BrendaWCooperMD

Oncology • Cleveland, OH

Hematologic Oncology

Professor of Medicine, Case West Res University

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Office
UH Cleveland Medical Center
11100 Euclid Ave Department of Medicine-Hematology and Oncology
Cleveland, OH 44106
Phone+1 216-844-3951

Fax+1 216-844-1256
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Education & Training

University of MarylandFellowship, Hematology and Medical Oncology, 1987 - 1989
Johns Hopkins University/Bayview Medical CenterResidency, Internal Medicine, 1984 - 1987
Johns Hopkins University School of MedicineClass of 1984

Certifications & Licensure

OH State Medical License 1989 - 2025
MD State Medical License 1986 - 1990
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Clinical Trials

Combination Chemotherapy in Treating Patients With Recurrent or Refractory Leukemia Start of enrollment: 1994 Aug 01
Completed
Phase 1
Umbilical Cord Blood Transplantation in Treating Patients With High-Risk Hematologic Cancer Start of enrollment: 1998 Jan 01
Completed
Phase 2
Chemotherapy Followed by Surgery in Treating Women With Stage II or Stage III Breast Cancer Start of enrollment: 1999 Feb 01
Completed
Phase 2
Fludarabine, Carboplatin, and Topotecan in Treating Patients With Relapsed/Refractory Acute Leukemia or Advanced Myelodysplastic Syndrome Start of enrollment: 1998 Sep 01
Completed
Phase 1
Adjuvant Stage 2-3A Breast Cancer With Positive Lymph Nodes Start of enrollment: 2000 Jul 01
Completed
Phase 2
Fludarabine/Carboplatin/Topotecan w/Thalidomide for Relapsed/Refractory AML, CML and MDS Start of enrollment: 2002 Sep 01
Completed
Phase 2
Midostaurin and Azacitidine in Treating Elderly Patients With Acute Myelogenous Leukemia Start of enrollment: 2009 Jul 01
Completed
Phase 1, Phase 2
Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Start of enrollment: 2007 Sep 01
Completed
Phase 2
Double Cord Versus Haploidentical (BMT CTN 1101) Start of enrollment: 2012 Jun 01
Completed
Phase 3
Decitabine, Cytarabine, and Daunorubicin Hydrochloride in Treating Patients With Acute Myeloid Leukemia Start of enrollment: 2011 Sep 16
Active, not recruiting
Phase 2
Cytarabine and Daunorubicin Hydrochloride or Idarubicin and Cytarabine With or Without Vorinostat in Treating Younger Patients With Previously Untreated Acute Myeloid Leukemia Start of enrollment: 2013 Feb 12
Completed
Phase 3
Ixazomib, Mitoxantrone Hydrochloride, Etoposide, and Intermediate-Dose Cytarabine in Relapsed or Refractory Acute Myeloid Leukemia Start of enrollment: 2014 Oct 08
Completed
Phase 1
Gilteritinib vs Midostaurin in FLT3 Mutated Acute Myeloid Leukemia Start of enrollment: 2019 Dec 06
Active, not recruiting
Phase 2
A Study of TAK-981 Given With Rituximab in Adults With Relapsed or Refractory CD20-Positive Non-Hodgkin Lymphoma Start of enrollment: 2019 Oct 15
Terminated
Phase 1, Phase 2
Roles: Principal Investigator
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Publications & Presentations

