AndreasKKleinMD

Hematology • Boston, MA

Hematologic Oncology

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Office
800 Washington St, Box 245
Boston, MA 02111
Phone+1 617-636-2694

Fax+1 617-636-8538
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Education & Training

Duke University HospitalFellowship, Hematology and Medical Oncology, 1998 - 2001
Tufts Medical CenterResidency, Internal Medicine, 1995 - 1998
Yale School of MedicineClass of 1995

Certifications & Licensure

MA State Medical License 2001 - 2025
ME State Medical License 2020 - 2021
NC State Medical License 1998 - 2001
American Board of Internal Medicine Hematology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014, 2016-2017, 2019-2022
Super Doctor SuperDoctors.com

Clinical Trials

Rituxan/BEAM vs Bexxar/BEAM in Autologous Hematopoietic Stem Cell Transplant for Non-Hodgkin's Lymphoma (BMTCTN0401) Start of enrollment: 2005 Dec 01
Completed
Phase 3
Safety Study of High Dose Temozolomide to Treat Relapsed/Refractory Central Nervous System (CNS) Malignancy Start of enrollment: 2004 Apr 01
Terminated
Phase 1
A Phase II Study of Umbilical Cord Blood Transplantation Start of enrollment: 2005 Jul 01
Terminated
Phase 2
Collecting Tissue Samples From Patients With Leukemia or Other Blood Disorders Planning to Enroll in an ECOG Leukemia Treatment Clinical Trial Start of enrollment: 2004 Sep 21
Completed
Zevalin for Patients With Incomplete Response to Chemo Prior to Autologous Stem Cell Transplant for Multiple Myeloma Start of enrollment: 2008 Apr 01
Terminated
Phase 2
Bendamustine and Dexamethasone in Patients With Relapsed AL Amyloidosis Start of enrollment: 2013 Jan 01
Completed
Phase 2
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) Start of enrollment: 2011 Oct 01
Recruiting
Pilot Study of Lymphoid Tumor Microenvironmental Dysruption Prior to Autologous Stem Cell Transplantation Start of enrollment: 2013 Jul 01
Terminated
Phase 1
Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacodynamics of Entospletinib in Adults With Relapsed or Refractory Hematologic Malignancies Start of enrollment: 2013 Mar 14
Terminated
Phase 2
Rituximab and Bendamustine Hydrochloride, Rituximab and Ibrutinib, or Ibrutinib Alone in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia Start of enrollment: 2013 Dec 09
Active, not recruiting
Phase 3
Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Start of enrollment: 2014 Feb 20
Active, not recruiting
Phase 3
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Publications & Presentations

