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Alexander Spira, MD, Oncology, Fairfax, VA

Alexander I Spira MD

Oncology•Fairfax, VA

Cancer Genetics/Cancer Risk Assessment, Hematologic Oncology, Sarcoma, Thoracic Cancer

Virginia Cancer Specialists

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  • 8613 Route 29200Fairfax, VA 22031

  • Phone+1 571-350-8400

  • Fax+1 703-940-8746

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Education & Training

  • Johns Hopkins University
    Johns Hopkins UniversityFellowship, Hematology and Medical Oncology, 2000 - 2003
  • University of Pennsylvania Health System
    University of Pennsylvania Health SystemResidency, Internal Medicine, 1997 - 2000
  • New York University School of Medicine
    New York University School of MedicineClass of 1997

Certifications & Licensure

  • VA State Medical License
    VA State Medical License 2003 - 2028
  • MD State Medical License
    MD State Medical License 2000 - 2003
  • PA State Medical License
    PA State Medical License 1998 - 2000
  • Medical Oncology
    American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

  • CMS Meaningful Use Stage 1 Certification iKnowMed EHR, McKesson, 2012, 2014-2017
  • CMS Meaningful Use Stage 2 Certification iKnowMed EHR, McKesson, 2012, 2014-2017
  • Top Doctors:Washington DC Area Castle Connolly, 2012

Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Differential Regulation of PD-L1 Expression by Immune and Tumor Cells in NSCLC and the Response to Treatment with Atezolizumab (Anti–PD-L1)  
    Alan Sandler, David S Shames, Hartmut Koeppen, Jamie Chaft, Scott N Gettinger, Alexander Spira, Daniel S Chen, Naiyer A Rizvi, David R Spigel, Proceedings of the National Academy of Sciences
  • Brigatinib Versus Crizotinib in ALK-Positive Non–Small-Cell Lung Cancer  
    D Ross Camidge, Scott N Gettinger, Alexander Spira, The New England Journal of Medicine
  • Cell-Free DNA NGS Prediction of Response and Resistance to a 3rd-Generation EGFR Inhibitor  
    Alexander I Spira, Helena A Yu, Clinical Lung Cancer

Abstracts/Posters

  • Safety, Efficacy and Biomarker Analysis of a Phase 1b/2 Study of Onvansertib (ONV), a Polo-like Kinase 1 (PLK1) Inhibitor, in Combination with Low-Dose Cytarabine (LDA...
    Alexander I. Spira, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
  • Interim Futility Analysis of a Phase 2 Study of Loncastuximab Tesirine, a Novel Pyrrolobenzodiazepine-Based Antibody-Drug Conjugate, in Patients with Relapsed or Refra...
    Alexander I. Spira, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

  • The Impact of Immunotherapy on a Community Practice. Integrating Immunotherapy Into Clinical Practice: Changes Over the Past Year (Part 2) 
    2018 ASCO Annual Meeting - Chicago, Illinois - 05/31/2018

Authored Content

  • WCLC 2021: Study Improvements Mean Nothing Without PatientsFebruary 2021
  • Cell-Free DNA NGS Prediction of Response and Resistance to a 3rd-Generation EGFR InhibitorAugust 2018

Press Mentions

  • New Molecular Targets, Technologies, and Cancer Treatments Take Center Stage at the AACR-NCI-EORTC Conference
    New Molecular Targets, Technologies, and Cancer Treatments Take Center Stage at the AACR-NCI-EORTC ConferenceNovember 5th, 2025
  • 16 Physicians and Surgeons from Virginia Cancer Specialists Named as Virginia Business 2025 Top Doctors
    16 Physicians and Surgeons from Virginia Cancer Specialists Named as Virginia Business 2025 Top DoctorsFebruary 11th, 2025
  • Unmet Needs in the Treatment and Management of Non–Small Cell Lung Cancer
    Unmet Needs in the Treatment and Management of Non–Small Cell Lung CancerSeptember 26th, 2024

Professional Memberships

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Dr. Alexander Spira, Dr. Alexander Spira, MD, Dr. A Spira, Dr. Alexander I Spira