BillyHoonChangMDPhD

PubMed

• 63 citations
  Integrative analysis of drug response and clinical outcome in acute myeloid leukemia.
  Daniel Bottomly, Nicola Long, Anna Reister Schultz, Stephen E Kurtz, Cristina E Tognon, Kara Johnson, Melissa Abel, Anupriya Agarwal, Sammantha Avaylon, Erik Benton, A...> ;Cancer Cell. 2022 Aug 8
• 5 citations
  Associating drug sensitivity with differentiation status identifies effective combinations for acute myeloid leukemia.
  Stephen E Kurtz, Christopher A Eide, Andy Kaempf, Nicola Long, Daniel Bottomly, Olga Nikolova, Brian J Druker, Shannon K McWeeney, Bill H Chang, Jeffrey W Tyner, Anupr...> ;Blood Advances. 2022 May 24
• 19 citations
  Decitabine and vorinostat with FLAG chemotherapy in pediatric relapsed/refractory AML: Report from the therapeutic advances in childhood leukemia and lymphoma (TACL) c...
  Pommert, L., Schafer, E., Malvar, J., Gossai, N., Florendo, E., Pulakanti, K., Heimbruch, K., Stelloh, C., Chi, Y., Sposto, R., Rao, S., Huynh, V., Brown, P., Chang, B...> ;American Journal of Hematology. 2022 May 1
• 6 citations
  Aurora A kinase as a target for therapy in TCF3-HLF rearranged acute lymphoblastic leukemia
  Jessica Leonard, Joelle Wolf, Michelle Degnin, Christopher A. Eide, Dorian LaTocha, Kyle Lenz, Beth Wilmot, Charles G. Mullighan, Mignon L. Loh, Stephen P. Hunger, Bri...> ;Haematologica. 2021 Jul 8
• 18 citations
  Concomitant use of a dual Src/ABL kinase inhibitor eliminates the in vitro efficacy of blinatumomab against Ph+ ALL
  Jessica Leonard, Yoko Kosaka, Pavani Malla, Dorian LaTocha, Adam J. Lamble, Brandon Hayes-Lattin, Kaelan Byrd, Brian J. Druker, Jeffrey W. Tyner, Bill H. Chang, Evan F...> ;Blood. 2021 Feb 18
• 15 citations
  A phase 1 study of entinostat in children and adolescents with recurrent or refractory solid tumors, including CNS tumors: Trial ADVL1513, Pediatric Early Phase-Clinic...
  Andrew Bukowinski, Bill H. Chang, Joel M. Reid, Xiaowei Liu, Charles G. Minard, Jane B. Trepel, Min-Jung Lee, Elizabeth Fox, Brenda J. Weigel> ;Pediatric Blood & Cancer. 2021 Jan 12
• 1 citations
  In Regard to Wong et al.
  Daphne B. Scarpelli, Blair Murphy, Bill H. Chang, Eneida R. Nemecek, Jerry J. Jaboin> ;International Journal of Radiation Oncology, Biology, Physics. 2020 Dec 1
• 22 citations
  Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study
  Michael J. Burke, Rumen Kostadinov, Richard Sposto, Lia Gore, Shannon Kelley, Cara A Rabik, Jane B. Trepel, Min-Jung Lee, Akira Yuno, Sunmin Lee, Deepa Bhojwani, Sima ...> ;Clinical Cancer Research. 2020 Jan 22
• 13 citations
  Simultaneous kinase inhibition with ibrutinib and BCL2 inhibition with venetoclax offers a therapeutic strategy for acute myeloid leukemia.
  Christopher A. Eide, Stephen E. Kurtz, Andy Kaempf, Nicola Long, Anupriya Agarwal, Cristina E. Tognon, Motomi Mori, Brian J. Druker, Bill H. Chang, Alexey V. Danilov, ...> ;Leukemia. 2020 Feb 24
• 9 citations
  Replication timing alterations in leukemia affect clinically relevant chromosome domains.
