BrendaJaneWeigelMD

Pediatric Hematology & Oncology • Minneapolis, MN

Associate Professor, Pediatrics, University of Minnesota Medical School

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Office
2450 Riverside Ave
Minneapolis, MN 55454
Phone+1 612-365-8100

Fax+1 612-365-8101
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Education & Training

University of MinnesotaFellowship, Pediatric Hematology/Oncology, 1996 - 2000
Michael G. DeGroote School of MedicineClass of 1993

Certifications & Licensure

MN State Medical License 2000 - 2024
American Board of Pediatrics Pediatrics

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
Super Doctor SuperDoctors.com

Clinical Trials

17-N-Allylamino-17-Demethoxygeldanamycin in Treating Young Patients With Relapsed or Refractory Solid Tumors or Leukemia Start of enrollment: 2004 Mar 01
Completed
Phase 1
High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma Start of enrollment: 2006 Jul 01
Completed
Phase 3
HSCT for High Risk Inherited Inborn Errors Start of enrollment: 2006 Sep 01
Completed
Phase 2
Yttrium Y 90 Anti-CD19 Antibody BU-12 in Patients With Advanced Relapsed or Refractory Acute Lymphoblastic Leukemia or Chronic Lymphocytic Leukemia Start of enrollment: 2008 Jan 01
Terminated
Phase 1
Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors Start of enrollment: 2009 Jan 01
Completed
Phase 2
Collecting and Storing Biological Samples From Patients With Ewing Sarcoma Start of enrollment: 2008 Feb 04
Completed
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma Start of enrollment: 1999 Mar 15
Completed
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 14
Active, not recruiting
Phase 3
Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Start of enrollment: 2010 Nov 22
Active, not recruiting
Phase 3
A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum Start of enrollment: 2012 Feb 01
Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission Start of enrollment: 2012 Feb 21
Active, not recruiting
Phase 3
Clofarabine, Cyclophosphamide and Etoposide for Minimal Residual Disease Positive Acute Leukemia Start of enrollment: 2013 Dec 01
Withdrawn
Phase 2
Cabozantinib S-Malate in Treating Younger Patients With Recurrent or Refractory Solid Tumors Start of enrollment: 2012 Nov 14
Completed
Phase 1
MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma Start of enrollment: 2013 Nov 01
Completed
Phase 1
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 01
A Study of Olaratumab (LY3012207) in Participants With Advanced Soft Tissue Sarcoma Start of enrollment: 2016 Mar 01
Completed
Phase 1, Phase 2
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Publications & Presentations

