BradleyE.BritiganMD

Infectious Disease • Omaha, NE

Dean and Professor, Internal Medicine,, U of NE Coll of Med

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Office
985520 Nebraska Medical Center
Omaha, NE 68198
Phone+1 402-559-4204

Fax+1 402-559-4148
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Education & Training

University of North Carolina HospitalsFellowship, Infectious Disease, 1983 - 1987
Brown UniversityResidency, Internal Medicine, 1980 - 1983
Keck School of Medicine of the University of Southern CaliforniaClass of 1980

Certifications & Licensure

NE State Medical License 2011 - 2024
OH State Medical License 2004 - 2013
IA State Medical License 1987 - 2004
NC State Medical License 1983 - 1988
RI State Medical License 1982 - 1983
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Infectious Disease

Publications & Presentations

PubMed

Combination Therapy with Gallium Protoporphyrin and Gallium Nitrate Exhibits Enhanced Antimicrobial Activityandagainst Methicillin-Resistant.
Seoung-Ryoung Choi, Geoffrey A Talmon, Kenneth Hearne, Jennifer Woo, Vu L Truong, Bradley E Britigan, Prabagaran Narayanasamy> ;Molecular Pharmaceutics. 2023 Aug 7
2 citations
Development of Gallium(III) as an Antimicrobial Drug Targeting Pathophysiologic Iron Metabolism of Human Pathogens.
Zachary W Scott, Seoung-Ryoung Choi, Bradley E Britigan, Prabagaran Narayanasamy> ;ACS Infectious Diseases. 2023 Apr 14
6 citations
Combining Gallium Protoporphyrin and Gallium Nitrate EnhancesandEfficacy against: Role of Inhibition of Bacterial Antioxidant Enzymes and Resultant Increase in Cytotox...
Zachary W Scott, Seoung-Ryoung Choi, Geoffrey A Talmon, Bradley E Britigan, Prabagaran Narayanasamy> ;ACS Infectious Diseases. 2022 Oct 14
3 citations
Synthesis and in vitro analysis of novel gallium tetrakis(4-methoxyphenyl)porphyrin and its long-acting nanoparticle as a potent antimycobacterial agent.
Seoung-Ryoung Choi, Bradley E Britigan, Prabagaran Narayanasamy> ;Bioorganic & Medicinal Chemistry Letters. 2022 Apr 15
Author Correction: Prolonged-acting, Multi-targeting Gallium Nanoparticles Potently Inhibit Growth of Both HIV and Mycobacteria in Co-Infected Human Macrophages.
Prabagaran Narayanasamy, Barbara L. Switzer, Bradley E. Britigan> ;Scientific Reports. 2021 Sep 1
8 citations
Nanoparticulate β-Cyclodextrin with Gallium Tetraphenylporphyrin Demonstrates in Vitro and in Vivo Antimicrobial Efficacy against Mycobacteroides abscessus and Mycobac...
Seoung Ryoung Choi, Geoffrey A. Talmon, Bradley E. Britigan, Prabagaran Narayanasamy> ;ACS Infectious Diseases. 2021 Jul 27
10 citations
Heme Oxygenase-1 Inhibition Potentiates the Effects of Nab-Paclitaxel-Gemcitabine and Modulates the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma.
Iman M. Ahmad, Alicia J. Dafferner, Kelly A. O'Connell, Kamiya Mehla, Bradley E. Britigan, Michael A. Hollingsworth, Maher Y. Abdalla> ;Cancers. 2021 May 8
20 citations
Gallium Porphyrin and Gallium Nitrate Synergistically Inhibit Mycobacterial Species by Targeting Different Aspects of Iron/Heme Metabolism
Seoung Ryoung Choi, Barb Switzer, Bradley E. Britigan, Prabagaran Narayanasamy> ;ACS Infectious Diseases. 2020 Sep 9
8 citations
Treatment of Virulent Mycobacterium tuberculosis and HIV Coinfected Macrophages with Gallium Nanoparticles Inhibits Pathogen Growth and Modulates Macrophage Cytokine P...
Seoung Ryoung Choi, Bradley E. Britigan, Prabagaran Narayanasamy> ;Msphere. 2019 Jul 24
40 citations
Dual Inhibition of Klebsiella pneumoniae and Pseudomonas aeruginosa Iron Metabolism Using Gallium Porphyrin and Gallium Nitrate
Seoung Ryoung Choi, Bradley E. Britigan, Prabagaran Narayanasamy> ;ACS Infectious Diseases. 2019 Jul 2
31 citations
Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition
Maher Y. Abdalla, Iman M. Ahmad, Satyanarayana Rachagani, Kasturi Banerjee, Christopher Thompson, H. Carlo Maurer, Kenneth P. Olive, Katie Bailey, Bradley E. Britigan,...> ;Translational Research. 2019 May 1
27 citations
Iron/heme metabolism-targeted gallium(III) nanoparticles are active against extracellular and intracellular pseudomonas aeruginosa and acinetobacter baumannii
Seoung Ryoung Choi, Bradley E. Britigan, Prabagaran Narayanasamy> ;Antimicrobial Agents and Chemotherapy. 2019 Mar 27
159 citations
Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections
Christopher H. Goss, Yukihiro Kaneko, Lisa Khuu, Gail D. Anderson, Sumedha Ravishankar, Moira L. Aitken, Noah Lechtzin, Guolin Zhou, Daniel M. Czyż, Kathryn McLean, Oy...> ;Science Translational Medicine. 2018 Sep 26
25 citations
In Vitro Efficacy of Free and Nanoparticle Formulations of Gallium(III) meso-Tetraphenylporphyrine against Mycobacterium avium and Mycobacterium abscessus and Gallium ...
Seoung Ryoung Choi, Bradley E. Britigan, Barbara L. Switzer, Traci Hoke, David Moran, Prabagaran Narayanasamy> ;Molecular Pharmaceutics. 2018 Feb 8
27 citations
Pseudomonas Quinolone Signal Induces Oxidative Stress and Inhibits Heme Oxygenase-1 Expression in Lung Epithelial Cells.
Maher Y. Abdalla, Traci Hoke, Javier Seravalli, Barbara L. Switzer, Melissa Bavitz, Jill D. Fliege, Peter J. Murphy, Bradley E. Britigan> ;Infection and Immunity. 2017 Sep 1
3 citations
Passive transfer of interferon-γ over-expressing macrophages enhances resistance of SCID mice to Mycobacterium tuberculosis infection
Rajamouli Pasula, William J. Martin, Banu Kesavalu, Maher Y. Abdalla, Bradley E. Britigan> ;Cytokine. 2017 Jul 1
38 citations
Gallium nanoparticles facilitate phagosome maturation and inhibit growth of virulent Mycobacterium tuberculosis in macrophages
Seoung Ryoung Choi, Bradley E. Britigan, David Moran, Prabagaran Narayanasamy> ;Plos One. 2017 May 18
26 citations
Ga(III) Nanoparticles Inhibit Growth of both Mycobacterium tuberculosis and HIV and Release of Interleukin-6 (IL-6) and IL-8 in Coinfected Macrophages.
Seoung Ryoung Choi, Bradley E. Britigan, Prabagaran Narayanasamy> ;Antimicrobial Agents and Chemotherapy. 2017 Mar 24
2 citations
Airway delivery of interferon-γ overexpressing macrophages confers resistance to Mycobacterium avium infection in SCID mice
Rajamouli Pasula, Bradley E. Britigan, Banurekha Kesavalu, Maher Y. Abdalla, William J. Martin> ;Physiological Reports. 2016 Nov 1
34 citations
Gallium compounds exhibit potential as new therapeutic agents against Mycobacterium abscessus
Maher Y. Abdalla, Barbara L. Switzer, Christopher H. Goss, Moira L. Aitken, Pradeep K. Singh, Bradley E. Britigan> ;Antimicrobial Agents and Chemotherapy. 2015 Aug 1
43 citations
Prolonged-acting, multi-targeting gallium nanoparticles potently inhibit growth of both HIV and mycobacteria in co-infected human macrophages.
Prabagaran Narayanasamy, Barbara L. Switzer, Bradley E. Britigan> ;Scientific Reports. 2015 Mar 6
48 citations
Induction of heme oxygenase-1 contributes to survival of Mycobacterium abscessus in human macrophages-like THP-1 cells.
Maher Y. Abdalla, Iman M. Ahmad, Barbara L. Switzer, Bradley E. Britigan> ;Redox Biology. 2015 Apr 1
16 citations
Iron acquisition by Mycobacterium tuberculosis residing within myeloid dendritic cells
Oyebode Olakanmi, Banurekha Kesavalu, Maher Y. Abdalla, Bradley E. Britigan> ;Microbial Pathogenesis. 2013 Dec 1
30 citations
GALLIUM NITRATE IS EFFICACIOUS IN MURINE MODELS OF TUBERCULOSIS AND INHIBITS KEY BACTERIAL FE-DEPENDENT ENZYMES
Oyebode Olakanmi, Banurekha Kesavalu, Rajamouli Pasula, Maher Y. Abdalla, Larry S. Schlesinger, Bradley E. Britigan> ;Antimicrobial Agents and Chemotherapy. 2013 Dec 1
10 citations
INACTIVATION OF THE POTENT Pseudomonas aeruginosa CYTOTOXIN PYOCYANIN BY AIRWAY PEROXIDASES AND NITRITE
Krzysztof J. Reszka, Ye Xiong, Larry Sallans, Rajamouli Pasula, Oyebode Olakanmi, Daniel J. Hassett, Bradley E. Britigan> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2012 May 15
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Press Mentions