PubMed

A multicenter study of posttransplantation low-dose inotuzumab ozogamicin to prevent relapse of acute lymphoblastic leukemia.
Leland L Metheny, Ronald Sobecks, Christina Cho, Pingfu Fu, Seunghee Margevicius, Jiasheng Wang, Lisa Ciarrone, Shelby Kopp, Robin D Convents, Navneet Majhail, Paolo F...> ;Blood Advances. 2024 Mar 26
Flow cytometry of DNMT1 as a biomarker of hypomethylating therapies.
Philip G Woost, Basem M William, Brenda W Cooper, Masumi Ueda Oshima, Folashade Otegbeye, Marcos J De Lima, David Wald, Reda Z Mahfouz, Yogen Saunthararajah, Tammy Ste...> ;Cytometry. Part B, Clinical Cytometry. 2024 Jan 1
2 citations
Targeted Marrow Irradiation Intensification of Reduced-Intensity Fludarabine/Busulfan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation.
Naveed Ali, Ashish Arunkumar Sharma, Ana Carolina Pires de Rezende, Folashade Otegbeye, Bilal Muhammad Latif, Mariana Nassif Kerbauy, Brenda W Cooper, Gabriela Sanchez...> ;Transplantation and Cellular Therapy. 2022 Jul 1
1 citations
Risk factors for cardiovascular events and mortality in patients diagnosed with diffuse large B-cell lymphoma and treated with anthracyclines.
Akiva Diamond, Sabarish Ayyappan, Shufen Cao, Nour Tashtish, Kirsten Boughan, Brenda Cooper, PingFu Fu, Paolo F Caimi> ;Hematological Oncology. 2022 Oct 1
8 citations
A Phase I Study to Determine the Maximum Tolerated Dose of ex Vivo Expanded Natural Killer Cells Derived from Unrelated, HLA-Disparate Adult Donors.
Folashade Otegbeye, Brenda Cooper, Paolo Caimi, Kayla Zamborsky, Jane Reese-Koc, Antoinette Hillian, Yeritza Hernandez-Collazo, Grace Lee, Kirsten Boughan, Benjamin To...> ;Transplantation and Cellular Therapy. 2022 May 1
2 citations
Tipifarnib as maintenance therapy did not improve disease-free survival in patients with acute myelogenous leukemia at high risk of relapse: Results of the phase III r...
Selina M. Luger, Victoria Wang, Jacob M. Rowe, Mark R. Litzow, Elisabeth Paietta, Rhett P. Ketterling, Hillard M. Lazarus, Witold B. Rybka, Michael Craig, Judith E. Ka...> ;Leukemia Research. 2021 Oct 28
2 citations
Diffuse Large B Cell Lymphoma in Patients 80 Years and Older: Worse Survival After Treatment Without Increased Relapse Rates.
Madison Keenan, Akiva Diamond, Kirsten M Boughan, Brenda W. Cooper, Molly Gallogly, Ehsan Malek, Leland Metheny, Timothy O’Brien, Folashade Otegbeye, Benjamin Tomlinso...> ;Clinical Lymphoma, Myeloma & Leukemia. 2021 Jun 24
3 citations
Physical Activity and Sleep Measures Using a Fitness Tracking Device during Hematopoietic Cell Transplantation: A Pilot Study.
, , , , , , , , , , , , , , , , , , > ;Transplantation and Cellular Therapy. 2021 Jun 1
2 citations
Significant costs and low utilization of stored peripheral blood stem cells for salvage autologous transplant in multiple myeloma patients including those meeting mSMA...
Nausheen Ahmed, Lucy Li, Patricio Rojas, Fahrettin Covut, Jane Reese-Koc, Merle Kolk, Ehsan Malek, Leland Metheny, Timothy O’Brien, Paolo Caimi, Marcos de Lima, Brenda...> ;Bone Marrow Transplantation. 2021 Jan 29
1 citations
Efficacy and cost-benefit of filgrastim administered after early assessment bone marrow biopsy during induction therapy for acute myeloid leukemia.
Jiasheng Wang, Marcos de Lima, Brenda W. Cooper, Kirsten M Boughan, Leland Metheny, Folashade Otegbeye, Paolo Caimi, Molly Gallogly, Ehsan Malek, Shufen Cao, Pingfu Fu...> ;Leukemia & Lymphoma. 2021 Jan 18
8 citations
Racial and age-related disparities in early mortality affect the outcomes of multiple myeloma patients.
Fahrettin Covut, James J. Driscoll, Brenda W. Cooper, Molly Gallogly, Marcos de Lima, Ehsan Malek> ;Leukemia. 2021 Jan 1
4 citations
A Phase II Trial of Imatinib Mesylate as Maintenance Therapy for Patients With Newly Diagnosed C-kit-positive Acute Myeloid Leukemia.
Anjali S. Advani, William Tse, Hong Li, Xuefei Jia, Paul Elson, Brenda W. Cooper, Francis Ali-Osman, Jino Park, Arati V. Rao, David A. Rizzieri, Eunice S. Wang, Claudi...> ;Clinical Lymphoma, Myeloma & Leukemia. 2012 Nov 16
Correction: History of drug use in allogeneic hematopoietic cell transplant recipients.
Mouhamed Yazan Abou-Ismail, Gayathri Ravi, Pingfu Fu, Shufen Cao, Sowjanya Vuyyala, Paolo Caimi, Merle Kolk, Nicole Ferrari, Kirsten M Boughan, Brenda W. Cooper, Molly...> ;Bone Marrow Transplantation. 2021 Mar 1
