BradleyJohnMolyneauxMDPhD

Neurology • Boston, MA

Vascular Neurology, Neurocritical Care

Division Chief, Neurocritical Care, Brigham and Women's Hospital

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Office
75 Francis Street
Boston, MA 02115
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Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Neurology, 2008 - 2011
Massachusetts General HospitalInternship, Internal Medicine, 2007 - 2008
Harvard Medical SchoolClass of 2007

Certifications & Licensure

MA State Medical License 2010 - 2025
PA State Medical License 2013 - 2024
MD State Medical License 2013 - 2021
WV State Medical License 2016 - 2019
NY State Medical License 2017 - 2019
American Board of Psychiatry and Neurology Neurology

Clinical Trials

Glyburide Advantage in Malignant Edema and Stroke - Remedy Pharmaceuticals Start of enrollment: 2013 Jun 13
Completed
Phase 2

Publications & Presentations

PubMed

1 citations
Bilateral medial medullary infarct causing stepwise tetraparesis: delayed appearance of the 'heart-shaped' sign.
Yasmin Aghajan, Lynn Daboul, Bradley J Molyneaux> ;Practical Neurology. 2023 Oct 1
2 citations
Safe Use of Cenobamate in Super Refractory Status Epilepticus: A Case Series.
Julia M Carlson, Bradley J Molyneaux, Jong Woo Lee> ;The Neurohospitalist. 2023 Apr 1
3 citations
Efficacy of novel SPAK inhibitor ZT-1a derivatives (1c, 1d, 1g & 1h) on improving post-stroke neurological outcome and brain lesion in mice.
Mohammad Iqbal H Bhuiyan, Sydney Fischer, Shivani M Patel, Helena Oft, Ting Zhang, Lesley M Foley, Jinwei Zhang, T Kevin Hitchens, Bradley J Molyneaux, Xianming Deng, ...> ;Neurochemistry International. 2023 Jan 1
4 citations
Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide.
Hannah J Irvine, Animesh Acharjee, Zsuzsanna Ament, H E Hinson, Bradley J Molyneaux, J Marc Simard, Kevin N Sheth, W Taylor Kimberly, Wolcott, Z., Zoe Wolcott> ;Cell Reports. Medicine. 2022 Jun 21
6 citations
NF-κB Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II-Hypertensive Mice.
Mohammad Iqbal H Bhuiyan, Cullen B Young, Israt Jahan, Md Nabiul Hasan, Sydney Fischer, Nur Farah Meor Azlan, Mingjun Liu, Ansuman Chattopadhyay, Huachen Huang, Kristo...> ;Stroke. 2022 May 1
7 citations
Remote Longitudinal Inpatient Acute Stroke Care Via Telestroke.
Fatemeh Sobhani, Shashvat M Desai, Evan S Madill, Matthew Starr, Marcelo Rocha, Bradley J. Molyneaux, Tudor G Jovin, Lawrence Wechsler, Ashutosh P Jadhav> ;Journal of Stroke and Cerebrovascular Diseases. 2021 Mar 27
8 citations
Delayed functional independence after thrombectomy: temporal characteristics and predictors.
Shashvat M Desai, Daniel A Tonetti, Andrew A Morrison, Bradley J. Molyneaux, Matthew Starr, Marcelo Rocha, Bradley A. Gross, Brian T Jankowitz, Tudor G Jovin, Ashutosh...> ;Journal of Neurointerventional Surgery. 2020 Sep 1
10 citations
Lessons from Recent Advances in Ischemic Stroke Management and Targeting Kv2.1 for Neuroprotection.
Chung-Yang Yeh, Anthony J. Schulien, Bradley J. Molyneaux, Elias Aizenman> ;International Journal of Molecular Sciences. 2020 Aug 25
4 citations
Osmotherapy for malignant cerebral edema in a phase 2 prospective, double blind, randomized, placebo-controlled study of IV glibenclamide.
Holly E. Hinson, Elizabeth Sun, Bradley J. Molyneaux, Rüdiger von Kummer, Andrew M. Demchuk, Javier Romero, W. Taylor Kimberly, Kevin N. Sheth> ;Journal of Stroke and Cerebrovascular Diseases. 2020 Jul 1
5 citations
Large Infarct Volume Post Thrombectomy: Characteristics, Outcomes, and Predictors
Daniel A Tonetti, Shashvat M Desai, Joseph S. Hudson, Bradley A. Gross, Ruchira M. Jha, Bradley J. Molyneaux, B. T. Jankowitz, Tudor G Jovin, A Jadhav> ;World Neurosurgery. 2020 Apr 27
20 citations
Interaction between time, ASPECTS, and clinical mismatch
Shashvat M Desai, Daniel A Tonetti, Bradley J. Molyneaux, Kunakorn Atchaneeyasakul, Marcelo Rocha, Tudor G Jovin, Ashutosh P Jadhav> ;Journal of Neurointerventional Surgery. 2020 Apr 3
60 citations
Modulation of brain cation-Cl- cotransport via the SPAK kinase inhibitor ZT-1a.
