AndrzejADlugoszMD

PubMed

• Corrigendum to "Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma" [Neoplasia, Volume 21, Issue 3 (2019) 322-330].
  Jae Eun Choi, Monique E Verhaegen, Sahr Yazdani, Rohit Malik, Paul W Harms, Doris Mangelberger, Jean Tien, Xuhong Cao, Yuping Wang, Marcin Cieślik, Jonathan Gurkan, Mi...> ;Neoplasia. 2024 May 1
• Predictive modeling provides insight into the clinical heterogeneity associated withloss-of-function mutations.
  Rebecca Meyer-Schuman, Allison R Cale, Jennifer A Pierluissi, Kira E Jonatzke, Young N Park, Guy M Lenk, Stephanie N Oprescu, Marina A Grachtchouk, Asim A Beg, Miriam ...> ;Biorxiv. 2024 Mar 27
• 4 citations
  Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury.
  Natalia A Veniaminova, Yunlong Y Jia, Adrien M Hartigan, Thomas J Huyge, Shih-Ying Tsai, Marina Grachtchouk, Seitaro Nakagawa, Andrzej A Dlugosz, Scott X Atwood, Sunny...> ;Cell Reports. 2023 Sep 26
• 3 citations
  Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury.
  Natalia A Veniaminova, Yunlong Jia, Adrien M Hartigan, Thomas J Huyge, Shih-Ying Tsai, Marina Grachtchouk, Seitaro Nakagawa, Andrzej A Dlugosz, Scott X Atwood, Sunny Y...> ;Biorxiv. 2023 May 5
• 7 citations
  Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin.
  Taihao Quan, Wei Xia, Tianyuan He, Kenneth Calderone, George Bou-Gharios, John J Voorhees, Andrzej A Dlugosz, Gary J Fisher> ;The Journal of Investigative Dermatology. 2023 Sep 1
• 3 citations
  Metastatic same-site squamous cell carcinoma arising during vismodegib therapy for basal cell carcinoma.
  Raymond Zhao, Bo Wang, Lori Lowe, Andrzej Dlugosz, Christopher K Bichakjian> ;JAAD Case Reports. 2022 Oct 1
• 1 citations
  Unique lingual expression of the Hedgehog pathway antagonist Hedgehog-interacting protein in filiform papillae during homeostasis and ectopic expression in fungiform p...
  Archana Kumari, Libo Li, Alexandre N Ermilov, Nicole E Franks, Andrzej A Dlugosz, Benjamin L Allen, Charlotte M Mistretta> ;Developmental Dynamics. 2022 Jul 1
• 3 citations
  Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease.
  Kenneth G Trieu, Shih-Ying Tsai, Markus Eberl, Virginia Ju, Noah C Ford, Owen J Doane, Jamie K Peterson, Natalia A Veniaminova, Marina Grachtchouk, Paul W Harms, Fredr...> ;Cell Reports. 2022 May 3
• 12 citations
  Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice.
  Monique E Verhaegen, Paul W Harms, Julia J Van Goor, Jacob Arche, Matthew T Patrick, Dawn Wilbert, Haley Zabawa, Marina Grachtchouk, Chia-Jen Liu, Kevin Hu, Michael C ...> ;The Journal of Clinical Investigation. 2022 Apr 1
• 6 citations
  DNA-methylation patterns imply a common cellular origin of virus- and UV-associated Merkel cell carcinoma.
  Jan Gravemeyer, Ivelina Spassova, Monique Verhaegen, Andrzej A. Dlugosz, Daniel Hoffmann, Anja Lange, Jürgen C. Becker> ;Oncogene. 2021 Oct 19
• 20 citations
  Genomic evidence suggests that cutaneous neuroendocrine carcinomas can arise from squamous dysplastic precursors
  Paul W. Harms, Monique Verhaegen, Kevin Hu, Steven M. Hrycaj, May P. Chan, Chia Jen Liu, Marina Grachtchouk, Rajiv M. Patel, Aaron M. Udager, Andrzej A. Dlugosz> ;Modern Pathology. 2021 Sep 30
• 9 citations
  Viral Status Predicts the Patterns of Genome Methylation and Decitabine Response in Merkel Cell Carcinoma.
