AnnaSuk-FongLokMD

Gastroenterology • Ann Arbor, MI

Hepatology & Liver Transplantation

Professor, Internal Medicine, University of Michigan Medical School

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Office
1500 East Medical Center Dr
3rd Floor Taubman Ctr Recp D
Ann Arbor, MI 48109
Phone+1 734-647-5944
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Education & Training

Rutgers Health/New Jersey Medical SchoolResidency, Internal Medicine, 1989 - 1991
University of Hong Kong Faculty of MedicineClass of 1977

Certifications & Licensure

MI State Medical License 1998 - 2027
LA State Medical License 1994 - 2005

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Long Term Interferon for Patients Who Did Not Clear Hepatitis C Virus With Standard Treatment Start of enrollment: 2000 Jun 01
Completed
Phase 3
Hepatitis B Research Network Adult Cohort Study Start of enrollment: 2010 Dec 01
Completed
Combination Entecavir and Peginterferon Therapy in HBeAg-Positive Immune-Tolerant Adults With Chronic Hepatitis B Start of enrollment: 2012 May 01
Terminated
Phase 3
Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir Versus Tenofovir Monotherapy in Chronic Hepatitis B Start of enrollment: 2012 Nov 01
Completed
Phase 3
Pilot Study to Assess the Pharmacokinetics of Intravenous Nabi 5% Hepatitis B Immune Globulin (Boca HBVIg) Used in Combination With Lamivudine for Patients With Hepatitis B Virus (HBV) Associated Liver Disease Undergoing Liver Transplantation Start of enrollment: 1999 Nov 01
Completed
Phase 1, Phase 2
HCV-TARGET- Hepatitis C Therapeutic Registry and Research Network Start of enrollment: 2011 Nov 01
Completed
Long Term Follow-up Registry of Individuals Treated in A Gilead-Sponsored Trial in Individuals With Chronic Hepatitis B Infection Start of enrollment: 2014 Dec 09
Terminated
The Patient-Reported Outcomes Project of HCV-TARGET Start of enrollment: 2015 Nov 01
Completed
Study of Oral Treatments for Hepatitis C Start of enrollment: 2016 Jun 01
Completed
Phase 4
Multi-Center, Randomized, Open-Label Study of G/P +/- RBV for NS5A + SOF Previously Treated GT1 HCV Subjects Start of enrollment: 2017 Apr 20
Completed
Phase 3
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Publications & Presentations

