BarryHofferMD

Neurosurgery • Cleveland, OH

Neurotrauma

MD University Hospitals Case

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Office
11100 Euclid Avenue
Hanna 5
Cleveland, OH 44106
Phone+1 216-286-6538

Fax+1 216-844-3014
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Education & Training

University of Rochester School of Medicine and DentistryClass of 1967

Publications & Presentations

PubMed

9 citations
3,6'-Dithiopomalidomide Ameliorates Hippocampal Neurodegeneration, Microgliosis and Astrogliosis and Improves Cognitive Behaviors in Rats with a Moderate Traumatic Bra...
Pen-Sen Huang, Ping-Yen Tsai, Ling Yu Yang, Daniela Lecca, Weiming Luo, Dong Seok Kim, Barry J. Hoffer, Yung-Hsiao Chiang, Nigel H. Greig, Jia Yi Wang> ;International Journal of Molecular Sciences. 2021 Jul 31
15 citations
CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury.
Man Hau Ho, Chia Hung Yen, Tsung Hsun Hsieh, Tzu Jen Kao, Jing Yuan Chiu, Yung Hsiao Chiang, Barry J. Hoffer, Wen Chang Chang, Szu Yi Chou> ;Redox Biology. 2021 Jul 17
10 citations
Administration of AAV-Alpha Synuclein NAC Antibody Improves Locomotor Behavior in Rats Overexpressing Alpha Synuclein.
Yun-Hsiang Chen, Kuo-Jen Wu, Wei Hsieh, Brandon K. Harvey, Barry J. Hoffer, Yun Wang, Seong-Jin Yu> ;Genes. 2021 Jun 21
15 citations
CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation.
Reni Ajoy, Yu Chun Lo, Man Hau Ho, You Yin Chen, Yun Wang, Yuan Hao Chen, Chiu Jing-Yuan, Chun A. Changou, Yuan Chin Hsiung, Hui Min Chen, Tzu Hao Chang, Cheng Yang Le...> ;Molecular Psychiatry. 2021 Apr 30
12 citations
N-adamantyl phthalimidine: a new thalidomide-like drug that lacks cereblon binding and mitigates neuronal and synaptic loss, neuroinflammation, and behavioral deficits...
Shih Chang Hsueh, Weiming Luo, David Tweedie, Dong Seok Kim, Yu Kyung Kim, Inho Hwang, Jung-Eun Gil, Baek-Soo Han, Yung-Hsiao Chiang, Warren R. Selman, Barry J. Hoffer...> ;ACS Pharmacology & Translational Science. 2021 Mar 30
12 citations
Drug Repurposing in the Treatment of Traumatic Brain Injury.
Michael K. Ghiam, Shrey D. Patel, Alan Hoffer, Warren R. Selman, Barry J. Hoffer, Michael E. Hoffer> ;Frontiers in Neuroscience. 2021 Mar 23
11 citations
Sustained Release GLP-1 Agonist PT320 Delays Disease Progression in a Mouse Model of Parkinson's Disease.
Vicki Wang, Tung Tai Kuo, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Yu-Ching Chou, Zhao Yang Fu, Li Wen Lai, Jin Jung, Hoi Ii Choi, Doo Sup Choi, Yazhou Li, Lars Olson, Nigel...> ;ACS Pharmacology & Translational Science. 2021 Mar 16
16 citations
Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury
David Tweedie, Hanuma Kumar Karnati, Roger J. Mullins, Chaim G. Pick, Barry J. Hoffer, Edward J. Goetzl, Dimitrios Kapogiannis, Nigel H. Greig> ;Elife. 2020 Aug 17
15 citations
PT320, Sustained-Release Exendin-4, Mitigates L-DOPA-Induced Dyskinesia in a Rat 6-Hydroxydopamine Model of Parkinson's Disease.
Seong Jin Yu, Shuchun Chen, Yung Yung Yang, Elliot J. Glotfelty, Jin Jung, Hee Kyung Kim, Ho Il Choi, Doo Sup Choi, Barry J. Hoffer, Nigel H. Greig, Yun Wang> ;Frontiers in Neuroscience. 2020 Aug 11
20 citations
3,6'-Dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation
Chih Tung Lin, Daniela Lecca, Ling Yu Yang, Weiming Luo, Michael T. Scerba, David Tweedie, Pen Sen Huang, Yoo Jin Jung, Dong Seok Kim, Chih Hao Yang, Barry J. Hoffer, ...> ;Elife. 2020 Jun 26
9 citations
Phenserine tartrate (PhenT) as a treatment for traumatic brain injury.
Nigel H. Greig, Daniela Lecca, Shih Chang Hsueh, Carlos Nogueras-Ortiz, Dimitrios Kapogiannis, David Tweedie, Elliot J. Glotfelty, Robert E. Becker, Yung Hsiao Chiang,...> ;CNS Neuroscience & Therapeutics. 2020 Jun 1
28 citations
The p53 inactivators pifithrin-μ and pifithrin-α mitigate TBI-induced neuronal damage through regulation of oxidative stress, neuroinflammation, autophagy and mitophagy
Ling Yu Yang, Nigel H. Greig, David Tweedie, Yoo Jin Jung, Yung Hsiao Chiang, Barry J. Hoffer, Jonathan P. Miller, Ke Hui Chang, Jia Yi Wang> ;Experimental Neurology. 2020 Feb 1
17 citations
Neurotrophic and neuroprotective effects of a monomeric GLP-1/GIP/Gcg receptor triagonist in cellular and rodent models of mild traumatic brain injury.