  Paul W. Harms, Monique Verhaegen, Josh N. Vo, Jean C. Tien, Drew Pratt, Fengyun Su, Saravana M. Dhanasekaran, Xuhong Cao, Doris Mangelberger, Julia VanGoor, Jae Eun Ch...> ;The Journal of Investigative Dermatology. 2021 Aug 30
• 3 citations
  Extended T-Cell Epitope Landscape in Merkel Cell Polyomavirus Large T and Small T Oncoproteins Identified Uniquely in Patients with Cancer.
  Ulla Kring Hansen, Rikke Birgitte Lyngaa, Dafina Ibrani, Candice D. Church, Monique Verhaegen, Andrzej A. Dlugosz, Jürgen C. Becker, Per thor Straten, Paul Nghiem, Sin...> ;The Journal of Investigative Dermatology. 2021 Jul 20
• 10 citations
  HDAC1/2 Control Proliferation and Survival in Adult Epidermis and Pre‒Basal Cell Carcinoma through p16 and p53.
  Xuming Zhu, Matthew R. LeBoeuf, Fang Liu, Marina Grachtchouk, John T. Seykora, Edward E. Morrisey, Andrzej A. Dlugosz, Sarah E. Millar> ;The Journal of Investigative Dermatology. 2021 Jul 17
• 48 citations
  Obesity accelerates hair thinning by stem cell-centric converging mechanisms
  Hironobu Morinaga, Yasuaki Mohri, Marina Grachtchouk, Kyosuke Asakawa, Hiroyuki Matsumura, Motohiko Oshima, Naoya Takayama, Tomoki Kato, Yuriko Nishimori, Yuriko Sorim...> ;Nature. 2021 Jun 23
• 1 citations
  Constitutive Hedgehog/GLI2 signaling drives extracutaneous basaloid squamous cell carcinoma development and bone remodeling
  Marina Grachtchouk, Jianhong Liu, Mark E. Hutchin, Paul W. Harms, Dafydd G. Thomas, Lebing Wei, Aiqin Wang, Donelle Cummings, Lori Lowe, Jonathan A. Garlick, James J. ...> ;Carcinogenesis. 2021 Aug 19
• 43 citations
  Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles.
  Nil Grunberg, Meirav Pevsner-Fischer, Tal Goshen-Lago, Judith Diment, Yaniv Stein, Hagar Lavon, Shimrit Mayer, Oshrat Levi-Galibov, Gil Friedman, Yifat Ofir-Birin, LiJ...> ;Cancer Research. 2021 Feb 5
• 117 citations
  Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer.
  Nina Steele, Giulia Biffi, Samantha Kemp, Yaqing Zhang, Donovan Drouillard, LiJyun Syu, Yuan Hao, Tobiloba E. Oni, Erin Brosnan, Ela Elyada, Abhishek Doshi, Christa Ha...> ;Clinical Cancer Research. 2021 Apr 1
• 9 citations
  Dermal Fibroblast CCN1 Expression in Mice Recapitulates Human Skin Dermal Aging.
  Taihao Quan, Yaping Xiang, Yingchun Liu, Zhaoping Qin, Yan Yang, George Bou-Gharios, John J. Voorhees, Andrzej A. Dlugosz, Gary J. Fisher> ;The Journal of Investigative Dermatology. 2021 Apr 1
• 21 citations
  Aim2-mediated/IFN-β–independent regulation of gastric metaplastic lesions via CD8+ T cells
  Mohamad El-Zaatari, Shrinivas Bishu, Min Zhang, Helmut Grasberger, Guoqing Hou, Henry R. Haley, Brock Humphries, LiJyun Syu, Andrzej A. Dlugosz, K. E. Luker, Gary D. L...> ;JCI Insight. 2020 Mar 12
• 28 citations
  Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin.