PubMed

A phase 1-2 trial of DA-EPOCH-R plus ixazomib for MYC-aberrant lymphoid malignancies: the DACIPHOR regimen.
Karmali, R., Reem Karmali, Carlos Galvez, Mehdi Hamadani, Leo Gordon, Jane Winter, Shuo Ma, Valerie Nelson, Timothy S Fenske, Nirav N Shah, Deepa Jagadeesh, Andreas Kl...> ;Blood Advances. 2024 Apr 9
Outcomes of patients with blastoid and pleomorphic variant mantle cell lymphoma.
Gerson, J., Handorf, E., Villa, D., Gerrie, A., Chapani, P., Li, S., Medeiros, L., Wang, M., Cohen, J., Churnetski, M., Hill, B., Sawalha, Y., Hernandez-Ilizaliturri, ...> ;Blood Advances. 2023 Dec 26
3 citations
Association of Preexisting Heart Failure With Outcomes in Older Patients With Diffuse Large B-Cell Lymphoma.
Jenica N Upshaw, Jason Nelson, Angie Mae Rodday, Anita J Kumar, Andreas K Klein, Marvin A Konstam, John B Wong, Iris Z Jaffe, Bonnie Ky, Jonathan W Friedberg, Matthew ...> ;JAMA Cardiology. 2023 May 1
3 citations
Safety of AFM11 in the treatment of patients with B-cell malignancies: findings from two phase 1 studies.
Max Topp, Monika Dlugosz-Danecka, Aleksander B Skotnicki, Galina Salogub, Andreas Viardot, Andreas K Klein, Georg Hess, Christian S Michel, Sebastian Grosicki, Alex Gu...> ;Trials. 2023 Jan 3
2 citations
Predicting In-Hospital Mortality After Acute Myeloid Leukemia Therapy: Through Supervised Machine Learning Algorithms.
Nauman S Siddiqui, Andreas Klein, Amandeep Godara, Rachel J Buchsbaum, Michael C Hughes> ;JCO Clinical Cancer Informatics. 2022 Dec 1
14 citations
Pembrolizumab plus dinaciclib in patients with hematologic malignancies: the phase 1b KEYNOTE-155 study.
Gregory, G., Kumar, S., Wang, D., Mahadevan, D., Walker, P., Wagner-Johnston, N., Escobar, C., Bannerji, R., Bhutani, D., Chang, J., Hernandez-Ilizaliturri, F., Klein,...> ;Blood Advances. 2022 Feb 22
12 citations
A phase I/II trial of brentuximab vedotin plus rituximab as frontline therapy for patients with immunosuppression-associated CD30+ and/or EBV + lymphomas.
William Pearse, Adam M. Petrich, Leo I. Gordon, Reem Karmali, Jane N. Winter, Shuo Ma, Jason B. Kaplan, Amir Behdad, Andreas K. Klein, Borko Jovanovic, Irene Helenowsk...> ;Leukemia & Lymphoma. 2021 Aug 2
17 citations
HIV-associated Burkitt lymphoma: Outcomes from a US-UK collaborative analysis
Juan Pablo Alderuccio, Adam J. Olszewski, Andrew M. Evens, Graham P. Collins, Alexey V. Danilov, Mark Bower, Deepa Jagadeesh, Catherine Zhu, Amy Sperling, Seo-Hyun Kim...> ;Blood Advances. 2021 Jul 27
12 citations
Rapid and sustained decline in CXCL-10 (IP-10) annotates clinical outcomes following TNF-α antagonist therapy in hospitalized patients with severe and critical COVID-1...
Hilal Hachem, Amandeep Godara, Courtney Schroeder, Daniel Fein, Hashim Mann, Christian Lawlor, Jill Marshall, Andreas K. Klein, Deborah Poutsiaka, Janis L. Breeze, Rag...> ;Medrxiv. 2021 Jun 2
12 citations
Outcomes of Burkitt lymphoma with central nervous system involvement: evidence from a large multicenter cohort study
Adam Zayac, Andrew M. Evens, Alexey V. Danilov, Stephen D. Smith, Deepa Jagadeesh, Lori A. Leslie, Catherine Wei, Seo-Hyun Kim, Seema Naik, Suchitra Sundaram, Nishitha...> ;Haematologica. 2021 Jul 1
25 citations
Burkitt Lymphoma International Prognostic Index
Adam J. Olszewski, Lasse Hjort Jakobsen, Graham P. Collins, Kate Cwynarski, Veronika Bachanova, Kristie A. Blum, Kirsten M Boughan, Mark Bower, Alessia Dalla Pria, Ale...> ;Journal of Clinical Oncology. 2021 Jan 27
44 citations
Burkitt lymphoma in the modern era: real-world outcomes and prognostication across 30 US cancer centers
Andrew M. Evens, Alexey V. Danilov, Deepa Jagadeesh, Amy Sperling, Seo-Hyun Kim, Ryan Vaca, Catherine Wei, Daniel Rector, Suchitra Sundaram, Nishitha Reddy, Yong Lin, ...> ;Blood. 2021 Jan 21
22 citations
Rapid and sustained decline in CXCL-10 (IP-10) annotates clinical outcomes following TNFα-antagonist therapy in hospitalized patients with severe and critical COVID-19...
Hilal Hachem, Amandeep Godara, Courtney Schroeder, Daniel Fein, Hashim Mann, Christian Lawlor, Jill Marshall, Andreas K. Klein, Deborah Poutsiaka, Janis L. Breeze, Rag...> ;Journal of Clinical and Translational Science. 2021 Jan 1
8 citations
Clinicopathologic characteristics of secondary squamous cell carcinoma of head and neck in survivors of allogeneic hematopoietic stem cell transplantation for hematolo...
Chakra P Chaulagain, Kellie Sprague, Monika Pilichowska, Janet M. Cowan, Andreas K. Klein, Esha Kaul, Kenneth B. Miller> ;Bone Marrow Transplantation. 2019 Apr 1
66 citations
Survival Outcomes of Younger Patients With Mantle Cell Lymphoma Treated in the Rituximab Era.
James N. Gerson, Elizabeth Handorf, Diego Villa, Alina S. Gerrie, Parv Chapani, Shaoying Li, L. Jeffrey Medeiros, Michael I. Wang, Jonathon B. Cohen, Oscar Calzada, Mi...> ;Journal of Clinical Oncology. 2019 Jan 7
13 citations
Daratumumab binds to mobilized CD34+ cells of myeloma patients in vitro without cytotoxicity or impaired progenitor cell growth
Xun Ma, Sandy W. Wong, Ping Zhou, Chakra P Chaulagain, Parul Doshi, Andreas K. Klein, Kellie Sprague, Adin Kugelmass, Denis Toskic, Melissa Warner, Kenneth B. Miller, ...> ;Experimental Hematology & Oncology. 2018 Oct 16
80 citations
Multicenter Phase II Study of Sequential Brentuximab Vedotin and Doxorubicin, Vinblastine, and Dacarbazine Chemotherapy for Older Patients With Untreated Classical Hod...
Andrew M. Evens, Ranjana H. Advani, Irene Helenowski, Michelle A. Fanale, Sonali M. Smith, Borko Jovanovic, Gregory Bociek, Andreas K. Klein, Jane N. Winter, Leo I. Go...> ;Journal of Clinical Oncology. 2018 Sep 4
49 citations
Autologous transplantation versus allogeneic transplantation in patients with follicular lymphoma experiencing early treatment failure.
Sonali M. Smith, James Godfrey, Kwang Woo Ahn, Alyssa DiGilio, Sairah Ahmed, Vaibhav Agrawal, Veronika Bachanova, Ulrike Bacher, Asad Bashey, Javier Bolaños-Meade, Mit...> ;Cancer. 2018 Jun 15
4 citations
Assessment of a shortened informed consent form for pediatric research: a pilot study
Peter D. Murray, Barbara E. Bierer, Steven Hirschfeld, Andreas K. Klein, Jonathan M. Davis> ;Pediatric Research. 2018 May 18
12 citations
Survival Analyses and Prognosis of Plasma-Cell Myeloma and Plasmacytoma-Like Posttransplantation Lymphoproliferative Disorders
Aaron S. Rosenberg, Robin Ruthazer, Jessica K. Paulus, David M. Kent, Andrew M. Evens, Andreas K. Klein> ;Clinical Lymphoma, Myeloma & Leukemia. 2016 Dec 1
3 citations
Cost Implications of Comorbidity for Autologous Stem Cell Transplantation in Elderly Patients with Multiple Myeloma Using SEER-Medicare.
Gunjan L. Shah, Aaron N. Winn, Pei-Jung Lin, Andreas K. Klein, Kellie Sprague, Hedy Smith, Rachel J. Buchsbaum, Joshua T. Cohen, Kenneth B. Miller, Raymond L. Comenzo,...> ;Bone Marrow Research. 2016 Oct 18
3 citations
Perforation of the Colon During Imatinib Mesylate (Gleevec) Treatment in a Patient with Chronic Myeloid Leukemia (CML).
Najla El Jurdi, Mark S. Bankoff, Andreas K. Klein, Muhammad Wasif Saif> ;Cureus. 2016 Jun 27
22 citations
Hodgkin lymphoma post-transplant lymphoproliferative disorder: A comparative analysis of clinical characteristics, prognosis, and survival
Aaron S. Rosenberg, Andreas K. Klein, Robin Ruthazer, Andrew M. Evens> ;American Journal of Hematology. 2016 Apr 26
7 citations
Success of an International Learning Health Care System in Hematopoietic Cell Transplantation: The American Society of Blood and Marrow Transplantation Clinical Case F...
Pere Barba, Linda J. Burns, Mark R. Litzow, Mark B. Juckett, Krishna V. Komanduri, Stephanie J. Lee, Sean M. Devlin, Luciano J. Costa, Shakila P. Khan, Andrea King, An...> ;Biology of Blood and Marrow Transplantation. 2016 Mar 1
44 citations
Reduced-Intensity Allografting as First Transplantation Approach in Relapsed/Refractory Grades One and Two Follicular Lymphoma Provides Improved Outcomes in Long-Term ...
Evgeny Klyuchnikov, Ulrike Bacher, Nicolaus Kröger, Parameswaran Hari, Kwang Woo Ahn, Jeanette Carreras, Veronika Bachanova, Asad Bashey, Jonathon B. Cohen, Anita D'So...> ;Biology of Blood and Marrow Transplantation. 2015 Dec 1
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Journal Articles

