BenjaminShneiderMD

Pediatric Gastroenterology • Houston, TX

Pediatric Hepatology and Liver Transplantation

Professor, Pediatrics, Baylor College of Medicine Chief of Section, Pediatric Gastroenterology, Hepatology and Nutrition

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Office
6701 Fannin St.
Pediatric Gastroenterology, Hepatology and Nutrition
Houston, TX 77030
Phone(832) 822-3608
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Education & Training

Boston Children's HospitalResidency, Pediatrics, 1986 - 1989
University of Chicago Pritzker School of MedicineClass of 1986
Stanford UniversityB.S, Chemistry, 1982

Certifications & Licensure

TX State Medical License 2014 - 2022
PA State Medical License 2007 - 2014
NY State Medical License 1997 - Present
CT State Medical License 1989 - 1997
American Board of Pediatrics Pediatric Gastroenterology
American Board of Pediatrics Pediatric Transplant Hepatology

Awards, Honors, & Recognition

Best Doctors in America 2007
Elected Member The American Society for Clinical Investigation, 2005
America's Top Pediatricians: Pediatric Gastroenterology 2004, 2008
Basil O'Connor Starter Scholar Research Award March of Dimes, 1995
Young Investigator Award North American Society for Pediatric Gastroenterology and Nutrition, 1994
Physician Scientist Award 1992
Phi Beta Kappa 1981
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Clinical Trials

Evaluation of LUM001 in the Reduction of Pruritus in Alagille Syndrome Start of enrollment: 2014 Aug 01Dorenbaum, A.,Miethke, A.,Klipsch, A.,Shneider, B.,Kamath, B.,Quammie, C.,Molleston, J.,Erlichman, J.,Murray, K.,Loomes, K.,Hite, M.,Kerkar, N.,Wedel, P.,Whitington, P.,Rosenthal, P.,Sokol, R.,Karpen, S.
A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency Start of enrollment: 2012 Jan 01Shneider, B.,Squires, R.H.,Perlmutter, D.H.,Chopra, K.B.,Zajko, A.B.,Michalopoulos, G.,Chu, A.,Bergman, I.,Hoberman, A.
Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis: A Pilot Withdrawal/Reinstitution Trial Start of enrollment: 2010 Oct 01Alonso, E.,Black, D.D.,Kerkar, N.,Miethke, A.,Miloh, T.,Rosenthal, P.,Shneider, B.,Sokol, R.
Longitudinal Study of Mitochondrial Hepatopathies Start of enrollment: 2010 Jul 01Bezerra, J.,Harber, B.,Hines, J.M.,Karpen, S.,Molleston, J.,Murray, K.,Ng, V.,Romero, R.,Rosenthal, P.,Schwarz, K.,Shneider, B.,Sokol, R.,Sokol, R.J.,Suchy, F.J.,Turmelle, Y.,Wang, K.,Whitington, P.
Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis Start of enrollment: 2007 Nov 01Bernard, B.,Dietz, J.,Erlichman, J.,Esterl, E.,Filipowski, D.,Kociela, V.,Magee, J.,Murray, K.,Nagy, R.,Parkar, S.,Pfeifer, K.,Pieplow, K.W.,Robuck, P.,Tuzinkiewicz, K.
Biliary Atresia Study in Infants and Children (BASIC) Start of enrollment: 2006 May 01Bezerra, J.,Haber, B.,Karpen, S.J.,Robuck, P.,Rosenthal, P.,Schwarz, K.,Shepherd, R.,Shneider, B.,Sokol, R.,Suchy, F.J.,Whitington, P.
A Prospective Database of Infants With Cholestasis Start of enrollment: 2004 May 01Kasper Wang, MD, Philip Rosenthal, MD, Ronald Sokol, MD, Cara Mack, MD, Michael Narkewicz, MD, Saul Karpen, MD, PhD, Peter Whitington, MD, Jean Molleston, MD, Kathleen Schwarz, MD, Yumi Turmelle, MD, Nand...
Expanded Access Protocol for an Intermediate Size Population - RAVICTI for Byler Disease Shneider, B.
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Publications & Presentations