  Natalia A. Veniaminova, Marina Grachtchouk, Owen J. Doane, Jamie K. Peterson, David A. Quigley, Madison V. Lull, Daryna V. Pyrozhenko, Raji R. Nair, Matthew Patrick, A...> ;Developmental Cell. 2019 Nov 4
• 41 citations
  The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity
  Allison C. Billi, Mehrnaz Gharaee-Kermani, Joseph Fullmer, Lam C. Tsoi, Brett D. Hill, Dennis Gruszka, J. Ludwig, Xianying Xing, Shannon N. Estadt, Sonya J. Wolf, Syed...> ;JCI Insight. 2019 Apr 18
• 5 citations
  Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma.
  Jae Eun Choi, Monique Verhaegen, Sahr Yazdani, Rohit Malik, Paul W. Harms, Doris Mangelberger, Jean Tien, Xuhong Cao, Yuping Wang, Marcin Cieślik, Jonathan Gurkan, Mis...> ;Neoplasia. 2019 Mar 1
• 7 citations
  Insight into the Etiology of Undifferentiated Soft Tissue Sarcomas from a Novel Mouse Model
  Jonathan T. Fleming, Emily Brignola, Lei Chen, Yan Guo, Shilin Zhao, Quan Wang, Bingshan Li, Hernan Correa, Alexandre N. Ermilov, Andrzej A. Dlugosz, Chin Chiang> ;Molecular Cancer Research. 2019 Jan 1
• 83 citations
  Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer.
  Jayati Chakrabarti, Loryn Holokai, LiJyun Syu, Nina Steele, Julie Chang, Jiang Wang, Syed Ahmed, Andrzej A. Dlugosz, Yana Zavros> ;Oncotarget. 2018 Dec 21
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Journal Articles

• Circulating Cell-Free miR-375 as Surrogate Marker of Tumor Burden in Merkel Cell Carcinoma  
  Andrzej Dlugosz, MD, Clinical Cancer Research
• Merkel cell carcinoma dependence on Bcl-2 family members for survival  
  Verhaegen ME, Mangelberger D, Weick JW, Vozheiko TD, Harms PW, Nash KT, Quintana E, Baciu P, Johnson TM, Bichakjian CK, Dlugosz AA, J Invest Dermatol, 3/1/2014
• Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance  
  Liu HX, Ermilov A, Grachtchouk M, Li L, Gumucio DL, Dlugosz AA, Mistretta CM, Dev Biol, 10/1/2013
• Transgenic expression of interferon in mouse stomach leads to inflammation, metaplasia, and dysplasia  
  Syu LJ, El-Zaatari M, Eaton KA, Liu Z, Tetarbe M, Keeley TM, Pero J, Ferris J, Wilbert D, Kaatz A, Zheng X, Qiao X, Grachtchouk M, Gumucio DL, Merchant JL, Samuelson L..., Am J Pathol, 12/1/2012
• Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells  
  Eberl M, Klingler S, Mangelberger D, Loipetzberger A, Damhofer H, Zoidl K, Schnidar H, Hache H, Bauer HC, Solca F, Hauser-Kronberger C, Ermilov AN, Verhaegen ME, Bicha..., EMBO Mol Med, 3/1/2012
• A transgenic mouse for imaging caspase-dependent apoptosis within the skin  
  Khanna D, Hamilton CA, Bhojani MS, Lee KC, Dlugosz A, Ross BD, Rehemtulla A, J Invest Dermatol, 7/1/2010
• Transient activation of beta-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice  
  Van Mater D, Kolligs FT, Dlugosz AA, Fearon ER, Genes Dev, 5/1/2003
• Macrophage-stimulating protein induces proliferation and migration of murinekeratinocytes  
