Brian Jesse Debosch MD PhD
Professor and Co-Division Chief, Gastroenterology, Hepatology and Nutrition, Indiana University Health
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705 Riley Hospital Dr,Indianapolis, IN 46202
Phone+1 317-944-2060
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Education & Training
Washington University/B-JH/SLCH ConsortiumFellowship, Pediatric Gastroenterology, 2010 - 2013- Washington University/B-JH/SLCH ConsortiumResidency, Pediatrics, 2008 - 2010
Washington University in St. LouisPh.D., Molecular Cell Biology, 2001 - 2008- WashU MedicineClass of 2008
- University of Michigan Medical SchoolBS, Cellular & Molecular Biology, Summa Cum Laude, 1997 - 2001
Awards, Honors, & Recognition
- Robert Wood Johnson Foundation Scholar Amos Medical Faculty Development Program, 2016
- Recognition Award St. Louis Children's Hosptial, 2015
- Scholars Award in Liver Disease American Gastroenterological Association / Gilead Sciences Research, 2015
Publications & Presentations
PubMed
- Breath volatile profiling reveals a diagnostic signature of MASLD in children.Amalia Z Berna, Jennifer Panganiban, Yang Liu, Joey Logan, Pierre Russo
Medrxiv. 2026-05-27 - Precision Xenogenomics: A Major Milestone in Bridging the Organ Gap.Harmeet Malhi, Brian J DeBosch
Gastroenterology. 2026-05-23 - Beyond the Alpha and Omega: Redefining the Peroxisome Proliferator-Activated Receptor α Gut-Liver Axis in Intestinal Failure-Associated Liver Disease.Chaowapong Jarasvaraparn, Brian J Debosch, Abigail E Russi
Cellular and Molecular Gastroenterology and Hepatology. 2026-05-05
Abstracts/Posters
- Transmissible Protection From Fructose Induced Hepatic Steatosis Using Microbiota From Mice With Defective Intestinal Chylomicron ProductionYan Xie, Hitoshi Matsumoto, Susan Kennedy, Brian J. DeBosch, Kelle H. Moley, Yanjiao Zhou, Phillip I. Tarr, Nicholas O. Davidson, American Gastroenterological Association Digestive Diseases Week, San Diego, CA, 1/1/2016
- GLUT8 (SLC2A8) Is a Mammalian Trehalose Transporter Required for Trehalose-Induced Autophagy.Brian DeBosch, Allyson L Mayer, Monique R Heitmeier, Paul Hruz and Cassandra B Higgins., American Gastroenterological Association Digestive Diseases Week, San Diego, CA, 1/1/2016
- Trehalose inhibits SLC2A Proteins to induce autophagy and prevent hepatic steatosis.BJ DeBosch, M Heitmeier, AL Mayer, CB Higgins, M Chi, K Yarasheski, J Crowley, Z Chen, BN Finck, PW Hruz, KH Moley., Midwest DDRCC Symposium, Washington University, St. Louis, MO, 1/1/2015
Lectures
- Trehalose, Cellular Action and Therapeutic Possibilities1/1/2016
- Treatment for Pediatric NAFLD: Sweet new therapies are coming through the portal!Washington University School of Medicine - 1/1/2015
- Spontaneous, Early-Onset Metabolic Syndrome in Mice Lacking the Enterocyte Urate Transporter1/1/2014
Press Mentions
Study Reveals New Insights into Urea Cycle's Role in Fatty Liver DiseaseAugust 15th, 2024- New Research Explores the Urea Cycle’s Strong Connection to Fatty Liver DiseaseAugust 14th, 2024
- Drug Mimics Beneficial Effects of Fasting in MiceJanuary 19th, 2022
Grant Support
- Leveraging arginase biology against metabolic diseaseINDIANA UNIVERSITY INDIANAPOLIS2023–2027
- Treating secondary cardiomyopathies by mimicking the adaptive hepatic glucose fasting responseINDIANA UNIVERSITY INDIANAPOLIS2025
- Leveraging glucose transport and the adaptive fasting response to modulate hepatic metabolismINDIANA UNIVERSITY INDIANAPOLIS2021–2025
- Leveraging glucose transport and the adaptive fasting response to modulate hepatic metabolismINDIANA UNIVERSITY INDIANAPOLIS2021–2025
Professional Memberships
- American Society for Clinical Investigation (ASCI)Member
- Society for Pediatric ResearchMember
- Member
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