PubMed

Presentation of the Julius M. Friedenwald Medal to M. Bishr Omary.
John M Inadomi, Anna S Lok> ;Gastroenterology. 2024 Apr 16
Implementation of a randomized mobile-technology lifestyle program in individuals with nonalcoholic fatty liver disease.
Nik Patel, Areesha Shahab, Haila Asefa, Monica A Tincopa, Anna S Lok> ;Scientific Reports. 2024 Mar 28
Toward a Functional Cure for Hepatitis B.
Anna S F Lok> ;Gut and Liver. 2024 Mar 27
Genome-wide association study identifies high-impact susceptibility loci for HCC in North America.
Manal M Hassan, Donghui Li, Younghun Han, Jinyoung Byun, Rikita I Hatia, Erping Long, Jiyeon Choi, Robin Kate Kelley, Sean P Cleary, Anna S Lok, Paige Bracci, Jennifer...> ;Hepatology. 2024 Feb 20
Minimal hepatic encephalopathy is associated with a higher risk of overt hepatic encephalopathy and poorer survival.
Simon Johannes Gairing, Chiara Mangini, Lisa Zarantonello, Stefania Gioia, Elise Jonasson Nielsen, Sven Danneberg, Anna S Lok, Philippe Sultanik, Peter Robert Galle, J...> ;Journal of Internal Medicine. 2024 Mar 1
4 citations
Hepatitis D: A Review.
Francesco Negro, Anna S Lok> ;JAMA. 2023 Dec 26
1 citations
Regional changes in intestinal permeability in cirrhosis are associated with mucosal bacteria.
Patricia P Bloom, Krishna Rao, Christine Bassis, Borko Nojkov, Vincent B Young, Anna Sf Lok> ;Hepatology Communications. 2023 Oct 1
2 citations
Improving alcohol treatment engagement using integrated behavioral interventions in alcohol-associated liver disease: A randomized pilot trial.
Jessica L Mellinger, Sarah Medley, Kelley M Kidwell, Haila Asefah, G Scott Winder, Anne C Fernandez, Anna S F Lok, Fred Blow> ;Hepatology Communications. 2023 Oct 1
Association of Alanine Aminotransferase Flares to Hepatitis B Surface Decline During Tenofovir Alone or With Pegylated Interferon Alfa.
Robert Perrillo, Anna S Lok, Kelsey Leonard, Marc G Ghany, Norah Terrault, Steven H Belle, Harry L A Janssen> ;The American Journal of Gastroenterology. 2023 Nov 1
3 citations
Progression to cirrhosis is similar among all ages in nonalcoholic fatty liver disease, but liver-related events increase with age.
Matthew J Miller, Emily Harding-Theobald, Jacob V DiBattista, Zhe Zhao, Karn Wijarnpreecha, Anna S Lok, Vincent L Chen> ;Hepatology Communications. 2023 Jun 1
Editorial: clinical outcomes in lean NAFLD - the devil is in the details. Authors' reply.
Karn Wijarnpreecha, Anna S Lok, Vincent L Chen> ;Alimentary Pharmacology & Therapeutics. 2023 May 1
1 citations
Use of HBV RNA and to predict change in serological status and disease activity in CHB.
Marc G Ghany, Wendy C King, Amanda S Hinerman, Anna Sf Lok, Mauricio Lisker-Melman, Raymond T Chung, Norah Terrault, Harry L A Janssen, Mandana Khalili, William M Lee,...> ;Hepatology. 2023 Nov 1
5 citations
New Perspectives on Development of Curative Strategies for Chronic Hepatitis B.
Jordan J Feld, Anna S Lok, Fabien Zoulim> ;Clinical Gastroenterology and Hepatology. 2023 Jul 1
3 citations
Racial Disparities in Treatment Initiation and Outcomes of Chronic Hepatitis B Virus Infection in North America.
