AlvaroPascual-LeoneMDPhD

Neurophysiology, Dementia & Geriatrics

Medical Director, Deanna and Sidney Wolk Center for Memory Health - Hebrew SeniorLife Professor of Neurology, Harvard Medical School

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Office
Hebrew SeniorLife
1200 Centre St
Boston, MA 02131
Phone+1 617-383-8600

Fax+1 289-271-4398
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Education & Training

University of MinnesotaResidency, Neurology, 1986 - 1990
Albert Ludwigs University Faculty of MedicineClass of 1985

Certifications & Licensure

MA State Medical License 1997 - 2025
MN State Medical License 1988 - 1997
American Board of Psychiatry and Neurology Neurology

Clinical Trials

tDCS and Physical Therapy in Stroke Start of enrollment: 2007 Sep 01
Completed
Not Applicable
Transcranial Magnetic Stimulation to Improve Speech in Aphasia Start of enrollment: 2002 Jul 01
Completed
Phase 1
rTMS for Motor and Mood Symptoms of Parkinson's Disease Start of enrollment: 2010 May 01
Completed
Not Applicable
TMS Measures of Plasticity and Excitatory/Inhibitory Ratio as Biomarkers: R-baclofen Effects in Normal Volunteers Start of enrollment: 2010 Oct 01
Terminated
Phase 1
Effects of a Combined Transcranial Magnetic Stimulation (TMS) and Cognitive Training in Alzheimer Patients Start of enrollment: 2010 Dec 01
Completed
Not Applicable
Therapeutic Efficacy of Transcranial Magnetic Stimulation in Schizophrenia Start of enrollment: 2012 Feb 01
Completed
Not Applicable
Effect of NeuroAD on the Cognitive Function of Alzheimer Patients Start of enrollment: 2013 Oct 01
Completed
Not Applicable
Transcranial Magnetic Stimulation in Spino-Cerebellar Ataxia Start of enrollment: 2013 Sep 01
Completed
Not Applicable
Effect of Modulating Gamma Oscillations Using tACS Start of enrollment: 2018 Aug 02
Completed
Not Applicable
Temporal Interference Brain Stimulation Start of enrollment: 2019 Sep 19
Active, not recruiting
Not Applicable
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Publications & Presentations

