AlexisKristineLeonardMD

PubMed

• Hematopoietic stem cell collection for sickle cell disease gene therapy.
  Mitchell J Weiss, Alexis Leonard> ;Current Opinion in Hematology. 2024 May 1
• 1 citations
  A new frontier: FDA approvals for gene therapy in sickle cell disease.
  Alexis Leonard, John F Tisdale> ;Molecular Therapy. 2024 Feb 7
• 2 citations
  Clinical outcomes of children and adolescents with sickle cell disease and COVID-19 infection: A year in review at a metropolitan tertiary pediatric hospital.
  Olufunke Y Martin, Deepika S Darbari, Stefanie Margulies, Robert S Nickel, Alexis Leonard, Barbara Speller-Brown, Brenda Martin, John R Barber, Jennifer Webb, Suvankar...> ;Frontiers in Medicine. 2023 Jan 1
• 7 citations
  Optimizing haematopoietic stem and progenitor cell apheresis collection from plerixafor-mobilized patients with sickle cell disease.
  Akshay Sharma, Alexis Leonard, Kamille West, Jeffrey M Gossett, Naoya Uchida, Sandhya Panch, David Stroncek, Leigh Poston, Salem Akel, Jane S Hankins, Courtney Fitzhug...> ;British Journal of Haematology. 2022 Aug 1
• 9 citations
  Gene Therapy for Hemoglobinopathies: Beta-Thalassemia, Sickle Cell Disease.
  Alexis Leonard, John F Tisdale, Melissa Bonner> ;Hematology/oncology Clinics of North America. 2022 Aug 1
• 7 citations
  Curative therapy for hemoglobinopathies: an International Society for Cell & Gene Therapy Stem Cell Engineering Committee review comparing outcomes, accessibility and ...
  Alexis Leonard, Alice Bertaina, Carmem Bonfim, Sandra Cohen, Susan Prockop, Duncan Purtill, Jaap Jan Boelens, Robert Wynn, Annalisa Ruggeri, Allistair Abraham, Russell...> ;Cytotherapy. 2022 Mar 1
• 8 citations
  CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell disease
  Selami Demirci, Alexis Leonard, Khaled Essawi, John F. Tisdale> ;Molecular Therapy. Methods & Clinical Development. 2021 Oct 1
• 21 citations
  Disease severity impacts plerixafor-mobilized stem cell collection in patients with sickle cell disease
  Alexis Leonard, Akshay Sharma, Naoya Uchida, David F. Stroncek, Sandhya R. Panch, Kamille A. West, Eoghan Molloy, Thomas E. Hughes, Sara Hauffe, Tiffani Taylor, Courtn...> ;Blood Advances. 2021 May 11
• 15 citations
  Preclinical evaluation for engraftment of CD34+ cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models
  Naoya Uchida, Linhong Li, Tina Nassehi, Claire M. Drysdale, Morgan Yapundich, Jackson Gamer, Juan J. Haro-Mora, Selami Demirci, Alexis Leonard, Aylin C. Bonifacino, Al...> ;Cell Reports. Medicine. 2021 Apr 20
• 26 citations
  A pause in gene therapy: Reflecting on the unique challenges of sickle cell disease.
  Alexis Leonard, John F. Tisdale> ;Molecular Therapy. 2021 Mar 19
• Correction to: Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation.
  Selami Demirci, Juan J Haro-Mora, Alexis Leonard, Claire Drysdale, Daniela Malide, Keyvan Keyvanfar, Khaled Essawi, Raul Vizcardo, Naritaka Tamaoki, Nicholas P Restifo...> ;Stem Cell Research & Therapy. 2020 Dec 17
• 33 citations
  Hematopoietic stem cells from pluripotent stem cells: Clinical potential, challenges, and future perspectives.
  Selami Demirci, Alexis Leonard, John F. Tisdale> ;Stem Cells Translational Medicine. 2020 Dec 1
• 40 citations
  BCL11A enhancer-edited hematopoietic stem cells persist in rhesus monkeys without toxicity.
  Selami Demirci, Jing Zeng, Yuxuan Wu, Naoya Uchida, Anne H. Shen, Danilo Pellin, Jackson Gamer, Morgan Yapundich, Claire M. Drysdale, Jasmine Bonanno, Aylin C. Bonifac...> ;The Journal of Clinical Investigation. 2020 Dec 1
• 9 citations
  Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation.