Yazhou Li, Elliot J. Glotfelty, Inbar Namdar, David Tweedie, Lars Olson, Barry J. Hoffer, Richard D. DiMarchi, Chagi G. Pick, Nigel H. Greig> ;Experimental Neurology. 2020 Feb 1
30 citations
Neuroprotective Effects and Treatment Potential of Incretin Mimetics in a Murine Model of Mild Traumatic Brain Injury.
Miaad Bader, Yazhou Li, David Tweedie, Nathan A. Shlobin, Adi Bernstein, Vardit Rubovitch, Luis B. Tovar-y-Romo, Richard D. DiMarchi, Barry J. Hoffer, Nigel H. Greig, ...> ;Frontiers in Cell and Developmental Biology. 2020 Jan 10
5 citations
Downregulation of α-Synuclein Protein Levels by an Intracellular Single-Chain Antibody.
Yun-Hsiang Chen, Seong-Jin Yu, Kuo-Jen Wu, Yu-Syuan Wang, Ho-Min Tsai, Li-Wen Liao, Shuchun Chen, Wei Hsieh, Hsi Chen, Shu-Ching Hsu, Mao-Liang Chen, Barry J. Hoffer, ...> ;Journal of Parkinson's Disease. 2020 Jan 1
15 citations
Delayed Dopamine Dysfunction and Motor Deficits in Female Parkinson Model Mice.
Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Yu-Ching Chou, Tung-Tai Kuo, Lars Olson, Barry J. Hoffer> ;International Journal of Molecular Sciences. 2019 Dec 11
16 citations
MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa.
Jessica H. Hartman, Christopher T. Richie, Kacy L. Gordon, Danielle Ferraz Mello, Priscila Castillo, April Zhu, Yun Wang, Barry J. Hoffer, David R. Sherwood, Joel N. M...> ;European Journal of Cell Biology. 2019 Dec 1
17 citations
Voluntary exercise delays progressive deterioration of markers of metabolism and behavior in a mouse model of Parkinson's disease.
Jing Huei Lai, Kai Yun Chen, John Chung Che Wu, Lars Olson, Stefan Brené, Chi Zong Huang, Yen Hua Chen, Shuo Jhen Kang, Kuo-Hsing Ma, Barry J. Hoffer, Tsung Hsun Hsieh...> ;Brain Research. 2019 Oct 1
26 citations
(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice.
Daniela Lecca, Miaad Bader, David Tweedie, Alexander F. Hoffman, Yoo Jin Jung, Shin-Chang Hsueh, Barry J. Hoffer, Robert E. Becker, Chaim G. Pick, Carl R. Lupica, Nige...> ;Neurobiology of Disease. 2019 Jul 8
8 citations
Release parameters during progressive degeneration of dopamine neurons in a mouse model reveal earlier impairment of spontaneous than forced behaviors
Yuan-Hao Chen, Tsung‐Hsun Hsieh, Tung-Tai Kuo, Jen-Hsin Kao, Kuo‐Hsing Ma, Eagle Yi-Kung Huang, Yu-Ching Chou, Lars Olson, Barry J. Hoffer> ;Journal of Neurochemistry. 2019 Jul 1
10 citations
(-)-Phenserine Ameliorates Contusion Volume, Neuroinflammation, and Behavioral Impairments Induced by Traumatic Brain Injury in Mice.
Shih Chang Hsueh, Daniela Lecca, Nigel H. Greig, Jia Yi Wang, Warren R. Selman, Barry J. Hoffer, Jonathan P. Miller, Yung Hsiao Chiang> ;Cell Transplantation. 2019 Jun 10
24 citations
Pharmacokinetics and efficacy of PT302, a sustained-release Exenatide formulation, in a murine model of mild traumatic brain injury.
Miaad Bader, Yazhou Li, Daniela Lecca, Vardit Rubovitch, David Tweedie, Elliot J. Glotfelty, Lital Rachmany, Hee Kyung Kim, Ho-Il Choi, Barry J. Hoffer, Chaim G. Pick,...> ;Neurobiology of Disease. 2019 Apr 1
14 citations
Pomalidomide Reduces Ischemic Brain Injury in Rodents
Yan Rou Tsai, David Tweedie, Ignacio Navas-Enamorado, Michael T. Scerba, Cheng Fu Chang, Jing Huei Lai, John Chung Che Wu, Yen Hua Chen, Shuo Jhen Kang, Barry J. Hoffe...> ;Cell Transplantation. 2019 Apr 1
7 citations
Role of Nogo Receptor-1 for Recovery of Balance, Cognition, and Emotion after Mild Traumatic Brain Injury in Mice.
Jing Huei Lai, Tobias Karlsson, John Chung Che Wu, Chi Zong Huang, Yen Hua Chen, Shuo Jhen Kang, Alvin T. S. Brodin, Barry J. Hoffer, Lars Olson, Yung Hsiao Chiang, Ka...> ;Journal of Neurotrauma. 2019 Mar 20
10 citations
Differences in Nicotine Encoding Dopamine Release between the Striatum and Shell Portion of the Nucleus Accumbens.
Yuan-Hao Chen, Bon-Jour Lin, Tsung Hsun Hsieh, Tung-Tai Kuo, Jonathan P. Miller, Yu-Ching Chou, Eagle Yi-Kung Huang, Barry J. Hoffer> ;Cell Transplantation. 2019 Mar 1
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Press Mentions

Your Mother's Genes Can Impact Your Own Aging Process, Study FindsAugust 21st, 2013
DNA from Our Mothers 'Influences Aging Process'February 10th, 2016
Maternal Genetics Hastens Aging Process of Offspring - Health NewsFebruary 10th, 2016
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