BarbaraKahnMD

PubMed

• 7 citations
  PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53.
  Maria F Rubin de Celis, Ruben Garcia-Martin, Ismail Syed, Jennifer Lee, Cristina Aguayo-Mazzucato, Susan Bonner-Weir, Barbara B Kahn> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Nov 22
• 49 citations
  ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids.
  Rucha Patel, Anna Santoro, Peter Hofer, Dan Tan, Monika Oberer, Andrew T Nelson, Srihari Konduri, Dionicio Siegel, Rudolf Zechner, Alan Saghatelian, Barbara B Kahn> ;Nature. 2022 Jun 1
• 12 citations
  High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control.
  , , , , , , , , , , , , , , , , , , , > ;Nature Communications. 2021 Nov 29
• 32 citations
  RBP4 increases lipolysis in human adipocytes and is associated with increased lipolysis and hepatic insulin resistance in obese women.
  Murat Kilicarslan, Barbara A. de Weijer, Kotryna Simonyté Sjödin, Pratik Aryal, Kasper W. ter Horst, Hamit Cakir, Johannes A. Romijn, Mariëtte T. Ackermans, Ignace M. ...> ;FASEB Journal. 2020 May 1
• 42 citations
  PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice
  Ismail Syed, Maria Fernandez Rubin De Celis, James F. Mohan, Pedro M. Moraes-Vieira, Archana Vijayakumar, Andrew T. Nelson, Dionicio Siegel, Alan Saghatelian, Diane Ma...> ;The Journal of Clinical Investigation. 2019 Sep 3
• 49 citations
  PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms
  Peng Zhou, Anna Santoro, Odile D. Peroni, Andrew T. Nelson, Alan Saghatelian, Dionicio Siegel, Barbara B. Kahn> ;The Journal of Clinical Investigation. 2019 Oct 1
• 49 citations
  Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation.
  Dan Tan, Meric Erikci Ertunc, Srihari Konduri, Justin Zhang, Antonio F. M. Pinto, Qian Chu, Barbara B. Kahn, Dionicio Siegel, Alan Saghatelian> ;Journal of the American Chemical Society. 2019 May 6
• 24 citations
  Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.
  Ismail Syed, Jennifer Lee, Odile D. Peroni, Mark M. Yore, Pedro M. Moraes-Vieira, Anna Santoro, Kerry Wellenstein, Ulf Smith, Timothy E. McGraw, Alan Saghatelian, Barb...> ;Cell Metabolism. 2018 Oct 2
• Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids.
  Hammarstedt, A.,Syed, I.,Vijayakumar, A.,Eliasson, B.,Gogg, S.,Kahn, B. B.,Smith, U.> ;Sci Rep. 2018 Oct 27
• 301 citations
  Metabolites as regulators of insulin sensitivity and metabolism
  Qin Yang, Archana Vijayakumar, Barbara B. Kahn> ;Nature Reviews. Molecular Cell Biology. 2018 Oct 1
• Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.
  Kong, X.,Yao, T.,Zhou, P.,Kazak, L.,Tenen, D.,Lyubetskaya, A.,Dawes, B. A.,Tsai, L.,Kahn, B. B.,Spiegelman, B. M.,Liu, T.,Rosen, E. D.> ;Cell Metab.. 2018 Aug 07
• 32 citations
  Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements
  Matthew J. Kolar, Andrew T. Nelson, Tina Chang, Meric Erikci Ertunc, Mitchell P. Christy, Lena Ohlsson, Magnus Härröd, Barbara B. Kahn, Dionicio Siegel, Alan Saghatelian> ;Analytical Chemistry. 2018 Mar 26
• 111 citations
  Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.
  Ismail Syed, Jennifer Lee, Pedro M. Moraes-Vieira, Cynthia J. Donaldson, Alexandra Sontheimer, Pratik Aryal, Kerry Wellenstein, Matthew J. Kolar, Andrew T. Nelson, Dio...> ;Cell Metabolism. 2018 Feb 6
• 43 citations
  Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat
  Shiki Okamoto, Tatsuya Sato, Michihiro Tateyama, Haruaki Kageyama, Yuko Maejima, Masanori Nakata, Satoshi Hirako, Takashi Matsuo, Sanda Kyaw, Tetsuya Shiuchi, Chitoku ...> ;Cell Reports. 2018 Jan 16
• 88 citations
  Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport
  Archana Vijayakumar, Pratik Aryal, Jennifer Wen, Ismail Syed, Reema P. Vazirani, Pedro M. Moraes-Vieira, Joao Paulo Camporez, Molly R. Gallop, Rachel J. Perry, Odile D...> ;Cell Reports. 2017 Oct 24
• 45 citations
  Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation
  Andrew T. Nelson, Matthew J. Kolar, Qian Chu, Ismail Syed, Barbara B. Kahn, Alan Saghatelian, Dionicio Siegel> ;Journal of the American Chemical Society. 2017 Mar 28
• 23 citations
  GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle
  Shawna McMillin, Denise L. Schmidt, Barbara B. Kahn, Carol A. Witczak> ;Diabetes. 2017 Jun 1
• 64 citations
  Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation.
  Candace M. Reno, Erwin C. Puente, Zhenyu Sheng, Dorit Daphna-Iken, Adam J. Bree, Vanessa H. Routh, Barbara B. Kahn, Simon J. Fisher> ;Diabetes. 2017 Mar 1
• 24 citations
  Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance
  John R. Grünberg, Jenny M. Hoffmann, Shahram Hedjazifar, Annika Nerstedt, Lachmi Jenndahl, Johannes Elvin, John J. Castellot, Lan Wei, Sofia Movérare-Skrtic, Claes Ohl...> ;Scientific Reports. 2017 Feb 27
• 73 citations
  Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice
  Seung-Ah Lee, Jason J. Yuen, Hongfeng Jiang, Barbara B. Kahn, William S. Blaner> ;Hepatology. 2016 Nov 1
• 83 citations
  Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses
  Jennifer Lee, Pedro M. Moraes-Vieira, Angela Castoldi, Pratik Aryal, Eric U. Yee, Christopher Vickers, Oren Parnas, Cynthia J. Donaldson, Alan Saghatelian, Barbara B. ...> ;The Journal of Biological Chemistry. 2016 Oct 14
• 46 citations
  Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase
  Matthew J. Kolar, Siddhesh S. Kamat, William H. Parsons, Edwin A. Homan, Tim Maher, Odile D. Peroni, Ismail Syed, Karianne Fjeld, Anders Molven, Barbara B. Kahn, Benja...> ;Biochemistry. 2016 Aug 10
• 50 citations
  A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons
  Dong Kong, Yossi Dagon, John N. Campbell, Yikun Guo, Zongfang Yang, Xinchi Yi, Pratik Aryal, Kerry Wellenstein, Barbara B. Kahn, Bernardo L. Sabatini, Bradford B. Lowell> ;Neuron. 2016 Jul 6
• 89 citations
  GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects
  Pedro M. Moraes-Vieira, Alan Saghatelian, Barbara B. Kahn> ;Diabetes. 2016 Jul 1
• 44 citations
  Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance.
  Pedro M. Moraes-Vieira, Angela Castoldi, Pratik Aryal, Kerry Wellenstein, Odile D. Peroni, Barbara B. Kahn> ;Diabetes. 2016 May 1
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Journal Articles

• Metabolites as Regulators of Insulin Sensitivity and Metabolism  
  Barbara B Kahn, Qin Yang, Nature