PubMed

Sex differences in osteosarcoma survival across the age spectrum: A National Cancer Database analysis (2004-2016).
Lindsay A Williams, Sofia Barragan, Zhanni Lu, Logan G Spector, Brenda J Weigel> ;Cancer Epidemiology. 2024 Apr 3
A phase 1 trial utilizing a pharmacokinetic endpoint to determine the optimal dose of ramucirumab in children and adolescents with relapsed or refractory solid tumors,...
Kristy L Pilbeam, Kamnesh Pradhan, James Croop, Charles G Minard, Xiaowei Liu, Stephan D Voss, Emasenyie Isikwei, Stacey L Berg, Joel M Reid, Elizabeth Fox, Brenda J W...> ;Pediatric Blood & Cancer. 2024 Mar 1
1 citations
Feasibility of pevonedistat combined with azacitidine, fludarabine, cytarabine in pediatric relapsed/refractory AML: Results from COG ADVL1712.
Katherine Tarlock, Xiaowei Liu, Emasenyie A Isikwei, Joel M Reid, Terzah M Horton, Elizabeth Fox, Brenda J Weigel, Todd Cooper, Minard, C.> ;Pediatric Blood & Cancer. 2023 Dec 1
Children's Oncology Group's 2023 blueprint for research: Developmental therapeutics.
Elizabeth Fox, D Williams Parsons, Brenda J Weigel> ;Pediatric Blood & Cancer. 2023 Sep 1
A pilot study evaluating the use of sirolimus in children and young adults with desmoid-type fibromatosis.
Aaron R Weiss, Sarah Dry, Clara Maygar, Anya Cutler, Christine W Lary, Carmen Khoo, Jillian E Fergione, Melanie M Hounchell, Kathleen Glick, Meghen Browning, Sun Ha Ch...> ;Pediatric Blood & Cancer. 2023 Jun 7
Rhabdomyosarcoma with isolated lung metastases: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group.
Juan C Vasquez, Leo Y Luo, Susan M Hiniker, Daniel S Rhee, Roshni Dasgupta, Sonja Chen, Brenda J Weigel, Wei Xue, Rajkumar Venkatramani, Carola A Arndt> ;Pediatric Blood & Cancer. 2023 Jun 1
11 citations
A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Kara L Davis, Elizabeth Fox, Emasenyie Isikwei, Joel M Reid, Xiaowei Liu, Charles G Minard, Stephan Voss, Stacey L Berg, Brenda J Weigel, Crystal L Mackall> ;Clinical Cancer Research. 2022 Dec 1
4 citations
Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors: ACCELERATE in collaboration with the European Medic...
Andrew Dj Pearson, Carl Allen, Jason Fangusaro, Caroline Hutter, Olaf Witt, Susan Weiner, Gregory Reaman, Mark Russo, Pratiti Bandopadhayay, Sama Ahsan, Amy Barone, El...> ;European Journal of Cancer. 2022 Dec 1
5 citations
ACCELERATE Paediatric Strategy Forums: an advance for oncological drug development?
Andrew D J Pearson, Teresa de Rojas, Dominik Karres, Gregory Reaman, Nicole Scobie, Elizabeth Fox, Giovanni Lesa, Franca Ligas, Koen Norga, Karsten Nysom, Alberto Papp...> ;The Lancet. Oncology. 2022 Nov 1
6 citations
Paediatric Strategy Forum for medicinal product development of multi-targeted kinase inhibitors in bone sarcomas: ACCELERATE in collaboration with the European Medicin...
Andrew Dj Pearson, Nathalie Gaspar, Katherine Janeway, Quentin Campbell-Hewson, Elizabeth R Lawlor, Chris Copland, Dominik Karres, Koen Norga, Fawzi Benzaghou, Susan W...> ;European Journal of Cancer. 2022 Sep 1
Congenital Infantile Fibrosarcoma Involving Pelvic Wall and Thigh Soft Tissues and Placenta, Presenting with Coagulopathy.
Brianna Naumchik, Brenda J Weigel, Michael A Murati, Erin Rudzinski, Christina M Lockwood, Michelle Dolan, Siobhan Flanagan, Mark Luquette, Paulson, V.> ;Pediatric and Developmental Pathology. 2022 Jul 14
3 citations
Wee1 kinase inhibitor adavosertib with radiation in newly diagnosed diffuse intrinsic pontine glioma: A Children's Oncology Group phase I consortium study.
Sabine Mueller, Tabitha Cooney, Xiaodong Yang, Sharmistha Pal, Ralph Ermoian, Amar Gajjar, Xiaowei Liu, Komal Prem, Charles G Minard, Joel M Reid, Marvin Nelson, Daphn...> ;Neuro-Oncology Advances. 2022 May 20
23 citations
ACCELERATE - Five years accelerating cancer drug development for children and adolescents.
Andrew D J Pearson, Susan L Weiner, Peter C Adamson, Dominik Karres, Gregory Reaman, Raphaël Rousseau, Patricia Blanc, Koen Norga, Jeffrey Skolnik, Pam Kearns, Nicole ...> ;European Journal of Cancer. 2022 May 1
13 citations
Successful management of an arteriovenous malformation with trametinib in a patient with capillary-malformation arteriovenous malformation syndrome and cardiac comprom...
Cynthia L Nicholson, Siobhan Flanagan, Michael Murati, Christina Boull, Erin McGough, Rebecca Ameduri, Brenda Weigel, Sheilagh Maguiness> ;Pediatric Dermatology. 2022 Mar 1
16 citations
