Brian P Brooks MD PhD

Pediatric & Strabismus

Chief, Ophthalmic Genetics & Visual Function Branch National Eye Insitute, NIH

10 Center DriveBldg. 10, Rm. 10N109, MSC 1860Bethesda, MD 20892
Phone+1 301-496-3577
Fax+1 301-402-1214

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Education & Training

National Institutes of Health Clinical CenterResidency, Medical Genetics and Genomics, 2002 - 2004
University of Michigan Health SystemResidency, Ophthalmology, 1998 - 2001
Graduate HospitalInternship, Internal Medicine, 1997 - 1998
Perelman School of Medicine at the University of PennsylvaniaClass of 1997
University of Michigan Health SystemFellowship, Pediatric Ophthalmology

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A self-designated specialty, subspecialty, or practice area neither implies nor is equivalent to ABMS board certification or the existence of specialized training by or competence of a physician or medical specialist.

Certifications & Licensure

DC State Medical License 2004 - 2027
MI State Medical License 1998 - 2005
PA State Medical License 1997 - 1998
American Board of Ophthalmology Ophthalmology
American Board of Medical Genetics and Genomics Clinical Genetics and Genomics

Clinical Trials

Family Studies of Uveal Coloboma Start of enrollment: 2006 Jul 28
Terminated
Repository for Inherited Eye Diseases Start of enrollment: 2006 Sep 20
COMPLETED
Cell Collection to Study Eye Diseases Start of enrollment: 2011 Sep 07
RECRUITING

Publications & Presentations

PubMed

A peripheral subpopulation of retinal pigment epithelium resists oxidative damage through SERPINE3-mediated Caspase-1 inhibition.
Huirong Li, Takerra Johnson-Stephenson, Vincent P Kunze, Wei Yan, David M McGaughey
The Journal of Clinical Investigation. 2026-07-07
Ampyrone is a direct agonist of human tyrosinase and a potential therapeutic for hypopigmentation disorders.
Monika B Dolinska, Yuhong A Wang, Nathan P Coussens, Vijay K Kalaskar, Zuhal Eraslan
JCI Insight. 2026-06-18
Gene therapy induces pigmentation in induced pluripotent stem cell-derived retinal pigment epithelium of OCA1A patients and albino rat eye.
Aman George, Arnold Leigh, Evan Selzer, Tyler Pfister, Charles DeYoung
Molecular Therapy. Advances. 2026-06-11

Journal Articles

The Henle Fiber Layer in Albinism: Comparison to Normal and Relationship to Outer Nuclear Layer Thickness and Foveal Cone Density
Daniel J Lee, Brian P Brooks, Brandon J Lujan, Investigative Ophthalmology and Visual Science
Minimal Efficacy of Nitisinone Treatment in a Novel Mouse Model of Oculocutaneous Albinism, Type 3
Jessica S Albert, Brian P Brooks, Investigative Ophthalmology and Visual Science

Press Mentions

Discovery Could Lead to Drug Therapy for Hypopigmentation ConditionsJuly 14th, 2026
COVID Vaccine Live Updates: Here’s What to Know in North Carolina on Nov. 2November 2nd, 2021
COVID Vaccine Live Updates: Here’s What to Know in North Carolina on Nov. 1November 1st, 2021

Grant Support

Microphthalmia, Anophthalmia, and Coloboma Genetic Epidemiology in Children (MAGIC) StudyEMORY UNIVERSITY2021–2026
The Genetics Of Uveal ColobomaNational Eye Institute2009–2011
Pre-Clinical Studies Of NTBC As A Potential Treatment For AlbinismNational Eye Institute2009–2011
Ophthalmic Genetics FellowshipNational Eye Institute2009–2011
Crx-Mediated Leber Congenital AmaurosisNational Eye Institute2009–2010