AndrewSloanMD

Brain & Spinal Tumor, Neurosurgical Spine Surgery, Pituitary Surgery

Professor & Vice-Chair of Neurological Surgery; Peter D. Cristal Chair of Neurosurgical Oncology; Director, Center for Brain Tumor & Neuro-Oncology; Director, Center of Excellence in Translational Neuro-Oncology; University Hospitals & Seidman Cancer Center Case Comprehensive Cancer Center, & Case Western Reserve University School of Medicine

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Office
UH Cleveland Medical Center
11100 Euclid Ave Department of Neurological Surgery
Cleveland, OH 44106
Phone+1 216-844-2724

Fax+1 216-844-3014
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Education & Training

UCLA David Geffen School of Medicine/UCLA Medical CenterResidency, Neurological Surgery, 1990 - 1997
Harvard Medical SchoolClass of 1990

Certifications & Licensure

MI State Medical License 1998 - 2026
CA State Medical License 1992 - 2025
FL State Medical License 2004 - 2024
OH State Medical License 2006 - 2024
GA State Medical License 2022 - 2024
American Board of Neurological Surgery Neurological Surgery

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
Fellow (FAANS) American Association of Neurological Surgeons
Fellow (FACS) American College of Surgeons
Whos Who in Medicine and Healthcare Marquis Whos Who
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Clinical Trials

Biological Therapy Following Surgery and Radiation Therapy in Treating Patients With Primary or Recurrent Astrocytoma or Oligodendroglioma Start of enrollment: 1997 Jun 01
Completed
Phase 2
Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer Start of enrollment: 2006 Dec 01
Active, not recruiting
Phase 3
Safety & Radiation Distribution Study of Cotara® in Patients With Recurrent Glioblastoma Multiforme Start of enrollment: 2006 Nov 01
Completed
Phase 1
Monteris AutoLITT™ FIM Safety Trial for Recurrent/Progressive Brain Tumors Start of enrollment: 2008 Aug 01
Completed
Phase 1
Imaging Procedure Using ALA in Finding Residual Tumor in Grade IV Malignant Astrocytoma Start of enrollment: 2009 Dec 08
Completed
Phase 2
BG & TMZ Therapy of Glioblastoma Multiforme Start of enrollment: 2011 Nov 22
Completed
Phase 1
A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma Start of enrollment: 2011 Dec 01
Completed
Phase 2
A Phase II Study of Oral LDE225 in Patients With Hedge-Hog (Hh)-Pathway Activated Relapsed Medulloblastoma (MB) Start of enrollment: 2013 May 06
Completed
Phase 2
Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery Start of enrollment: 2013 May 01
Terminated
Phase 2
Laser Interstitial Thermotherapy (LITT) Combined With Checkpoint Inhibitor for Recurrent GBM (RGBM) Start of enrollment: 2017 Nov 29
Recruiting
Phase 1, Phase 2
LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma Start of enrollment: 2020 Oct 21
Active, not recruiting
Phase 2
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Publications & Presentations

