AlvinFWellsMDPhD

PubMed

• Relevance of Adalimumab Product Attributes to Patient Experience in the Biosimilar Era: A Narrative Review.
  Jessica R Allegretti, Jessica H Brady, Ann Wicker, Mark Latymer, Alvin Wells> ;Advances in Therapy. 2024 May 1
• Long-Term Efficacy and Safety of Upadacitinib in Patients with Rheumatoid Arthritis: Final Results from the BALANCE-EXTEND Open-Label Extension Study.
  Alan Kivitz, Alvin F Wells, Juan I Vargas, Herbert S B Baraf, Maureen Rischmueller, Justin Klaff, Nasser Khan, Yihan Li, Kyle Carter, Alan Friedman, Patrick Durez> ;Rheumatology and Therapy. 2023 Aug 1
• 3 citations
  Baseline Disease Activity Predicts Achievement of cDAPSA Treatment Targets With Apremilast: Phase III Results in DMARD-naïve Patients With Psoriatic Arthritis.
  Philip J Mease, Arthur Kavanaugh, Alexis Ogdie, Alvin F Wells, Martin Bergman, Dafna D Gladman, Sven Richter, Lichen Teng, Shauna Jardon, Josef S Smolen> ;The Journal of Rheumatology. 2022 Jul 1
• 4 citations
  Telemedicine and psoriatic arthritis: best practices and considerations for dermatologists and rheumatologists.
  Alice B Gottlieb, Alvin F Wells, Merola, J. F., Merola, J. F., Merola, J. F., Joseph F Merola> ;Clinical Rheumatology. 2022 May 1
• 13 citations
  A Molecular Signature Response Classifier to Predict Inadequate Response to Tumor Necrosis Factor-α Inhibitors: The NETWORK-004 Prospective Observational Study
  Stanley N. Cohen, Alvin F. Wells, Jeffrey R. Curtis, Rajat Dhar, Theodore Mellors, Lixia Zhang, Johanna B. Withers, Alex Jones, Susan Dina Ghiassian, Mengran Wang, Eri...> ;Rheumatology and Therapy. 2021 Jun 19
• 4 citations
  Apremilast monotherapy for long-term treatment of active psoriatic arthritis in DMARD-naive patients.
  Alvin F. Wells, Christopher J Edwards, Alan Kivitz, Paul Bird, Benoit Guerette, N. Delev, Maria Paris, L. Teng, Jacob A. Aelion> ;Rheumatology. 2021 Jun 8
• 2 citations
  Efficacy of Long-Term Treatment with Once-Daily Baricitinib 2 mg in Patients with Active Rheumatoid Arthritis: Post Hoc Analysis of Two 24-Week, Phase III, Randomized,...
  Alvin F. Wells, Bochao Jia, Li Xie, Guillermo J. Valenzuela, Edward C. Keystone, Zhanguo Li, Amanda Quebe, Kirstin Griffing, Susan Otawa, Boulos Haraoui> ;Rheumatology and Therapy. 2021 May 24
• 14 citations
  Upadacitinib monotherapy improves patient-reported outcomes in rheumatoid arthritis: results from SELECT-EARLY and SELECT-MONOTHERAPY
  Vibeke Strand, Namita Tundia, Alvin F. Wells, Maya H Buch, Sebastião Cezar Radominski, Heidi S. Camp, Alan Friedman, J. Suboticki, K. Dunlap, Debbie Goldschmidt, Marti...> ;Rheumatology. 2020 Dec 11
• 19 citations
  Immunogenicity of Sarilumab Monotherapy in Patients with Rheumatoid Arthritis Who Were Inadequate Responders or Intolerant to Disease-Modifying Antirheumatic Drugs
  Alvin F. Wells, Janie Parrino, E.K. Mangan, Anne Paccaly, Yong Lin, Christine Xu, Chunpeng Fan, Neil M.H. Graham, Hubert van Hoogstraten, Albert Torri> ;Rheumatology and Therapy. 2019 May 14
• 4 citations
  Baricitinib in Patients with Rheumatoid Arthritis and an Inadequate Response to Conventional Disease-Modifying Antirheumatic Drugs in United States and Rest of World: ...
