AntonioMarcilio PadulaOmuroMD

Neurology • New Haven, CT

Neurooncology

Chief- Division of Neuro-Oncology Yale School of Medicine and Yale Cancer Center

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Office
15 York Street
LLCI 920
New Haven, CT 06510
Phone+1 203-737-7084
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Education & Training

Universidade de Sao Paulo Faculty of MedicineClass of 1994

Certifications & Licensure

NY State Medical License 2008 - 2025
CT State Medical License Active through 2024
FL State Medical License 2017 - 2019

Clinical Trials

Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma Start of enrollment: 2007 Jun 01
Completed
Phase 2
Methotrexate and Temozolomide Versus Methotrexate, Procarbazine, Vincristine and Cytarabine Start of enrollment: 2007 Jul 01
Unknown status
Phase 2
Intensive Chemotherapy and Autotransplantation for Patients With Newly Diagnosed Anaplastic Oligodendroglioma Start of enrollment: 2002 Sep 01
Completed
Phase 2
Combined Immunochemotherapy Followed By Reduced Dose Radiation Therapy (RT) for Patients With Newly Diagnosed Primary Central Nervous System Lymphoma Start of enrollment: 2002 Aug 28
Completed
Not Applicable
Rituximab, Methotrexate, Procarbazine and Vincristine Followed by High-dose Chemotherapy With Autologous Stem-cell Rescue in Newly-diagnosed Primary CNS Lymphoma Start of enrollment: 2004 Dec 01
Completed
Phase 2
A Study of 131I-TM601 in Adults With Recurrent Malignant Glioma Start of enrollment: 2008 Aug 01
Unknown status
Phase 1, Phase 2
Bevacizumab, Temozolomide and Hypofractionated Radiotherapy for Patients With Newly Diagnosed Malignant Glioma Start of enrollment: 2008 Oct 28
Completed
Phase 2
Safety and Tolerability of Carboxyamidotriazole Orotate (CTO) in Solid Tumors or With Temodar® in Glioblastoma or Other Recurrent Malignant Gliomas or in Combination With Temodar® and Radiation Therapy for Patients With Newly Diagnosed Glioblastoma and Malignant Gliomas Start of enrollment: 2010 May 01
Active, not recruiting
Phase 1
RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Start of enrollment: 2010 May 01
Completed
Phase 1
Carboplatin and Bevacizumab for Recurrent Ependymoma Start of enrollment: 2011 Apr 27
Completed
Phase 2
Hypofractionated Stereotactic Radiotherapy With Bevacizumab in the Treatment of Recurrent Malignant Glioma Start of enrollment: 2011 Jul 08
Completed
Phase 1
Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma Start of enrollment: 2011 Sep 01
Completed
Phase 2
Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme Start of enrollment: 2012 Nov 01
Completed
Phase 1, Phase 2
A Study of the Effectiveness and Safety of Nivolumab Compared to Bevacizumab and of Nivolumab With or Without Ipilimumab in Glioblastoma Patients Start of enrollment: 2014 Feb 07
Active, not recruiting
Phase 3
Pembrolizumab (MK-3475) in Patients With Recurrent Malignant Glioma With a Hypermutator Phenotype Start of enrollment: 2016 Jan 22
Active, not recruiting
Not Applicable
Study of the Effect NT-I7 on CD4 Counts in Patients With High Grade Gliomas Start of enrollment: 2018 Oct 30
Terminated
Phase 1
Study of Tirabrutinib (ONO-4059) in Patients With Primary Central Nervous System Lymphoma (PROSPECT Study) Start of enrollment: 2021 Dec 29
Recruiting
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