Mandana Khalili, Kelsey R Leonard, Marc G Ghany, Mohamed Hassan, Lewis R Roberts, Richard K Sterling, Steven H Belle, Anna S Lok> ;JAMA Network Open. 2023 Apr 3
4 citations
What will it take to cure hepatitis B?
Wen-Juei Jeng, Anna S F Lok> ;Hepatology Communications. 2023 Apr 1
6 citations
Prevalence of Minimal Hepatic Encephalopathy in Patients With Liver Cirrhosis: A Multicenter Study.
Simon Johannes Gairing, Chiara Mangini, Lisa Zarantonello, Stefania Gioia, Elise Jonasson Nielsen, Sven Danneberg, Maria Gabriel, Alena F Ehrenbauer, Patricia P Bloom,...> ;The American Journal of Gastroenterology. 2023 Dec 1
1 citations
Long-term weight changes are associated with initial weight changes after nonalcoholic fatty liver disease diagnosis.
Jacob V DiBattista, Anna S Lok, Vincent L Chen> ;Hepatology Communications. 2023 Mar 1
17 citations
Higher mortality among lean patients with non-alcoholic fatty liver disease despite fewer metabolic comorbidities.
Karn Wijarnpreecha, Fang Li, Sori K Lundin, Deepika Suresh, Michael W Song, Cui Tao, Vincent L Chen, Anna S F Lok> ;Alimentary Pharmacology & Therapeutics. 2023 May 1
Hepatitis B.
Wen-Juei Jeng, George V Papatheodoridis, Anna S F Lok> ;Lancet. 2023 Mar 25
18 citations
PNPLA3 Genotype and Diabetes Identify Patients With Nonalcoholic Fatty Liver Disease at High Risk of Incident Cirrhosis.
Vincent L Chen, Antonino Oliveri, Matthew J Miller, Karn Wijarnpreecha, Xiaomeng Du, Yanhua Chen, Kelly C Cushing, Anna S Lok, Elizabeth K Speliotes> ;Gastroenterology. 2023 May 1
3 citations
Withdrawal of Long-Term Nucleotide Analog Therapy in Chronic Hepatitis B: Outcomes From the Withdrawal Phase of the HBRN Immune Active Treatment Trial.
Jordan J Feld, Abdus S Wahed, Michael Fried, Marc G Ghany, Adrian M Di Bisceglie, Robert P Perrillo, Mandana Khalili, Xue Yang, Steven H Belle, Harry L A Janssen, Nora...> ;The American Journal of Gastroenterology. 2023 Jul 1
24 citations
The scientific basis of combination therapy for chronic hepatitis B functional cure.
Seng Gee Lim, Thomas F Baumert, Carolina Boni, Ed Gane, Massimo Levrero, Anna S Lok, Mala K Maini, Norah A Terrault, Fabien Zoulim> ;Nature Reviews. Gastroenterology & Hepatology. 2023 Apr 1
4 citations
Randomized Trial of Tenofovir With or Without Peginterferon Alfa Followed by Protocolized Treatment Withdrawal in Adults With Chronic Hepatitis B.
Norah A Terrault, Anna S Lok, Abdus S Wahed, Marc G Ghany, Robert P Perrillo, Michael W Fried, David K Wong, Mandana Khalili, Daryl T Y Lau, Richard K Sterling, Adrian...> ;The American Journal of Gastroenterology. 2023 Jul 1
1 citations
Development and Implementation of a Hepatocellular Carcinoma Surveillance Quality Metric.
Neehar D Parikh, Cheryl Dehmlow, Tammy Ellies, Elliot B Tapper, Anna S F Lok> ;Clinical Gastroenterology and Hepatology. 2023 Mar 1
Reply to: "Expert opinion vs. meta-analysis: To be or not to be?"
George V Papatheodoridis, Vasileios Lekakis, Anna S Lok, K Rajender Reddy> ;Journal of Hepatology. 2023 Mar 1
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Journal Articles