Jinwei Zhang, Mohammad Iqbal H. Bhuiyan, Ting Zhang, Jason K. Karimy, Zhijuan Wu, Victoria M. Fiesler, Zhang Jingfang, Huachen Huang, Nabiul Hasan, Anna E. Skrzypiec, ...> ;Nature Communications. 2020 Jan 7
1 citations
Reliability of the Telemedicine Examination in the Neurologic Diagnosis of Death
Joseph M. Darby, Lori Shutter, Jonathan Elmer, Mohammad I. Hirzallah, Namir Khandker, Bradley J. Molyneaux, A. Murat Kaynar, Karen R. Nigra, Lawrence R. Wechsler> ;Neurology. Clinical Practice. 2019 Dec 11
13 citations
Organ donation after resuscitation from cardiac arrest.
Jonathan Elmer, Bradley J. Molyneaux, Kurt Shutterly, Susan A. Stuart, Clifton W. Callaway, Joseph M. Darby, Amy R. Weisgerber> ;Resuscitation. 2019 Dec 1
47 citations
Intravenous Glibenclamide Reduces Lesional Water Uptake in Large Hemispheric Infarction.
Pongpat Vorasayan, Matthew B. Bevers, Lauren A. Beslow, Gordon Sze, Bradley J. Molyneaux, Holly E. Hinson, J. Marc Simard, Rüdiger von Kummer, Kevin N. Sheth, W. Taylo...> ;Stroke. 2019 Sep 20
31 citations
Automated Calculation of Alberta Stroke Program Early CT Score Validation in Patients With Large Hemispheric Infarct
Gregory W. Albers, Michael J Wald, Michael Mlynash, Juergen Endres, Roland Bammer, Matus Straka, Andreas Maier, Holly E. Hinson, Kevin N. Sheth, W. Taylor Kimberly, Br...> ;Stroke. 2019 Sep 10
25 citations
Acute Ischemic Stroke with Vessel Occlusion-Prevalence and Thrombectomy Eligibility at a Comprehensive Stroke Center.
Shashvat M Desai, Matthew Starr, Bradley J. Molyneaux, Marcelo Rocha, Tudor G Jovin, Ashutosh P Jadhav> ;Journal of Stroke and Cerebrovascular Diseases. 2019 Aug 10
34 citations
A Novel Na+-K+-Cl- Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke.
Huachen Huang, Mohammad Iqbal H. Bhuiyan, Tong Jiang, Shanshan Song, Sandhya Shankar, Taraneh Taheri, Eric Li, Philipp Schreppel, Michael Hintersteininger, Sung-Sen Ya...> ;Stroke. 2019 Apr 1
11 citations
Differential association of subtypes of epileptiform activity with outcome after cardiac arrest.
John Faro, Patrick J Coppler, Cameron Dezfulian, Maria Baldwin, Bradley J. Molyneaux, Alexandra Urban, Jon C Rittenberger, Clifton W. Callaway, Jonathan Elmer> ;Resuscitation. 2019 Mar 1
51 citations
Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial.
W. Taylor Kimberly, Matthew B. Bevers, Rüdiger von Kummer, Andrew M. Demchuk, Javier Romero, Jordan J. Elm, Holly E. Hinson, Bradley J. Molyneaux, J. Marc Simard, Kevi...> ;Neurology. 2018 Dec 4
58 citations
Thrombectomy 6-24 hours after stroke in trial ineligible patients.
Shashvat M Desai, Marcelo Rocha, Bradley J. Molyneaux, Matthew Starr, Cynthia L. Kenmuir, Bradley A. Gross, Brian T. Jankowitz, Tudor G Jovin, Ashutosh P Jadhav> ;Journal of Neurointerventional Surgery. 2018 Nov 1
42 citations
Care of the Post-Thrombectomy Patient.
Ashutosh P Jadhav, Bradley J. Molyneaux, Michael D. Hill, Tudor G Jovin> ;Stroke. 2018 Nov 1
32 citations
Glibenclamide Produces Region-Dependent Effects on Cerebral Edema in a Combined Injury Model of Traumatic Brain Injury and Hemorrhagic Shock in Mice.
Ruchira M. Jha, Bradley J. Molyneaux, Travis C. Jackson, Jessica Wallisch, Seo Young Park, Samuel M. Poloyac, Vincent Vagni, Keri Janesko-Feldman, Keito Hoshitsuki, M....> ;Journal of Neurotrauma. 2018 Sep 1
8 citations
Laterality is an Independent Predictor of Endovascular Thrombectomy in Patients With Low National Institute of Health Stroke Scale.
Shashvat M Desai, Marcelo Rocha, Matthew Starr, Bradley J. Molyneaux, Cynthia L. Kenmuir, Bradley A. Gross, Brian T. Jankowitz, Tudor G Jovin, Ashutosh P Jadhav> ;Journal of Stroke and Cerebrovascular Diseases. 2018 Aug 2
42 citations
Long-Term Outcomes in Patients Aged ≤70 Years With Intravenous Glyburide From the Phase II GAMES-RP Study of Large Hemispheric Infarction: An Exploratory Analysis.
Kevin N. Sheth, Nils H Petersen, Ken Cheung, Jordan J. Elm, Holly E. Hinson, Bradley J. Molyneaux, Lauren A. Beslow, Gordon Sze, J. Marc Simard, W. Taylor Kimberly> ;Stroke. 2018 Jun 1
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