PubMed

3 citations
Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism.
Zhao, L., Qiu, Z., Yang, Z., Xu, L., Pearce, T., Wu, Q., Yang, K., Li, F., Saulnier, O., Fei, F., Yu, H., Gimple, R., Varadharajan, V., Liu, J., Hendrikse, L., Fong, V...> ;Nature Cancer. 2024 Jan 1
3 citations
Association of partial T2-FLAIR mismatch sign and isocitrate dehydrogenase mutation in WHO grade 4 gliomas: results from the ReSPOND consortium.
Matthew D Lee, Sohil H Patel, Suyash Mohan, Hamed Akbari, Spyridon Bakas, MacLean P Nasrallah, Evan Calabrese, Jeffrey Rudie, Javier Villanueva-Meyer, Pamela LaMontagn...> ;Neuroradiology. 2023 Sep 1
Multiple plasma membrane reporters discern LHFPL5 region that blocks trafficking to the plasma membrane.
David C Soler, Angela Ballesteros, Andrew E Sloan, Thomas S McCormick, Ruben Stepanyan> ;Scientific Reports. 2023 Feb 13
1 citations
Author Correction: Federated learning enables big data for rare cancer boundary detection.
Pati, S., Baid, U., Edwards, B., Sheller, M., Wang, S., Reina, G., Foley, P., Gruzdev, A., Karkada, D., Davatzikos, C., Sako, C., Ghodasara, S., Bilello, M., Mohan, S....> ;Nature Communications. 2023 Jan 26
Comparison of Near-Infrared Imaging Agents Targeting the PTPmu Tumor Biomarker.
Mette L Johansen, Jason Vincent, Marissa Rose, Andrew E Sloan, Susann M Brady-Kalnay> ;Molecular Imaging and Biology. 2023 Aug 1
2 citations
Glioma stem cells activate platelets by plasma-independent thrombin production to promote glioblastoma tumorigenesis.
Anthony R Sloan, Christine Lee-Poturalski, Harry C Hoffman, Peggy L Harris, Theresa E Elder, Brian Richardson, Amber Kerstetter-Fogle, Gino Cioffi, Julia Schroer, Ansh...> ;Neuro-Oncology Advances. 2022 Nov 7
1 citations
Stereotactic radiosurgery and resection for treatment of multiple brain metastases: a systematic review and analysis.
Uma V Mahajan, Ansh Desai, Yang Cai, Austin Anthony, Collin M Labak, Eric Z Herring, Olindi Wijesekera, Debraj Mukherjee, Andrew E Sloan, Tiffany R Hodges, Shost, M.> ;Neurosurgical Focus. 2022 Nov 1
4 citations
Novel 3D magnetic resonance fingerprinting radiomics in adult brain tumors: a feasibility study.
Charit Tippareddy, Louisa Onyewadume, Andrew E Sloan, Gi-Ming Wang, Nirav T Patil, Siyuan Hu, Jill S Barnholtz-Sloan, Rasim Boyacıoğlu, Vikas Gulani, Jeffrey Sunshine,...> ;European Radiology. 2023 Feb 1
Multidisciplinary approaches to gliosarcoma: A case report and review of the literature.
Collin M Labak, Nicholas M Rabah, Jasmine P Kipke, Uma V Mahajan, Kyle B Labak, S Ahmed Ali, Nicole Fowler, Andrew E Sloan> ;Clinical Case Reports. 2022 Aug 1
8 citations
Integrin α3β1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis.
Eunnyung Bae, Ping Huang, Gaёlle Müller-Greven, Dolores Hambardzumyan, Andrew Edward Sloan, Amy S Nowacki, Nicholas Marko, Cathleen R Carlin, Candece L Gladson> ;Nature Communications. 2022 Jul 25
Commentary: A Novel 5-Aminolevulinic Acid-Enabled Surgical Loupe System-A Consecutive Brain Tumor Series of 11 Cases.
Andrew E Sloan> ;Operative Neurosurgery. 2022 Jun 1
2 citations
A volume-independent conformity index for stereotactic radiosurgery.
Seungjong Oh, Musaddiq J Awan, James I Monroe, Yun Liang, Rodney E Wegner, Stephen Karlovits, Mitchell Machtay, Simon S Lo, Andrew Sloan, Jason W Sohn> ;Medical Physics. 2022 May 1
19 citations
Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrentwild-type glioblastoma.
John F de Groot, Albert H Kim, Sujit Prabhu, Ganesh Rao, Adrian W Laxton, Peter E Fecci, Barbara J O'Brien, Andrew Sloan, Veronica Chiang, Stephen B Tatter, Alireza M ...> ;Neuro-Oncology Advances. 2022 Apr 6
8 citations
Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors.
Grayson A Herrgott, Karam P Asmaro, Michael Wells, Thais S Sabedot, Tathiane M Malta, Maritza S Mosella, Kevin Nelson, Lisa Scarpace, Jill S Barnholtz-Sloan, Andrew E ...> ;Neuro-Oncology. 2022 Jul 1
21 citations