  Wang MH, Dlugosz AA, Sun Y, Suda T, Skeel A, Leonard EJ, Exp Cell Res, 7/1/1996
• Regulating normal skin function by polypeptide growth factors  
  Glick AB, Dlugosz AA and Yuspa S, Cosmetics and Toiletries, 1/1/1994
• Interactions between IF's, microtubules and myofibrils in fibrogenic and myogenic cells  
  Holtzer H, Forry-Schaudies S, Dlugosz A, Antin P and Dubyak G, Ann NY Acad Sci, 1/1/1985
• The relationship between stress fiber-like structures and nascent myofibrils in cultured cardiac myocytes  
  Dlugosz AA, Antin PB, Nachmias VT, Holtzer H, J Cell Biol, 12/1/1984
• Properties of cell lineages as indicated by the effects of ts-RSV and TPA on the generation of cell diversity  
  Holtzer H, Pacifici M, Croop J, Boettiger D, Toyama Y, Payette R, Biehl J, Dlugosz A and Holtzer S, Fortsch. Zool, 1/1/1981
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Books/Book Chapters

• Fitzpatrick’s Dermatology in General Medicine 
  Chapter: Chemical Carcinogenesis 
  Glick AB and Dlugosz AAEditors: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, and Wolff K.McGraw-Hill, Inc., New YorkEdition 8th,2012
• Fitzpatrick’s Dermatology in General Medicine 
  Chapter: Carcinogenesis: Chemical 
  Dlugosz AA and Yuspa SHEditors: Wolff K, Goldsmith, LA, Katz, SI, Gilchrest BA, Paller, AS, and Leffell, DJ.McGraw-Hill, Inc., New YorkEdition 7th,2008
• Skin Cancer: Mechanisms and Human Relevance 
  Chapter: Biochemical regulation of keratinocyte differentiation and neoplastic transformation 
  Dlugosz AAEditors: Mukhtar H.CRC Press, Boca Raton, FL1995
• Dermatology in General Medicine 
  Chapter: Carcinogenesis: Chemical 
  Dlugosz AA and Yuspa SHEditors: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IA and Austen KF.McGraw-Hill, Inc., New YorkEdition 4th,1993
• Physiology Biochemistry and Molecular Biology of The Skin 
  Chapter: Cutaneous carcinogenesis: natural and experimental 
  Yuspa SH and Dlugosz AAEditors: Goldsmith L.Oxford University Press, New York1991
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Abstracts/Posters

• Oncogene addiction distinguishes malignant from benign skin tumors caused by deregulated Hedgehog signaling
  Grachtchouk M. Wilbert D, Pero J, Fiehler K, Crowley J, Photenhauer A, Ermilov AN, Dlugosz AA, J Invest Dermatol, 1/1/2013
• Lgr5+ stem cells give rise to Hedgehog pathway-driven gastric adenocarcinomas
  Syu LJ, Zhao X, Grachtchouk M, Ermilov A, Greenson J, Zheng X, Kaatz A, Pero J, Wilbert D, Gumucio D, Samuelson L, Merchant J, Dlugosz AA, J Invest Dermatol, 1/1/2013
• Targeting Merkel cell carcinoma dependence on Bcl-2 family members promotes efficient cell death in vitro and in vivo
  Verhaegen, ME, Weick JW, Vozheiko TD, Mangelberger DM, Pero JC, Johnson TM, Bichakjian, Dlugosz AA, J Invest Dermatol, 1/1/2013
• Blockade of Gli transcriptional activity in mature anagen hair follicles leads to impaired matrix cell proliferation, aberrant differentiation, and defective hair shaf...