PubMed

A Learning Collaborative Approach Increases Specificity of Diagnosis of Acute Liver Failure in Pediatric Patients.
Michael R. Narkewicz, Simon Horslen, Regina M. Hardison, Benjamin L. Shneider, Norberto Rodriguez-Baez, Estella M. Alonso, Vicky L. Ng, Mike A. Leonis, Kathleen M. Loo...> ;Clinical Gastroenterology and Hepatology. 2018 Nov 1
Accuracy of the Pediatric End-stage Liver Disease Score in Estimating Pretransplant Mortality Among Pediatric Liver Transplant Candidates
Chung-Chou H. Chang, Cindy L. Bryce, Benjamin L. Shneider, Jonathan G. Yabes, Yi Ren, Gabriel L. Zenarosa, Heather E. Tomko, Drew Michael S. Donnell, Robert H. Squires...> ;JAMA Pediatrics. 2018 Nov 1
The Medication Level Variability Index (MLVI) Predicts Poor Liver Transplant Outcomes: A Prospective Multi-Site Study.
Eyal Shemesh, John Bucuvalas, Ravinder Anand, George V. Mazariegos, Estella M. Alonso, Robert S. Venick, Miguel Reyes-Múgica, Rachel A. Annunziato, Benjamin L. Shneider> ;American Journal of Transplantation. 2017 Oct 1
2 citations
Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia
Benjamin L. Shneider, John C. Magee, Saul J. Karpen, Elizabeth B. Rand, Michael R. Narkewicz, Lee M. Bass, Kathleen B. Schwarz, Peter F. Whitington, Jorge A. Bezerra, ...> ;The Journal of Pediatrics. 2016 Mar 1
Possible Phenylacetate Hepatotoxicity During 4-Phenylbutyrate Therapy of Byler Disease.
Benjamin L. Shneider, Amy Morris, Jerry Vockley> ;Journal of Pediatric Gastroenterology and Nutrition. 2016 Mar 1
Liver Transplantation for Biliary Atresia: Is There a Difference in Outcome for Infants?
Ronen Arnon, Rachel A. Annunziato, Guiseppe D’Amelio, Jaime Chu, Benjamin L. Shneider> ;Journal of Pediatric Gastroenterology and Nutrition. 2016 Feb 1
Baseline Analysis of a Young α-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension
Jeffrey Teckman, Philip J. Rosenthal, Robert Abel, Lee M. Bass, Sonia Michail, Karen F. Murray, David A. Rudnick, Daniel W. Thomas, Cathie Spino, Ronen Arnon, Paula M....> ;Journal of Pediatric Gastroenterology and Nutrition. 2015 Jul 23
Bile Acid Pool Dynamics in Progressive Familial Intrahepatic Cholestasis with Partial External Bile Diversion
Hilary Jericho, Elizabeth Kaurs, Renze Boverhof, Alex S. Knisely, Benjamin L. Shneider, Henkjan J. Verkade, Peter F. Whitington> ;Journal of Pediatric Gastroenterology and Nutrition. 2015 Mar 1
Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia.
Veena Venkat, Benjamin L. Shneider, John C. Magee, Yumirle P. Turmelle, Ronen Arnon, Jorge A. Bezerra, Paula M. Hertel, Saul J. Karpen, Nanda Kerkar, Kathleen M. Loome...> ;Journal of Pediatric Gastroenterology and Nutrition. 2014 Dec 1
Medical status of 219 children with biliary atresia surviving long-term with their native livers: results from a North American multicenter consortium.
Vicky L. Ng, Barbara H. Haber, John C. Magee, Alexander Miethke, Karen F. Murray, Sonia Michail, Saul J. Karpen, Nanda Kerkar, Jean P. Molleston, Rene Romero, Philip J...> ;The Journal of Pediatrics. 2014 Sep 1
