AllenMarkSamarelMDProf Med & Physiol

Cardiology • Maywood, IL

William B. Knapp Professor of Medicine and Physiology

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Office
2160 S 1st Ave
Maywood, IL 60153
Phone+1 708-327-2829

Fax+1 708-327-2849
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Education & Training

McGaw Medical Center of Northwestern UniversityFellowship, Cardiovascular Disease, 1982
Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalResidency, Internal Medicine, 1976 - 1979
Harvard Medical SchoolClass of 1976

Certifications & Licensure

IL State Medical License 1979 - 2020
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Publications & Presentations

PubMed

5 citations
Regulation of Focal Adhesion Kinase through a Direct Interaction with an Endogenous Inhibitor
Taylor J. Zak, Yevgeniya E. Koshman, Allen M. Samarel, Seth L. Robia> ;Biochemistry. 2017 Aug 23
12 citations
Inhibition of cAMP-Dependent PKA Activates β2-Adrenergic Receptor Stimulation of Cytosolic Phospholipase A2 via Raf-1/MEK/ERK and IP3-Dependent Ca2+ Signaling in Atria...
Mallikarjuna R. Pabbidi, Xiang Ji, Joshua T. Maxwell, Gregory A. Mignery, Allen M. Samarel, Stephen L. Lipsius> ;Plos One. 2016 Dec 15
Global comparison of phosphoproteins in human and rodent hearts: implications for translational studies of myosin light chain and troponin phosphorylations
Kumar Kotlo, Allen M. Samarel, Hua Yun Chen, Jared Aldstadt, Robert S. Danziger> ;Springerplus. 2016 Jun 21
1 citations
Myocardial infarction sensitizes medial prefrontal cortex to inhibitory effect of locus coeruleus stimulation in rats.
Jaimee Glasgow, Yevgeniya E. Koshman, Allen M. Samarel, Kuei Y. Tseng, Karie E. Scrogin> ;Psychopharmacology. 2016 May 6
25 citations
Connective tissue growth factor regulates cardiac function and tissue remodeling in a mouse model of dilated cardiomyopathy.
Yevgeniya E. Koshman, Mark D. Sternlicht, Taehoon Kim, Christopher P. O'Hara, Christopher A. Koczor, William Lewis, Todd W. Seeley, Kenneth E. Lipson, Allen M. Samarel> ;Journal of Molecular and Cellular Cardiology. 2015 Dec 1
80 citations
PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis.
Hayley Mylroie, Odile Dumont, Andrea Bauer, Clare C. Thornton, John B. G. Mackey, Damien Calay, Shahir S. Hamdulay, Joan R. Choo, Joseph J. Boyle, Allen M. Samarel, An...> ;Cardiovascular Research. 2015 Jun 1
12 citations
Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated c...
Yevgeniya E. Koshman, Miensheng Chu, Taehoon Kim, Olivia A. Kalmanson, Mariam Farjah, Mohit Kumar, William Lewis, David L. Geenen, Pieter P. de Tombe, Paul H. Goldspin...> ;Journal of Molecular and Cellular Cardiology. 2014 Jul 1
39 citations
Focal adhesion signaling in heart failure
Allen M. Samarel> ;Pflugers Archiv. 2014 Feb 12
15 citations
Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation
Christopher A. Koczor, Rebecca A. Torres, Earl Fields, Amy Boyd, Stanley He, Nilamkumar Patel, Eva K. Lee, Allen M. Samarel, William Lewis> ;Physiological Genomics. 2013 Jul 15
38 citations
Detection of differentially methylated gene promoters in failing and nonfailing human left ventricle myocardium using computation analysis
Christopher A. Koczor, Eva K. Lee, Rebecca A. Torres, Amy Boyd, J. David Vega, Karan Uppal, Fan Yuan, Earl Fields, Allen M. Samarel, William Lewis> ;Physiological Genomics. 2013 Jul 15
48 citations
Regulation of Connective Tissue Growth Factor Gene Expression and Fibrosis in Human Heart Failure
Yevgeniya E. Koshman, Nilamkumar Patel, Miensheng Chu, Rekha Iyengar, Taehoon Kim, Çağatay Erşahin, William Lewis, Alain Heroux, Allen M. Samarel> ;Journal of Cardiac Failure. 2013 Apr 1
10 citations
Syndecan-4: A component of the mechanosensory apparatus of cardiac fibroblasts
Allen M. Samarel> ;Journal of Molecular and Cellular Cardiology. 2013 Mar 1
23 citations
Chronic fluoxetine reduces autonomic control of cardiac rhythms in rats with congestive heart failure
Marcus Henze, Ruslan Tiniakov, Allen M. Samarel, Earl W. Holmes, Karie E. Scrogin> ;American Journal of Physiology. Heart and Circulatory Physiology. 2013 Feb 1
57 citations
Talin1 Has Unique Expression versus Talin 2 in the Heart and Modifies the Hypertrophic Response to Pressure Overload