Clinicopathologic Characteristics of Secondary Squamous Cell Carcinoma of Head and Neck in Survivors of Allogeneic Hematopoietic Stem Cell Transplantation for Hematolo...
Kenneth B Miller, Kellie A Sprague, Chakra P Chaulagain, Esha Kaul, Andreas K Klein, Janet Cowan, Nature

Abstracts/Posters

Supervised Machine Learning Algorithms Using Patient Related Factors to Predict in-Hospital Mortality Following Acute Myeloid Leukemia Therapy
Andreas Klein, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
The Evaluation and Treatment (Tx) of Burkitt Lymphoma (BL) in the Modern Era: Real World (RW) Outcomes and Prognostication across 26 US Cancer Centers (CC)
Andreas Klein, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
A Phase I/II Trial of Brentuximab Vedotin (BV) Plus Rituximab (R) As Frontline Therapy for Patients with Immunosuppression-Associated CD30+ and/or EBV+ Lymphomas
Andreas Klein, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Press Mentions

Development and Clinical Application of CD19xCD3 and CD20xCD3 Bispecific AntibodiesJanuary 17th, 2022
Old Idea, New Desperation: Can Plasma from Recovered Patients Help Those Now Battling COVID-19?May 22nd, 2020
How Plasma Transfusions May Heal COVID-19 PatientsMay 10th, 2020
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