Use of Corticosteroids After Hepatoportoenterostomy for Bile Drainage in Infants With Biliary Atresia: The START Randomized Clinical Trial
Jorge A. Bezerra, Cathie Spino, John C. Magee, Benjamin L. Shneider, Philip J. Rosenthal, Kasper S. Wang, Jessi Erlichman, Barbara A. Haber, Paula M. Hertel, Saul J. K...> ;JAMA. 2014 May 7
Liver transplantation for pediatric metabolic disease.
George V. Mazariegos, Benjamin L. Shneider, Barbara K. Burton, Ira J. Fox, Nedim Hadzic, Priya S. Kishnani, D. Holmes Morton, Sara C. McIntire, Ronald J. Sokol, Marsha...> ;Molecular Genetics and Metabolism. 2014 Apr 1
Intravenous N‐acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: A placebo‐controlled clinical trial
Robert H. Squires, Anil Dhawan, Estella M. Alonso, Michael R. Narkewicz, Benjamin L. Shneider, Norberto Rodriguez-Baez, Dominic Dell Olio, Saul J. Karpen, John C. Bucu...> ;Hepatology. 2013 Apr 1
King's College Hospital Criteria for Non-Acetaminophen Induced Acute Liver Failure in an International Cohort of Children
Vinay Sundaram, Benjamin L. Shneider, Anil Dhawan, Vicky L. Ng, KyungAh Im, Steven H. Belle, Robert H. Squires> ;The Journal of Pediatrics. 2013 Feb 1
Phospholipase D2 mediates signaling by ATPase class I type 8B membrane 1
Frank Chen, Ayantika Ghosh, Benjamin L. Shneider> ;Journal of Lipid Research. 2013 Feb 1
Portal hypertension in children and young adults with biliary atresia.
Benjamin L. Shneider, Bob Abel, Barbara A. Haber, Saul J. Karpen, John C. Magee, Rene Romero, Kathleen B. Schwarz, Lee M. Bass, Nanda Kerkar, Alexander Miethke, Philip...> ;Journal of Pediatric Gastroenterology and Nutrition. 2012 Nov 1
Efficacy of Fat-Soluble Vitamin Supplementation in Infants With Biliary Atresia
Benjamin L. Shneider, John C. Magee, Jorge A. Bezerra, Barbara A. Haber, Saul J. Karpen, Trivellore E. Raghunathan, Philip J. Rosenthal, Kathleen B. Schwarz, Frederick...> ;Pediatrics. 2012 Sep 1
Portal Hypertension in Children: Expert Pediatric Opinion on the Report of the Baveno V Consensus Workshop on Methodology of Diagnosis and Therapy in Portal Hypertension
Benjamin L. Shneider, Jaime Bosch, Roberto de Franchis, Sukru Emre, Roberto J. Groszmann, Simon C. Ling, Jonathan M. Lorenz, Robert H. Squires, Riccardo A. Superina, A...> ;Pediatric Transplantation. 2012 Aug 1
Diagnostic and therapeutic challenges in pediatric primary sclerosing cholangitis
Benjamin L. Shneider> ;Liver Transplantation. 2012 Mar 1
Successful split liver-kidney transplant for factor H associated hemolytic uremic syndrome
Jeffrey M. Saland, Benjamin L. Shneider, Jonathan S. Bromberg, Patricia A. Shi, Stephen C. Ward, Margret S. Magid, Corinne Benchimol, Mouin G. Seikaly, Sukru Emre, Ele...> ;Clinical Journal of The American Society of Nephrology. 2009 Jan 1
Biliary Atresia: A Transplant Perspective
Benjamin L. Shneider, George V. Mazariegos> ;Liver Transplantation. 2007 Nov 1
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Journal Articles