  Alvin F. Wells, Maria Greenwald, John D. Bradley, Jahangir Alam, Vipin Arora, Cynthia E. Kartman> ;Rheumatology and Therapy. 2018 Apr 21
• 64 citations
  Apremilast monotherapy in DMARD-naive psoriatic arthritis patients: results of the randomized, placebo-controlled PALACE 4 trial
  Alvin F. Wells, Christopher J Edwards, Alan Kivitz, Paul Bird, D. Nguyen, Maria Paris, L. Teng, Jacob A. Aelion> ;Rheumatology. 2018 Jul 1
• 11 citations
  Systematic Literature Review and Meta-analysis of Tumor Necrosis Factor-Alpha Experienced Rheumatoid Arthritis.
  Alvin F. Wells, Jeffrey R. Curtis, Keith A. Betts, K. Douglas, Ella X Du, Arijit Ganguli> ;Clinical Therapeutics. 2017 Aug 1
• 268 citations
  Ixekizumab for the treatment of patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors: results from the 24-week rand...
  Peter Nash, Bruce Kirkham, Masato Okada, Proton Rahman, B. Combe, Gerd Burmester, David H. Adams, Lisa Kerr, Chin Lee, Catherine L Shuler, Mark C. Genovese, Khalid Ahm...> ;Lancet. 2017 Jun 10
• 9 citations
  An assessment of the current treatment landscape for rheumatology patients in Qatar: Recognising unmet needs and moving towards solutions
  Samar Al Emadi, Mohammed Hammoudeh, Mohamed Mounir, Ruediger B Mueller, Alvin F. Wells, Housam Aldeen Sarakbi> ;The Journal of International Medical Research. 2017 Mar 7
• 15 citations
  Changes in Ultrasonographic Vascularity Upon Initiation of Adalimumab Combination Therapy in Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate.
  Gurjit S. Kaeley, Midori J. Nishio, Janak R. Goyal, Daryl K. MacCarter, Alvin F. Wells, Su Chen, Hartmut Kupper, Jasmina Kalabic> ;Arthritis & Rheumatology. 2016 Sep 29
• 27 citations
  Apremilast: a PDE4 inhibitor for the treatment of psoriatic arthritis.
  Hunar Abdulrahim, Samuel Thistleton, Adewale Adebajo, Tim Shaw, Christopher J Edwards, Alvin F. Wells> ;Expert Opinion on Pharmacotherapy. 2015 Apr 17
• 51 citations
  Benefits and risks of low-dose glucocorticoid treatment in the patient with rheumatoid arthritis.
  Arthur Kavanaugh, Alvin F. Wells> ;Rheumatology. 2014 Oct 1
• 11 citations
  A critical evaluation of the role of subcutaneous abatacept in the treatment of rheumatoid arthritis: patient considerations.
  Alvin F. Wells, Nicole Jodat, Michael Schiff> ;Biologics. 2014 Feb 17
• 4 citations
  Integrating health information technology and electronic health records into the management of fibromyalgia.
  Alvin F. Wells, Lesley M. Arnold, Cassandra E. Curtis, L. Jean Dunegan, Charles W. Lapp, Bill McCarberg, Andrew Clair> ;Postgraduate Medicine. 2013 Jul 1
• Proceedings of the 2013 Rheumatology Winter Clinical Symposia.
  Arthur Kavanaugh, Roy Fleischmann, Martin J. Bergman, Eric Ruderman, Orrin Troum, Alvin F. Wells, George Martin, Leonard H. Calabrese, Allan Gibofsky, Vibeke Strand, J...> ;Seminars in Arthritis and Rheumatism. 2013 Jun 1
• Proceedings from the 5th Annual International Society for Musculoskeletal Imaging in Rheumatology Annual Conference.
