AxelGrotheyMD

PubMed

• Efficacy of immune checkpoint inhibitors for metastatic colorectal cancer with microsatellite instability in second or latter line using synthetic control arms: A non-...
  Cohen, R., Raeisi, M., Chibaudel, B., Yoshino, T., Shi, Q., Zalcberg, J., Adams, R., Cremolini, C., Grothey, A., Mayer, R., Van Cutsem, E., Tabernero, J., Bando, H., M...> ;European Journal of Cancer. 2024 Mar 1
• Improving Rectal Cancer Treatments 1 Study at a Time.
  Noam VanderWalde, Axel Grothey> ;JAMA Network Open. 2023 Oct 2
• Corrigendum to "Evaluating sex as a predictive marker for response to bevacizumab in metastatic colorectal carcinoma: Pooled analysis of 3369 patients in the ARCAD dat...
  Ofer Margalit, William S Harmsen, Einat Shacham-Shmueli, Molly M Voss, Ben Boursi, Anna D Wagner, Romain Cohen, Curtis L Olswold, Leonard B Saltz, Daniel A Goldstein, ...> ;European Journal of Cancer. 2023 Nov 1
• Evaluation of Intratumoral Response Heterogeneity in Metastatic Colorectal Cancer and Its Impact on Patient Overall Survival: Findings from 10,551 Patients in the ARCA...
  Fang-Shu Ou, Daniel H Ahn, Jesse G Dixon, Axel Grothey, Yiyue Lou, Pashtoon M Kasi, Joleen M Hubbard, Eric Van Cutsem, Leonard B Saltz, Hans-Joachim Schmoll, Richard M...> ;Cancers. 2023 Aug 15
• 12 citations
  Final results of DESTINY-CRC01 investigating trastuzumab deruxtecan in patients with HER2-expressing metastatic colorectal cancer.
  Yoshino, T., Di Bartolomeo, M., Raghav, K., Masuishi, T., Loupakis, F., Kawakami, H., Yamaguchi, K., Nishina, T., Wainberg, Z., Elez, E., Rodriguez, J., Fakih, M., Cia...> ;Nature Communications. 2023 Jun 7
• 3 citations
  Napabucasin Plus FOLFIRI in Patients With Previously Treated Metastatic Colorectal Cancer: Results From the Open-Label, Randomized Phase III CanStem303C Study.
  Shah, M., Yoshino, T., Tebbutt, N., Grothey, A., Tabernero, J., Xu, R., Cervantes, A., Oh, S., Yamaguchi, K., Fakih, M., Falcone, A., Wu, C., Chiu, V., Tomasek, J., Be...> ;Clinical Colorectal Cancer. 2023 Mar 1
• 18 citations
  ANCHOR CRC: Results From a Single-Arm, Phase II Study of Encorafenib Plus Binimetinib and Cetuximab in Previously Untreated-Mutant Metastatic Colorectal Cancer.
  Eric Van Cutsem, Julien Taieb, Rona Yaeger, Takayuki Yoshino, Axel Grothey, Evaristo Maiello, Elena Elez, Jeroen Dekervel, Paul Ross, Ana Ruiz-Casado, Janet Graham, Ta...> ;Journal of Clinical Oncology. 2023 May 10
• 3 citations
  Clinical and exploratory biomarker findings from the MODUL trial (Cohorts 1, 3 and 4) of biomarker-driven maintenance therapy for metastatic colorectal cancer.
  Michel Ducreux, Josep Tabernero, Axel Grothey, Dirk Arnold, Peter J O'Dwyer, Frank Gilberg, Alexander Abbas, Meghna Das Thakur, Hen Prizant, Natsumi Irahara, Anila Tah...> ;European Journal of Cancer. 2023 May 1
• 11 citations
  Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study.
  Jingyuan Wang, Joanne Xiu, Alex Farrell, Yasmine Baca, Hiroyuki Arai, Francesca Battaglin, Natsuko Kawanishi, Shivani Soni, Wu Zhang, Joshua Millstein, Anthony F Shiel...> ;The Lancet. Oncology. 2023 Feb 1
• 1 citations
  Evaluating sex as a predictive marker for response to bevacizumab in metastatic colorectal carcinoma: Pooled analysis of 3,369 patients in the ARCAD database.
  Ofer Margalit, William S Harmsen, Einat Shacham-Shmueli, Molly M Voss, Ben Boursi, Anna D Wagner, Romain Cohen, Curtis L Olswold, Leonard B Saltz, Daniel A Goldstein, ...> ;European Journal of Cancer. 2023 Jan 1
• 1 citations
  Pembrolizumab in metastatic mismatch repair deficient colorectal cancer: the beginning of a journey into the land of immunotherapies for all cancers.
  Axel Grothey> ;Chinese Clinical Oncology. 2022 Oct 1
• 1 citations
  Clinical Trial Endpoints in Metastatic Cancer: Using Individual Participant Data to Inform Future Trials Methodology.
  Richard M Goldberg, Richard Adams, Marc Buyse, Cathy Eng, Axel Grothey, Thierry André, Alberto F Sobrero, Stuart M Lichtman, Al B Benson, Cornelis J A Punt, Tim Maugha...> ;Journal of the National Cancer Institute. 2022 Jun 13
• 13 citations
  Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer.
