BonnieJHowellMD

PubMed

• 28 citations
  A long-acting formulation of the integrase inhibitor raltegravir protects humanized BLT mice from repeated high-dose vaginal HIV challenges
  Martina Kovarova, Michael D. Swanson, Rosa I. Sanchez, Caroline E. Baker, Justin Steve, Rae Ann Spagnuolo, Bonnie J. Howell, Daria J. Hazuda, J. Victor Garcia> ;The Journal of Antimicrobial Chemotherapy. 2016 Jun 1
• 45 citations
  In vivo analysis of the effect of panobinostat on cell-associated HIV RNA and DNA levels and latent HIV infection
  Perry Tsai, Guoxin Wu, Caroline E. Baker, William O. Thayer, Rae Ann Spagnuolo, Rosa I. Sanchez, Stephanie E. Barrett, Bonnie J. Howell, David J. Margolis, Daria J. Ha...> ;Retrovirology. 2016 May 21
• 24 citations
  Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates.
  Stephanie E. Barrett, Rob S. Burke, Marc Abrams, Carol Bason, Marina Busuek, Edward J. Carlini, Brian A. Carr, Louis S. Crocker, Haihong Fan, Robert M. Garbaccio, Erin...> ;Journal of Controlled Release. 2014 Jun 10
• 9 citations
  An in vivo evaluation of amphiphilic, biodegradable peptide copolymers as siRNA delivery agents
  Stephanie E. Barrett, Marc Abrams, Rob S. Burke, Brian A. Carr, Louis S. Crocker, Robert M. Garbaccio, Bonnie J. Howell, Eric Kemp, Robert A. Kowtoniuk, Andrew H. Lath...> ;International Journal of Pharmaceutics. 2014 May 15
• 18 citations
  Novel endosomolytic poly(amido amine) polymer conjugates for systemic delivery of siRNA to hepatocytes in rodents and nonhuman primates.
  Rubina G. Parmar, Micheal Poslusney, Marina Busuek, J. Michael Williams, Robert M. Garbaccio, Karen R. Leander, Eileen S. Walsh, Bonnie J. Howell, Laura Sepp-Lorenzino...> ;Bioconjugate Chemistry. 2014 May 5
• 14 citations
  Improving the in vivo therapeutic index of siRNA polymer conjugates through increasing pH responsiveness.
  Erin N. Guidry, Julie Farand, Arash Soheili, Craig A. Parish, Nancy J. Kevin, Brenda Pipik, Kathleen Calati, Nori Ikemoto, Jacob H. Waldman, Andrew H. Latham, Bonnie J...> ;Bioconjugate Chemistry. 2014 Jan 10
• 27 citations
  Endosomolytic bioreducible poly(amido amine disulfide) polymer conjugates for the in vivo systemic delivery of siRNA therapeutics.
  Rubina G. Parmar, Marina Busuek, Eileen S. Walsh, Karen R. Leander, Bonnie J. Howell, Laura Sepp-Lorenzino, Eric Kemp, Louis S. Crocker, Anthony Leone, Christopher J. ...> ;Bioconjugate Chemistry. 2013 Mar 25
• 81 citations
  Biodistribution of Small Interfering RNA at the Organ and Cellular Levels after Lipid Nanoparticle-mediated Delivery
  Bin Shi, Edward Keough, Andrea Matter, Karen R. Leander, Stephanie Young, Ed Carlini, Alan B. Sachs, Weikang Tao, Marc Abrams, Bonnie J. Howell, Laura Sepp-Lorenzino> ;The Journal of Histochemistry and Cytochemistry. 2011 Aug 1
• 49 citations
  Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles.
  Randy Crawford, Belma Dogdas, Edward Keough, R. Matthew Haas, Wickliffe Wepukhulu, Steven Krotzer, Paul A. Burke, Laura Sepp-Lorenzino, Ansuman Bagchi, Bonnie J. Howell> ;International Journal of Pharmaceutics. 2011 Jan 17
• 54 citations
  An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo
  Craig Cherrin, Kathleen M. Haskell, Bonnie J. Howell, Raymond E. Jones, Karen R. Leander, Ronald G. Robinson, Aubrey Watkins, Mark T. Bilodeau, Jacob M. Hoffman, Sande...> ;Cancer Biology & Therapy. 2010 Apr 1
• 7 citations
  Cell Imaging Assays for G Protein‐Coupled Receptor Internalization: Application to High‐Throughput Screening
  Seungtaek Lee, Bonnie J Howell, Priya Kunapuli> ;Methods in Enzymology. 2006 Jan 1
• 5 citations
  Development and implementation of multiplexed cell-based imaging assays.
