AshleyHall(Hall)ShoemakerMD

Pediatric Endocrinology • Nashville, TN

Pediatric Diabetes Endocrinology, Pediatric Obesity

Assistant Professor of Pediatrics, Vanderbilt University School of Medicine

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Office
1500 21st Ave South
Villiage at Vanderbilt, Suite 1514
Nashville, TN 37212
Phone+1 615-343-8116

Fax+1 615-875-7633
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Summary

I am a pediatric endocrinologist with an NIH funded research program focused on hypothalamic obesity including genetic disorders. I conduct translational research on the pathophysiology of hypothalamic obesity including phase 2-3 clinical trials. I also direct the VUMC Pediatric Prediabetes Clinic and the Prader-Willi Multispecialty Clinic.

Education & Training

Vanderbilt UniversityMS, Clinical Investigation, 2010 - 2012
Vanderbilt University Medical CenterFellowship, Pediatric Endocrinology, 2009 - 2012
Johns Hopkins UniversityResidency, Pediatrics, 2007 - 2009
Johns Hopkins UniversityInternship, Pediatrics, 2006 - 2007
Virginia Commonwealth University School of MedicineClass of 2006

Certifications & Licensure

TN State Medical License 2009 - 2026
AL State Medical License 2020 - 2020
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Endocrinology

Awards, Honors, & Recognition

Elected member Society for Pediatric Research, 2018
T2D Registry - Most Annual Updates Pediatric Diabetes Consortium, 2017-2018
T2D Registry - Highest Enrollment Pediatric Diabetes Consortium, 2016-2017
Early Investigators Award Endocrine Society, 2016
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Clinical Trials

Safety and Efficacy Study of Exenatide Once Weekly in Adolescents With Type 2 Diabetes Start of enrollment: 2011 Dec 02
Completed
Phase 3
Clinical Study of Diazoxide Choline Controlled-Release Tablet (DCCR) in Patients With Prader-Willi Syndrome Start of enrollment: 2014 Apr 01
Completed
Phase 1, Phase 2
Early-onset Obesity and Cognitive Impairment in Children With Pseudohypoparathyroidism Start of enrollment: 2014 Dec 01
Completed
Energy Balance & Weight Loss in Craniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic Obesity Start of enrollment: 2016 Mar 01
Completed
Phase 3
Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers Start of enrollment: 2016 Sep 28
Completed
Vanderbilt Childhood Obesity Registry Start of enrollment: 2012 Nov 01
Active, not recruiting
Theophylline Treatment for Pseudohypoparathyroidism Start of enrollment: 2018 Sep 01
Recruiting
Phase 2
A Study of GLWL-01 in Patients With Prader-Willi Syndrome Start of enrollment: 2018 Feb 20
Completed
Phase 2
Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TM Start of enrollment: 2018 Mar 20
Completed
Phase 3
Open-Label Extension Study of DCCR in PWS Followed by Double-Blind, Placebo-Controlled, Randomized Withdrawal Period Start of enrollment: 2018 Oct 01
Active, not recruiting
Phase 3
Glucose Homeostasis in Pseudohypoparathyroidism Start of enrollment: 2019 Jun 19
Terminated
A Phase IV Safety and Efficacy Study of VI-0521 in Adolescents With Obesity Start of enrollment: 2019 May 02
Completed
Phase 4
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Publications & Presentations