  Philip G Conaghan, Mikkel Ostergaard, Maria Antonietta D'Agostino, Norman Gaylis, William Arnold, Ewa Olech, Alvin Wells, Charles Peterfy, Judy L Seraphine, Orrin Troum> ;Seminars in Arthritis and Rheumatism. 2013 Feb 1
• Proceedings of the 2012 Rheumatology Winter Clinical Symposia
  Arthur Kavanaugh, George Martin, John J. Cush, Martin J. Bergman, Roy Fleischmann, Orrin Troum, Vibeke Strand, Eric Ruderman, Alvin F. Wells> ;Seminars in Arthritis and Rheumatism. 2012 Jun 1
• 21 citations
  African American patients with gout: efficacy and safety of febuxostat vs allopurinol
  Alvin F. Wells, Patricia A. MacDonald, Solomon Chefo, Robert L. Jackson> ;BMC Musculoskeletal Disorders. 2012 Feb 9
• 19 citations
  Abatacept Plus Methotrexate Provides Incremental Clinical Benefits Versus Methotrexate Alone in Methotrexate-naive Patients with Early Rheumatoid Arthritis Who Achieve...
  Alvin F. Wells, Rene Westhovens, Diane Moniz Reed, Luciana Fanti, Jean-Claude Becker, A Covucci, Edward C. Keystone> ;The Journal of Rheumatology. 2011 Nov 1
• 13 citations
  EMERGING ROLE OF ULTRASONOGRAPHY IN RHEUMATOID ARTHRITIS: OPTIMIZING DIAGNOSIS, MEASURING DISEASE ACTIVITY AND IDENTIFYING PROGNOSTIC FACTORS
  Alvin F. Wells, Richard H. Haddad> ;Ultrasound in Medicine & Biology. 2011 Aug 1
• Join now to see all

Journal Articles

• Uveitis and Arthritis Induced by Systemic Injection of Streptococcal Cell Walls.  
  AF Wells, Geeta Pararajasegaram, Marsha Baldwin, Chang Hsu Yang, Mark Hammer, and Alvin Fox, Investigative Ophthalmology and Visual Science
• Sedimentation Field Flow Fractionation and Gas Chromatography Mass Spectrometry for Characterization of Streptococcal Cell Wall Particles.  
  James Gilbart, AF Wells, Mee H. Hoe, and Alvin Fox, Journal of Chromatography
• Systemic Injection of Group A Streptococcal Peptidoglycan Polysaccharide Complexes Elicits Persistent Neutrophilia and Monocytosis Associated with Polyarthritis in Rats.  
  AF Wells, James A. Hightower, Cheryl D. Parks, Ernesto Kufoy, and Alvin Fox, Infection and Immunity
• Keratoconjunctivitis sicca with associated secondary uveitis elicited in rats after systemic Xylazine/Ketamine anesthesia.  
  Ernesto A. Kufoy, Cheryl D. Parks, AF Wells, A. Pakalnis, and Alvin Fox, Experimental Eye Research
• The Specific Localization of Hyaluronan in Normal and Rejected Kidney Sections: A Possible Marker for Renal Disease.  
  AF Wells, Sten Hellström, Anders Tengblad, Erik Larsson, Bengt Fellström, Gunnar Tufveson, Lars Klareskog and Torvard C. Laurent, Transplantation
• Hyaluronan in Normal Synovia and in Biopsies from Rheumatoid Arthritis and Other Rheumatic Diseases.  
  AF Wells, Staffan Lindblad, Anders Tengblad, Lars Klareskog, and Torvard Laurent, Scand J Immunol
• Localization of hyaluronan in various muscular tissues: A morphological study in the rat.  
  Claude Laurent, Gina Johnson-Wells, Sten Hellström, Anna Engström-Laurent, AF Wells, Cell Tissue Res
• Cytokine gene expression: Analysis using northern blotting, polymerase chain reaction, and in situ hybridization.  
  MJ Dallman, RA Montgomery, CP Larsen, A Wanders, AF Wells, Immunol Rev
• Histochemical Localization of Hyaluronan in Psoriasis, Allergic Contact Dermatitis and Normal Skin.  
  AF Wells, Åsa Lundin, and G. Michaëlsson, Acta Derm Venereol
• Hyaluronan in basal cell carcinoma.  
  AF Wells and Åsa Lundin, Acta Derm Venereol
• Lung hyaluronan during development: A quantitative and morphologic study.  
  SJ Allen, G Serdin, A Jonzon, AF Wells, TC Laurent, Am J Physiol
• Localization of hyaluronan in regions of the human reproductive tract.  
  Edelstam, GAB, ÖE Lundkvist, AF Wells, TC Laurent, J Histochem Cytochem
• Gamma-Interferon-Like Substance is Expressed in Myocytes of Cardiac Allografted Rats Treated with Cyclosporine A.  
