AriJosephRosenbergMD

Head & Neck Cancer

Assistant Professor of Medicine

Overview of Dr. Rosenberg

I am Assistant Professor of Medicine at the University of Chicago. My academic interest is in developing novel therapeutic strategies for patients with head and neck cancer. As a clinical investigator, I develop and conduct clinical trials for patients with head and neck cancer. My particular focus is incorporating novel therapeutics and immunotherapeutic strategies for the treatment of head and neck cancer, as well as developing strategies to reduce treatment-related toxicity.

Office
5841 S. MARYLAND
M/C 2115
Chicago, IL 60637
Book by Phone+1(844) 527-0672

Fax+1 773-702-3163
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Education & Training

McGaw Medical Center of Northwestern UniversityFellowship, Hematology and Medical Oncology, 2016 - 2019
University of Illinois College of Medicine at ChicagoResidency, Internal Medicine, 2013 - 2016
Tel Aviv University SacklerClass of 2013, MD
University of Illinois at Urbana-ChampaignBS, Chemistry, Music, Cum Laude, 2004 - 2008

Certifications & Licensure

IL State Medical License 2013 - 2026
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Clinical Trials

NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy Start of enrollment: 2019 Jan 16
Recruiting
Phase 1
Pilot Study of Chemotherapy for HPV-Associated Oropharyngeal Cancer Start of enrollment: 2020 Oct 01
Completed
Phase 1
A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer Start of enrollment: 2022 Oct 17
Recruiting
Phase 2
Roles: Contact, Principal Investigator
Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancer Start of enrollment: 2023 Mar 07
Recruiting
Phase 1
Roles: Contact, Principal Investigator
TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers Start of enrollment: 2022 Aug 04
Recruiting
Phase 1, Phase 2
Oral AHR Antagonist in Combination With Nivolumab in Patients With PD-1 Resistant Metastatic or Recurrent Head and Neck Cancer Start of enrollment: 2023 Mar 01
Withdrawn
Phase 1
Roles: Contact
Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors Start of enrollment: 2018 Jun 25
Recruiting
Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Evolutionary dynamics of tipifarnib in HRAS mutated head and neck squamous cell carcinoma.
Jagadeeshan, S., Suryamohan, K., Shin, N., Mathukkada, S., Boyko, A., Melikhova, D., Tsareva, A., Yunusova, L., Pravdivtseva, E., Stupichev, D., Shaposhnikov, K., Pete...> ;Oral Oncology. 2024 Feb 1
2 citations
A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging.
Frank W Pun, Geoffrey Ho Duen Leung, Hoi Wing Leung, Jared Rice, Tomas Schmauck-Medina, Sofie Lautrup, Xi Long, Bonnie Hei Man Liu, Chun Wai Wong, Ivan V Ozerov, Alex ...> ;Aging Cell. 2023 Dec 1
New insights into RAS in head and neck cancer.
Sankar Jagadeeshan, Ofra Z Novoplansky, Oded Cohen, Ina Kurth, Jochen Hess, Ari J Rosenberg, Jennifer R Grandis, Moshe Elkabets> ;Biochimica Et Biophysica Acta. Reviews on Cancer. 2023 Nov 1
1 citations
A multicenter, open-label, randomized, phase II study of cediranib with or without lenalidomide in iodine 131-refractory differentiated thyroid cancer.
A J Rosenberg, C-Y Liao, T Karrison, J A de Souza, F P Worden, B Libao, M K Krzyzanowska, D N Hayes, E Winquist, V Saloura, K Prescott, V M Villaflor, T Y Seiwert, R B...> ;Annals of Oncology. 2023 Aug 1
1 citations
"Timing is Everything": the evolving role of immune checkpoint inhibition in nasopharyngeal carcinoma.
A J Rosenberg, E E Vokes> ;Annals of Oncology. 2023 Mar 1
3 citations
Mutated HRAS Activates YAP1-AXL Signaling to Drive Metastasis of Head and Neck Cancer.
Sankar Jagadeeshan, Manu Prasad, Mai Badarni, Talal Ben-Lulu, Vijayasteltar Belsamma Liju, Sooraj Mathukkada, Claire Saunders, Avital Beeri Shnerb, Jonathan Zorea, Kse...> ;Cancer Research. 2023 Apr 4
1 citations
Author Correction: A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer.
Manijeh Goldberg, Aaron Manzi, Amritpreet Birdi, Brandon Laporte, Peter Conway, Stefanie Cantin, Vasudha Mishra, Alka Singh, Alexander T Pearson, Eric R Goldberg, Sam ...> ;Nature Communications. 2022 Dec 21
3 citations
Recommendations for Care of Survivors of Head and Neck Cancer.
Samuel Auger, Andrew Davis, Ari J Rosenberg> ;JAMA. 2022 Oct 25
16 citations
A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer.
Manijeh Goldberg, Aaron Manzi, Amritpreet Birdi, Brandon Laporte, Peter Conway, Stefanie Cantin, Vasudha Mishra, Alka Singh, Alexander T Pearson, Eric R Goldberg, Sam ...> ;Nature Communications. 2022 Aug 17
2 citations
Phase I study of nab-paclitaxel-based induction followed by nab-paclitaxel-based concurrent chemotherapy and re-irradiation in previously treated head and neck squamou...