  Ermilov AN, Pero J, Wilbert D, Photenhauer A, Zabawa H, Grachtchouk M, Dlugosz AA, J Invest Dermatol, 1/1/2013
• GLI2 engages the mTOR pathway to drive development of malignant peripheral nerve sheath tumors (MPNSTs) in skin
  Ermilov AN, DeLassua E, Ferris J, Hong D, Pero J, Liu J, Grachtchouk M, Conway SJ, Lucas DR, Dlugosz AA, J Invest Dermatol, 1/1/2012
• Exploiting deregulated apoptotic signaling as a therapeutic strategy for Merkel cell carcinoma
  Verhaegen ME, Bichakjian CK, Vozheiko T, Weick J, Voutsalath M, Johnson TM, Dlugosz AA, J Invest Dermatol, 1/1/2012
• Targeting deregulated HIF1 signaling in human melanoma by conditional HIF1 knockdown promotes tumor progression
  Nash KT, Ayar AE, Verhaegen ME, Johnson TJ, Dlugosz AA, J Invest Dermatol, 1/1/2011
• Oncogene addiction to Merkel cell polyomavirus large T antigen in Merkel cell carcinoma
  Verhaegen ME, Bichakjian CK, Voutsalath M, Weick J, Baciu P, Quintana E, Stromer TD, Pero J, Nash KT, Ayar AE, Johnson TM, Dlugosz AA, J Invest Dermatol, 1/1/2011
• Basal cell carcinoma tumor subtype is defined by its cell of origin
  Grachtchouk M, Pero J, Ermilov AN, Michael LE, Wilbert D, Lim S, Dlugosz AA, J Invest Dermatol, 1/1/2011
• Deregulated hedgehog signaling in the pathogenesis of Barrett’s disease and gastric adenocarcinoma
  Ermilov, AN, Ferris J, Pero J, Hong D, Dlugosz AA, J Invest Dermatol, 1/1/2010
• Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin in vivo
  Rittie L, Stoll SW, Kang S, Dlugosz AA, Voorhees JJ, Fisher GJ, J Invest Dermatol, 1/1/2009
• Unscheduled melanogenesis in response to oncogenic Hedgehog signaling in skin
  Yang SH, Verhaegen M, Grachtchouk V, Wang A, Liu J, Syu L, Ferris J, Dlugosz AA, J Invest Dermatol, 1/1/2009
• Obligatory role for Bmi1 in hedgehog-pathway driven medulloblastoma expansion
  Michael LE, Westerman BA, Ermilov AN, Ferris J, Liu J, Blom M. van Lohuizen M, Dlugosz AA, J Invest Dermatol, 1/1/2008
• Hedgehog signaling and sebaceous gland maintenance
  Grachtchouk M, Wang A, Gudjonsson J, Liu J, Ferris J, Dlugosz AA, J Invest Dermatol, 1/1/2008
• A conditional mouse model defines temporal and spatial requirements for deregulated Hedgehog signaling in medulloblastoma
  Michael LE, Liu J, Wang A, Ferris JE, Grachtchouk M, Ermilov AN, Dlugosz AA, J Invest Dermatol, 1/1/2007
• Lack of evidence for activation of the Hedgehog pathway in psoriasis
  Aphale A, Gudjonsson JE, Grachtchouk M, Johnson T, Voorhees JJ, Dlugosz A, Elder JT, J Invest Dermatol, 1/1/2007
• Hedgehog-driven epitheial bud development is associated with activation of cannonical Wnt signaling
  Yang S, Grachtchouk V, Wang A, Liu J, Syu L, Dlugosz A, J Invest Dermatol, 1/1/2007
• Constitutive Hedgehog signaling activity, via GLI2 expression, is sufficient for salivary gland tumorigenesis
  Ermilov AE, Brown J, Roessler E, Wang A, Liu J, D’Silva N, Ramirez A, Jorcano J, Muenke M, Dlugosz AA, J Invest Dermatol, 1/1/2006
• Cellular context dictates tumorigenic potential of activated Smo in vivo
  Michael LE, Brown JE, Liu J, Wang A, Ermilov AN, Glick AB, Dlugosz AA, J Invest Dermatol, 1/1/2006
• Full-length human GLI2 contains a previously undescribed transcriptional repressor domain
  Ermilov A, Roessler E, Wang A, Grachtchouk M, Dlugosz A, Muenke M, J Invest Dermatol, 1/1/2005