Paediatric Strategy Forum for medicinal product development of chimeric antigen receptor T-cells in children and adolescents with cancer: ACCELERATE in collaboration w...
Andrew D.J. Pearson, Claudia Rossig, Crystal L. Mackall, Nirali N. Shah, André Baruchel, Gregory H. Reaman, Rosanna Ricafort, Delphine Heenen, Abraham Bassan, Michael ...> ;European Journal of Cancer. 2021 Nov 25
32 citations
Second Paediatric Strategy Forum for anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies: ACCELERATE in collaboration with the European Medicines Ag...
Andrew D.J. Pearson, Elly Barry, Yael P. Mosse, Franca Ligas, Nick Bird, Teresa de Rojas, Zachary Franklin Zimmerman, Keith D. Wilner, Willi Woessmann, Susan L. Weiner...> ;European Journal of Cancer. 2021 Sep 15
5 citations
Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning.
Kelly M. Makielski, Alicia J. Donnelly, Ali Khammanivong, Milcah C. Scott, Andrea R Ortiz, Dana C. Galvan, Hirotaka Tomiyasu, Clarissa N. Amaya, K.A. Ward, Alexa Monto...> ;Laboratory Investigation; a Journal of Technical Methods and Pathology. 2021 Sep 6
20 citations
Phase 1/2 Trial of Vorinostat and Radiation and Maintenance Vorinostat in Children with Diffuse Intrinsic Pontine Glioma: A Children's Oncology Group Report.
Jack Su, Lindsay Kilburn, David B Mansur, Mark Krailo, Allen Buxton, Adesina Adekunle, Amar Gajjar, Peter C Adamson, Brenda J. Weigel, Elizabeth Fox, Susan M. Blaney, ...> ;Neuro-Oncology. 2021 Aug 4
4 citations
Toxicity and pharmacokinetics of actinomycin-D and vincristine in children and adolescents: Children's Oncology Group Study ADVL06B1.
Jeffrey M. Skolnik, David Hall, Donald A. Barkauskas, Ganesh S. Moorthy, Thomas R. Larson, Elizabeth Fox, Brenda J. Weigel, Stacey L. Berg, Joel M. Reid> ;Cancer Chemotherapy and Pharmacology. 2021 May 22
15 citations
A phase 1 study of prexasertib (LY2606368), a CHK1/2 inhibitor, in pediatric patients with recurrent or refractory solid tumors, including CNS tumors: A report from th...
Thomas Cash, Elizabeth Fox, Xiaowei Liu, Charles G. Minard, Joel M. Reid, Adrienne C. Scheck, Brenda J. Weigel, Cynthia Wetmore> ;Pediatric Blood & Cancer. 2021 Apr 21
49 citations
Activity of Crizotinib in Patients with ALK-Aberrant Relapsed/Refractory Neuroblastoma: A Children's Oncology Group Study (ADVL0912)
Jennifer Foster, Stephan D. Voss, David Hall, Charles G. Minard, Frank M. Balis, Keith D. Wilner, Stacey L. Berg, Elizabeth Fox, Peter C. Adamson, Susan M. Blaney, Bre...> ;Clinical Cancer Research. 2021 Feb 10
1 citations
Phase 1 trial of olaratumab monotherapy and in combination with chemotherapy in pediatric patients with relapsed/refractory solid and central nervous system tumors
Leo Mascarenhas, Chitose Ogawa, Theodore W. Laetsch, Brenda J. Weigel, Michael W. Bishop, Julie Krystal, Scott C. Borinstein, Emily K. Slotkin, Jodi A. Muscal, Pooja H...> ;Cancer Medicine. 2021 Jan 20
15 citations
A phase 1 study of entinostat in children and adolescents with recurrent or refractory solid tumors, including CNS tumors: Trial ADVL1513, Pediatric Early Phase-Clinic...
Andrew Bukowinski, Bill H. Chang, Joel M. Reid, Xiaowei Liu, Charles G. Minard, Jane B. Trepel, Min-Jung Lee, Elizabeth Fox, Brenda J. Weigel> ;Pediatric Blood & Cancer. 2021 Jan 12
18 citations
Metabolic response as assessed by 18 F-fluorodeoxyglucose positron emission tomography-computed tomography does not predict outcome in patients with intermediate- or h...
Douglas J. Harrison, Yueh-Yun Chi, Jing Tian, Pooja Hingorani, Leo Mascarenhas, Geoffrey McCowage, Brenda J. Weigel, Rajkumar Venkatramani, Suzanne L. Wolden, Torunn I...> ;Cancer Medicine. 2021 Feb 1
17 citations
ADVL1522: A phase 2 study of lorvotuzumab mertansine (IMGN901) in children with relapsed or refractory wilms tumor, rhabdomyosarcoma, neuroblastoma, pleuropulmonary bl...
James I. Geller, Joseph G. Pressey, Malcolm A. Smith, Rachel A. Kudgus, Mariana M. Cajaiba, Joel M. Reid, David Hall, Donald A. Barkauskas, Stephen D. Voss, Steve Y. C...> ;Cancer. 2020 Dec 15
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Press Mentions

TWiPO #93: CureWorks & Caring Cross: Pathways to Advance Cell & Gene Therapy with Dr. Rimas OrentasJanuary 20th, 2022
Best of the Best: Minnesota Monthly Honors over 400 of Our Physicians as 2021 “Top Doctors”August 26th, 2021
Bringing the Best to You: Hundreds Honored as “Top Doctors” by Minnesota Monthly in 2020August 27th, 2020
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