  Selami Demirci, Juan J Haro-Mora, Alexis Leonard, Claire Drysdale, Daniela Malide, Keyvan Keyvanfar, Khaled Essawi, Raul Vizcardo, Naritaka Tamaoki, Nicholas P Restifo...> ;Stem Cell Research & Therapy. 2020 Nov 24
• Safe and efficient peripheral blood stem cell collection in patients with sickle cell disease using plerixafor.
  Naoya Uchida, Alexis Leonard, David Stroncek, Sandhya R Panch, Kamille West, Eoghan Molloy, Thomas E Hughes, Sara Hauffe, Tiffani Taylor, Courtney Fitzhugh, Jane S Han...> ;Haematologica. 2020 Oct 1
• 11 citations
  Genome editing strategies for fetal hemoglobin induction in beta-hemoglobinopathies.
  Selami Demirci, Alexis Leonard, John F. Tisdale> ;Human Molecular Genetics. 2020 Sep 30
• 22 citations
  Curative options for sickle cell disease: haploidentical stem cell transplantation or gene therapy?
  Alexis Leonard, John F. Tisdale, Allistair Abraham> ;British Journal of Haematology. 2020 Feb 7
• 19 citations
  Low-Dose Busulfan Reduces Human CD34+ Cell Doses Required for Engraftment in c-kit Mutant Immunodeficient Mice
  Alexis Leonard, Morgan Yapundich, Tina Nassehi, Jackson Gamer, Claire M. Drysdale, Juan J. Haro-Mora, Selami Demirci, Matthew M. Hsieh, Naoya Uchida, John F. Tisdale> ;Molecular Therapy. Methods & Clinical Development. 2019 Dec 13
• 39 citations
  Bone marrow characterization in sickle cell disease: inflammation and stress erythropoiesis lead to suboptimal CD34 recovery.
  Alexis Leonard, Aylin C. Bonifacino, Venina Marcela Dominical, Min Luo, Juan J. Haro-Mora, Selami Demirci, Naoya Uchida, Francis J. Pierciey, John F. Tisdale> ;British Journal of Haematology. 2019 Jul 1
• 25 citations
  High-Efficiency Lentiviral Transduction of Human CD34+ Cells in High-Density Culture with Poloxamer and Prostaglandin E2.
  Naoya Uchida, Tina Nassehi, Claire M. Drysdale, Jackson Gamer, Morgan Yapundich, Selami Demirci, Juan J. Haro-Mora, Alexis Leonard, Matthew M. Hsieh, John F. Tisdale> ;Molecular Therapy. Methods & Clinical Development. 2019 Jan 25
• 15 citations
  Identification of red blood cell antibodies in maternal breast milk implicated in prolonged hemolytic disease of the fetus and newborn.
  Alexis Leonard, Lauren Hittson Boal, Philippe P. Pary, Y. Delores Mo, Cyril Jacquot, Naomi L.C. Luban, Deepika S. Darbari, Jennifer Webb> ;Transfusion. 2019 Apr 1
• 31 citations
  CRISPR/Cas9 for Sickle Cell Disease: Applications, Future Possibilities, and Challenges.
  Selami Demirci, Alexis Leonard, Juan J. Haro-Mora, Naoya Uchida, John F. Tisdale> ;Advances in Experimental Medicine and Biology. 2019 Jan 1
• 9 citations
  Early initiation of inhaled corticosteroids does not decrease acute chest syndrome morbidity in pediatric patients with sickle cell disease.
  Alexis Leonard, Nihal Godiwala, Nicole Herrera, Robert McCarter, Matthew Sharron, Emily Riehm Meier> ;Blood Cells, Molecules & Diseases. 2018 Jul 1
• 28 citations
  Stem cell transplantation in sickle cell disease: therapeutic potential and challenges faced.
  Alexis Leonard, John F. Tisdale> ;Expert Review of Hematology. 2018 Jun 20
• 24 citations
  Etoposide improves survival in high-grade glioma: A meta-analysis
  Alexis Leonard, Johannes E. A. Wolff> ;Anticancer Research. 2013 Aug 1
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Abstracts/Posters

• Durable and Robust Fetal Globin Induction without Anemia in Rhesus Monkeys Following Autologous Hematopoietic Stem Cell Transplant with BCL11A Erythroid Enhancer Editing
  Alexis Leonard, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

• Safe and Efficient Peripheral Blood Stem Cell Collection in Patients with Sickle Cell Disease Using Plerixafor 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019