  Andreas Seeber, Francesca Battaglin, Kai Zimmer, Florian Kocher, Yasmine Baca, Joanne Xiu, Gilbert Spizzo, Veronica Novotny-Diermayr, Dietmar Rieder, Alberto Puccini, ...> ;Clinical Cancer Research. 2022 May 2
• 3 citations
  Metastatic Colorectal Cancer Outcomes by Age Among ARCAD First- and Second-Line Clinical Trials.
  Nadine J McCleary, William S Harmsen, Ellana Haakenstad, James M Cleary, Jeffrey A Meyerhardt, John Zalcberg, Richard Adams, Axel Grothey, Alberto F Sobrero, Eric Van ...> ;JNCI Cancer Spectrum. 2022 Mar 2
• 6 citations
  Efficacy of anti-epidermal growth factor receptor agents in patients with RAS wild-type metastatic colorectal cancer ≥ 70 years.
  Demetris Papamichael, Guilherme S Lopes, Curt L Olswold, Jean-Yves Douillard, Richard A Adams, Timothy S Maughan, Eric Van Cutsem, Alan P Venook, Heinz-Josef Lenz, Vol...> ;European Journal of Cancer. 2022 Mar 1
• 30 citations
  Impact of Circulating Tumor DNA-Based Detection of Molecular Residual Disease on the Conduct and Design of Clinical Trials for Solid Tumors.
  Pashtoon M Kasi, Gordon Fehringer, Hiroya Taniguchi, Naureen Starling, Yoshiaki Nakamura, Daisuke Kotani, Thomas Powles, Bob T Li, Lajos Pusztai, Vasily N Aushev, Ekat...> ;JCO Precision Oncology. 2022 Mar 1
• 38 citations
  Landscape of, Associated Genomic Alterations, and Interrelation With Immuno-Oncology Biomarkers in-Mutated Cancers.
  Mohamed E Salem, Sherif M El-Refai, Wei Sha, Alberto Puccini, Axel Grothey, Thomas J George, Jimmy J Hwang, Bert O'Neil, Alexander S Barrett, Kunal C Kadakia, Laura W ...> ;JCO Precision Oncology. 2022 Mar 1
• 2 citations
  Association of Homologous Recombination-DNA Damage Response Gene Mutations with Immune Biomarkers in Gastroesophageal Cancers.
  Michael Cerniglia, Joanne Xiu, Axel Grothey, Michael J. Pishvaian, Yasmine Baca, Jimmy J. Hwang, John L. Marshall, Ari M. Vanderwalde, Anthony F. Shields, Heinz-Josef ...> ;Molecular Cancer Therapeutics. 2021 Nov 1
• 52 citations
  Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines
  Glenn Kunnath Bonney, Claire Alexandra Zhen Chew, Peter Lodge, Joleen M. Hubbard, Karim J. Halazun, Pavel Trunecka, Paolo Muiesan, Darius F. Mirza, John Isaac, Richard...> ;The Lancet. Gastroenterology & Hepatology. 2021 Nov 1
• 7 citations
  Molecular differences between lymph nodes and distant metastases compared with primaries in colorectal cancer patients.
  Alberto Puccini, Andreas Seeber, Joanne Xiu, Richard M. Goldberg, Davide Soldato, Axel Grothey, Anthony F. Shields, Mohamed E. Salem, Francesca Battaglin, Martin D. Be...> ;NPJ Precision Oncology. 2021 Oct 27
• 13 citations
  BESPOKE study protocol: a multicentre, prospective observational study to evaluate the impact of circulating tumour DNA guided therapy on patients with colorectal cancer.
  Pashtoon Murtaza Kasi, S Sawyer, Jessica Guilford, Michelle Munro, Sascha Ellers, Jacob Wulff, Nicole Hook, Shifra Krinshpun, Allyson Koyen Malashevich, Meenakshi Malh...> ;BMJ Open. 2021 Sep 24
• 6 citations
  Re-Evaluating Disease-Free Survival as an Endpoint vs Overall Survival in Stage III Adjuvant Colon Cancer Trials
  Jun Yin, Mohamed E. Salem, Jesse G. Dixon, Zhaohui Jin, Romain Cohen, Aimery de Gramont, Eric Van Cutsem, Julien Taieb, Steven R. Alberts, Norman Wolmark, Hans-Joachim...> ;Journal of the National Cancer Institute. 2021 Sep 10
• 9 citations
  Clinical and functional characterization of atypical KRAS/NRAS mutations in metastatic colorectal cancer
  Jonathan M. Loree, Yucai Wang, Muddassir A. Syed, Alexey V. Sorokin, Oluwadara Coker, Joanne Xiu, Benjamin A. Weinberg, Ari M. Vanderwalde, Anteneh Tesfaye, Victoria M...> ;Clinical Cancer Research. 2021 Aug 15
• 4 citations
  Microsatellite Stable Colorectal Liver Metastases-Understanding the Mechanisms of Immune Resistance.
  Sepideh Gholami, Axel Grothey, Heinz-Josef Lenz> ;JAMA Network Open. 2021 Aug 2
• 80 citations
  Management of BRAF-mutant metastatic colorectal cancer: a review of treatment options and evidence-based guidelines.
  A. Grothey, Josep Tabernero> ;Annals of Oncology. 2021 Aug 1
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