Ana Maria Manso, Ruixia Li, Susan J. Monkley, Nathalia M. Cruz, Shannon Ong, Dieu H. Lao, Yevgeniya E. Koshman, Yusu Gu, Kirk L. Peterson, Ju Chen, E. Dale Abel, Allen...> ;The Journal of Biological Chemistry. 2013 Feb 8
12 citations
Protein kinase Cϵ activity induces anti-inflammatory and anti-apoptotic genes via an ERK1/2- and NF-κB-dependent pathway to enhance vascular protection
Odile Dumont, Hayley Mylroie, Andrea Bauer, Damien Calay, Andrea Sperone, Clare C. Thornton, Shahir S. Hamdulay, Nadira Ali, Joseph J. Boyle, Joan R. Choo, Allen M. Sa...> ;The Biochemical Journal. 2012 Oct 15
5 citations
Contractile Activity Regulates Inducible Nitric Oxide Synthase Expression and NO(i) Production in Cardiomyocytes via a FAK-Dependent Signaling Pathway.
Miensheng Chu, Yevgeniya E. Koshman, Rekha Iyengar, Taehoon Kim, Brenda Russell, Allen M. Samarel> ;Journal of Signal Transduction. 2012 Jul 26
8 citations
Microdomain heterogeneity in 3D affects the mechanics of neonatal cardiac myocyte contraction.
Matthew W. Curtis, Elisa Budyn, Tejal A. Desai, Allen M. Samarel, Brenda Russell> ;Biomechanics and Modeling in Mechanobiology. 2013 Jan 1
24 citations
Serine 910 Phosphorylation of Focal Adhesion Kinase is Critical for Sarcomere Reorganization In Cardiomyocyte Hypertrophy
Miensheng Chu, Rekha Iyengar, Yevgeniya E. Koshman, Taehoon Kim, Brenda Russell, Jody L. Martin, Alain Heroux, Seth L. Robia, Allen M. Samarel> ;Cardiovascular Research. 2011 Dec 1
11 citations
Focal Adhesion Kinase–Related Nonkinase Inhibits Vascular Smooth Muscle Cell Invasion by Focal Adhesion Targeting, Tyrosine 168 Phosphorylation, and Competition for p1...
Yevgeniya E. Koshman, Miensheng Chu, Steven J. Engman, Taehoon Kim, Rekha Iyengar, Seth L. Robia, Allen M. Samarel> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2011 Nov 1
26 citations
Protein kinase C-ε activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules
Grazyna Nowak, Diana Bakajsova, Allen M. Samarel> ;American Journal of Physiology. Renal Physiology. 2011 Jul 1
14 citations
Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes.
Jose L. Puglisi, Weilong Yuan, Valeriy Timofeyev, Richard E. Myers, Nipavan Chiamvimonvat, Allen M. Samarel, Donald M. Bers> ;American Journal of Physiology. Heart and Circulatory Physiology. 2011 Feb 1
8 citations
FRNK overexpression limits the depth and frequency of vascular smooth muscle cell invasion in a three-dimensional fibrin matrix.
Luke P. Brewster, Areck A. Ucuzian, Eric M. Brey, M. Liwanag, Allen M. Samarel, Howard P. Greisler> ;Journal of Cellular Physiology. 2010 Nov 1
16 citations
FRNK Inhibition of Focal Adhesion Kinase–Dependent Signaling and Migration in Vascular Smooth Muscle Cells
Yevgeniya E. Koshman, Taehoon Kim, Miensheng Chu, Steven J. Engman, Rekha Iyengar, Seth L. Robia, Allen M. Samarel> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2010 Nov 1
85 citations
Mechanical Stress-Induced Sarcomere Assembly for Cardiac Muscle Growth in Length and Width
Brenda Russell, Matthew W. Curtis, Yevgeniya E. Koshman, Allen M. Samarel> ;Journal of Molecular and Cellular Cardiology. 2010 May 1
7 citations
Role of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration
Yevgeniya E. Koshman, Steven J. Engman, Taehoon Kim, Rekha Iyengar, Kyle K. Henderson, Allen M. Samarel> ;Cardiovascular Research. 2010 Feb 1
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Press Mentions

New Approach to Keeping Coronary Arteries Open After AngioplastiesSeptember 30th, 2011

Grant Support

CA Transporter Expression In Hypertrophy &Heart FailureNational Heart, Lung, And Blood Institute2000–2003
Developmental Alterations In Cardiac Protein TurnoverNational Heart, Lung, And Blood Institute1988–2003
Development Alterations In Cardiac Protein TurnoverNational Heart, Lung, And Blood Institute1991–1994
Molecular And Cellular Biology Of Cardiac InterstitiumNational Heart, Lung, And Blood Institute1989–1993
Developmental Alterations In Cardiac Protein TurnoverNational Heart, Lung, And Blood Institute1988–1989
Prophet II Basic WorkstationNational Center For Research Resources1987
Developmental Alterations In Cardiac Protein TurnoverNational Heart, Lung, And Blood Institute1985–1987

AllenMarkSamarelMDProf Med & Physiol

Dr. Samarel is on Doximity

Education & Training

Certifications & Licensure

Publications & Presentations

Press Mentions

Grant Support

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