Bile acid pool dynamics in progressive familial intrahepatic cholestasis with partial external biliary diversion
J. Pediatr. Gastroenterol. Nutr, 1/1/2015
Byler's Disease-Early natural history, A single center case series
J. Pediatr. Gastroenterol. Nutr, 1/1/2015
c-Fos mediates repression of the apical sodium dependent bile acid transporter by fibroblast growth factor-19 in mice
Am. J. Physiol.: GI and Liver, 1/1/2014
Effect of high dose corticosteroids following hepatoportoenterostomy on bile drainage in infants with biliary atresia: The START randomized clinical trial
JAMA, 1/1/2014
Medical status of 219 children with biliary atresia surviving long-term with their native livers: Results of a North American multicenter consortium
J. Pediatr., 1/1/2014
The Medication Level Variability Index (MLVI) predicts rejection, possibly due to nonadherence, in adult liver transplant recipients
Liver Transplantation, 1/1/2014
A single element in the 3'UTR of the Apical Sodium-Dependent Bile Acid Transporter controls both stabilization and destabilization of mRNA
Biochemical Journal, 1/1/2014
Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia
J. Pediatr. Gastroenterol. Nutr, 1/1/2014
Liver transplantation for pediatric metabolic disease
Molec. Genet. Metabol, 1/1/2014
Autosomal recessive polycystic kidney disease: Report of an international clinical care conference
J. Pediatr, 1/1/2014
Delta4-3-oxosteroid 5beta-reductase deficiency causing neonatal liver failure and hemochromatosis
J Ped, 1/1/2014
King's College Hospital criteria for nonacetaminophen induced acute liver failure in an international cohort of children
J. Pediatr, 1/1/2013
Intravenous N-acetylcysteine in pediatric patients with non-acetaminophen acute liver failure: A placebo-controlled clinical trial
Hepatology, 1/1/2013
Phospholipase D2 mediates signaling by ATPase Class I Type 8B Membrane 1
J. Lipid Res, 1/1/2013
Liver Transplantation for children with biliary atresia in the PELD era: Role of insurance status
Liver Transplantation, 1/1/2013
Extra-hepatic anomalies in infants with biliary atresia: Results of a large prospective North American multi-center study
Hepatology, 1/1/2013
Preventing variceal bleeding in infants and children: Is less more?
Gastroenterology, 1/1/2013
Liver transplantation for classical maple syrup urine disease: Long term follow-up in 37 patients and comparative UNOS experience
J Pediatr, 1/1/2012
Congenital hepatic fibrosis and autosomal recessive polycystic kidney disease: An analytic review of the literature
J. Pediatr. Gastroenterol. Nutr., 1/1/2012
Efficacy of fat soluble vitamin supplementation in infants with biliary atresia
Pediatrics, 1/1/2012
Cross-sectional multi-center analysis of portal hypertension in 163 children and young adults with biliary atresia
J. Pediatr. Gastroenterol. Nutr, 1/1/2012
Giant cell hepatitis and immune thrombocytopenic purpura-Reversal of liver failure with Rituximab therapy
J. Pediatr. Gastroenterol. Nutr, 1/1/2012
To transplant or not to transplant-Certainly one of the questions
J. Pediatr. Gastroenterol. Nutr., 1/1/2012
Diagnostic and therapeutic challenges in pediatric primary sclerosing cholangitis
Liver Transplantation, 1/1/2012
Portal hypertension in children: Expert pediatric opinion on the report of the Baveno V consensus workshop on methodology of diagnosis and management of portal hyperte...
Pediatr Transpl, 1/1/2012
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Books/Book Chapters

Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop
Chapter: Portal hypertension in children. Current practice and the need for evidence
Editors: R. de Franchis.Wiley-Blackwell, Hoboken, NJ2011
Nelson Textbook of Pediatrics
Chapter: Autoimmune Hepatitis
Editors: RM Kliegman, BF Stanton, JW St. Geme, NF Schor and RE Berman.Elsevier Saunders, Philadelphia, PAEdition 19th,2011
Practical Gastroenterology and Hepatology, Liver and Biliary Disease
Chapter: Biliary atresia and cystic fibrosis: Transitioning care from pediatrics to internal medicine
Editors: N.J. Talley, K.D. Lindor and H.E. Vargas.Wiley-Blackwell, Hoboken, NJ2010
The pediatric transplant manual
Chapter: Chronic liver disease and the pediatric patient
Editors: Remaley L, McGhee B, Reyes J, Mazariegos G.Lexi-Comp, Hudson, OH2009
Walker's Pediatric Gastrointestinal Disease
BC Decker Publisher, Lewiston, NYEdition 5th,2008
Liver Disease in Children
Chapter: Portal Hypertension
Editors: F.J. Suchy, R.J. Sokol and W.F. Balistreri.Edition 3rd,2007
Liver Disease in Children
Chapter: Familial Hepatocellular Cholestasis
Editors: F.J. Suchy, R.J. Sokol and W.F. Balistreri.Edition 3rd,2007
Physiology of the Gastrointestinal Tract
Chapter: Bile formation and the enterohepatic circulation of bile acids
Editors: L.R. Johnson.Edition 4th,2007
Bile Acids: Biological Actions and Clinical Relevance
Chapter: Regulation of intestinal bile acid transport in health and disease
Editors: U Beuers, D Keppler, L Leuschner, A Stiehl, and M Trauner.2007
Nuclear Medicine in Clinical Diagnosis and Treatment
Chapter: Neonatal hyperbilirubinemia
Editors: Ell PJ and Gambhir SS.Churchill Livingstone, London, UKEdition 3rd,2004
Walker's Pediatric Gastrointestinal Disease
Chapter: Disorders of Biliary Transport
Editors: W.A. Walker, O.J. Goulet, R.E. Kleinman, P. Sherman, B.L. Shneider, I.R. Sanderson.BC Decker Publisher, Lewiston, NY2004
Portal Hypertension in the 21st Century
Chapter: Approaches to the management of pediatric portal hypertension: Results of an informal survey
Editors: Groszmann R, Tygat N, Bosche J.Kluwer Academic Publishers, Boston, MA2004
Pediatric Gastrointestinal Disease
BC Decker Publisher, Lewiston, NYEdition 4th,2004
The Pediatric Clinical Advisor
Chapter: Extrahepatic Biliary Atresia
Editors: L. Garfunkel, C. Christy and J. Kaczorowski.Harcourt, Inc2002
Rudolph's Pediatrics
Chapter: Metabolic Liver Disease
Editors: A.M. Rudolph and C.D. Rudolph.Edition 21st,2002
Pediatric Gastrointestinal Disease:Pathophysiology, Diagnosis and Management
Chapter: Disorders of Biliary Transport
Editors: W.A. Walker, P.R. Durie, J.R. Hamilton, J.A. Walker-Smith, J.B. Watkins.Edition 3rd,2000
Liver Disease in Children
2000
Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, Management
Chapter: Portal Hypertension
Editors: R. Wyllie and J. Hyams.W.B. Saunders, Philadelphia, PAEdition 2nd,1999
Nelson's Textbook of Pediatrics
Chapter: Autoimmune (Chronic) Hepatitis
Editors: RE Berman.W.B. Saunders, Philadelphia, PAEdition 16th,1999
Liver diseases in children
Chapter: Portal Hypertension
Editors: F Suchy.Mosby Year Book1995
Gellis and Kagan's Current pediatric therapy
Chapter: Chronic active hepatitis
Editors: F Burg, J Ingelfinger and E Wald.W.B. SaundersEdition 14th,1993
Liver and biliary diseases
Chapter: Neonatal jaundice and cholestasis
Editors: N. Kaplowitz.Williams and Wilkins1992
Common problems in pediatric gastroenterology and nutrition
Chapter: Choledochal cysts
Editors: J Snyder and W Walker.Yearbook medical publishers1989
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Lectures