Ari J Rosenberg, Nishant Agrawal, Alexander T Pearson, Zhen Gooi, Elizabeth Blair, Louis Portugal, John F Cursio, Aditya Juloori, Jeffrey Chin, Kathryn Rouse, Victoria...> ;British Journal of Cancer. 2022 Nov 1
12 citations
AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling.
Renata Ferrarotto, Vasudha Mishra, Elad Herz, Adar Yaacov, Oz Solomon, Rami Rauch, Adi Mondshine, Maria Motin, Tal Leibovich-Rivkin, Matti Davis, Joel Kaye, Christophe...> ;Cell Death & Disease. 2022 Aug 5
Characterizing Lymph Node Burden With Elective Unilateral Neck Irradiation in Human Papillomavirus-Positive Tonsil Squamous Cell Carcinoma: Defining the Upper Limits.
Jared H Hara, Stanley I Gutiontov, Sophia Uddin, Ari J Rosenberg, Alexander T Pearson, Zhen Gooi, Elizabeth A Blair, Nishant Agrawal, Everett E Vokes, Daniel T Ginat, ...> ;Cureus. 2022 Jul 1
2 citations
Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma.
Vivek Nair, Samuel Auger, Sara Kochanny, Frederick M Howard, Daniel Ginat, Olga Pasternak-Wise, Aditya Juloori, Evgeny Izumchenko, Nishant Agrawal, Ari Rosenberg, Ever...> ;JAMA Network Open. 2022 Apr 1
14 citations
Application of liquid biopsy as multi-functional biomarkers in head and neck cancer.
Vasudha Mishra, Alka Singh, Xiangying Chen, Ari J Rosenberg, Alexander T Pearson, Alex Zhavoronkov, Peter A Savage, Mark W Lingen, Nishant Agrawal, Evgeny Izumchenko> ;British Journal of Cancer. 2022 Feb 1
4 citations
Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and respons...
Ari J Rosenberg, Evgeny Izumchenko, Alexander Pearson, Zhen Gooi, Elizabeth Blair, Theodore Karrison, Aditya Juloori, Daniel Ginat, Nicole Cipriani, Mark Lingen, Hilla...> ;BMC Cancer. 2022 Jan 3
1 citations
Induction Chemotherapy in Low-Risk HPV+ Oropharyngeal Cancer.
James M Dolezal, Ari J Rosenberg> ;Current Treatment Options in Oncology. 2022 Jan 1
9 citations
Risk and response adapted de-intensified treatment for HPV-associated oropharyngeal cancer: Optima paradigm expanded experience.
Ari Rosenberg, Nishant Agrawal, Alexander T. Pearson, Zhen Gooi, Elizabeth A. Blair, John F. Cursio, Aditya Juloori, Daniel Thomas Ginat, Adam Howard, Jeffrey Chin, Sa...> ;Oral Oncology. 2021 Oct 18
4 citations
A robust and interpretable gene signature for predicting the lymph node status of primary T1/T2 oral cavity squamous cell carcinoma.
Yasmin Ghantous, Mohamed Omar, Esther Channah Broner, Nishant Agrawal, Alexander T. Pearson, Ari Rosenberg, Vasudha Mishra, Alka Singh, Imad Abu El-Naaj, Peter A. Sava...> ;International Journal of Cancer. 2021 Sep 27
11 citations
Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma.
Esther Channah Broner, Jonathan A. Trujillo, Michael Korzinkin, Tejaswini Subbannayya, Nishant Agrawal, Ivan V. Ozerov, Alex Zhavoronkov, Lisa M. Rooper, Nikita Kotlov...> ;Frontiers in Oncology. 2021 Jul 16
Neoantigen evolution in head and neck cancer progression: where do we go from here?
Ari Rosenberg, Evgeny Izumchenko> ;Oncotarget. 2021 Jun 8
52 citations
Optimizing Treatment De-Escalation in Head and Neck Cancer: Current and Future Perspectives.
Ari Rosenberg, Everett E. Vokes> ;The Oncologist. 2021 Jan 1
2 citations
Multimodality Therapy for Locoregional Nasopharyngeal Carcinoma-A Decision Tool for Treatment Optimization.
Ari Rosenberg> ;JAMA Network Open. 2020 Dec 1
21 citations
Novel Strategies to Effectively De-escalate Curative-Intent Therapy for Patients With HPV-Associated Oropharyngeal Cancer: Current and Future Directions
Katharine A. Price, Anthony C. Nichols, Colette J. Shen, Almoaidbellah Rammal, Pencilla Lang, David A. Palma, Ari Rosenberg, B.S. Chera, Nishant Agrawal> ;American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 2020 Mar 26
14 citations
Docetaxel, Oxaliplatin, and 5‐Fluorouracil (DOF) in Metastatic and Unresectable Gastric/Gastroesophageal Junction Adenocarcinoma: A Phase II Study with Long‐Term Follo...
Ari Rosenberg, Alfred Rademaker, Howard S. Hochster, Theresa Ryan, Thomas A. Hensing, Veena Shankaran, Lisa Baddi, Devalingam Mahalingam, Mary F. Mulcahy, Al B. Benson> ;The Oncologist. 2019 Aug 1
17 citations
Indoleamine 2,3-dioxygenase 1 and overall survival of patients diagnosed with esophageal cancer.
Ari Rosenberg, Derek A. Wainwright, Alfred Rademaker, Carlos Galvez, Matthew Genet, Lijie Zhai, Kristen L. Lauing, Mary F. Mulcahy, John P. Hayes, David D. Odell, Crai...> ;Oncotarget. 2018 May 4
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Press Mentions

ASCO Annual Meeting Returns to Chicago, Celebrates New Progress in CancerJune 15th, 2022
Multimodality Therapy for Locoregional Nasopharyngeal Carcinoma—A Decision Tool for Treatment OptimizationDecember 1st, 2020
The Growing Role for cfHPV-DNA Testing in OPSCC Therapeutic DevelopmentApril 18th, 2024
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