  Juan Carlos Rivera-Mulia, Takayo Sasaki, Claudia Trevilla-Garcia, Naoto Nakamichi, David J.H.F. Knapp, Colin A. Hammond, Bill H. Chang, Jeffrey W. Tyner, Meenakshi Dev...> ;Blood Advances. 2019 Nov 12
• 186 citations
  The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells
  Tamilla Nechiporuk, Stephen E. Kurtz, Olga Nikolova, Tingting Liu, Courtney L. Jones, Angelo D'Alessandro, Rachel Culp-Hill, Amanda d’Almeida, Sunil K. Joshi, Mara Ros...> ;Cancer Discovery. 2019 Jul 1
• 36 citations
  Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche
  Sherif Abdelhamed, John T. Butler, Ben Doron, Amber Halse, Eneida R. Nemecek, Phillip A. Wilmarth, Daniel L. Marks, Bill H. Chang, Terzah M. Horton, Peter Kurre> ;EMBO Reports. 2019 Jul 1
• 18 citations
  Phenotype switch in acute lymphoblastic leukaemia associated with 3 years of persistent CAR T cell directed-CD19 selective pressure
  Olivia M. Lucero, Kellee Parker, Tracy Funk, Jennifer Dunlap, Richard D. Press, Rebecca Gardner, Bill H. Chang> ;British Journal of Haematology. 2019 Feb 27
• 702 citations
  Functional genomic landscape of acute myeloid leukaemia
  Jeffrey W. Tyner, Cristina E. Tognon, Daniel Bottomly, Beth Wilmot, Stephen E. Kurtz, Samantha L. Savage, Nicola Long, Anna Reister Schultz, Elie Traer, Melissa L. Abe...> ;Nature. 2018 Oct 17
• 13 citations
  Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia.
  Chelsea Jenkins, Samuel B. Luty, Julia E. Maxson, Christopher A. Eide, Melissa L. Abel, Corinne Togiai, Eneida R. Nemecek, Daniel Bottomly, Shannon K. McWeeney, Beth W...> ;Science Signaling. 2018 Jul 17
• 7 citations
  Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL.
  Marilynn Chow, Lina Gao, Jason D. MacManiman, Vincent T Bicocca, Bill H. Chang, Joshi J. Alumkal, Jeffrey W. Tyner> ;Oncogene. 2018 May 30
• 145 citations
  Dasatinib plus intensive chemotherapy in children, adolescents, and young adults with philadelphia chromosome–positive acute lymphoblastic leukemia: Results of childre...
  William B. Slayton, Kirk R. Schultz, John A. Kairalla, Meenakshi Devidas, Xinlei Mi, Michael A. Pulsipher, Bill H. Chang, Charles G. Mullighan, Ilaria Iacobucci, Lewis...> ;Journal of Clinical Oncology. 2018 May 29
• 80 citations
  Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study.
  Weili Sun, Jemily Malvar, Richard Sposto, Anupam Verma, Jennifer J. Wilkes, Robyn M. Dennis, Kenneth Heym, Theodore W. Laetsch, Melissa Widener, Susan R. Rheingold, Ja...> ;Leukemia. 2018 Mar 15
• 1 citations
  Investigating the biology of relapsed acute leukemia: Proceedings of the Therapeutic Advances for Childhood Leukemia & Lymphoma (TACL) Consortium Biology Working Group.
  Deepa Bhojwani, Michael J. Burke, Terzah M. Horton, David S. Ziegler, Maria Luisa Sulis, Kirk R. Schultz, Alan S. Wayne, Shai Izraeli, Bill H. Chang> ;Pediatric Hematology and Oncology. 2017 Nov 30
• 245 citations
  Clinical and immunological responses after CD30-specific chimeric antigen receptor–redirected lymphocytes
  Carlos A. Ramos, Brandon Ballard, Huimin Zhang, Olga Dakhova, Adrian P. Gee, Zhuyong Mei, Mrinalini Bilgi, Meng Fen Wu, Hao Liu, Bambi J. Grilley, Catherine M. Bollard...> ;The Journal of Clinical Investigation. 2017 Sep 1
• 19 citations
  Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia
  Takayo Sasaki, Juan Carlos Rivera-Mulia, Daniel L. Vera, Jared Zimmerman, Sunny Das, Michelle Padget, Naoto Nakamichi, Bill H. Chang, Jeffrey W. Tyner, Brian J. Druker...> ;Experimental Hematology. 2017 Jul 1
• 161 citations
  Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia.
