AprilFitzsimmonsEichlerMDMPH

Neurology • Boston, MA

Neurooncology

Assistant Professor of Neurology, Massachusetts General Hospital

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Office
55 Fruit Street Yaw 9E
Massachusetts General Hospital
Boston, MA 02114
Phone+1 617-724-8770

Fax+1 617-724-8769
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Education & Training

Massachusetts General HospitalFellowship, Neuro-Oncology, 2005 - 2006
Harvard School of Public HealthMPH, Clinical effectiveness, 2005 - 2006
Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Neurology, 2002 - 2005
Brigham and Women's HospitalInternship, Internal Medicine, 2001 - 2002
University of Pittsburgh School of MedicineClass of 2001

Certifications & Licensure

MA State Medical License 2004 - 2025
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012

Clinical Trials

Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung Cancer Start of enrollment: 2009 Aug 01
Terminated
Phase 1

Publications & Presentations

PubMed

2 citations
Neurotoxicity and management of primary and secondary central nervous system lymphoma after adoptive immunotherapy with CD19-directed chimeric antigen receptor T-cells.
Philipp Karschnia, Isabel C Arrillaga-Romany, April Eichler, Deborah A Forst, Elizabeth Gerstner, Justin T Jordan, Ina Ly, Scott R Plotkin, Nancy Wang, Maria Martinez-...> ;Neuro-Oncology. 2023 Dec 8
34 citations
Phase II study of ipilimumab and nivolumab in leptomeningeal carcinomatosis.
Priscilla K. Brastianos, Matthew R. Strickland, Eudocia Q. Lee, Nancy Wang, Justine V. Cohen, Ugonma Chukwueke, Deborah Forst, April F. Eichler, Beth Overmoyer, Nan Li...> ;Nature Communications. 2021 Oct 12
8 citations
Pemetrexed in Recurrent or Progressive Central Nervous System Lymphoma: A Phase I Multicenter Clinical Trial.
Jorg Dietrich, Laura Versmée, Jan Drappatz, April F. Eichler, Lakshmi Nayak, Andrew D. Norden, Eric T. Wong, Michelle Pisapia, SooAe Jones, Amanda Gordon, Bruce A. Cha...> ;The Oncologist. 2020 Sep 1
12 citations
Phase II Study of Iniparib with Concurrent Chemoradiation in Patients with Newly Diagnosed Glioblastoma
Jaishri O. Blakeley, Stuart A. Grossman, Andrew S. Chi, Tom Mikkelsen, Myrna R. Rosenfeld, Manmeet Ahluwalia, L. Burt Nabors, April F. Eichler, Ignacio Garcia Ribas, S...> ;Clinical Cancer Research. 2019 Jan 1
15 citations
Early changes in glioblastoma metabolism measured by MR spectroscopic imaging during combination of anti-angiogenic cediranib and chemoradiation therapy are associated...
Ovidiu C. Andronesi, Morteza Esmaeili, Ronald Borra, Kyrre E. Emblem, Elizabeth R. Gerstner, Marco Da Cunha Pinho, Scott R. Plotkin, Andrew S. Chi, April F. Eichler, J...> ;NPJ Precision Oncology. 2017 Jun 12
7 citations
Impact of histopathological transformation and overall survival in patients with progressive anaplastic glioma.
Allen L Ho, Matthew J. Koch, Shota Tanaka, April F. Eichler, Tracy T. Batchelor, Jantima Tanboon, David N. Louis, Daniel P. Cahill, Andrew S. Chi, William T. Curry> ;Journal of Clinical Neuroscience. 2016 Sep 1
29 citations
Vandetanib plus sirolimus in adults with recurrent glioblastoma: results of a phase I and dose expansion cohort study
Milan G. Chheda, Patrick Y. Wen, Fred H. Hochberg, Andrew S. Chi, Jan Drappatz, April F. Eichler, Daniel Yang, Rameen Beroukhim, Andrew D. Norden, Elizabeth R. Gerstne...> ;Journal of Neuro-Oncology. 2015 Feb 1
20 citations
Phase II trial of patupilone in patients with brain metastases from breast cancer
David M. Peereboom, Conleth G. Murphy, Manmeet Ahluwalia, Alison Conlin, April F. Eichler, Catherine Van Poznak, Joseph Baar, Paul Elson, Andrew D. Seidman> ;Neuro-Oncology. 2014 Apr 1
44 citations
A phase I study of lapatinib with whole brain radiotherapy in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer brain metastases
Nan Lin, Rachel A. Freedman, Naren Ramakrishna, Jerry Younger, Anna Maria Storniolo, Jennifer R. Bellon, Steven E. Come, Rebecca Gelman, Gordon J. Harris, Mark A. Hend...> ;Breast Cancer Research and Treatment. 2013 Nov 7
259 citations
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation
Tracy T. Batchelor, Elizabeth R. Gerstner, Kyrre E. Emblem, Dan G. Duda, Jayashree Kalpathy-Cramer, Matija Snuderl, Marek Ancukiewicz, Pavlina Polaskova, Marco Da Cunh...> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 Nov 19