Translational Investigations of Byler's Disease
Houston, TX - 1/16/2015
Stratifying Risk and Individualizing Care for Portal Hypertenson- Controversies and Challenges in Pediatrics
Baveno, Italy - 1/11/2015
Controversies in the Management of Varices in Children
Baveno, Italy - 1/11/2015
Complexities in the Regulation of Intestinal Bile Acid Transport
Houston, TX - 1/5/2015
Molecular Mechanisms of Intestinal Lipid Transport and Metabolism -Session Chair: Intestinal Bile Acid Metabolism, Regulation of the Intestinal Bile Acid Transporter a...
1/6/2014
Biliary Atresia-Challenges and Opportunities
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA - 1/6/2014
Sociedade Portugesa de Gastroenterologia-Pediatric Portal Hypertension and Familial Cholestasis, Recent Advances in Molecular Mechanisms, Diagnosis and Management
Estoril, Portugal - 1/4/2014
Primera jornada de Hepatologia infantil y transplante de higado pediatrico de la Fondacion Favaloro
Buenos Aires, Argentina - 1/31/2013
PSC in Children: The Same Disease?
Pittsburgh, PA - 1/27/2013
Neonatal Cholestasis and When to send children to a liver transplant center: Indications and controversies
Boston Children's Hospital, Cambridge, MA - 1/25/2013
Liver Transplantation for Metabolic Disease: Complex Clinical Decision Making
Mount Sinai School of Medicine, New York, NY - 1/7/2013
Liver Transplantation for Metabolic Disease: Traditional Indications
Barcelona, Spain - 1/5/2013
Cholestasis in Pediatric Hepatology-Future Impact of Advances in Understanding Molecular Pathophysiology
Tokyo, Japan - 1/3/2013
Hepatitis C and B in Children-Clinical Decision Making
West Virginia University, Morgantown, WV - 1/23/2012
Rare Liver Diseases in Children
Westbrook, CT - 1/16/2012
Management Controversies in Cystic Fibrosis Liver Disease
Boston, MA - 1/11/2012
Molecular Diagnostics in Pediatric Hepatology and Evaluation of Neonatal Cholestasis
Bronx, NY - 1/7/2012
Challenging the Paradigms: Liver Transplantation for Metabolic Disease
Pittsburgh, PA - 1/4/2012
Familial Cholestasis, Molecular Mechansims, Diagnosis and Treatment
Institute of Liver and Biliary Sciences, Delhi, India - 1/21/2011
Complexities in the Regulation of Ileal Bile Acid Transport
Pittsburgh, PA - 1/12/2011
Approaches to the Management of Portal Hypertension in Children- Expert Pediatric Comentary on Baveno V
Pittsburgh, PA - 1/8/2011
Familial Cholestasis, Molecular Mechanisms, Diagnosis and Treatment
ISMETT, Palermo, Italy - 1/6/2011
Portal Hypertension in Children
San Francisco, CA - 1/5/2011
Update on Pediatric Autoimmune Diseases-Diagnostic and Therapeutic Challenges in Pediatric Primary Sclerosing Cholangitis
San Francisco, CA - 1/4/2011
Current Consensus and Future Directions in the Diagnosis and Treatment of Portal Hypertension - Portal Hypertension, Do the Rules Change in Children
Stresa, Italy - 1/22/2010
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Other

ATP8B1 Deficiency.
GeneReviews
University of Washington, Seattle, WA - 1/1/2009
Low-gGT Familial Interhepatic Cholestasis
GeneReviews at GeneTests: Medical Genetics Information Resource
http://www.genetests.org
University of Washington, Seattle, WA - 1/1/2006
Developmental aspects of hepatic bile acid transport. Proceedings of the 2nd Ringberg conference on cell biology and molecular basis of liver transport
Projekt
Verlag, Dortmund - 1/1/1995

Press Mentions

Maraxilibat Reduces Debilitating Itching in Children with Alagille SyndromeNovember 20, 2020 13:05
Mirum Pharmaceuticals Announces Data Presented During AASLD Highlighting Durable Improvements in Pruritus and Quality of Life in Children with Alagille Syndrome Treated with MaralixibatNovember 16, 2020 13:48
Mirum Pharmaceuticals Provides Third Quarter 2020 Financial Results and Business Update, and Announces Virtual Investor DayNovember 13, 2020 11:18
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