  Viktoras Frismantas, Maria Pamela Dobay, Anna Rinaldi, Joelle Tchinda, Samuel H. Dunn, Joachim B. Kunz, Paulina Richter-Pechanska, Blerim Marovca, Orrin Pail, Silvia J...> ;Blood. 2017 Mar 16
• 25 citations
  Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.
  Nameeta P. Richard, Raffaella Pippa, Megan M. Cleary, Alka Puri, Deanne Tibbitts, Shawn Mahmood, Dale J. Christensen, Sophia Jeng, Shannon K. McWeeney, A. Thomas Look,...> ;Oncotarget. 2016 Oct 1
• 61 citations
  Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia.
  Jessica Leonard, Joelle Rowley, Christopher A. Eide, Elie Traer, Brandon Hayes-Lattin, Marc M. Loriaux, Stephen E. Spurgeon, Brian J. Druker, Jeffrey W. Tyner, Bill H....> ;Science Translational Medicine. 2016 Aug 31
• 50 citations
  A Phase I Study of Quizartinib Combined With Chemotherapy in Relapsed Childhood Leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study
  Todd M. Cooper, Jeannette Cassar, Elena Eckroth, Jemily Malvar, Richard Sposto, Paul S. Gaynon, Bill H. Chang, Lia Gore, Keith J. August, Jessica A. Pollard, Steven G....> ;Clinical Cancer Research. 2016 Aug 15
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Journal Articles

• Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening  
  Tyner JT, Yang WF, Bankhead III A, Fan G, Fletcher LB, Bryant J, Glover JM, Chang BH, Spurgeon SE, Fleming WH, Kovacsovics T, Gotlib JR, Oh ST, Deininger MW, Zwaan CM,..., Cancer Res, 1/1/2013
• Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia  
  Bicocca VT, Chang BH, Kharabi Masouleh B, Muschen M, Loriaux MM, Druker BJ, Tyner JW, Cancer Cell, 1/1/2012
• Abnormal developmental control of replication timing domains in pediatric acute lymphoblastic leukemia  
  Ryba T., Battaglia D., Chang B.H., Shirley J.W., Druker B.J., & Gilbert D.M., Genome Res, 1/1/2012
• Imatinib resistant BCR-ABL1 mutations at relapse in children with Ph+ALL: a Children’s Oncology Group (COG) study  
  Chang B.H., Willis S.G., Stork L., Hunger S.P., Carroll W.L., Camitta B.M., Winick N.J., Druker B.J., & Schultz K.R., British Journal of Haematology, 1/1/2012
• In vitro sensitivity to Dasatinib in lymphoblasts from a patient with t(17;19)(q22;p13) gene rearrangement pre B Acute Lymphoblastic Leukemia  
  Glover J., Loriaux M., Tyner J.W., Druker BJ., & Chang B.H., Pediatric Blood and Cancer, 1/28/2011
• Targeting Survivin and p53 in Pediatric Acute Lymphoblastic Leukemia  
  Tyner J.W., Jemal A., Thayer M., Druker B.J., & Chang B.H., Leukemia, 1/1/2011
• RNAi Screen for Rapid Therapeutic Target Identification in Leukemia Patients  
  Tyner J.W., Deininger M.W., Loriaux M.M., Chang B.H., Gotlib J.R., Willis S.G., Erickson H., Kovacsovics T., O’Hare T., Heinrich M.C., and B.J. Druker, PNAS, 1/1/2009
• A Unique Case of Adolescent CD56-Negative Extranodal NK/T-CellLymphoma, Nasal Type  
  Chang BH, Stork L, and Fan G, Pediatr Dev Pathol, 1/1/2008
• Management of Menstrual Bleeding and Cycle Control After Hematopoietic Stem Cell Transplant  
