AneeshBhimSinghalMD

Vascular Neurology

Vice Chair of Neurology | Quality and Safety, Massachusetts General Hospital; Director, MGH Comprehensive Stroke Center; Associate Professor of Neurology, Harvard Medical School; Director, Stroke and Neuro-ICU Observership Program, Massachusetts General Hospital; Director, Neurology Consultations, Spaulding Rehabilitation Hospital;

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Office
15 Parkman St
Wang 835
Boston, MA 02114
Phone+1 617-726-8459

Fax+1 617-726-5043
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Education & Training

Massachusetts General Hospital/Brigham and Women's Hospital/Harvard Medical SchoolFellowship, Vascular Neurology, 1999 - 2001
Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Neurology, 1995 - 1999
BYL Nair Charitable HospitalMD, Internal Medicine, 1992 - 1995
Seth G.S. Medical CollegeClass of 1992

Certifications & Licensure

ME State Medical License 2011 - 2026
NY State Medical License 2023 - 2025
NH State Medical License 2011 - 2025
MA State Medical License 1998 - 2025
MO State Medical License 2022 - 2025
KS State Medical License 2022 - 2024
FL State Medical License 1999 - 2005
American Board of Psychiatry and Neurology Neurology
American Board of Psychiatry and Neurology Vascular Neurology

