BernardinoGhettiMD

PubMed

• 1 citations
  MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study.
  Rebecca R Valentino, William J Scotton, Shanu F Roemer, Tammaryn Lashley, Michael G Heckman, Maryam Shoai, Alejandro Martinez-Carrasco, Nicole Tamvaka, Ronald L Walton...> ;The Lancet. Neurology. 2024 May 1
• Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces.
  Christina D Orrú, Bradley R Groveman, Andrew G Hughson, Tomás Barrio, Kachi Isiofia, Brent Race, Natalia C Ferreira, David A Schneider, Kentaro Masujin, Kohtaro Miyaza...> ;Plos Pathogens. 2024 Apr 1
• 3 citations
  Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
  Robert I Horne, Ewa A Andrzejewska, Parvez Alam, Z Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C Gregory, Roxine Staats, Andrea Posse...> ;Nature Chemical Biology. 2024 May 1
• 1 citations
  Cryo-EM structures of amyloid-β and tau filaments in Down syndrome.
  Anllely Fernandez, Md Rejaul Hoq, Grace I Hallinan, Daoyi Li, Sakshibeedu R Bharath, Frank S Vago, Xiaoqi Zhang, Kadir A Ozcan, Holly J Garringer, Wen Jiang, Ruben Vid...> ;Nature Structural & Molecular Biology. 2024 Mar 29
• Thiophene-Based Ligands for Specific Assignment of Distinct Aβ Pathologies in Alzheimer's Disease.
  Therése Klingstedt, Linda Lantz, Hamid Shirani, Junyue Ge, Jörg Hanrieder, Ruben Vidal, K Peter R Nilsson, Bernardino Ghetti> ;ACS Chemical Neuroscience. 2024 Apr 3
• Association of Structural Forms of 17q21.31 with the Risk of Progressive Supranuclear Palsy andSub-haplotypes.
  Hui Wang, Timothy S Chang, Beth A Dombroski, Po-Liang Cheng, Ya-Qin Si, Albert Tucci, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Mo...> ;Medrxiv. 2024 Feb 28
• 1 citations
  Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage.
  Nelly Joseph-Mathurin, Rebecca L Feldman, Ruijin Lu, Zahra Shirzadi, Carmen Toomer, Junie R Saint Clair, Yinjiao Ma, Nicole S McKay, Jeremy F Strain, Collin Kilgore, K...> ;Alzheimer's & Dementia. 2024 Apr 1
• 1 citations
  Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy.
  Wang, H., Chang, T., Dombroski, B., Cheng, P., Patil, V., Valiente-Banuet, L., Farrell, K., Mclean, C., Molina-Porcel, L., Rajput, A., De Deyn, P., Bastard, N., Gearin...> ;Medrxiv. 2024 Jan 30
• 3 citations
  TAF15 amyloid filaments in frontotemporal lobar degeneration.
  Stephan Tetter, Diana Arseni, Alexey G Murzin, Yazead Buhidma, Sew Y Peak-Chew, Holly J Garringer, Kathy L Newell, Ruben Vidal, Liana G Apostolova, Tammaryn Lashley, B...> ;Nature. 2024 Jan 1
• 2 citations
  Cryo-EM structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy.
  Yang Yang, Alexey G Murzin, Sew Peak-Chew, Catarina Franco, Holly J Garringer, Kathy L Newell, Bernardino Ghetti, Michel Goedert, Sjors H W Scheres> ;Acta Neuropathologica Communications. 2023 Dec 4
• Efficient transmission of human prion diseases to a glycan-free prion protein-expressing host.
  Laura Cracco, Ignazio Cali, Mark L Cohen, Rabail Aslam, Silvio Notari, Qingzhong Kong, Kathy L Newell, Bernardino Ghetti, Brian S Appleby, Pierluigi Gambetti> ;Brain. 2024 Apr 4
• Distinct Heterocyclic Moieties Govern the Selectivity of Thiophene-Vinylene-Based Ligands Towards Aβ or Tau Pathology in Alzheime's Disease.
  Linnea Björk, Hamid Shirani, Yogesh Todarwal, Mathieu Linares, Ruben Vidal, Patrick Norman, Therése Klingstedt, K Peter R Nilsson, Bernardino Ghetti> ;European Journal of Organic Chemistry. 2023 Nov 2
• 1 citations
  White matter hyperintensities are higher among early-onset Alzheimer's disease participants than their cognitively normal and early-onset nonAD peers: Longitudinal Ear...
  Turner, R., Eloyan, A., Thangarajah, M., An, N., Borowski, B., Reddy, A., Aisen, P., Dage, J., Foroud, T., Ghetti, B., Griffin, P., Hammers, D., Iaccarino, L., Jack, C...> ;Alzheimer's & Dementia. 2023 Nov 1