UNMC Mourns Surgeon Killed in Plane CrashAugust 9th, 2021
Family Confirms Omaha Surgeon and Two Relatives Killed in Plane Crash in VictoriaAugust 8th, 2021
Dr. Are Joins National Cancer Institute Advisory BoardJuly 29th, 2021
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Grant Support

Iron Acquisition By Mycobacterium Tuberculosis Within PhagocytesVeterans Affairs2011
Iron Acquisition By Mycobacterium Tuberculosis Within PhagocytesClinical Science Research &Development2009
Use Of Gallium To Prevent Pseudomonas Biofilm FormationNational Institute Of Allergy And Infectious Diseases2004–2005
Pseudomonas Products, Oxygen Radicals, And Lung InjuryNational Institute Of Allergy And Infectious Diseases1994–2003
Research Training In Infectious DiseasesNational Institute Of Allergy And Infectious Diseases1994–2002
Modulation Of Neutrophil Hydoxyl Radical FormationNational Institute Of Allergy And Infectious Diseases1989–1993
Core--Cell Preparation And CultureNational Institute Of Allergy And Infectious Diseases1989–1993
Monocyte/Macrophage Free Radical Biology Assessed By EPRNational Heart, Lung, And Blood Institute1989–1993

Hospital Affiliations

Nebraska Medicine - Nebraska Medical CenterOmaha, Nebraska
Omaha VA Medical CenterOmaha, Nebraska

BradleyE.BritiganMD

Dr. Britigan is on Doximity

Education & Training

Certifications & Licensure

Publications & Presentations

Press Mentions

Grant Support

Hospital Affiliations

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