1 citations
PACS-Integrated Tools for Peritumoral Edema Volumetrics Provide Additional Information to RANO-BM-Based Assessment of Lung Cancer Brain Metastases after Stereotactic R...
Manpreet Kaur, Gabriel Cassinelli Petersen, Leon Jekel, Marc von Reppert, Sunitha Varghese, Irene Dixe de Oliveira Santo, Arman Avesta, Sanjay Aneja, Antonio Omuro, Ve...> ;Cancers. 2023 Sep 30
1 citations
Systematic Literature Review of Machine Learning Algorithms Using Pretherapy Radiologic Imaging for Glioma Molecular Subtype Prediction.
Jan Lost, Tej Verma, Leon Jekel, Marc von Reppert, Niklas Tillmanns, Sara Merkaj, Gabriel Cassinelli Petersen, Ryan Bahar, Ayyüce Gordem, Muhammad A Haider, Harry Subr...> ;AJNR. American Journal of Neuroradiology. 2023 Oct 1
Long-term Outcomes in Primary CNS Lymphoma After R-MVP and High-Dose Chemotherapy With Autologous Hematopoietic Stem Cell Transplant.
Kate Elizabeth Therkelsen, Lauren R Schaff, Subhiksha Nandakumar, Antonio M P Omuro, Lisa M DeAngelis, Christian Grommes> ;Neurology. 2023 Aug 15
Comparing Detection Schemes for Adversarial Images against Deep Learning Models for Cancer Imaging.
Marina Z Joel, Arman Avesta, Daniel X Yang, Jian-Ge Zhou, Antonio Omuro, Roy S Herbst, Harlan M Krumholz, Sanjay Aneja> ;Cancers. 2023 Mar 1
1 citations
Top advances of the year: Neuro-oncology.
Mary M Barden, Antonio M Omuro> ;Cancer. 2023 May 15
1 citations
Multicenter Phase II Trial of the PARP Inhibitor Olaparib in Recurrentand-mutant Glioma.
Kristina Fanucci, Mary Jo Pilat, Derek Shyr, Yu Shyr, Scott Boerner, Jing Li, Diane Durecki, Jan Drappatz, Vinay Puduvalli, Frank Scott Lieberman, Javier Gonzalez, Pie...> ;Cancer Research Communications. 2023 Feb 1
11 citations
Real-time PACS-integrated longitudinal brain metastasis tracking tool provides comprehensive assessment of treatment response to radiosurgery.
Gabriel Cassinelli Petersen, Khaled Bousabarah, Tej Verma, Marc von Reppert, Leon Jekel, Ayyuce Gordem, Benjamin Jang, Sara Merkaj, Sandra Abi Fadel, Randy Owens, Anto...> ;Neuro-Oncology Advances. 2022 Jul 26
5 citations
Identifying clinically applicable machine learning algorithms for glioma segmentation: recent advances and discoveries.
Niklas Tillmanns, Avery E Lum, Gabriel Cassinelli, Sara Merkaj, Tej Verma, Tal Zeevi, Lawrence Staib, Harry Subramanian, Ryan C Bahar, Waverly Brim, Jan Lost, Leon Jek...> ;Neuro-Oncology Advances. 2022 Jun 14
5 citations
Immune-checkpoint inhibitors for glioblastoma: what have we learned?
Antonio Omuro> ;Arquivos De Neuro-Psiquiatria. 2022 May 1
133 citations
Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: An international randomized phase III trial.
Antonio Omuro, Alba A Brandes, Antoine F Carpentier, Ahmed Idbaih, David A Reardon, Timothy Cloughesy, Ashley Sumrall, Joachim Baehring, Martin van den Bent, Oliver Bä...> ;Neuro-Oncology. 2023 Jan 5
3 citations
Phase I/randomized phase II trial of TRC105 plus bevacizumab versus bevacizumab in recurrent glioblastoma: North Central Cancer Treatment Group N1174 (Alliance).
Evanthia Galanis, S Keith Anderson, Erin Twohy, Nicholas A Butowski, Adilia Hormigo, David Schiff, Antonio Omuro, Kurt A Jaeckle, Shaji Kumar, Timothy J Kaufmann, Susa...> ;Neuro-Oncology Advances. 2022 Apr 4
6 citations
Machine Learning in Differentiating Gliomas from Primary CNS Lymphomas: A Systematic Review, Reporting Quality, and Risk of Bias Assessment.
G I Cassinelli Petersen, J Shatalov, T Verma, W R Brim, H Subramanian, A Brackett, R C Bahar, S Merkaj, T Zeevi, L H Staib, J Cui, A Omuro, R A Bronen, A Malhotra, M S...> ;AJNR. American Journal of Neuroradiology. 2022 Apr 1
11 citations
Machine Learning Applications for Differentiation of Glioma from Brain Metastasis-A Systematic Review.
Leon Jekel, Waverly R Brim, Marc von Reppert, Lawrence Staib, Gabriel Cassinelli Petersen, Sara Merkaj, Harry Subramanian, Tal Zeevi, Seyedmehdi Payabvash, Khaled Bous...> ;Cancers. 2022 Mar 8