170 citations
Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma.
Christine Lu-Emerson, Matija Snuderl, Nathaniel D. Kirkpatrick, Jermaine Goveia, Christian Davidson, Yuhui Huang, Lars Riedemann, Jennie Taylor, Percy Ivy, Dan G. Duda...> ;Neuro-Oncology. 2013 Aug 1
107 citations
Phase I Study of GRN1005 in Recurrent Malignant Glioma
Jan Drappatz, Andrew Brenner, Eric T. Wong, April F. Eichler, David Schiff, Morris D. Groves, Tom Mikkelsen, Steve Rosenfeld, John Sarantopoulos, Christina A. Meyers, ...> ;Clinical Cancer Research. 2013 Mar 15
126 citations
Randomized Controlled Trial of a Video Decision Support Tool for Cardiopulmonary Resuscitation Decision Making in Advanced Cancer
Angelo E. Volandes, Michael K. Paasche-Orlow, Susan L. Mitchell, Areej El-Jawahri, Aretha Delight Davis, Michael J. Barry, Kevan L. Hartshorn, Vicki A. Jackson, Muriel...> ;Journal of Clinical Oncology. 2013 Jan 20
119 citations
Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases
David P. Kodack, Euiheon Chung, Hiroshi Yamashita, Joao Incio, Annique M M J Duyverman, Youngchul Song, Christian T. Farrar, Yuhui Huang, Eleanor I Ager, Walid S. Kamo...> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov 6
364 citations
The biology of brain metastases—translation to new therapies
April F. Eichler, Euiheon Chung, David P. Kodack, Jay S. Loeffler, Dai Fukumura, Rakesh K. Jain> ;Nature Reviews. Clinical Oncology. 2011 Jun 1
38 citations
Initial treatment patterns over time for anaplastic oligodendroglial tumors.
, , , , , , , , , , , , , , , , , , , , , , , , , > ;Neuro-Oncology. 2012 Jun 1
73 citations
Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard...
Elizabeth R. Gerstner, April F. Eichler, Scott R. Plotkin, Jan Drappatz, Colin Doyle, Lei Xu, Dan G. Duda, Patrick Y. Wen, Rakesh K. Jain, Tracy T. Batchelor> ;Journal of Neuro-Oncology. 2011 Jun 1
208 citations
EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer
April F. Eichler, Kristopher T. Kahle, Daphne L. Wang, Victoria A. Joshi, Henning Willers, Jeffrey A. Engelman, Thomas J. Lynch, Lecia V. Sequist> ;Neuro-Oncology. 2010 Nov 1
391 citations
Phase II Study of Cediranib, an Oral Pan–Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent Glioblastoma
Tracy T. Batchelor, Dan G. Duda, Emmanuelle di Tomaso, Marek Ancukiewicz, Scott R. Plotkin, Elizabeth R. Gerstner, April F. Eichler, Jan Drappatz, Fred H. Hochberg, Th...> ;Journal of Clinical Oncology. 2010 Jun 10
192 citations
Use of Video to Facilitate End-of-Life Discussions With Patients With Cancer: A Randomized Controlled Trial
Areej El-Jawahri, Lisa M. Podgurski, April F. Eichler, Scott R. Plotkin, Jennifer S. Temel, Susan L. Mitchell, Yuchiao Chang, Michael J. Barry, Angelo E. Volandes> ;Journal of Clinical Oncology. 2010 Jan 10
57 citations
Leukodystrophies: classification, diagnosis, and treatment.
Daniel J. Costello, April F. Eichler, Florian Eichler> ;The Neurologist. 2009 Nov 1
65 citations
Polysomy for chromosomes 1 and 19 predicts earlier recurrence in anaplastic oligodendrogliomas with concurrent 1p/19q loss.
Matija Snuderl, April F. Eichler, Keith L. Ligon, Quynh Vu, Michael Silver, Rebecca A. Betensky, Azra H. Ligon, Patrick Y. Wen, David N. Louis, A. John Iafrate> ;Clinical Cancer Research. 2009 Oct 15
55 citations
Utility of administrative claims data for the study of brain metastases: a validation study
April F. Eichler, Elizabeth B. Lamont> ;Journal of Neuro-Oncology. 2009 Jun 27
Phase Ib study of cediranib in combination with daily temozolomide and radiation in patients with newly diagnosed glioblastoma.
Chi AS, Gerstner ER, Eichler AF, Chea HK, Drappatz J, Wen PY, Ivy SP, Loeffler JS, Sorensen AG, Jain RK, Batchelor TT> ;J. Clin. Oncol.. 2009-05-20
Phase I trial of vatalanib (PTK787) in combination with standard radiation and temozolomide in patients with newly diagnosed glioblastoma.
Batchelor T, Eichler AF, Plotkin SR, Drappatz J, Wen P, Sorensen AG, Gerstner E> ;J. Clin. Oncol.. 2009-05-20
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Journal Articles

Phase II Study of Iniparib with Concurrent Chemoradiation in Patients with Newly Diagnosed Glioblastoma
Louis B Nabors, April Eichler, Clinical Cancer Research