Clinical Trials

Normobaric Oxygen Therapy in Acute Ischemic Stroke Trial Start of enrollment: 2007 Jan 01
Terminated
Phase 2
Normobaric Oxygen (NBO) Therapy in Acute Migraine Start of enrollment: 2012 Jul 01
Completed
Phase 2
Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome Start of enrollment: 2013 Nov 01
Recruiting
Effect of Natalizumab on Infarct Volume in Acute Ischemic Stroke Start of enrollment: 2014 Jan 01
Completed
Phase 2
Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS) Start of enrollment: 2014 Nov 27
Completed
Phase 3
Safety and Efficacy of Intravenous Natalizumab in Acute Ischemic Stroke Start of enrollment: 2016 Jul 18
Completed
Phase 2
AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke Start of enrollment: 2018 Jan 19
Terminated
Phase 3
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Automated Extraction of Stroke Severity from Unstructured Electronic Health Records using Natural Language Processing.
Marta Fernandes, M Brandon Westover, Aneesh B Singhal, Sahar F Zafar> ;Medrxiv. 2024 Mar 11
Characterizing coma in large vessel occlusion stroke.
Regenhardt, R., Michael J Young, Amine Awad, Alexander Andreev, Anna K Bonkhoff, Markus D Schirmer, Adam A Dmytriw, Justin E Vranic, James D Rabinov, Omer Doron, Chris...> ;Journal of Neurology. 2024 May 1
Safety and Feasibility of an Emergency Department-to-Outpatient Pathway for Patients With TIA and Nondisabling Stroke.
Alexis Roy, Anirudh Sreekrishnan, Erica Camargo Faye, Scott Silverman, Kori S Zachrison, Andrea M Harriott, Marcelo Matiello, Giovanna S Manzano, Mrinalini Prasanna, S...> ;Neurology. Clinical Practice. 2023 Dec 1
Stroke-Related Visceral Alterations: A Voxel-Based Neuroanatomic Localization Study.
Ethem Murat Arsava, Ken Chang, Ahmed Tawakol, Marco L Loggia, Joshua N Goldstein, James Brown, Kwang-Yeol Park, Aneesh B Singhal, Jayashree Kalpathy-Cramer, Alma Grego...> ;Annals of Neurology. 2023 Dec 1
1 citations
Left ventricular hypertrophy and left atrial size are associated with ischemic strokes among non-vitamin K antagonist oral anticoagulant users.
Alvin S Das, Elif Gökçal, Avia Abramovitz Fouks, Mitchell J Horn, Robert W Regenhardt, Anand Viswanathan, Aneesh B Singhal, Lee H Schwamm, Steven M Greenberg, M Edip G...> ;Journal of Neurology. 2023 Nov 1
1 citations
Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial.
Sven Poli, Joshua Mbroh, Jean-Claude Baron, Aneesh B Singhal, Daniel Strbian, Carlos Molina, Robin Lemmens, Guillaume Turc, Robert Mikulik, Patrik Michel, Turgut Tatli...> ;International Journal of Stroke. 2024 Jan 1
Outcomes of recurrent stroke in patients with atrial fibrillation according to presumed etiology.
Bruno Bacellar Pedreira, Korilyn Sauser Zachrison, Aneesh Singhal, Zhiyu Yan, Jamary Oliveira-Filho, Lee H Schwamm> ;Arquivos De Neuro-Psiquiatria. 2023 Jul 1
2 citations
Reversible cerebral vasoconstriction syndrome: A review of pathogenesis, clinical presentation, and treatment.
Aneesh B Singhal> ;International Journal of Stroke. 2023 Dec 1
1 citations
Case 6-2023: A 68-Year-Old Man with Recurrent Strokes.
Aneesh B Singhal, Scott B Silverman, Javier M Romero, Melanie Lang-Orsini> ;The New England Journal of Medicine. 2023 Feb 23
1 citations
Percent Insular Ribbon Infarction for Predicting Infarct Growth Rate and 90-Day Outcomes in Large-Vessel Occlusive Stroke: Secondary Analysis of Prospective Clinical T...
Robert W Regenhardt, Aneesh B Singhal, Julian He, R Gilberto Gonzalez, Michael H Lev> ;AJR. American Journal of Roentgenology. 2023 Jul 1
2 citations
Spoke-administered thrombolysis improves large vessel occlusion early recanalization: the real-world experience of a large academic hub-and-spoke telestroke network.
Andrew W Kraft, Robert W Regenhardt, Amine Awad, Joseph A Rosenthal, Adam A Dmytriw, Justin E Vranic, Anna K Bonkhoff, Martin Bretzner, Joshua A Hirsch, James D Rabino...> ;Stroke. 2023 Jan 1
1 citations
Symmetric collateral pattern on CTA predicts favorable outcomes after endovascular thrombectomy for large vessel occlusion stroke.
Michael H Lev, Julian He, Adam A Dmytriw, Justin E Vranic, James D Rabinov, Christopher J Stapleton, Aman B Patel, Aneesh B Singhal, R Gilberto Gonzalez, Regenhardt, R...> ;Plos One. 2023 Jan 1
Outcomes among patients with primary angiitis of the CNS: A Nationwide United States analysis.
Smit D Patel, Fadar Otite Oliver, Ahmed Elmashad, Neel Patel, Tapan Mehta, Jason Hinman, David S Liebeskind, Aneesh B Singhal, Anne Ducros, Jeffrey L Saver> ;Journal of Stroke and Cerebrovascular Diseases. 2022 Nov 1
4 citations
Direct to angio-suite large vessel occlusion transfers achieve faster arrival-to-puncture times and improved outcomes.
Robert W Regenhardt, Joseph A Rosenthal, Adam A Dmytriw, Justin E Vranic, Anna K Bonkhoff, Martin Bretzner, Joshua A Hirsch, James D Rabinov, Christopher J Stapleton, ...> ;Stroke. 2022 Nov 1
6 citations
Characterizing reasons for stroke thrombectomy ineligibility among potential candidates transferred in a hub-and-spoke network.
Robert W Regenhardt, Amine Awad, Andrew W Kraft, Joseph A Rosenthal, Adam A Dmytriw, Justin E Vranic, Anna K Bonkhoff, Martin Bretzner, Mark R Etherton, Joshua A Hirsc...> ;Stroke. 2022 Sep 1
Pulse on Stroke in Pulseless Disease (Takayasu Arteritis).
Alexis T Roy, Aneesh B Singhal> ;Stroke. 2022 May 1
Case 12-2022: A 41-Year-Old Woman with Transient Ischemic Attack and Mitral Valve Masses.
Mark A Matza, Sandra P Rincon, Evin Yucel, April M Jorge, Aneesh B Singhal, Carrie A Coleman, Sacha N Uljon> ;The New England Journal of Medicine. 2022 Apr 21
1 citations
Neurology Morbidity and Mortality Conferences and Quality Improvement: Single-Center Experience and National Survey.
Sophia L Ryan, Kathleen E McKee, Lizbeth Londono-Sanchez, Sarah Dougherty, Aneesh B Singhal> ;The Neurohospitalist. 2022 Apr 1
2 citations
Use of Prolonged Cardiac Rhythm Monitoring to Identify Atrial Fibrillation After Cryptogenic Stroke.
Alexis T Roy, Lee H Schwamm, Aneesh B Singhal> ;Current Cardiology Reports. 2022 Apr 1
29 citations
Stroke Prevention in Symptomatic Large Artery Intracranial Atherosclerosis Practice Advisory: Report of the AAN Guideline Subcommittee.
Turan, T., Zaidat, O., Gronseth, G., Chimowitz, M., Culebras, A., Furlan, A., Goldstein, L., Gonzalez, N., Latorre, J., Messé, S., Nguyen, T., Sangha, R., Schneck, M.,...> ;Neurology. 2022 Mar 22
5 citations
Prognostication in Acute Neurological Emergencies.
Kelly L Sloane, Julie J Miller, Amanda Piquet, Brian L Edlow, Eric S Rosenthal, Aneesh B Singhal> ;Journal of Stroke and Cerebrovascular Diseases. 2022 Mar 1
4 citations
Impact of Pre-Stroke Antiplatelet Use on 3-Month Outcome After Ischemic Stroke.
P N Sylaja, Sruthi S Nair, Jeyaraj Pandian, Dheeraj Khurana, M V Padma Srivastava, Subhash Kaul, Deepti Arora, P Sankara Sarma, Aneesh B Singhal> ;Neurology India. 2022 Jan 4
19 citations
Symmetric CTA Collaterals Identify Patients with Slow-progressing Stroke Likely to Benefit from Late Thrombectomy
Robert W. Regenhardt, R. Gilberto Gonzalez, Julian He, Michael H. Lev, Aneesh B. Singhal> ;Radiology. 2021 Nov 2
15 citations
Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome as Syndromes of Cerebrovascular Dysregulation.
Aneesh B. Singhal> ;Continuum. 2021 Oct 1
478 citations
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
, , , Ewan C Goligher, Charlotte A Bradbury, Bryan J McVerry, Patrick R Lawler, Jeffrey S Berger, Michelle N Gong, Marc Carrier, Harmony R Reynolds, Anand Kumar, Alexi...> ;The New England Journal of Medicine. 2021 Aug 26
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Journal Articles