  Chang BH, Edelman A, and Godder K, IJGO, 1/1/2008
• P300/CBP interacts with ATR and is required for the DNA Replication Checkpoint  
  Stauffer D., Chang B., Huang J., Dunn A., and Thayer T., J Biol Chem, 1/1/2007
• Chromosomes with Delayed Replication Timing Lead to Checkpoint Activation, Delayed Recruitment of Aurora B, and Chromosome Instability  
  Chang B.H., Smith L., Huang J., and Thayer T., Oncogene, 1/1/2007
• Neuroblastoma found in a 4-year Old after Rituximab Therapy for Opsoclonus Myoclonus  
  Chang B.H., Koch T., Hopkins K., and Malempati S., Pediatric Neurology, 1/1/2006
• Cellular signaling through multifunctional Ca2+/calmodulin-dependent protein kinase II  
  Soderling T.R., Chang B.H., and Brickey D., JBC, 1/1/2001
• Calcium/calmodulin-dependent protein kiinase II inhibitor protein: localization of isoforms in rat brain  
  Chang B.H., Mukherji S., and Soderling T.R., Neuroscience, 1/1/2001
• Characterization of a CaM-KII inhibitory protein in brain  
  Chang B.H., Mukherji S., and Soderling T.R., Proc Natl Acad Sci USA, 1/1/1998
• Ca2+/ calmodulin-dependent kinase II mediates simultaneous enhancement of gap-junctional conductance and glutamatergic transmission  
  Pereda A., Bell T., Chang B.H., Czernik A.J., Nairn A.C., Soderling T.R., and Faber D.S., Proc Natl Acad Sci USA, 1/1/1998
• Identification in the Calcineurin A subunit of the Domain that binds the Regulatory B subunit  
  Watanabe Y., Perrino B.A., Chang B.H., and Soderling T.R., JBC, 1/1/1995
• The essential mitotic target of calmodulin is the 110kD component of the spindle pole body in Saccharomyces cerevisiae  
  Geiser J.R., Sundberg H.A., Chang B.H., Muller E.G.D., and Davis T.N., MCB, 1/1/1993
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Abstracts/Posters

• Targeting BCL-2 and BCR-ABL1 activity in Ph+ALL.
  Leonard J., Traer E, Hayes-Lattin B, Tyner JW, Druker BJ, & Chang BH, BMT Tandem Meeting, 1/11/2015
• Synergy between targeted BCR-ABL1 and BCL-2 inhibitors is enhanced by the dual SRC/ABL inhibitors in Ph+ Acute lymphoblastic leukemia.
  Leonard J., Traer E., Tyner JW., Hayes-Lattin B., Loriaux M, Druker BJ, & Chang BH, Annual American Society of Clinical Oncology Meeting, Chicago, IL, 1/1/2015
• Invasive Candida Infections in Pediatric Patients Treated on the Pilot Study of Decitabine and Vorinostat with Chemotherapy for Relapsed ALL: A Report from the Therape...
  Burke MJ, Brown P, Gore L, Sposto R, Bhojwani D, Chang BH, Dubois SG, Gaynon PS, Glade-Bender J, Heym KM, Sulis ML, Pollard JA, Verma A, & Huynh V, 56th Annual American Society of Hematology Meeting, 1/4/2014
• Enforcing Feedback Activation Between BCL6 and Tonic Pre-B Cell Receptor Signaling in Acute Lymphoblastic Leukemia.
  Geng H, Hurtz C, Baumjohann D, Chen Z, Chen W, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Tyner JW, Chang BH, K..., 56th Annual American Society of Hematology Meeting, 1/4/2014
• Coordinate Regulation of Residual Bone Marrow Function in Acute Myeloid Leukemia By Exosomal MicroRNA.
