AverellHirschSherkerMD

Gastroenterology • Bethesda, MD

Hepatology & Liver Transplantation

Associate Professor, Medicine, Georgetown University School of Medicine

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Office
6707 Democracy
Bethesda, MD 20817
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Education & Training

Queen's University at KingstonClass of 1982

Certifications & Licensure

CA State Medical License 1989 - 2024
DC State Medical License 2001 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Gastroenterology

Clinical Trials

A Randomized, Double-Blinded, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterostomy Start of enrollment: 2005 Nov 01
Completed
Not Applicable
Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis Start of enrollment: 2010 Jan 12
Completed
Multi-Center African-American Inflammatory Bowel Disease Study (MAAIS) Start of enrollment: 2003 Jun 01
Recruiting
Combination Entecavir and Peginterferon Therapy in HBeAg-Positive Immune-Tolerant Adults With Chronic Hepatitis B Start of enrollment: 2012 May 01
Terminated
Phase 3
A2ALL-Patients Safety System Improvements in Living Donor Liver Transplantation Start of enrollment: 2010 Oct 01
Completed
MRI to Characterize and Predict CF Liver Disease in PUSH Cohort Start of enrollment: 2017 Jan 27
Completed
Longitudinal Assessment of Transient Elastography in Cystic Fibrosis Start of enrollment: 2017 Mar 08
Completed
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Publications & Presentations