• 1 citations
  The Sporadic Early-onset Alzheimer's Disease Signature Of Atrophy: Preliminary Findings From The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) Cohort.
  Turner, R., Turner, R., Alexandra Touroutoglou, Yuta Katsumi, Michael Brickhouse, Alexander Zaitsev, Ryan Eckbo, Paul Aisen, Laurel Beckett, Jeffrey L Dage, Ani Eloyan...> ;Alzheimer's & Dementia. 2023 Nov 1
• Detection of TDP-43 seeding activity in the olfactory mucosa from patients with frontotemporal dementia.
  Elena Fontana, Matilde Bongianni, Alberto Benussi, Erika Bronzato, Carlo Scialo, Luca Sacchetto, Annachiara Cagnin, Santina Castriciano, Emanuele Buratti, Fabrizio Gar...> ;Alzheimer's & Dementia. 2024 Feb 1
• 1 citations
  β-Bracelets: Macrocyclic Cross-β Epitope Mimics Based on a Tau Conformational Strain.
  Benjamin H Rajewski, Kamlesh M Makwana, Isaac J Angera, Danielle K Geremia, Anna R Zepeda, Grace I Hallinan, Ruben Vidal, Bernardino Ghetti, Arnaldo L Serrano, Juan R ...> ;Journal of the American Chemical Society. 2023 Oct 25
• Comorbidities in Early-Onset Sporadic versus Presenilin-1 Mutation-Associated Alzheimer's Disease Dementia: Evidence for Dependency on Alzheimer's Disease Neuropatholo...
  Diego Sepulveda-Falla, Carlos Andrés Villegas Lanau, Charles White 3rd, Geidy E Serrano, Juliana Acosta-Uribe, Barbara Mejía-Cupajita, Nelson David Villalba-Moreno, Pi...> ;Medrxiv. 2023 Aug 16
• 18 citations
  TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP.
  Diana Arseni, Renren Chen, Alexey G Murzin, Sew Y Peak-Chew, Holly J Garringer, Kathy L Newell, Fuyuki Kametani, Andrew C Robinson, Ruben Vidal, Bernardino Ghetti, Mas...> ;Nature. 2023 Aug 1
• 5 citations
  Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN).
  Nicole S McKay, Brian A Gordon, Russ C Hornbeck, Aylin Dincer, Shaney Flores, Sarah J Keefe, Nelly Joseph-Mathurin, Clifford R Jack, Robert Koeppe, Peter R Millar, Bea...> ;Nature Neuroscience. 2023 Aug 1
• 6 citations
  Mutation ∆K281 in MAPT causes Pick's disease.
  Manuel Schweighauser, Holly J Garringer, Therése Klingstedt, K Peter R Nilsson, Masami Masuda-Suzukake, Jill R Murrell, Shannon L Risacher, Ruben Vidal, Sjors H W Sche...> ;Acta Neuropathologica. 2023 Aug 1
• Creating the Pick's disease International Consortium: Association study ofH2 haplotype with risk of Pick's disease.
  White, C. L., White, C. L., Rebecca R Valentino, William J Scotton, Shanu F Roemer, Tammaryn Lashley, Michael G Heckman, Maryam Shoai, Alejandro Martinez-Carrasco, Nic...> ;Medrxiv. 2023 Apr 24
• 4 citations
  A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer's disease.
  Gennifer E Merrihew, Deanna Plubell, Brian C Searle, C Dirk Keene, Eric B Larson, Randall Bateman, Richard J Perrin, Jasmeer P Chhatwal, Martin R Farlow, Catriona A Mc...> ;Scientific Data. 2023 Apr 14
• 3 citations
  Cross-β helical filaments of Tau and TMEM106B in gray and white matter of multiple system tauopathy with presenile dementia.
  Md Rejaul Hoq, Sakshibeedu R Bharath, Grace I Hallinan, Anllely Fernandez, Frank S Vago, Kadir A Ozcan, Daoyi Li, Holly J Garringer, Ruben Vidal, Bernardino Ghetti, We...> ;Acta Neuropathologica. 2023 May 1
• 8 citations
  Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir.
  Yang Shi, Bernardino Ghetti, Michel Goedert, Sjors H W Scheres> ;Journal of Molecular Biology. 2023 Jun 1
• 18 citations
  Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains.
  Yang Yang, Wenjuan Zhang, Alexey G Murzin, Manuel Schweighauser, Melissa Huang, Sofia Lövestam, Sew Y Peak-Chew, Takashi Saito, Takaomi C Saido, Jennifer Macdonald, Is...> ;Acta Neuropathologica. 2023 Mar 1
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Journal Articles

• Structures of Filaments from Pick’s Disease Reveal a Novel Tau Protein Fold  
  Bernardino Ghetti, MD, Nature