PubMed

Use of Lecanemab for Patients With Cardiovascular Disease: The Challenge of Uncertainty.
Darae Ko, Alvaro Pascual-Leone, Sachin J Shah> ;JAMA. 2024 Apr 2
Multichannel tDCS with Advanced Targeting for Major Depressive Disorder: A Tele-Supervised At-Home Pilot Study.
Giulio Ruffini, Ricardo Salvador, Davide Cappon, Francesca Castaldo, Thais Baleeiro, Alvaro Pascual-Leone> ;Medrxiv. 2024 Mar 4
Clinical classification of memory and cognitive impairment with multimodal digital biomarkers.
Banks, R., Higgins, C., Greene, B., Jannati, A., Gomes-Osman, J., Tobyne, S., Bates, D., Pascual-Leone, A.> ;Alzheimer's & Dementia. 2024 Feb 23
Functional brain connectivity prior to the COVID-19 outbreak predicts mental health trajectories during two years of pandemic.
María Cabello-Toscano, Lídia Vaqué-Alcázar, Ivet Bayes-Marin, Gabriele Cattaneo, Javier Solana-Sánchez, Lídia Mulet-Pons, Nuria Bargalló, Josep M Tormos, Alvaro Pascua...> ;Psychiatry and Clinical Neurosciences. 2024 Apr 1
Harnessing Placebo Effects for the Treatment of Functional Cognitive Disorder: A Feasibility Pilot Study.
Cappon, D., Santarnecchi, E., Burke, M., Perez, D., Pascual-Leone, A.> ;The Journal of Neuropsychiatry and Clinical Neurosciences. 2024 Feb 12
Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer's disease, Alzheimer's disease-related dementias, and oth...
Sandeep R Pagali, Rakesh Kumar, Allison M LeMahieu, Michael R Basso, Bradley F Boeve, Paul E Croarkin, Jennifer R Geske, Leslie C Hassett, John Huston 3rd, Simon Kung,...> ;International Psychogeriatrics. 2024 Feb 8
Transcranial random noise stimulation to augment hand function in individuals with moderate-to-severe stroke: A pilot randomized clinical trial.
Amit Sethi, Alvaro Pascual-Leone, Emiliano Santarnecchi, Ghaleb Almalki, Chandramouli Krishnan> ;Restorative Neurology and Neuroscience. 2023 Jan 1
Digital Clock and Recall is superior to the Mini-Mental State Examination for the detection of mild cognitive impairment and mild dementia.
Jannati, A., Toro-Serey, C., Gomes-Osman, J., Banks, R., Ciesla, M., Showalter, J., Bates, D., Tobyne, S., Pascual-Leone, A.> ;Alzheimer's Research & Therapy. 2024 Jan 2
Dysexecutive difficulty and subtle everyday functional disabilities: the digital Trail Making Test.
David J Libon, Rod Swenson, Sean Tobyne, Ali Jannati, Daniel Schulman, Catherine C Price, Melissa Lamar, Alvaro Pascual-Leone> ;Frontiers in Neurology. 2024 Jan 1
1 citations
Resting-state EEG signatures of Alzheimer's disease are driven by periodic but not aperiodic changes.
Kopčanová, M., Tait, L., Donoghue, T., Stothart, G., Smith, L., Davila-Perez, P., Fried, P., Benwell, C., Buss, S., Shafi, M., Pascual-Leone, A., Flores-Sandoval, A.> ;Neurobiology of Disease. 2024 Jan 1
Publisher Correction: Non-invasive temporal interference electrical stimulation of the human hippocampus.
Ines R Violante, Ketevan Alania, Antonino M Cassarà, Esra Neufeld, Emma Acerbo, Romain Carron, Adam Williamson, Danielle L Kurtin, Edward Rhodes, Adam Hampshire, Niels...> ;Nature Neuroscience. 2023 Dec 1
Reliability of resting-state EEG modulation by continuous and intermittent theta burst stimulation of the primary motor cortex: a sham-controlled study.
Andrei Rodionov, Recep A Ozdemir, Christopher S Y Benwell, Peter J Fried, Pierre Boucher, Davide Momi, Jessica M Ross, Emiliano Santarnecchi, Alvaro Pascual-Leone, Mou...> ;Scientific Reports. 2023 Nov 2
1 citations
Heat Waves, Climate Change, and Implications for an Aging Population.
Amir Baniassadi, Lewis A Lipsitz, David Sailor, Alvaro Pascual-Leone, Brad Manor> ;The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2023 Dec 1
16 citations
Non-invasive temporal interference electrical stimulation of the human hippocampus.
Ines R Violante, Ketevan Alania, Antonino M Cassarà, Esra Neufeld, Emma Acerbo, Romain Carron, Adam Williamson, Danielle L Kurtin, Edward Rhodes, Adam Hampshire, Niels...> ;Nature Neuroscience. 2023 Nov 1
Successful aging after elective surgery II: Study cohort description.
Michelle Ward, Tammy T Hshieh, Eva M Schmitt, Steven E Arnold, Michele Cavallari, Bradford C Dickerson, Simon T Dillon, Tamara G Fong, Richard N Jones, Towia A Liberma...> ;Journal of the American Geriatrics Society. 2024 Jan 1
Brain Connectivity Correlates of Cognitive Dispersion in a Healthy Middle-Aged Population: Influence of Subjective Cognitive Complaints.
Lídia Mulet-Pons, Cristina Solé-Padullés, María Cabello-Toscano, Kilian Abellaneda-Pérez, Ruben Perellón-Alfonso, Gabriele Cattaneo, Javier Solana Sánchez, Vanessa Alv...> ;The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences. 2023 Nov 14
1 citations
An Educational Program for Remote Training and Supervision of Home-Based Transcranial Electrical Stimulation: Feasibility and Preliminary Effectiveness.
Davide Cappon, Tim den Boer, Wanting Yu, Nicole LaGanke, Rachel Fox, Marina Brozgol, Jeffrey M Hausdorff, Brad Manor, Alvaro Pascual-Leone> ;Neuromodulation. 2023 Aug 8
Association of Choroid Plexus Volume With Serum Biomarkers, Clinical Features, and Disease Severity in Patients With Frontotemporal Lobar Degeneration Spectrum.
Martina Assogna, Enrico Premi, Stefano Gazzina, Alberto Benussi, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Roberto Gasparotti, Alessandro Padovani, Ehsan Tada...> ;Neurology. 2023 Sep 19
3 citations
Resting-state EEG signatures of Alzheimer's disease are driven by periodic but not aperiodic changes.
Martina Kopčanová, Luke Tait, Thomas Donoghue, George Stothart, Laura Smith, Aimee Arely Flores Sandoval, Paula Davila-Perez, Stephanie Buss, Mouhsin M Shafi, Alvaro P...> ;Biorxiv. 2023 Jun 12
3 citations
Spectral power ratio as a measure of EEG changes in mild cognitive impairment due to Alzheimer's disease: a case-control study.
Aimee A Flores-Sandoval, Paula Davila-Pérez, Stephanie S Buss, Kevin Donohoe, Margaret O'Connor, Mouhsin M Shafi, Alvaro Pascual-Leone, Christopher S Y Benwell, Peter ...> ;Neurobiology of Aging. 2023 Oct 1
Reliability of resting-state EEG modulation by continuous and intermittent theta burst stimulation of the primary motor cortex: A sham-controlled study.
Andrei Rodionov, Recep A Ozdemir, Christopher S Y Benwell, Peter J Fried, Pierre Boucher, Davide Momi, Jessica M Ross, Emiliano Santarnecchi, Alvaro Pascual-Leone, Mou...> ;Biorxiv. 2023 May 12
46 citations
A framework for concepts of reserve and resilience in aging.
Yaakov Stern, Marilyn Albert, Carol A Barnes, Roberto Cabeza, Alvaro Pascual-Leone, Peter R Rapp> ;Neurobiology of Aging. 2023 Apr 1
1 citations
Association of Retrospectively Reported Concussion Symptoms with Objective Cognitive Performance in Former American-Style Football Players.
Roger W Strong, Rachel Grashow, Andrea L Roberts, Eliza Passell, Luke Scheuer, Douglas P Terry, Sarah Cohan, Alvaro Pascual-Leone, Marc G Weisskopf, Ross D Zafonte, La...> ;Archives of Clinical Neuropsychology. 2023 Aug 24
1 citations
Sensorimotor and Frontoparietal Network Connectivity Are Associated With Subsequent Maintenance of Gait Speed and Episodic Memory in Older Adults.
Chun Liang Hsu, Brad Manor, Thomas Travison, Alvaro Pascual-Leone, Lewis A Lipsitz> ;The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2023 Mar 1
3 citations
The age-related contribution of cognitive function to dual-task gait in middle-aged adults in Spain: observations from a population-based study.
Junhong Zhou, Gabriele Cattaneo, Wanting Yu, On-Yee Lo, Natalia A Gouskova, Selma Delgado-Gallén, Maria Redondo-Camós, Goretti España-Irla, Javier Solana-Sánchez, Jose...> ;The Lancet. Healthy Longevity. 2023 Mar 1
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Journal Articles

Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis
Brian J Wainger, Nicholas J Maragakis, Richard Bedlack, Namita A Goyal, Seward B Rutkove, Michael H Rivner, Stephen A Goutman, Shafeeq S Ladha, Elizabeth A Mauricio, R..., JAMA Neurology

Lectures

An Introduction to the Clinical Practice of Transcranial Magnetic Stimulation
Harvard Medical School ,Department Of Continuing Education, Boston, Massachusetts - 6/24/2013
Intensive Course in Transcranial Magnetic Stimulation
Harvard Medical School ,Department Of Continuing Education, Boston, Massachusetts - 6/24/2013
Introduction to Transcranial Direct Current Stimulation in Neuropsychiatric Research
Harvard Medical School, Boston, Massachusetts - 11/3/2012
Intensive Course in Transcranial Magnetic Stimulation
Harvard Medical School, Boston, Massachusetts - 10/29/2012
An Introduction to the Clinical Practice of Transcranial Magnetic Stimulation
Harvard Medical School, Boston, Massachusetts - 10/29/2012
An Introduction to the Clinical Practice of Transcranial Magnetic Stimulation
Harvard Medical School, Boston, Massachusetts - 6/25/2012
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Press Mentions

Results from New Studies Support Role of Digital Tools in Streaming Dementia Detection; Findings to Be Revealed at American Academy of Neurology's Annual MeetingApril 21st, 2023
Study Suggests Strong Sense of Purpose in Life Promotes Cognitive Resilience Among Middle-Aged AdultsApril 19th, 2023
A New Alzheimer’s Drug Is Finally Here – Our Healthcare System Is Far from ReadyApril 13th, 2023
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