PubMed

Bardet-Biedl syndrome: A clinical overview focusing on diagnosis, outcomes and best-practice management.
Ashley Shoemaker> ;Diabetes, Obesity & Metabolism. 2024 Apr 1
Risk Factors for Progression to Type 2 Diabetes in a Pediatric Prediabetes Clinic Population.
Natasha Belsky, Jaclyn Tamaroff, Ashley H Shoemaker> ;Journal of the Endocrine Society. 2023 Oct 9
3 citations
Prevalence of genetic causes of obesity in clinical practice.
Jaclyn Tamaroff, Dylan Williamson, James C Slaughter, Meng Xu, Gitanjali Srivastava, Ashley H Shoemaker> ;Obesity Science & Practice. 2023 Oct 1
8 citations
Diazoxide Choline Extended-Release Tablet in People With Prader-Willi Syndrome: A Double-Blind, Placebo-Controlled Trial.
Jennifer L Miller, Evelien Gevers, Nicola Bridges, Jack A Yanovski, Parisa Salehi, Kathryn S Obrynba, Eric I Felner, Lynne M Bird, Ashley H Shoemaker, Moris Angulo, Me...> ;The Journal of Clinical Endocrinology and Metabolism. 2023 Jun 16
3 citations
Approach to the Patient With Hypothalamic Obesity.
Ashley H Shoemaker, Jaclyn Tamaroff> ;The Journal of Clinical Endocrinology and Metabolism. 2023 Apr 13
2 citations
Prolonged lapses between pediatric and adult care are associated with rise in HbA1c and inpatient days among patients with type 1 diabetes.
Daniel R Tilden, Benjamin French, Ashley H Shoemaker, Sarah Corathers, Sarah S Jaser> ;Diabetes Research and Clinical Practice. 2022 Oct 1
25 citations
The Coronavirus Disease 2019 Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes.
Sheela N Magge, Risa M Wolf, Laura Pyle, Elizabeth A Brown, Valeria C Benavides, Monica E Bianco, Lily C Chao, Anna Cymbaluk, Pinar Gumus Balikcioglu, Kelsee Halpin, D...> ;The Journal of Pediatrics. 2022 Dec 1
34 citations
Phentermine/Topiramate for the Treatment of Adolescent Obesity.
Aaron S Kelly, Megan O Bensignor, Daniel S Hsia, Ashley H Shoemaker, Winnie Shih, Craig Peterson, Santosh T Varghese> ;NEJM Evidence. 2022 Jun 1
4 citations
The Efficacy, Safety, and Pharmacology of a Ghrelin O-Acyltransferase Inhibitor for the Treatment of Prader-Willi Syndrome.
Jennifer L Miller, André Lacroix, Lynne M Bird, Ashley H Shoemaker, Andrea Haqq, Cheri L Deal, Kristie A Clark, Michael H Ames, Jeffrey G Suico, Amparo de la Peña, Car...> ;The Journal of Clinical Endocrinology and Metabolism. 2022 May 17
10 citations
Energy balance in hypothalamic obesity in response to treatment with a once-weekly GLP-1 receptor agonist.
Ashley H Shoemaker, Heidi J Silver, Maciej Buchowski, James C Slaughter, Jack A Yanovski, Clinton Elfers, Christian L Roth, M Jennifer Abuzzahab> ;International Journal of Obesity. 2022 Mar 1
Calcitriol and Levothyroxine Dosing for Patients With Pseudohypoparathyroidism.
Jacqueline Antoun, Dylan Williamson, Merla Hubler, Ashley H. Shoemaker> ;Journal of the Endocrine Society. 2021 Oct 27
8 citations
Racial and Ethnic Disparities in Comorbidities in Youth With Type 2 Diabetes in the Pediatric Diabetes Consortium (PDC).
Fida Bacha, Peiyao Cheng, Robin L. Gal, Lindsey C. Beaulieu, Craig Kollman, Anne L. Adolph, Ashley H. Shoemaker, Risa M. Wolf, Georgeanna J. Klingensmith, William V. T...> ;Diabetes Care. 2021 Aug 30
10 citations
MRI measures of hypothalamic injury are associated with glucagon-like peptide-1 receptor agonist treatment response in people with hypothalamic obesity.
Francisco A. Perez, Clinton Elfers, Jack A. Yanovski, Ashley H. Shoemaker, M. Jennifer Abuzzahab, Christian L. Roth> ;Diabetes, Obesity & Metabolism. 2021 Jul 1
21 citations
A phase 3 randomized clinical trial using a once-weekly glucagon-like peptide-1 receptor agonist in adolescents and young adults with hypothalamic obesity.
Christian L. Roth, Francisco A. Perez, Kathryn B. Whitlock, Clinton Elfers, Jack A. Yanovski, Ashley H. Shoemaker, M. Jennifer Abuzzahab> ;Diabetes, Obesity & Metabolism. 2021 Feb 1
14 citations
Evaluation of the MC4R gene across eMERGE network identifies many unreported obesity-associated variants.