Case 26-2020: A 60-Year-Old Woman with Altered Mental Status and Weakness on the Left Side
Aneesh B Singhal, Bart K Chwalisz, Shibani S Mukerji, The New England Journal of Medicine

Lectures

Reversible Vasoconstriction Syndromes and CNS Vasculitis
Boston, MA - 2/12/2014
Nonatherosclerotic Vasculopathies Have Distinct Characteristics
American Stroke Association, International Stroke Conference 2014, San Diego, California, USA
Nonatherosclerotic Vasculopathies Have Distinct Characteristics
International Stroke Conference 2014, San Diego, California, USA

Authored Content

Case 26-2020: A 60-Year-Old Woman with Altered Mental Status and Weakness on the Left SideAugust 2020
Case 26-2020: A 60-Year-Old Woman with Altered Mental Status and Weakness on the Left SideAugust 2020
Case 26-2020: A 60-Year-Old Woman with Altered Mental Status and Weakness on the Left SideAugust 2020
Case 26-2020: A 60-Year-Old Woman with Altered Mental Status and Weakness on the Left SideAugust 2020
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Press Mentions

ISC 2021 Session: Prognostication and Early Withdrawal of Care in Ischemic Stroke and ICHMarch 17th, 2021
Association Between Reduced Myocardial Contraction Fraction and Cardiovascular Disease Outcomes: The Multi-Ethnic Study of AtherosclerosisApril 1st, 2020
Clinical Features, Triggers, and Risk Factors Identified for Post-Stroke RecrudescenceSeptember 18th, 2017
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Grant Support

NIH StrokeNet (Deputy PI, New England Regional Coordinating Center)NIH-NINDS2013–2018
Indo-Us Collaborative Stroke Registry And Infrastructure DevelopmentNational Institute Of Neurological Disorders And Stroke2011
Normobaric Hyperoxia In Acute Ischemic StrokeNational Institute Of Neurological Disorders And Stroke2006–2010
Normobaric O2 In Ischemic StrokeNational Institute Of Neurological Disorders And Stroke2006–2009