  Bonnie J Howell, Seungtaek Lee, Laura Sepp-Lorenzino> ;Methods in Enzymology. 2006 Jan 1
• 26 citations
  High-content screening: emerging hardware and software technologies.
  Seungtaek Lee, Bonnie J Howell> ;Methods in Enzymology. 2006 Jan 1
• 273 citations
  Spindle Checkpoint Protein Dynamics at Kinetochores in Living Cells
  Bonnie Howell, Ben Moree, Emily M Farrar, Scott R. Stewart, Guowei Fang, Edward D. Salmon> ;Current Biology. 2004 Jun 8
• 134 citations
  Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores.
  Jennifer G. DeLuca, Bonnie Howell, Julie C. Canman, Jennifer M. Hickey, Guowei Fang, Edward D. Salmon> ;Current Biology. 2003 Dec 2
• 416 citations
  Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation
  Bonnie Howell, B.F. McEwen, Julie C. Canman, David B. Hoffman, E.M. Farrar, Conly L. Rieder, Edward D. Salmon> ;The Journal of Cell Biology. 2001 Dec 24
• 118 citations
  Rapid dynamics of the microtubule binding of ensconsin in vivo.
  J. Chloë Bulinski, David J. Odde, Bonnie Howell, Ted D. Salmon, Clare M. Waterman-Storer> ;Journal of Cell Science. 2001 Nov 1
• 289 citations
  Microtubule-dependent Changes in Assembly of Microtubule Motor Proteins and Mitotic Spindle Checkpoint Proteins at PtK1 Kinetochores
  David B. Hoffman, Chad G. Pearson, Tim J. Yen, Bonnie Howell, Edward D. Salmon> ;Molecular Biology of the Cell. 2001 Jul 1
• 418 citations
  Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells
  Daniela Cimini, Bonnie Howell, Paul S. Maddox, Alexey Khodjakov, Francesca Degrassi, Edward D. Salmon> ;The Journal of Cell Biology. 2001 Apr 30
• 55 citations
  The Catastrophe-promoting Activity of Ectopic Op18/Stathmin Is Required for Disruption of Mitotic Spindles But Not Interphase Microtubules
  Per Holmfeldt, Niklas Larsson, Bo Segerman, Bonnie Howell, Justin Morabito, Lynne Cassimeris, Martin Gullberg> ;Molecular Biology of the Cell. 2001 Jan 1
• 291 citations
  Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells.
  Bonnie Howell, David B. Hoffman, Guowei Fang, Andrew W. Murray, Edward D. Salmon> ;The Journal of Cell Biology. 2000 Sep 18
• 69 citations
  Decreasing oncoprotein 18/stathmin levels reduces microtubule catastrophes and increases microtubule polymer in vivo.
  Bonnie Howell, Heather W. Deacon, Lynne Cassimeris> ;Journal of Cell Science. 1999 Nov 1
• 59 citations
  Op18/stathmin mediates multiple region-specific tubulin and microtubule-regulating activities.
  Niklas Larsson, Bo Segerman, Bonnie Howell, Kajsa Fridell, Lynne Cassimeris, Martin Gullberg> ;The Journal of Cell Biology. 1999 Sep 20
• 155 citations
  Dissociation of the Tubulin-sequestering and Microtubule Catastrophe-promoting Activities of Oncoprotein 18/Stathmin
  Bonnie Howell, Niklas Larsson, Martin Gullberg, Lynne Cassimeris> ;Molecular Biology of the Cell. 1999 Jan 1
• 340 citations
  Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.
  Robert J. Vasquez, Bonnie Howell, A.-M. C. Yvon, P. Wadsworth, Lynne Cassimeris> ;Molecular Biology of the Cell. 1997 Jun 1
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