoria Tobin, Jason A ...> ;Nature Communications. 2022 Apr 1
• 13 citations
  Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage.
  Iulia Rusu, Elvira Mennillo, Jared L Bain, Zhongmei Li, Xiaofei Sun, Kimberly M Ly, Yenny Y Rosli, Mohammad Naser, Zunqiu Wang, Rommel Advincula, Philip Achacoso, Ling...> ;The Journal of Clinical Investigation. 2022 Mar 1
• 1 citations
  ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8T Cell Effector and Memory Responses.
  Jun Hyung Sin, Sujit Kashyap, Dante Acenas, Jessica T Cortez, James Lee, Alexander Marson, Mehrdad Matloubian, Michael R Waterfield> ;Journal of Immunology. 2022 Mar 1
• 13 citations
  CRISPR-Cas9-mediated nuclear transport and genomic integration of nanostructured genes in human primary cells.
  Enrique Lin-Shiao, Wolfgang G Pfeifer, Brian R Shy, Mohammad Saffari Doost, Evelyn Chen, Vivasvan S Vykunta, Jennifer R Hamilton, Elizabeth C Stahl, Diana M Lopez, Cin...> ;Nucleic Acids Research. 2022 Feb 22
• 28 citations
  CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.
  Dan Liu, Lihui Duan, Lauren B Rodda, Erick Lu, Ying Xu, Jinping An, Longhui Qiu, Fengchun Liu, Mark R Looney, Zhiyong Yang, Christopher D C Allen, Zhongmei Li, Alexand...> ;Science. 2022 Feb 11
• 90 citations
  CRISPR activation and interference screens decode stimulation responses in primary human T cells.
  Ralf Schmidt, Zachary Steinhart, Madeline Layeghi, Jacob W Freimer, Raymund Bueno, Vinh Q Nguyen, Franziska Blaeschke, Chun Jimmie Ye, Alexander Marson> ;Science. 2022 Feb 4
• 9 citations
  Robust T cell activation requires an eIF3-driven burst in T cell receptor translation.
  Dasmanthie De Silva, Lucas Ferguson, Grant H Chin, Benjamin E Smith, Ryan A Apathy, Theodore L Roth, Franziska Blaeschke, Marek Kudla, Alexander Marson, Nicholas T Ing...> ;Elife. 2021 Dec 31
• 15 citations
  PICS2: Next-generation fine mapping via probabilistic identification of causal SNPs.
  Kimberly E. Taylor, K. Mark Ansel, Alexander Marson, Lindsey A. Criswell, Kyle Kai-How Farh> ;Bioinformatics. 2021 Sep 29
• 26 citations
  Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients
  Carole Le Coz, David N. Nguyen, Chun Su, Brian Nolan, Amanda V. Albrecht, Suela Xhani, Di Sun, Benjamin Demaree, Piyush Pillarisetti, Caroline Khanna, Francis Wright, ...> ;The Journal of Experimental Medicine. 2021 Jul 5
• 6 citations
  Genome editing to define the function of risk loci and variants in rheumatic disease.
  Yuriy Baglaenko, Dana Macfarlane, Alexander Marson, Peter A. Nigrovic, Soumya Raychaudhuri> ;Nature Reviews. Rheumatology. 2021 Jun 29
• 3 citations
  Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.
  Finn D. Wolfreys, David N. Nguyen, Moriah Sandy, Ying Xu, Jinping An, Zhongmei Li, Alexander Marson, Erick Lu, Jason G. Cyster> ;Science Immunology. 2021 Jun 4
• 74 citations
  Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering
  Jennifer R. Hamilton, Connor A. Tsuchida, David N. Nguyen, Brian R. Shy, E. Riley McGarrigle, Cindy R. Sandoval Espinoza, Daniel Carr, Franziska Blaeschke, Alexander M...> ;Cell Reports. 2021 Jun 1
• 26 citations
  Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins
  Joseph Hiatt, Devin A. Cavero, Michael J. McGregor, Weihao Zheng, Jonathan M. Budzik, Theodore L. Roth, Kelsey M. Haas, David Wu, Ujjwal Rathore, Anke Meyer-Franke, Mo...> ;Cell Reports. 2021 May 11
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Journal Articles

• Reprogramming Human T Cell Function and Specificity with Non-Viral Genome Targeting  
  Neil Romberg, Antoni Ribas, Michael R Lee, Ruby Yu, Gary M Kupfer, Julia Carnevale, Jonathan H Esensten, P Jonathan Li, Han Li, Kevan C Herold, Alexander Marson, Nature
• Author Correction: Discovery of Stimulation-Responsive Immune Enhancers with CRISPR Activation  
  Alexander Marson, Ansuman T Satpathy, Howard Y Chang, Nature
• CRISPR/Cas9-mediated PD-1 Disruption Enhances Anti-Tumor Efficacy of Human Chimeric Antigen Receptor T Cells  
  Alexander Marson, MD, Nature