PubMed

7 citations
Chronic Hepatitis Is Common and Often Untreated Among Children with Hepatitis B Infection in the United States and Canada.
Simon C. Ling, Hsing-Hua S Lin, Karen F. Murray, Philip J. Rosenthal, Douglas Mogul, Norberto Rodriguez-Baez, Sarah Jane Schwarzenberg, Jeffrey Teckman, Kathleen B. Sc...> ;The Journal of Pediatrics. 2021 Oct 1
In decompensated cirrhosis, targeted albumin infusions did not improve an in-hospital composite outcome at 15 d.
Julian Hercun, Averell H. Sherker> ;Annals of Internal Medicine. 2021 Aug 1
47 citations
Efficacy and Safety of Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients: Moving Toward Personalized Management.
Sandy Feng, John C. Bucuvalas, George V. Mazariegos, John C. Magee, Alberto Sanchez-Fueyo, K. Spain, Andrew Lesniak, Sai Kanaparthi, Emily R. Perito, Veena Venkat, Bry...> ;Hepatology. 2021 May 1
5 citations
Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hyp...
Jeffrey Teckman, Philip J. Rosenthal, Kieran Hawthorne, Cathie Spino, Lee M. Bass, Karen F. Murray, Nanda Kerkar, John C. Magee, Saul J. Karpen, James E. Heubi, Jean P...> ;The Journal of Pediatrics. 2020 Dec 1
22 citations
Heterogeneous Liver on Research Ultrasound Identifies Children with Cystic Fibrosis at High Risk of Advanced Liver Disease: Interim Results of a Prospective Observatio...
Marilyn J. Siegel, A. Jay Freeman, Wen Ye, Joseph J. Palermo, Jean P. Molleston, Shruti M. Paranjape, Janis Stoll, Daniel H Leung, Prakash Masand, Boaz Karmazyn, Roger...> ;The Journal of Pediatrics. 2020 Feb 12
75 citations
United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts.
Hellen A. Oketch-Rabah, Amy L. Roe, Cynthia V. Rider, Herbert L. Bonkovsky, Gabriel I. Giancaspro, Víctor M. Navarro, Mary F. Paine, Joseph M. Betz, Robin J. Marles, S...> ;Toxicology Reports. 2020 Feb 15
1 citations
HBV Genotype-Specific Levels of Hepatitis B Surface Antigen Improve HBV Phenotype Definition.
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,...> ;Clinical Gastroenterology and Hepatology. 2020 Jan 1
48 citations
Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome.
John-Paul Berauer, Anya Mezina, David T. Okou, Aniko Sabo, Donna M. Muzny, Richard A. Gibbs, Madhuri Hegde, Pankaj Chopra, David J. Cutler, David H. Perlmutter, Laura ...> ;Hepatology. 2019 Sep 1
127 citations
Diagnostic Accuracy of Noninvasive Fibrosis Models to Detect Change in Fibrosis Stage.
Mohammad S. Siddiqui, Goro Yamada, Raj Vuppalanchi, Mark L. Van Natta, Rohit Loomba, Cynthia D. Guy, Danielle Brandman, James Tonascia, Naga Chalasani, Brent A. Neusch...> ;Clinical Gastroenterology and Hepatology. 2019 Aug 1
21 citations
A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia
Cathie Spino, Estella M. Alonso, Jorge A. Bezerra, Jeffrey S. Moore, Catherine J. Goodhue, Vicky L. Ng, Saul J. Karpen, Veena Venkat, Kathleen M. Loomes, Kasper S. Wan...> ;Journal of Pediatric Gastroenterology and Nutrition. 2019 Apr 1
14 citations
Correlation of Immune Markers With Outcomes in Biliary Atresia Following Intravenous Immunoglobulin Therapy.
, , , , , , , , , , , , , , , > ;Hepatology Communications. 2019 Mar 25
21 citations
Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis
Kathleen M. Loomes, Cathie Spino, Nathan P. Goodrich, Thomas N. Hangartner, Amanda E. Marker, James E. Heubi, Binita M. Kamath, Benjamin L. Shneider, Philip J. Rosenth...> ;Hepatology. 2019 Jan 1
95 citations
Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants
Sandy Feng, John C. Bucuvalas, Anthony J. Demetris, Bryna E. Burrell, Katherine M. Spain, Sai Kanaparthi, John C. Magee, David Ikle, Andrew Lesniak, Juan José Lozano, ...> ;Gastroenterology. 2018 Dec 1
15 citations
Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multicenter Steroids in Biliary Atresia Randomized Trial.
Estella M. Alonso, Wen Ye, Kieran Hawthorne, Veena Venkat, Kathleen M. Loomes, Cara L. Mack, Paula M. Hertel, Saul J. Karpen, Nanda Kerkar, Jean P. Molleston, Karen F....> ;The Journal of Pediatrics. 2018 Nov 1
40 citations
A Learning Collaborative Approach Increases Specificity of Diagnosis of Acute Liver Failure in Pediatric Patients.
Michael R. Narkewicz, Simon Horslen, Regina M. Hardison, Benjamin L. Shneider, Norberto Rodriguez-Baez, Estella M. Alonso, Vicky L. Ng, Mike A. Leonis, Kathleen M. Loo...> ;Clinical Gastroenterology and Hepatology. 2018 Nov 1
22 citations
Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study.
Zeeshan Butt, Andrea DiMartini, Qian Liu, Mary Ann Simpson, Abigail R. Smith, Jarcy Zee, Brenda W. Gillespie, Susan Holtzman, Daniela P. Ladner, Kim M. Olthoff, Robert...> ;Liver Transplantation. 2018 Sep 1
30 citations
Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study.
Vicky L. Ng, Lisa G. Sorensen, Estella M. Alonso, Emily M. Fredericks, Wen Ye, Jeffrey S. Moore, Saul J. Karpen, Benjamin L. Shneider, Jean P. Molleston, Jorge A. Beze...> ;The Journal of Pediatrics. 2018 May 1
26 citations
Safety, tolerability, and pharmacokinetics of l-ornithine phenylacetate in patients with acute liver injury/failure and hyperammonemia
R. Todd Stravitz, Michelle Gottfried, Valerie Durkalski, Robert J. Fontana, A. James Hanje, David G. Koch, Bilal Hameed, Daniel Ganger, Ram Subramanian, Stan Bukofzer,...> ;Hepatology. 2018 Mar 1
21 citations
Prevalence and Predictors of Patient-Reported Long-term Mental and Physical Health After Donation in the Adult-to-Adult Living-Donor Liver Transplantation Cohort Study.
Mary Amanda Dew, Zeeshan Butt, Qian Liu, Mary Ann Simpson, Jarcy Zee, Daniela P. Ladner, Susan Holtzman, Abigail R. Smith, Elizabeth A. Pomfret, Robert M. Merion, Bren...> ;Transplantation. 2018 Jan 1
26 citations
Hepatic Hemodynamics and Portal Flow Modulation: The A2ALL Experience.
Jean C. Emond, Nathan P. Goodrich, James J. Pomposelli, Abhinav Humar, David R. Grant, Peter L. Abt, Chris E. Friese, Robert A. Fisher, Igal Kam, Averell H. Sherker, B...> ;Transplantation. 2017 Oct 1
81 citations
Death and liver transplantation within 2 years of onset of drug-induced liver injury.
Paul H. Hayashi, Don C. Rockey, Robert J. Fontana, Hans L. Tillmann, Neil Kaplowitz, Huiman X. Barnhart, Jiezhan Gu, Naga Chalasani, K. Rajender Reddy, Averell H. Sher...> ;Hepatology. 2017 Oct 1
77 citations
The Natural History of Severe Acute Liver Injury
David G. Koch, Jaime L. Speiser, Valerie Durkalski, Robert J. Fontana, Timothy Davern, Brendan M. McGuire, Richard T. Stravitz, Anne M. Larson, Iris Liou, Oren K. Fix,...> ;The American Journal of Gastroenterology. 2017 Sep 1
30 citations
Initial assessment of the infant with neonatal cholestasis--Is this biliary atresia?
Benjamin L. Shneider, Jeffrey S. Moore, Nanda Kerkar, John C. Magee, Wen Ye, Saul J. Karpen, Binita M. Kamath, Jean P. Molleston, Jorge A. Bezerra, Karen F. Murray, Ka...> ;Plos One. 2017 May 11
3 citations
Hepatitis C: Down but Not Out.
Jay H. Hoofnagle, Averell H. Sherker> ;Annals of Internal Medicine. 2017 May 2
30 citations
Psychological Outcomes of Living Liver Donors From a Multicenter Prospective Study: Results From the Adult-to-Adult Living Donor Liver Transplantation Cohort Study2 (A...
Zeeshan Butt, Mary Amanda Dew, Qian Liu, Mary Ann Simpson, Abigail R. Smith, Jarcy Zee, Brenda W. Gillespie, Susan E. Abbey, Daniela P. Ladner, Robert M. Weinrieb, Rob...> ;American Journal of Transplantation. 2017 May 1
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Press Mentions

Steroids After Surgery Do Not Help Infants with Rare Liver DiseaseMay 4th, 2014