Awareness and Knowledge of Nonalcoholic Fatty Liver Disease Among Office Employees in Beijing, China
Anna S Lok, Stephanie Chen, Samantha Chao, Digestive Diseases and Sciences
Frailty, Psychoactive Medications, and Cognitive Dysfunction Are Associated with Poor Patient‐Reported Outcomes in Cirrhosis
Elliot B Tapper, Neehar D Parikh, Anna S Lok, Hepatology

Other

Spike in Hep C Infections Mutes Thrill of Recent Cure
Anna Lok, MD, U-M Health System
https://www.doximity.com/articles/6ec15d6f-c828-4ef0-ab64-dbb58284003e
UpToDate, Wolters Kluwer Health - 2013-02-07
Hepatitis B virus infection in renal transplant recipients
Lok AS, Rose BD
http://www.uptodate.com/contents/hepatitis-b-virus-infection-in-renal-transplant-recipients
UpToDate, Wolters Kluwer Health - 2011-02-17
Hepatitis B virus reactivation associated with immunosuppression
Lok AS, Bonis PA
http://www.uptodate.com/contents/hepatitis-b-virus-reactivation-associated-with-immunosuppression
UpToDate, Wolters Kluwer Health - 2013-02-05
Investigational treatments of chronic hepatitis B virus infection
Lok AS
http://www.uptodate.com/contents/investigational-treatments-of-chronic-hepatitis-b-virus-infection
UpToDate, Wolters Kluwer Health - 2011-04-20
Lamivudine monotherapy for chronic hepatitis B virus infection
Lok AS
http://www.uptodate.com/contents/lamivudine-monotherapy-for-chronic-hepatitis-b-virus-infection
UpToDate, Wolters Kluwer Health - 2013-02-07
Overview of the management of hepatitis B and case examples
Lok AS
http://www.uptodate.com/contents/overview-of-the-management-of-hepatitis-b-and-case-examples
UpToDate, Wolters Kluwer Health - 2013-02-07
Renal disease associated with hepatitis B virus infection
Lok AS, Chan T
http://www.uptodate.com/contents/renal-disease-associated-with-hepatitis-b-virus-infection
UpToDate, Wolters Kluwer Health - 2012-09-20
Telbivudine in the treatment of chronic hepatitis B virus infection
Lok AS
http://www.uptodate.com/contents/telbivudine-in-the-treatment-of-chronic-hepatitis-b-virus-infection
UpToDate, Wolters Kluwer Health - 2012-07-12
Clinical manifestations and natural history of hepatitis B virus infection
Lok AS
http://www.uptodate.com/contents/clinical-manifestations-and-natural-history-of-hepatitis-b-virus-in
UpToDate, Wolters Kluwer Health - 2013-02-26
Tenofovir disoproxil fumarate in the treatment of adults with chronic HBV infection who do not have HIV infection
Lok AS
http://www.uptodate.com/contents/tenofovir-disoproxil-fumarate-in-the-treatment-of-adults-with-chron
UpToDate, Wolters Kluwer Health - 2012-05-25
Epidemiology, transmission, and prevention of hepatitis B virus infection
Lok AS, Teo E
http://www.uptodate.com/contents/epidemiology-transmission-and-prevention-of-hepatitis-b-virus-infec
UpToDate, Wolters Kluwer Health - 2013-01-31
Hepatitis B virus vaccination
Lok AS, Teo E
http://www.uptodate.com/contents/hepatitis-b-virus-vaccination
UpToDate, Wolters Kluwer Health - 2012-11-02
Standard and pegylated interferon for chronic hepatitis B virus infection
Lok AS
http://www.uptodate.com/contents/standard-and-pegylated-interferon-for-chronic-hepatitis-b-virus-inf
UpToDate, Wolters Kluwer Health - 2012-07-02
Hepatitis D virus reinfection following liver transplantation
Lok AS
http://www.uptodate.com/contents/hepatitis-d-virus-reinfection-following-liver-transplantation
UpToDate, Wolters Kluwer Health - 2013-01-07
Hepatitis B and pregnancy
Lok AS, Lee H
http://www.uptodate.com/contents/hepatitis-b-and-pregnancy
UpToDate, Wolters Kluwer Health - 2013-02-01
Diagnosis of hepatitis D virus infection
Lok AS, Negro F
http://www.uptodate.com/contents/diagnosis-of-hepatitis-d-virus-infection
UpToDate, Wolters Kluwer Health - 2012-10-10
Liver transplantation for chronic hepatitis B virus infection
Lok AS
http://www.uptodate.com/contents/liver-transplantation-for-chronic-hepatitis-b-virus-infection
UpToDate, Wolters Kluwer Health - 2013-03-15
Pathogenesis, epidemiology, natural history, and clinical manifestations of hepatitis D virus infection
Lok AS, Negro F
http://www.uptodate.com/contents/pathogenesis-epidemiology-natural-history-and-clinical-manifestatio
UpToDate, Wolters Kluwer Health - 2013-02-06
Serologic diagnosis of hepatitis B virus infection
Lok AS
http://www.uptodate.com/contents/serologic-diagnosis-of-hepatitis-b-virus-infection
UpToDate, Wolters Kluwer Health - 2013-03-06
Treatment and prevention of hepatitis D virus infection
Lok AS, Negro F
http://www.uptodate.com/contents/treatment-and-prevention-of-hepatitis-d-virus-infection
UpToDate, Wolters Kluwer Health - 2012-10-10
Adefovir dipivoxil in the treatment of chronic hepatitis B virus infection
Lok AS
http://www.uptodate.com/contents/adefovir-dipivoxil-in-the-treatment-of-chronic-hepatitis-b-virus-in
UpToDate, Wolters Kluwer Health - 2012-09-06
Clinical significance and molecular characteristics of common hepatitis B virus variants
Lok AS, Chu C
http://www.uptodate.com/contents/clinical-significance-and-molecular-characteristics-of-common-hepat
UpToDate, Wolters Kluwer Health - 2013-02-05
Clinical significance of hepatitis B virus genotypes
Lok AS, Chu C
http://www.uptodate.com/contents/clinical-significance-of-hepatitis-b-virus-genotypes
UpToDate, Wolters Kluwer Health - 2013-02-05
Combination therapy for chronic hepatitis B virus infection
Lok AS
http://www.uptodate.com/contents/combination-therapy-for-chronic-hepatitis-b-virus-infection
UpToDate, Wolters Kluwer Health - 2013-02-28
Entecavir in the treatment of chronic hepatitis B virus infection
Lok AS
http://www.uptodate.com/contents/entecavir-in-the-treatment-of-chronic-hepatitis-b-virus-infection
UpToDate, Wolters Kluwer Health - 2013-02-07
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Authored Content

Spike in Hep C Infections Mutes Thrill of Recent CureAugust 2018

Press Mentions

No Racial Disparities Observed in Chronic HBV Treatment Rates Among Eligible PatientsApril 12th, 2023
Five Faculty Members with Diverse Backgrounds Elected to National Academy of MedicineOctober 17th, 2022
Then and Now: Demographics of the AGAJune 1st, 2022
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