BrentonGarrettMarMDPhD

PubMed

• 1 citations
  Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
  Andreas Varkaris, Ermira Pazolli, Hakan Gunaydin, Qi Wang, Levi Pierce, Alessandro A Boezio, Artemisa Bulku, Lucian DiPietro, Cary Fridrich, Adam Frost, Fabrizio Giord...> ;Cancer Discovery. 2024 Feb 8
• 1 citations
  Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.
  Paolino, J., Dimitrov, B., Apsel Winger, B., Sandoval-Perez, A., Rangarajan, A., Ocasio-Martinez, N., Tsai, H., Li, Y., Robichaud, A., Khalid, D., Hatton, C., Gillani,...> ;Clinical Cancer Research. 2023 Nov 14
• 5 citations
  Avapritinib versus Placebo in Indolent Systemic Mastocytosis.
  Gotlib, J., Castells, M., Elberink, H., Siebenhaar, F., Hartmann, K., Broesby-Olsen, S., George, T., Panse, J., Alvarez-Twose, I., Radia, D., Tashi, T., Bulai Lividean...> ;NEJM Evidence. 2023 Jun 1
• Psychometric evaluation of the Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF) and determination of a threshold score for moderate symptoms.
  Alan L Shields, Fiona Taylor, Roger E Lamoureux, Brad Padilla, Kas Severson, Tanya Green, Anthony L Boral, Cem Akin, Frank Siebenhaar, Brenton Mar> ;Orphanet Journal of Rare Diseases. 2023 Mar 25
• 58 citations
  Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial.
  DeAngelo, D., Radia, D., George, T., Robinson, W., Quiery, A., Drummond, M., Bose, P., Hexner, E., Winton, E., Horny, H., Tugnait, M., Schmidt-Kittler, O., Evans, E., ...> ;Nature Medicine. 2021 Dec 1
• 4 citations
  Psychometric evaluation of the Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF) in a phase 2 clinical study.
  Brad Padilla, Alan L. Shields, Fiona Taylor, Xiaoran Li, Jeffrey G. McDonald, Tanya Green, Anthony L. Boral, Hui-Min Lin, Cem Akin, Frank Siebenhaar, Brenton G. Mar> ;Orphanet Journal of Rare Diseases. 2021 Oct 18
• 7 citations
  Development of symptom-focused outcome measures for advanced and indolent systemic mastocytosis: the AdvSM-SAF and ISM-SAF©.
  Fiona Taylor, Cem Akin, Roger E. Lamoureux, Brad Padilla, Tanya Green, Anthony L. Boral, Iyar Mazar, Brenton G. Mar, Alan L. Shields, Frank Siebenhaar> ;Orphanet Journal of Rare Diseases. 2021 Oct 9
• 5 citations
  Psychometric evaluation of the Advanced Systemic Mastocytosis Symptom Assessment Form (AdvSM-SAF).
  Fiona Taylor, Xiaoran Li, Christine Yip, Brad Padilla, Brenton G. Mar, Tanya Green, Ronny G. Oren, Anthony L. Boral, Hui-Min Lin, Alan L. Shields, Jason Gotlib> ;Leukemia Research. 2021 May 1
• Whole exome sequencing of a breast tumor in a patient with Diamond Blackfan anemia.
  Anupama Narla, Kathryn J. Ruddy, Benjamin L. Ebert, Brenton G. Mar> ;Blood Cells, Molecules & Diseases. 2021 Apr 1
• 130 citations
  PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells.
  Josephine Kahn, Peter Miller, Alexander J. Silver, Rob S. Sellar, Shruti Bhatt, Christopher J. Gibson, Marie McConkey, Dylan N. Adams, Brenton G. Mar, Philipp Mertins,...> ;Blood. 2018 Sep 13
• 84 citations
  SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia
  Brenton G. Mar, S. Haihua Chu, Josephine Kahn, Andrei V. Krivtsov, Richard Koche, Cecilia A. Castellano, Jacob L. Kotlier, Rebecca L. Zon, Marie McConkey, Jonathan Cha...> ;Blood. 2017 Dec 14
• 41 citations
  The relative utilities of genome-wide, gene panel, and individual gene sequencing in clinical practice
  Frank C. Kuo, Brenton G. Mar, R. Coleman Lindsley, Neal I. Lindeman> ;Blood. 2017 Jul 27
• 68 citations
  Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations
