AmyWangMD

PubMed

• 2 citations
  Discovery and Optimization of a 4-Aminopiperidine Scaffold for Inhibition of Hepatitis C Virus Assembly.
  Adam Rolt, Daniel C. Talley, Seung Bum Park, Zongyi Hu, Andrés E. Dulcey, Christopher D. Ma, Parker H. Irvin, Madeleine Leek, Amy Wang, Andrew V. Stachulski, Xin Xu, N...> ;Journal of Medicinal Chemistry. 2021 Jun 29
• 12 citations
  Urinary polycyclic aromatic hydrocarbon metabolites and mortality in the United States: A prospective analysis
  Achal P. Patel, Suril S. Mehta, Alexandra J. White, Nicole M. Niehoff, Whitney D. Arroyave, Amy Wang, Ruth M. Lunn> ;Plos One. 2021 Jun 4
• 13 citations
  A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome
  Mark J. Henderson, Kathleen A. Trychta, Shyh Ming Yang, Susanne Bäck, Adam Yasgar, Emily S. Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo Jen Wu, Amy...> ;Cell Reports. 2021 Apr 27
• 6 citations
  Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease
  Betty S. Pace, Susan P. Perrine, Biaoru Li, Levi Makala, Hongyan Xu, Mayuko Takezaki, Roman F. Wolf, Amy Wang, Xin Xu, Junfeng Huang, Asaf Alimardanov, Gregory J. Tawa...> ;Blood Cells, Molecules & Diseases. 2021 Mar 12
• 12 citations
  Formulation, Stability, Pharmacokinetic, and Modeling Studies for Tests of Synergistic Combinations of Orally Available Approved Drugs against Ebola Virus In Vivo
  Courtney L. Finch, Julie Dyall, Shuang Xu, Elizabeth A. Nelson, Elena Postnikova, Janie Y. Liang, Huanying Zhou, Lisa Evans DeWald, Craig J. Thomas, Amy Wang, Xin Xu, ...> ;Microorganisms. 2021 Mar 10
• 97 citations
  Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro
  Qi Zhang, Catherine Z. Chen, Manju Swaroop, Miao Xu, Lihui Wang, Juhyung Lee, Amy Wang, Manisha Pradhan, Natalie Hagen, Lu Chen, Min Shen, Zhiji Luo, Xin Xu, Yue Xu, W...> ;Cell Discovery. 2020 Nov 4
• 15 citations
  Torin 2 Derivative, NCATS-SM3710, Has Potent Multistage Antimalarial Activity through Inhibition of P. falciparum Phosphatidylinositol 4-Kinase (Pf PI4KIIIβ).
  Karthik Krishnan, Peter D. Ziniel, Hao Li, Xiuli Huang, Daniel Hupalo, Nita Gombakomba, Sandra Mendoza Guerrero, Thoai Dotrang, Xiao Lu, Diana Caridha, Anna R. Sternbe...> ;ACS Pharmacology & Translational Science. 2020 Sep 11
• 8 citations
  Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion
  Christopher D. Ma, Michio Imamura, Daniel C. Talley, Adam Rolt, Xin Xu, Amy Wang, Derek Le, Takuro Uchida, Mitsutaka Osawa, Yuji Teraoka, Kelin Li, Xin Hu, Seung Bum P...> ;Nature Microbiology. 2020 Aug 31
• 20 citations
  Targeting AML-associated FLT3 mutations with a type I kinase inhibitor
  LaQuita M Jones, Katelyn Melgar, Lyndsey Bolanos, Kathleen Hueneman, Morgan M. Walker, Jian-kang Jiang, Kelli M. Wilson, Xiaohu Zhang, Jian Shen, Fan Jiang, Patrick Su...> ;The Journal of Clinical Investigation. 2020 Apr 1
• 54 citations
  Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors.
  Ashish Thakur, Gregory J. Tawa, Mark J. Henderson, Carina Danchik, Suiyang Liu, Pranav Shah, Amy Wang, Garrett Dunn, Elias C. Padilha, Xin Xu, Anton Simeonov, Surender...> ;Journal of Medicinal Chemistry. 2020 Mar 26
• 5 citations
  Metabolism and pharmacokinetics characterization of metarrestin in multiple species
  Elias C. Padilha, Pranav Shah, Amy Wang, Marc Singleton, Emma Hughes, Dandan Li, Kelly A. Rice, Kylie M. Konrath, Samarjit Patnaik, Juan J. Marugan, Udo Rudloff, Xin Xu> ;Cancer Chemotherapy and Pharmacology. 2020 Mar 17
• 6 citations
  Quantitation of cytidine-5'-monophospho-N-acetylneuraminic acid in human leukocytes using LC-MS/MS: method development and validation.