  Hornick NI, Huan J, Goloviznina NA, Cambronne L, Shen R, Chang BH, & Kurre P, 56th Annual American Society of Hematology meeting, 1/4/2014
• Dasatinib Shows Therapeutic Potential in the Murine Xenograft Model forTCF3 rearranged Acute Lymphoblastic Leukemia.
  Lenz K, Thompson S, Goloviznina N, Huan J, LaTocha DH, Druker BJ, Tyner JW, Kurre P, & Chang BH, 56th Annual American Society of Hematology Meeting, 1/4/2014
• A Phase I Study of AC220 in Combination with Cytarabine and Etoposide in Relapsed/Refractory Childhood ALL and AML: A Therapeutic Advances in Childhood Leukemia & Lymp...
  Cooper TM, Sposto R, Cassar J, Eckroth E, Malvar J, Gaynon P, DuBois S, Chang BH, Gore L, August K, Thomson B, Gammon G, Magoon D, Annesley C, & Brown P, 54th Annual American Society of Hematology meeting, 1/10/2013
• Continuous Dose Dasatinib Is Safe and Feasible in Combination with Intensive Chemotherapy in Pediatric Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (P...
  Slayton WB, Schultz KR, Jones T, Raetz E, Devidas M, Pulsipher MA, Loh M, Chang BH, Carroll WL, Borowitz MJ, Silverman LB, Brown VI, Winick N, Carroll AJ, Heerema NA, ..., 54th Annual American Society of Hematology meeting, 1/10/2013
• YM155 sensitivity in Pediatric Acute Lymphoblastic Leukemia 2012.
  Chang BH, Jemal A., Tyner JW., Thayer M., Müschen M., & Druker BJ, Annual ASCO Meeting, Chicago, IL, 1/1/2012
• Targeting Survivin with YM155 as a Potential Therapy in Pediatric Acute Lymphoblastic Leukemia.
  Jemal AM., Tyner JW., Thayer M., Muschen M., Druker BJ., & Chang BH, 53rd Annual ASH meeting, 1/10/2011
• Exploring Novel Targets in the Tyrosine Kinase Family in Neuroblastoma.
  Glover J., Chang BH., Tyner J., & Druker BJ, Annual ASHPO Meeting, Baltimore, MD, 1/1/2011
• Exploring Novel Kinase Targets in Neuroblastoma Using Small Molecule Inhibitor Panels.
  Glover J., Chang BH., Tyner J., & Druker BH, Neuroblastoma and Medulloblastoma Translational Research Consortium, Van Andel Institute, Grand Rapids, MI, 1/1/2011
• Small Molecule Inhibitor Panel identifies a new target for dasatinib therapy in pediatric Acute Lymphoblastic Leukemia.
  Chang B.H., Bicocca V., Jemal A., Willis S.G., Druker B.J., Loriaux M., and Tyner J.W., COG semi-annual meeting, 1/20/2010
• A High Throughput Kinase Inhibitor Screen Identifies Aurora Kinase Family Sensitivity in Neuroblastoma.
  Glover J., Tyner J.W., Chang B.H., and Druker B.J., COG semi-annual meeting, 1/20/2010
• RNAi Screen Reveals TYK2 as a Novel Therapeutic Gene Target In T-Cell Acute Lymphoblastic Leukemia.
  Tyner J, Sanda T, Gutierrez A, Glover JM, Chang, BH, Willis SG, Ahn Y, Look AT, and Druker BJ, 52nd Annual ASH Meeting, 1/3/2010
• ROR1 as a Therapeutic Target In E2A-PBX1-Positive Acute Lymphoblastic Leukemia.
  Bicocca V, Chang BH, Muschen M, Druker BJ, & Tyner JW, 52nd Annual ASH Meeting, 1/3/2010
• Pathway Dependence on the Tyrosine Kinase TYK2 and Its Mediator STAT1 In T-Cell Acute Lymphoblastic Leukemia.