, , , , , , , , , , , , , , , , , , > ;International Journal of Obesity. 2021 Jan 1
31 citations
Recommendations for Diagnosis and Treatment of Pseudohypoparathyroidism and Related Disorders: An Updated Practical Tool for Physicians and Patients
Giovanna Mantovani, Murat Bastepe, David Monk, Luisa De Sanctis, Susanne Thiele, S Faisal Ahmed, Roberto Bufo, Timothee Choplin, Gianpaolo De Filippo, Guillemette Deve...> ;Hormone Research in Paediatrics. 2020 Aug 5
5 citations
Trends in pediatric obesity management, a survey from the Pediatric Endocrine Society Obesity Committee.
Ashley H. Shoemaker, Stephanie T. Chung, Amy Fleischman> ;Journal of Pediatric Endocrinology & Metabolism. 2020 Apr 28
Liraglutide in Children and Adolescents with Type 2 Diabetes.
Tamborlane WV, Barrientos-Pérez M, Fainberg U, Frimer-Larsen H, Hafez M, Hale PM, Jalaludin MY, Kovarenko M, Libman I, Lynch JL, Rao P, Shehadeh N, Turan S, Weghuber D...> ;The New England journal of medicine. 2019-04-28
3 citations
Two teenage males with hypocalcemia and elevated parathyroid hormone levels
Ashley H. Shoemaker, Andrew A. Bremer> ;Pediatric Annals. 2012 Apr 1
2 citations
A Clinic-based Approach to Diagnosis and Management of Prediabetes in High-risk Children and Adolescents.
Chelsea Lawson, S Naseeruddin Ahmed, Cassandra Brady, Ashley H. Shoemaker> ;Journal of the Endocrine Society. 2020 Mar 21
Impaired amygdala-based learning and decreased anxiety in a murine model of pseudohypoparathyroidism type 1A.
Ashley H. Shoemaker, Krista C. Paffenroth, Nathan Bingham, Fiona E. Harrison> ;Behavioural Brain Research. 2019 Jul 23
40 citations
A multidisciplinary approach to the clinical management of Prader-Willi syndrome.
Jessica Duis, Pieter Joost van Wattum, Ann O. Scheimann, Parisa Salehi, Elly Brokamp, Laura Fairbrother, Anna Childers, Althea Robinson Shelton, Nathan C. Bingham, Ash...> ;Molecular Genetics & Genomic Medicine. 2019 Jan 29
33 citations
Hypothalamic Obesity: Prologue and Promise.
M. Jennifer Abuzzahab, Christian L. Roth, Ashley H. Shoemaker> ;Hormone Research in Paediatrics. 2019 Jan 1
9 citations
Glucose Homeostasis and Energy Balance in Children With Pseudohypoparathyroidism
Katia M. Perez, Kathleen L Curley, James C. Slaughter, Ashley H. Shoemaker> ;The Journal of Clinical Endocrinology and Metabolism. 2018 Nov 1
163 citations
Diagnosis and management of pseudohypoparathyroidism and related disorders: First international Consensus Statement
Giovanna Mantovani, Murat Bastepe, David Monk, Luisa De Sanctis, Susanne Thiele, Alessia Usardi, S Faisal Ahmed, Roberto Bufo, Timothee Choplin, Gianpaolo de Filippo, ...> ;Nature Reviews. Endocrinology. 2018 Aug 1
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Journal Articles

Diagnosis and Management of Pseudohypoparathyroidism and Related Disorders: First International Consensus Statement
Robert Pignolo, Ashley H Shoemaker, Michael A Levine, Nature

Press Mentions

Doctors Urged to Take More Active Role Against Childhood ObesityJanuary 11th, 2023
Rhythm Pharmaceuticals Announces Presentation of Updated Clinical Data from Phase 2 Basket Studies Evaluating Setmelanotide in Alström Syndrome at ObesityWeek 2018November 15th, 2018
Cognition in Rare Hormonal DisorderFebruary 13th, 2018
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Grant Support

Phase 2 study of theophylline for the treatment of pseudohypoparathyroidismNIDDK2021–2025
Glucose homeostasis and beta cell function in pseudohypoparathyroidismNIDDK2019–2021
Clinical Scientist Development AwardDoris Duke Foundation2018–2021
Glucagon-like peptide-1 agonist effects on energy balance in hypothalamic obesityNIDDK2015–2019
K23 Mentored Career Development AwardNIDDK2014–2019

Committees

Member, Master of Science in Clinical Investigation Admissions Committee 2017 - Present
Member, Sleep Core Faculty Advisory Committee 2015 - Present
Member, Pediatric Endocrine Society Obesity Committee 2013 - Present