  Ram Ajore, David M. Raiser, Marie McConkey, Magnus Jöud, Bernd Boidol, Brenton G. Mar, Gordon Saksena, David M. Weinstock, Scott A. Armstrong, Steven R. Ellis, Benjami...> ;EMBO Molecular Medicine. 2017 Apr 1
• 465 citations
  Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation.
  R. Coleman Lindsley, Wael Saber, Brenton G. Mar, Robert A. Redd, Tao Wang, Michael D. Haagenson, Peter V. Grauman, Zhen-Huan Hu, Stephen R. Spellman, Stephanie J. Lee,...> ;The New England Journal of Medicine. 2017 Feb 8
• 61 citations
  The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.
  Hubo Li, Brenton G. Mar, Huadi Zhang, Rishi V. Puram, Francisca Vazquez, Barbara A. Weir, William C. Hahn, Benjamin L. Ebert, David Pellman> ;Blood. 2017 Jan 26
• 34 citations
  Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia.
  Patrick Bhola, Brenton G. Mar, R. Coleman Lindsley, Jeremy Ryan, Leah Hogdal, Thanh Trang T. Vo, Daniel J. DeAngelo, Ilene Galinsky, Benjamin L. Ebert, Anthony Letai> ;The Journal of Clinical Investigation. 2016 Oct 3
• 617 citations
  Acute myeloid leukemia ontogeny is defined by distinct somatic mutations
  R. Coleman Lindsley, Brenton G. Mar, Emanuele Mazzola, Peter V. Grauman, Sarah Shareef, Steven L. Allen, Arnaud Pigneux, Meir Wetzler, Robert K. Stuart, Harry P. Erba,...> ;Blood. 2015 Feb 26
• 2752 citations
  Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
  Siddhartha Jaiswal, Pierre Fontanillas, Jason Flannick, Alisa K. Manning, Peter V. Grauman, Brenton G. Mar, R. Coleman Lindsley, Craig H. Mermel, Noël P. Burtt, Alejan...> ;The New England Journal of Medicine. 2014 Dec 24
• 292 citations
  Somatic Mutations Predict Poor Outcome in Patients With Myelodysplastic Syndrome After Hematopoietic Stem-Cell Transplantation
  Rafael Bejar, Kristen E. Stevenson, Bennett A. Caughey, R. Coleman Lindsley, Brenton G. Mar, Petar Stojanov, Gad Getz, David P. Steensma, Jerome Ritz, Robert J. Soiffe...> ;Journal of Clinical Oncology. 2014 Sep 1
• 147 citations
  Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia
  Brenton G. Mar, Lars Bullinger, Kathleen M. McLean, Peter V. Grauman, Marian H. Harris, Kristen E. Stevenson, Donna Neuberg, Amit U. Sinha, Stephen E. Sallan, Lewis B....> ;Nature Communications. 2014 Mar 24
• 62 citations
  Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia.
  Brenton G. Mar, Lars Bullinger, E Basu, Krysta D. Schlis, Lewis B. Silverman, Konstanze Döhner, Scott A. Armstrong> ;Leukemia. 2012 Mar 1
• 34 citations
  Self-renewal related signaling in myeloid leukemia stem cells
  Florian H. Heidel, Brenton G. Mar, Scott A. Armstrong> ;International Journal of Hematology. 2011 Jul 29
• 48 citations
  The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis.
  B G Mar, D Amakye, Iannis Aifantis, Silvia Buonamici> ;Leukemia. 2011 Jun 10
• 200 citations
  CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
  Silvia Buonamici, Thomas Trimarchi, Maria Grazia Ruocco, Linsey Reavie, Séverine Cathelin, Brenton G. Mar, Apostolos Klinakis, Yevgeniy Lukyanov, Jen-Chieh Tseng, Fili...> ;Nature. 2009 Jun 18
• 16 citations
  Membrane-associated and secreted genes in breast cancer
  Nathan O. Stitziel, Brenton G. Mar, Jie Liang, Carol A. Westbrook> ;Cancer Research. 2004 Dec 1
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Journal Articles

• PPM1D Truncating Mutations Confer Resistance to Chemotherapy and Sensitivity to PPM1D Inhibition in Hematopoietic Cells  
  Peter G Miller, Brenton Mar, Benjamin L Ebert, Shaunt Fereshetian, Anthony Letai, Siddhartha Jaiswal, Blood