History of drug use in allogeneic hematopoietic cell transplant recipients.
Mouhamed Yazan Abou-Ismail, Gayathri Ravi, Pingfu Fu, Shufen Cao, Sowjanya Vuyyala, Paolo Caimi, Merle Kolk, Nicole Ferrari, Kirsten M Boughan, Brenda W. Cooper, Molly...> ;Bone Marrow Transplantation. 2021 Mar 1
7 citations
Aggressive Lymphoma Subtype Is A Risk Factor for Venous Thrombosis. Development of Lymphoma - Specific Venous Thrombosis Prediction Models.
Gouri Dharmavaram, Shufen Cao, Suchitra Sundaram, Sabarish Ayyappan, Kirsten M Boughan, Molly Gallogly, Ehsan Malek, Leland Metheny, Benjamin Tomlinson, Folashade Oteg...> ;American Journal of Hematology. 2020 Apr 20
17 citations
A Phase II Study of Midostaurin and 5-Azacitidine for Untreated Elderly and Unfit Patients With FLT3 Wild-type Acute Myelogenous Leukemia
Benjamin Tomlinson, Molly Gallogly, Donna Kane, Leland Metheny, Hillard M. Lazarus, Basem M. William, Michael Craig, Mark J. Levis, Brenda W. Cooper> ;Clinical Lymphoma, Myeloma & Leukemia. 2020 Apr 1
8 citations
Phase I Trial of Lithium and Tretinoin for Treatment of Relapsed and Refractory Non-promyelocytic Acute Myeloid Leukemia.
Masumi Ueda, Tammy Stefan, Lindsay Stetson, James J. Ignatz-Hoover, Benjamin Tomlinson, Richard J. Creger, Brenda W. Cooper, Hillard M. Lazarus, Marcos de Lima, David ...> ;Frontiers in Oncology. 2020 Mar 10
1 citations
Treatment-related mortality following autologous hematopoietic stem cell transplantation is unaffected by timing of G-CSF administration.
Naveed Ali, Brenda W. Cooper, Benjamin Tomlinson, Leland Metheny, Paolo Caimi, Kirsten M Boughan, Molly Gallogly, Folashade Otegbeye, Ehsan Malek, Hillard M. Lazarus, ...> ;Bone Marrow Transplantation. 2020 Feb 5
31 citations
Gastrointestinal Microbiome and Mycobiome Changes during Autologous Transplantation for Multiple Myeloma: Results of a Prospective Pilot Study.
Najla El Jurdi, Ali Filali-Mouhim, Iman Salem, Mauricio Retuerto, Nina Dambrosio, Linda Baer, Hillard M. Lazarus, Paolo Caimi, Brenda W. Cooper, Benjamin Tomlinson, Le...> ;Biology of Blood and Marrow Transplantation. 2019 Aug 1
28 citations
A Phase I/II Trial of MEC (Mitoxantrone, Etoposide, Cytarabine) in Combination with Ixazomib for Relapsed Refractory Acute Myeloid Leukemia.
Anjali S. Advani, Brenda W. Cooper, Valeria Visconte, Paul Elson, Ricky Chan, Jennifer S. Carew, Wei Wei, Sudipto Mukherjee, Aaron T. Gerds, Hetty E. Carraway, Aziz Na...> ;Clinical Cancer Research. 2019 Jul 15
8 citations
Low-Dose Azacitidine with DNMT1 Level Monitoring to Treat Post-Transplantation Acute Myelogenous Leukemia or Myelodysplastic Syndrome Relapse
Masumi Ueda, Najla El-Jurdi, Brenda W. Cooper, Paolo Caimi, Linda Baer, Merle Kolk, Lauren Brister, David N. Wald, Folashade Otegbeye, Hillard M. Lazarus, Brenda M. Sa...> ;Biology of Blood and Marrow Transplantation. 2019 Jun 1
55 citations
The impact of the graft-versus-leukemia effect on survival in acute lymphoblastic leukemia
Moshe Yeshurun, Daniel J. Weisdorf, Jacob M. Rowe, Martin S. Tallman, Mei-Jie Zhang, Hai-Lin Wang, Wael Saber, Marcos de Lima, Brenda M. Sandmaier, Geoffrey L. Uy, Ram...> ;Blood Advances. 2019 Feb 26
1 citations
Comparison of Peripheral Blast Clearance and Day 14 Bone Marrow Biopsy in Predicting Remission Status and Survival After 7+3 Induction in Acute Myeloid Leukemia.
Fahrettin Covut, Divya Gupta, Raisa Pinto, Nina Dambrosio, Najla El Jurdi, Howard J. Meyerson, Masumi Ueda, Merle Kolk, Richard J. Creger, Leland Metheny, Brenda W. Co...> ;Clinical Lymphoma, Myeloma & Leukemia. 2019 Feb 1
29 citations
Comparative Analysis of Calcineurin Inhibitor-Based Methotrexate and Mycophenolate Mofetil-Containing Regimens for Prevention of Graft-versus-Host Disease After Reduce...
Saurabh Chhabra, Ying Liu, Michael T. Hemmer, Luciano J. Costa, Joseph Pidala, Daniel R. Couriel, Amin M. Alousi, Navneet S. Majhail, Robert K. Stuart, Dennis Dong Hwa...> ;Biology of Blood and Marrow Transplantation. 2019 Jan 1
10 citations
Low dose anti-thymocyte globulin reduces chronic graft-versus-host disease incidence rates after matched unrelated donor transplantation.
Anand Tandra, Fahrettin Covut, Brenda W. Cooper, Richard J. Creger, Lauren Brister, Bernadette McQuigg, Paolo Caimi, Ehsan Malek, Ben K. Tomlinson, Hillard M. Lazarus,...> ;Leukemia & Lymphoma. 2018 Jul 1
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Abstracts/Posters