  A. Wanders, AF Wells, G. Tufveson, L. Klareskog, Transplantation Proceedings
• Gamma interferon-like substance in normal and transplanted rat heart tissue.  
  Wanders, A, AF Wells, E Larsson, G Tufveson, T Olsson, Å Ljungdahl, and L Klareskog, J Heart Transplantation
• Role of hyaluronan in chronic and acutely rejecting kidneys.  
  AF Wells, E Larsson, B Fellström, L Klareskog, T Laurent, Transplantation Proceedings
• Increased hyaluronan in acutely rejecting human kidney grafts.  
  AF Wells, E Larsson, E Hanás, TC Laurent, R Hällgren, G Tufveson, Transplantation
• Localization of hyaluronan in normal breast tissue, radial scar, and tubular breast carcinoma.  
  M de la Torre, AF Wells, J Bergh, TC Laurent, Human Pathology
• Increased hyaluronan and IL-2 in capsular biopsies of women with silicone breast implants.  
  AF Wells, S Daniels, S Gunasekaran, KE Wells, Annals of Plastic Surgery
• Expression of IL-2 receptor  (IL-2) mRNA and protein in ovarian carcinoma.  
  D Barton, K Blanchard, AF Wells, S Nicosia, WS Roberts, D Cavanagh, J Djeu, Anticancer Research
• Localization and quantity of hyaluronan in urogenital organs of male and female rats.  
  C Laurent, S Hellström, A Engström-Laurent, AF Wells, A Bergh, Cell Tissue Res
• The human thymus during aging.  
  BF Haynes, GD Sempowski, AF Wells, LP Hale, Immunologic Research
• Anti-Cytokine Therapies in Rheumatoid Arthritis: From the Pipette to the Patient.  
  AF Wells, Drug Discovery Today: Therapeutic Strategies
• New biologic agents in patients with rheumatoid arthritis.  
  Fleischmann R, AF Wells, Update to Rheumatic Disease Clinics of North America
• Newer imaging modalities: Their use in rheumatic diseases.  
  Troum, O, E Olech, AF Wells, Update to Rheumatic Disease Clinics of North America
• African American patients with gout: Efficacy and safety of febuxostat vs allopurinol.  
  AF Wells, PA MacDonald, S Chefo and RL Jackson, BMC Musculoskeletal Disorders
• Join now to see all

Books/Book Chapters

• Biological Properties of Peptidoglycan. 
  Chapter: Chemical and Immunochemical Studies of the in vivo and in vitro Degradation of Peptidoglycan Subunits and Cell Wall Complexes in Relation to Inflammatory Diseases 
  A. Fox, J. Harrison, G. Pararajasegaram, J. Gilbart, AF Wells, R. S. Whiton, and S. L. MorganEditors: P. H. Seidl and K. H. Schleifer.

Abstracts/Posters

• An Enzyme Linked Immunoassay for the Detection of Streptococcal Cell Wall Fragments in Experimental Uveitis.
  Pararajasegaram, G., J. Harrison, A. Wells, M. Hammer, P. Lill, and A. Fox, ular Microbiology and Immunology Group Meeting
• Uveitis and Arthritis Induced by Systemic Injection of Streptococcal Cell Walls.
  Wells, A., A. Fox, M. Hammer, and Chang Hsu Yang, Southeastern Branch of the American Society for Microbiology Annual Meeting
• Differential Distribution of Streptococcal Cell Wall Complexes: Correlation With Induction of Uveitis and Polyarthritis.
  Pararajasegaram, G., A. Wells, M. Hammer, C. Yang, and A. Fox, The American Society For Microbiology Annual Meeting
• Dissemination of Streptococcal Cell Wall Complexes to the Eye in Experimental Uveitis.
  Pararajasegaram, G., A. Wells, M. Hammer, C. Yang, and A. Fox, The Association For Research in Vision and Ophthalmology Annual Meeting
• Chronic Neutrophilia in Rats Following the Systemic Administration of Group A Streptococcal Cell Wall Complexes.
  Wells, AF, James A. Hightower, and Alvin Fox, The American Association of Anatomists Annual Meeting
• Hyaluronan in Normal and Rejected Kidney Sections.