Three-dimensional organoid culture unveils resistance to clinical therapies in adult and pediatric glioblastoma.
Swetha J. Sundar, Sajina Shakya, Austin Barnett, Lisa C. Wallace, Hyemin Jeon, Andrew E. Sloan, Violette Recinos, Christopher G. Hubert> ;Translational Oncology. 2022 Jan 1
8 citations
Using chimeric antigen receptor T-cell therapy to fight glioblastoma multiforme: past, present and future developments.
David C. Soler, Amber Kerstetter-Fogle, Thomas S. McCormick, Andrew E. Sloan> ;Journal of Neuro-Oncology. 2021 Nov 26
12 citations
Independently validated sex-specific nomograms for predicting survival in patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825
Nirav Patil, Eashwar Somasundaram, Kristin A Waite, Justin D. Lathia, Mitchell Machtay, Mark R. Gilbert, James R. Connor, Joshua B. Rubin, Michael E. Berens, Robin Bue...> ;Journal of Neuro-Oncology. 2021 Nov 10
2 citations
Treating Recurrent Brain Metastases Using GammaTile Brachytherapy: A Case Report and Dosimetric Modeling Method
Theodore Arsenault, Collin M. Labak, Raymond F. Muzic, Arash Kardan, Andrew E. Sloan, Serah Choi, Tarun Podder, Zi Ouyang, K.V. Chaung> ;Cureus. 2021 Nov 3
2 citations
A region within the third extracellular loop of rat Aquaporin 6 precludes trafficking to plasma membrane in a heterologous cell line.
David C. Soler, Thomas Kowatz, Andrew E. Sloan, Thomas S. McCormick, Kevin D. Cooper, Ruben Stepanyan, Andrew G. Engel, Ardeschir Vahedi-Faridi> ;Scientific Reports. 2021 Jul 1
18 citations
Radiation Necrosis from Stereotactic Radiosurgery-How Do We Mitigate?
Balamurugan Vellayappan, Tresa McGranahan, Jerome J. Graber, Lynne Taylor, Vyshak Venur, Richard G. Ellenbogen, Andrew E Sloan, Kristin J. Redmond, Matthew Foote, Samu...> ;Current Treatment Options in Oncology. 2021 Jun 7
5 citations
Limited brain metastases: a narrative review.
K.V. Chaung, Andrew E. Sloan, Serah Choi> ;Annals of Palliative Medicine. 2021 Apr 26
10 citations
Guidelines in the management of CNS tumors
Navid Redjal, Andrew S. Venteicher, Danielle Dang, Andrew E. Sloan, Remi A. Kessler, Rebecca R. Baron, Constantinos G. Hadjipanayis, Clark C. Chen, Mateo Ziu, Jeffrey ...> ;Journal of Neuro-Oncology. 2021 Feb 1
27 citations
Laser interstitial thermotherapy (LITT) for the treatment of tumors of the brain and spine: a brief review.
Clark C. Chen, Ian Lee, Claudio E. Tatsui, Theresa Elder, Andrew E. Sloan> ;Journal of Neuro-Oncology. 2021 Feb 1
9 citations
Impact of race on care, readmissions, and survival for patients with glioblastoma: an analysis of the National Cancer Database.
Tiffany R Hodges, Collin M. Labak, Uma V Mahajan, Christina Huang Wright, James Wright, Gino Cioffi, Haley Gittleman, Eric Z Herring, Xiaofei Zhou, Kelsey Duncan, Caro...> ;Neuro-Oncology Advances. 2021 Jan 1
3 citations
Monte Carlo Dose Calculation Using MRI Based Synthetic CT Generated by Fully Convolutional Neural Network for Gamma Knife Radiosurgery
Jiankui Yuan, Elisha T. Fredman, J.Y. Jin, Serah Choi, David B. Mansur, Andrew E Sloan, Mitchell Machtay, Y. Zheng> ;Technology in Cancer Research & Treatment. 2021 Jan 1
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Lectures

NRG BN002: Phase I study of checkpoint inhibitors anti-CTLA-4, anti-PD-1, the combination in patients with newly diagnosed glioblastoma.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018
Phase I/II study of laser interstitial thermotherapy (LITT) combined with checkpoint inhibitor for recurrent glioblastoma (rGBM).
2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018

Press Mentions

Immunotherapy Response Linked to Low TMB in Recurrent GlioblastomaJanuary 20th, 2021
Medtronic Selects UH Cleveland Medical Center for Stealth Autoguide Precision Robotic Platform for Brain SurgeryNovember 11th, 2020
Bevacizumab for the Treatment of Non-Small Cell Lung Cancer Patients with Synchronous Brain MetastasesNovember 28th, 2019
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