• Dominant negative tuberin collaborates with Patched (PTCH) deficiency in the development of neoplasia in transgenic mice
  Govindarajan B, Arbiser JL, Brat DJ, Dlugosz A, J Invest Dermatol, 1/1/2005
• Hedgehog signaling and sebocyte development
  Grachtchouk M, Liu J, Hutchin M, Wang A, Glick AB, Dlugosz A, J Invest Dermatol, 1/1/2005
• Deregulated hedgehog signaling in extracutaneous basaloid squamous cell carcinomas
  Grachtchouk M, Wang A, Lei L, Hutchin M, Lowe L, Glick A, and Dlugosz AA, J Invest Dermatol, 1/1/2004
• Defining the Hedgehog-PTHrP signaling axis in the skin
  Gocken T, Sheng H, Gonterman R, Billings SD, Diamond A, Dlugosz AA, and Foley J, J Invest Dermatol, 1/1/2004
• Odontogenic keratocysts in transgenic mice overexpressing the hedgehog signaling effector Gli2
  Grachtchouk M, Wei L, Liu J, Wang A, and Dlugosz AA, J Invest Dermatol, 1/1/2003
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Lectures

• Dissecting the transforming potential of Merkel cell polyomavirus 
  Denver, CO - 3/21/2014
• Basal cell carcinoma drug therapy and side effects: from bench to clinic and back again 
  2/27/2014
• Hedgehog signaling level, tumor phenotype, and oncogene addiction 
  Il Ciocco, Italy - 5/14/2013
• Hedgehog signaling in skin biology and tumorigenesis: where, when and how? 
  Edinburgh, Scotland - 5/10/2013
• Hedgehog functions in skin biology and cancer 
  New Haven, CT - 4/3/2013
• Immunobullous Disease 
  1/1/2013
• Multiple determinants contribute to basal cell carcinoma development 
  Dermatogenetics, Miami, FL - 2/10/2012
• Hedgehog and basal cell carcinoma: where, when and how 
  Skamania Lodge, WA - 10/14/2011
• Mechanism-Based Medical Approaches to Treating Skin Cancer 
  Napa, CA - 9/18/2011
• Hedgehog signaling in non-melanoma skin cancer 
  Tubingen, Germany - 2/17/2011
• Cell of Origin and Basal Cell Carcinoma Subtype: Location, Location, Location 
  1/1/2011
• Hedgehog signaling; current understanding and clinical implications 
  Vienna, Austria - 11/20/2010
• Deregulated Hedgehog signaling in basal cell carcinoma initiation, progression, and maintenance: therapeutic implications 
  Gothenburg, Sweden - 10/8/2010
• From bench to clinic with a Hedgehog: targeted therapeutics for basal cell carcinoma 
  Atlanta, GA - 5/5/2010
• Hedgehog Signaling in Skin Biology and Tumorigenesis 
  10/22/2009
• Defining the cell of origin for Hedgehog-driven cancer 
  University of California, San Diego - 10/22/2009
• Shh signaling in development and disease 
  Gleneden Beach, OR - 10/8/2009
• Hedgehog signaling & skin tumorigenesis: from bench to bedside 
  3/24/2009
• Hedgehog signaling in skin development and cancer 
  11/9/2007
• Hedgehog signaling in cancer initiation 
  Smithville, TX - 11/10/2006
• Hedgehog signaling in skin appendage biology and cancer 
  Infinity Pharmaceuticals, Inc., Cambridge, MA - 3/20/2006
• Hedgehog signaling in tumor initiation and maintenance 
  1/1/2006
• Hedgehog signaling in skin biology and disease 
  Sophia Antipolis, France - 11/21/2005
• Hedgehog Signaling and Sebocyte Development 
  St. Louis, MO - 5/4/2005
• From Lab Bench to Clinic with a Hedgehog 
  3/9/2005
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