  Meng Fang, Xin Xu, Michael Zhang, Yifan Shi, Guodong Gu, Wanjing Liu, Bradley Class, Carla Ciccone, William A. Gahl, Marjan Huizing, Nuria Carrillo, Amy Wang> ;Biomedical Chromatography. 2020 Feb 1
• 38 citations
  The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them
  Martyn T. Smith, Kathryn Z. Guyton, Nicole Kleinstreuer, Alexandre Borrel, Andres Cardenas, Weihsueh A. Chiu, Dean W. Felsher, Catherine F. Gibbons, William H. Goodson...> ;Cancer Epidemiology, Biomarkers & Prevention. 2020 Jan 1
• 5 citations
  Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts
  Kirill Gorshkov, Amy Wang, Wei Sun, Ethan G. Fisher, Marta Frigeni, Marc Singleton, Natasha Thorne, Bradley Class, Wenwei Huang, Nicola Longo, Minh-Ha Do, Elizabeth A....> ;Pharmacology Research & Perspectives. 2019 Dec 1
• 44 citations
  Overcoming adaptive therapy resistance in AML by targeting immune response pathways
  Katelyn Melgar, Morgan M. Walker, LaQuita M Jones, Lyndsey Bolanos, Kathleen Hueneman, Mark Wunderlich, Jiang-Kang Jiang, Kelli M. Wilson, Xiaohu Zhang, Patrick Sutter...> ;Science Translational Medicine. 2019 Sep 4
• 24 citations
  High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma
  Sarah Wang, Elizabeth Hwang, Rajarshi Guha, Allison F. O'Neill, Nicole Melong, Chansey J. Veinotte, Amy Conway Saur, Kellsey Wuerthele, Min Shen, Crystal McKnight, Gab...> ;Clinical Cancer Research. 2019 Jul 15
• 34 citations
  Efficacy of Oral Encochleated Amphotericin B in a Mouse Model of Cryptococcal Meningoencephalitis.
  R. Lu, Christopher Hollingsworth, Jin Qiu, Amy Wang, E. Hughes, X. Xin, K. M. Konrath, Waleed Elsegeiny, Yoon-Dong Park, L. Atakulu, J. C. Craft, Edmund C. Tramont, R....> ;Mbio. 2019 May 28
• 23 citations
  Impact of Polymer-TLR-7/8 Agonist (Adjuvant) Morphology on the Potency and Mechanism of CD8 T Cell Induction.
  Geoffrey M. Lynn, Petr Chytil, Joseph R. Francica, Anna Lagová, Gray Kueberuwa, Andrew S. Ishizuka, Neeha Zaidi, Ramiro A. Ramirez-Valdez, Nicolas J. Blobel, Faezzah B...> ;Biomacromolecules. 2019 Jan 4
• 35 citations
  Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine.
  Jaclyn N. Highland, Patrick J. Morris, Panos Zanos, Jacqueline Lovett, Soumita Ghosh, Amy Wang, Carlos A. Zarate, Craig J. Thomas, Ruin Moaddel, Todd D. Gould> ;Journal of Psychopharmacology. 2019 Jan 1
• 27 citations
  Key Characteristics Approach to Carcinogenic Hazard Identification
  Kathryn Z. Guyton, Linda Rieswijk, Amy Wang, Weihsueh A. Chiu, Martyn T. Smith> ;Chemical Research in Toxicology. 2018 Dec 6
• 9 citations
  Discovery and lead identification of quinazoline-based BRD4 inhibitors.
  Shyh-Ming Yang, Daniel J. Urban, Makoto Yoshioka, Jeffrey W. Strovel, Steven Fletcher, Amy Wang, Xin Xu, Pranav Shah, Xin Hu, Matthew D. Hall, Ajit Jadhav, David J. Ma...> ;Bioorganic & Medicinal Chemistry Letters. 2018 Nov 15
• 13 citations
  Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors.
  Jian-kang Jiang, Xiuli Huang, Khalida Shamim, Paresma R. Patel, Arthur Lee, Amy Wang, Kimloan Nguyen, Gregory J. Tawa, Gregory D. Cuny, Paul B. Yu, Wei Zheng, Xin Xu, ...> ;Bioorganic & Medicinal Chemistry Letters. 2018 Nov 1
• 18 citations
  In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy.
  Nathan P. Wiederhold, Xin Xu, Amy Wang, Laura K. Najvar, Edward P. Garvey, Elizabeth A. Ottinger, Asaf Alimardanov, Jim Cradock, Mark Behnke, William J. Hoekstra, Step...> ;Antimicrobial Agents and Chemotherapy. 2018 Oct 24
• 7 citations
  Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancr...
  Tomas Vilimas, Amy Wang, Samarjit Patnaik, Emma Hughes, Marc D. Singleton, Zachary Knotts, Dandan Li, Kevin J. Frankowski, Jerome J. Schlomer, Theresa Guerin, Stephani...> ;Cancer Chemotherapy and Pharmacology. 2018 Oct 10
• 7 citations
  Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile
  Kenneth Wilson, Jingbo Xiao, Catherine Z. Chen, Zaohua Huang, Irina U. Agoulnik, Marc Ferrer, Noel Southall, Xin Hu, Wei Zheng, Xin Xu, Amy Wang, Courtney Myhr, Elena ...> ;European Journal of Medicinal Chemistry. 2018 Aug 5
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