Andrej Spec MD , MSCI

Transplant/Immunocompromised States

Assistant Professor of Medicine Associate Director of Infectious Disease Clinical Research Unit

620 S Taylor Ave# DvSt. Louis, MO 63110
Phone+1 314-362-9098
Fax+1 314-362-9851

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Education & Training

WashU MedicineMSCI, 2015 - 2017
Washington University/B-JH/SLCH ConsortiumFellowship, Infectious Disease, 2013 - 2015
Rush University Medical CenterResidency, Internal Medicine, 2010 - 2013
University of Illinois College of MedicineClass of 2010
Loyola University ChicagoB.S., Major in Molecular Biology, Minors in Chemistry and Biostatistics, Magna Cum Laude, 2001 - 2005

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Certifications & Licensure

MO State Medical License 2016 - 2027
FL State Medical License 2021 - 2023
IL State Medical License 2010 - 2013

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification Allscripts TouchWorks EHR, Allscripts, 2017
Mentorship Award IDSA, 2014
IDSA Mentorship Award 2014

Clinical Trials

Oral Ibrexafungerp (SCY-078) vs Standard-of-Care Following IV Echinocandin in the Treatment of Invasive Candidiasis
COMPLETED
PHASE2
CD101 Compared to Caspofungin Followed by Oral Step Down in Subjects With Candidemia and/or Invasive Candidiasis-Bridging Extension Start of enrollment: 2016 Jul 26
COMPLETED
PHASE2
Study to Evaluate the Efficacy and Safety of Ibrexafungerp in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment Start of enrollment: 2017 Apr 01
COMPLETED
PHASE3

Publications & Presentations

PubMed

Olorofim in Treatment of Patients With Poorly Controlled Disseminated Coccidioidomycosis : A Single-Group, Open-Label, Phase 2b, Multicenter Study.
Fariba M Donovan, Royce H Johnson, Thomas F Patterson, Martin Hoenigl, Andrej Spec
Annals of Internal Medicine. 2026-07-21
A Call to Investigate the Association Between Histoplasmosis and Fatigue.
Christian Hendrix, Julio Zuniga-Moya, Andrej Spec, Patrick Mazi
Open Forum Infectious Diseases. 2026-07-01
Exploring Early Antifungal Activity of Rezafungin as a Stepping-Stone for Shorter Treatment Duration for Candidemia: Pooled Analysis of 2 Randomized Trials.
Luis Ostrosky-Zeichner, Jalal A Aram, Mark Redell, George R Thompson 3rd, Oliver A Cornely
Open Forum Infectious Diseases. 2026-04-01

Journal Articles

AST to ALT Ratio is Elevated in Disseminated Histoplasmosis as Compared to Localized Pulmonary Disease and Other Endemic Mycoses
Spec A, Barrios CR, Ahmad U, Proia LA, Medical Mycology, 1/1/2016
Community-associated methicillin-resistant Staphylococcus aureus colonization burden in HIV-infected patients
Popovich KJ, Hota B, Aroutcheva A, Kurien L, Patel J, Lyles-Banks R, Grasso AE, Spec A, Beavis KG, Hayden MK, Weinstein RA, Clinical Infectious Disease, 1/1/2013

Books/Book Chapters

The Washington Manuel Infectious Disease Subspecialty Consult.
Chapter: Dimorphic Fungal Infections
Raval K, Spec AEditors: Liang S, Kirmani N.Lippincott Williams and Wilkins2018

Abstracts/Posters

Risk factors and mortality associated with fluconazole resistant candida bloodstream infections.
Spec A, Hsueh K, Kronen R, Lin C, Powderly W, 8th Trends in Medical Mycology, Belgrade, Serbia, 1/1/2017
Risk factors predicting Candida glabrata fungemia.
O’Halloran J, Hsueh K, Kronen R, Lin C, Powderly W, Spec A., Infectious Disease Society of America, San Diego, CA, 1/1/2017
Retrospective analysis of cryptococcal Presentation and Outcomes in HIV, Transplant and Non-HIV/Non-Transplant cohort
Raval K, Powderly W, Spec A, Infectious Disease Society of America, San Diego, CA, 1/1/2017

Lectures

The Three Guianas, Time Capsules for Understanding the Role of Development in Global Health
Rush University Medical Center, Chicago, IL - 1/1/2018
New Updates and New Horizons in Medical Mycology
Washington University of School of Medicine, St Louis, MO - 1/1/2018
Creation and Assessment of a Clinical Predictive Calculator and Mortality Associated with Candida krusei Bloodstream Infections.
San Diego, CA - 1/1/2017

Press Mentions

4 Key Things to Know About Lung Infections Caused by FungiJanuary 10th, 2023
Fungi That Cause Serious Lung Infections Are Now Found Throughout the U.S.January 4th, 2023
Fungi That Cause Lung Infections May Be Spreading Across the U.S.November 28th, 2022