  Wells, AF, Erik Larsson, and Torvard Laurent, The European Society of Pathologists Annual Meeting, Porto, Portugal
• Histochemical Localization of Hyaluronan in Normal and Inflamed Tissues.
  Wells, AF, Cell Biology of the Extracellular Matrix and Cell Surface. Medevi Brunn, Sweden
• Hyaluronan in normal synovia and in biopsies from rheumatoid arthritis and other arthropathies: Histochemical and in vitro regulation.
  Wells, AF, S Lindblad, L Klareskog, TC Laurent, 10th European Workshop for Rheumatology Research, Copenhagen, Denmark
• Reactivity of the gamma interferon antibody DB1 with muscle cells in normal and transplanted rat hearts.
  Wanders, A, AF Wells, E Larsson, A Gobl, G Tufveson, B Gerdin, G Smedegård, L Klareskog, 21st Meeting of the Scandinavian Society for Immunology, Stockholm, Sweden
• Urate-lowering therapy with Febuxostat in African American gout subjects.
  AF Wells, PA MacDonald, S Chefo, RL Jackson, National Medical Association Meeting, Washington, DC
• Radiographic progression correlates well with patient-reported RAPID3 disease activity levels in MTX-naïve patients with early rheumatoid arthritis: Insights from the ...
  E Keystone, R Westhovens, D Moniz-Reed, A Covucci, AF Wells, American College of Rheumatology meeting, Atlanta, GA
• Early treatment with adalimumab and MTX induces remission in orbital myositis: Report of 2 cases.
  AF Wells, N Jodat, D Michel, EULAR, Rome, Italy
• Impact of Certolizumab pegol on health-related quality of life: Rheumatoid arthritis patients approach population US norms in mental health and vitality domains.
  V Strand, R Fleischmann, TK Kvien, A Kavanaugh, J Smolen, AF Wells, E. Nikaï, G Coteur, B. Combe, ISPOR 12th Annual European Congress. Paris, France
• Certolizumab pegol added to methotrexate provides lasting improvements in patient-reported outcomes (pros) over 2 years.
  V Strand, R Fleischmann, TK Kvien, A Kavanaugh, J Smolen, AF Wells, E. Nikaï, G Coteur, B. Combe, American College of Rheumatology meeting, Philadelphia, PA
• Early inhibition of progression of structural damage in Certolizumab Pegol-treated patients: 16-week efficacy results from RAPID.
  D. van der Heijde, M Weinblatt, R Landewe, N Goel, AF Wells, RM Fleischmann, EULAR, Paris, France
• Inhibition of progression of structural damage by week 16 with Certolizumab Pegol: Results from the RAPID trials.
  D. van der Heijde, M Weinblatt, R Landewe, N Goel, AF Wells, RM Fleischmann, American College of Rheumatology meeting, San Francisco, CA
• Ultrasound waves across the Atlantic: The intercontinental musculoskeletal ultrasound exercise.
  E Kissin, J Nishio, M Yang, et al, American College of Rheumatology meeting, San Francisco, CA
• A phase 3 randomized, controlled, multicenter, double-blind trial comparing efficacy and safety of daily febuxostat and allopurinol in subjects with gout.
  MA Becker, HR Schumacher, L Espinoza, AF Wells, P MacDonald, E Lloyd, C Lademacher, American College of Rheumatology meeting, San Francisco, CA
• Use of abatacept + methotrexate delivers incremental clinical benefit (including remission) versus MTX monotherapy in MTX naïve early RA patients who achieve radiograp...
  AF Wells, R Westhovens, D Moniz Reed, L Fanti, J Becker, G Vratsanos, S Park, E Keystone, EULAR, Copenhagen, Denmark
• Borrelia burgdorferi inhibits hyaluronan synthesis but increases IL-6 production by fibroblasts.
  AF Wells, N Jones, FB Vasey, American College of Rheumatology Southeast Regional Meeting. Orlando, FL
• IL-6 and multinucleated giant cells in capsular biopsies from patients with silicone breasts implants.
  32. AF Wells, S Daniels, KE Wells, FB Vasey, American College of Rheumatology National Meeting. Minneapolis, MN
• Prospective clinical status comparison between women retaining gel breast implants versus women removing implants.