Lymphoma-Specific Venous Thromboembolism Score (LyV-Score): Use of Lymphoma Subtype to Refine Risk Prediction
Brenda Cooper, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
A Double-Blind, Placebo-Controlled, Phase 3 Registration Trial to Evaluate the Efficacy of Uproleselan (GMI-1271) with Standard Salvage Chemotherapy in Patients with R...
Brenda Cooper, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Filgrastim Administered after Early Assessment Bone Marrow Biopsy during 7+3 Induction Therapy for Acute Myeloid Leukemia Reduces Length of Hospital Stay
Brenda Cooper, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Phase 1 Study of on Site Manufactured Anti-CD19 CAR-T Cells: Responses in Subjects with Rapidly Progressive Refractory Lymphomas
Brenda Cooper, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Inotuzumab Ozogamicin Post-Transplant for Acute Lymphocytic Leukemia
Brenda Cooper, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Preclinical Studies and Phase I Trial of Vactosertib in Combination with Pomalidomide in Relapsed Multiple Myeloma: A Corticosteroid-Free Approach By Targeting TGF-_ S...
Brenda Cooper, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
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Grant Support

SB-715992 In Acute LeukemiasNational Center For Research Resources2005–2006
Mechanism Based Phase I Trial Of Topotecan In LeukemiaNational Cancer Institute1999–2000
Sequential Topotecan &Etoposide For Patients With Myeloid LeukemiaNational Center For Research Resources1997–1999