23 citations
Nivolumab plus radiotherapy with or without temozolomide in newly diagnosed glioblastoma: Results from exploratory phase I cohorts of CheckMate 143.
Antonio Omuro, David A Reardon, John H Sampson, Joachim Baehring, Solmaz Sahebjam, Timothy F Cloughesy, Alexandros-Georgios Chalamandaris, Von Potter, Nicholas Butowsk...> ;Neuro-Oncology Advances. 2022 Feb 26
11 citations
Using Adversarial Images to Assess the Robustness of Deep Learning Models Trained on Diagnostic Images in Oncology.
Marina Z Joel, Sachin Umrao, Enoch Chang, Daniel X Yang, James S Duncan, Antonio Omuro, Roy Herbst, Harlan M Krumholz, Sanjay Aneja, Choi, R.> ;JCO Clinical Cancer Informatics. 2022 Feb 1
Editorial: Advances in neuro-oncology: stepping in the right direction.
Antonio Omuro> ;Current Opinion in Neurology. 2021 Oct 6
6 citations
T cell dysfunction in glioblastoma: a barrier and an opportunity for the development of successful immunotherapies.
Josephina A Jansen, Antonio Omuro, Liliana E. Lucca> ;Current Opinion in Neurology. 2021 Sep 24
11 citations
Comparison of radiomic feature aggregation methods for patients with multiple tumors
Enoch Chang, Marina Joel, Hannah Y. Chang, Justin Du, Omaditya Khanna, Antonio Omuro, Veronica Chiang, Sanjay Aneja> ;Scientific Reports. 2021 May 7
27 citations
A Shortage of Neurologists – We Must Act Now: A Report From the AAN 2019 Transforming Leaders Program
Jennifer J. Majersik, Aiesha Ahmed, I-Hweii Amy Chen, Holly A. Shill, Gregory P Hanes, Victoria S. Pelak, Jennifer L. Hopp, Antonio Omuro, Benzi M. Kluger, Thabele M L...> ;Neurology. 2021 Apr 30
2 citations
Genetic characterization of an aggressive optic nerve pilocytic glioma
Christopher S. Hong, Greg Fliney, Adeniyi Fisayo, Yi An, Pallavi P. Gopal, Antonio Omuro, Renelle Pointdujour-Lim, E. Zeynep Erson-Omay, S. Bulent Omay> ;Brain Tumor Pathology. 2021 Jan 1
3 citations
Sporadic adamantinomatous craniopharyngioma with double-hit somatic APC mutations.
Christopher S. Hong, Antonio Omuro, Yi An, Silvio E. Inzucchi, Anita A. Kohli, Eugenia M. Vining, Sacit Bulent Omay, E. Zeynep Erson-Omay> ;Neuro-Oncology Advances. 2021 Jan 1
10 citations
Comparison of Radiomic Feature Aggregation Methods for Patients with Multiple Tumors.
Enoch Chang, Marina Joel, Hannah Y. Chang, Justin Du, Omaditya Khanna, Antonio Omuro, Veronica Chiang, Sanjay Aneja> ;Medrxiv. 2020 Nov 6
24 citations
A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma.
Mark R. Gilbert, Ying Yuan, Jimin Wu, Tito R. Mendoza, Elizabeth Vera, Antonio Omuro, Frank S. Lieberman, H. Ian Robins, Elizabeth R. Gerstner, Jing Wu, Patrick Y. Wen...> ;Neuro-Oncology. 2021 Mar 25
2 citations
Erdheim-Chester Disease Presenting With Diplopia: A Challenging Diagnosis With Effective Treatment.
Mehdi Tavakoli, Shiva Roghaee, Manasa Gunturu, Antonio M. Omuro, Byron L. Lam, Carlos E. Mendoza-Santiesteban> ;Journal of Neuro-Ophthalmology. 2021 Sep 1
6 citations
Consolidation Therapy in Primary Central Nervous System Lymphoma.
Peter B Kim, Antonio Omuro> ;Current Treatment Options in Oncology. 2020 Jul 28
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Journal Articles

Effect of Nivolumab vs Bevacizumab in Patients with Recurrent Glioblastoma
David A Reardon, Antonio Omuro, Joachim Baehring, Surasak Phuphanich, Solmaz Sahebjam, JAMA Oncology

Authored Content

Effect of Nivolumab vs Bevacizumab in Patients with Recurrent GlioblastomaMay 2020
Effect of Nivolumab vs Bevacizumab in Patients with Recurrent GlioblastomaMay 2020

Press Mentions

Tactical Therapeutics New Drug Carboxyamidotriazole Orotate (CTO) Is Getting Notoriety for Its Success in Treating Brain Cancer Patients Who Went Through a Phase 1 Trial at the Memorial Sloan Kettering Cancer Center in New York, NYDecember 6th, 2022
While Doctors Cut Out His Brain Tumor, He Sang ’80s SongsNovember 16th, 2019