  FB Vasey, N Aziz, D Havice, AF Wells, American College of Rheumatology Southeast Regional Meeting. Puerto Rico
• The role of ciliary neurotropic factor in regulation of thymopoeisis.
  AF Wells, G Sempowski, R Scearce, BF Haynes, Experimental Biology Meeting. Orlando, FL
• Incidence of injection-site reactions associated with Adalimumab (D2E7) given subcutaneously for at least 6 months: A retrospective analysis of 4 phase II/III clinical...
  AF Wells, H Kupper, S Fischkoff, E Chartash, American College of Rheumatology National Meeting, New Orleans, Louisiana
• Incidence of injection-site reactions associated with Adalimumab (D2E7) given subcutaneously for at least 6 months.
  AF Wells, H Kupper, S Fischkoff, E Chartash, EULAR, Lisbon, Portugal
• Join now to see all

Lectures

• Updates in Rheumatology 2011: Highlights from the ACR and EULAR Meetings 
  University of California San Diego, La Jolla, California - 12/10/2011
• Use of Imaging in Rheumatic Diseases. 
  Vanderbilt University Medical Center, Grand Rounds, Nashville, TN
• Clinical Applications of Musculoskeletal Ultrasound in Rheumatology. 
  Ohio State University Medical Center, Columbus, OH, 2009
• Clinical Trials: To have or not to have? 
  American College of Rheumatology national meeting, Philadelphia, PA
• Musculoskeletal Ultrasound for Rheumatologists – Intermediate Level. 
  Multiple locations, 2009, 2010
• Rheumatology Grand Rounds Update on Gout and Musculoskeletal Ultrasound for Rheumatologists. 
  Louisiana State University, Shreveport, LO
• Imaging in rheumatology: Update on ultrasound and application to the clinic. 
  Rheumatology Fellows Mentoring Workshop, Rancho Mirage, CA
• Update on Imaging in Rheumatology. 
  Duke University Rheumatology Grand Rounds, Durham, NC
• Rheumatology Winter Clinical Symposium. 
  Various lectures, Maui, HI
• Inflammatory Eye Disease. 
  Multiple locations, 2009
• Ultrasound Anatomy and Shoulder Evaluation. 
  Albert Einstein College of Medicine Musculoskeletal Ultrasound Conference, New York, NY
• Ultrasound evaluation of the foot and ankle. 
  Canadian Rheumatology Musculoskeletal Ultrasound Conference, Vancouver, Canada
• Various ultrasound lectures. 
  Clinical Applications of Musculoskeletal Ultrasound; Ohio State University, Columbus, OH
• Musculoskeletal ultrasound. 
  Multiple locations, 2009
• CORE Presentation: Optimizing Biologic Therapies. 
  Annual American College of Rheumatology meeting, San Francisco, CA
• Musculoskeletal Ultrasound for Rheumatologists. 
  Reginato Ultrasound Course, Philadelphia, PA
• State of the Art in Rheumatology: An Update on OA and RA. 
  West Allis Memorial Hospital Medical Grand Rounds, West Allis, WI
• Update on the Treatment of Rheumatoid Arthritis. 
  Veterans Naval Hospital Rheumatology Grand Rounds, Roanoke, VA
• TNF Antagonists in Autoimmune Disorders. 
  Inflammatory Diseases and Drug Discovery Meeting, Baltimore, MD
• Identifying Unmet Needs in the Treatment of Rheumatoid Arthritis. 
  American College of Rheumatology State of the Art Symposium, Chicago, IL, 2004
• Evolution of the Role of Cytokines in Autoimmune Disorders. 
  University of Miami Rheumatology Grand Rounds, Miami, FL
• State of the Art in Rheumatology: An Update on RA. 
  NC/SC Rheumatology Fellows Orientation Program, Winston-Salem, NC
• State of the Art in Rheumatology. 
  University of Hawaii, Medical Grand Rounds, Honolulu, HI, 2004; Decatur Memorial Hospital,Decatur,IL
• Alternative Treatments for Rheumatic Diseases. 
  Wisconsin Arthritis Foundation Lecture, Milwaukee, WI
• Hyperuricemia and gout. 
  Rheumatology Winter Clinical Symposium,Maui, HI
• Join now to see all