  Sanda T, Tyner JW, Gutierrez A, Ngo VN, Moriggl R, Ahn Y, Glover JM, Chang BH, Willis SG, Staudt LM, Druker BJ, & Look AT, 52nd Annual ASH Meeting, 1/3/2010
• Functional Screening of the Tyrosine Kinome in Glioblastoma and Astrocytoma Cell Lines.
  Glover J., Tyner J., Chang BH., & Druker BJ, Annual SIOP Meeting, Boston, MA, 1/1/2010
• Mutational Analysis of BCR-Abl from subjects with Relapsed PH+ALL treated on the COG Protocol AALL0031: A Report from the Chilrden’s Oncology Group.
  Chang B.H., Willis S.G, Stork L., Hunger S.P., Carroll W.L., Camitta B.M., Winick N.J., Druker B.J., and Schultz K.R., 51st Annual ASH Annual Meeting, 1/5/2009
• RAPID siRNA Screen for Identification of Therapeutic Gene Targets in Patients with Hematologic Malignancies.
  Tyner J.W., Loriaux M., Willis S.G., Chang B.H., Bicocca V.T., Oh S.T., Hollink I.H.I.M., Segers S., DenBoer M.L., van den Heuvel-Eibrink M.M., Zwaan M., Gotlib J.R., ..., 51st Annual ASH Annual Meeting, 1/5/2009
• RNAi Screening of the Tyrosine Kinome Identifies Therapeutic Targets in Leukemia Patients.
  Tyner J.W., Loriaux M., Willis S.G., Chang B., Bicocca V.T., Oh S., Hollink I.H.I.M., Segers S., den Boer M.L., Zwaan C.M., Gotlib J.R., Deininger M.W.N., and Druker B.J., 50th Annual American Society of Hematology Meeting, San Francisco, CA, 1/6/2008
• The role of survivin and its potential as a target for therapy in pediatric Philadelphia Chromosome Acute Lymphoblastic.
  Chang B.H., Tyner J, Thayer M, and Druker B.J., National Institute of Child Health and Human Development, Child Health Research Centers Annual Retreat, 1/6/2008
• Genetic engineering of chromosomes that display a Delay in Replication Timing and a Delay in Mitotic Chromosome Condensation.
  Breger K. S., Smith L., Chang B., and Thayer M., Cancer Genetics and Epigenetics, Gordon Research Conference, Ventura, CA, 1/5/2003
• Characterization of a CaM-KII inhibitory protein in brain.
  Chang B. H., Mukherji S., and Soderling T.R., Cell Calcium, FASEB Summer Research Conference, Snowmass Village, CO, 1/4/1997
• An essential nuclear filament-related protein is a mitotic target of calmodulin.
  Geiser J., Sundberg H., Chang B., and Davis T., Yeast Cell Biology, Cold Spring Harbor, NY, 1/17/1993
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Lectures

• CAR therapy. 
  Portland, OR - 1/1/2014
• Dasatinib Sensitivity in Ph(-)ALL. 
  1/1/2012
• -nibs, -mibs, and –mabs. Modern Cancer Warfare 
  Portland, OR - 1/1/2012
• Recurring cytogenetic abnormalities in Leukemia and their prognostic significance. 
  Portland, OR - 1/1/2012
• Survivin as a potential target for therapy Pediatric Acute Lymphoblastic Leukemia 
  Philadelphia, PA - 1/1/2010
• Q & A for The Kiwanians 
  Vancouver, WA - 1/1/2010
• The use of siRNA and small molecular inhibitors to identify new targets for therapy in pediatric leukemias: a pilot project using samples from the COG Cell Bank. 
  Dallas, TX - 1/1/2009
• Current Status on Relapsed Leukemias 
  Portland, OR - 1/1/2006
• Common Presentations of Childhood Cancer 
  Portland, OR - 1/1/2004
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Other

• Cloning and characterization of a novel family of inhibitory proteins of CaM-kinase II. Thesis Dissertation 
  Chang BH, Neuroscience Graduate Program
  1/1/2000