BrianAlexanderJohnsMD

PubMed

• 10 citations
  The safety, tolerability, and pharmacokinetic profile of GSK2838232, a novel 2nd generation HIV maturation inhibitor, as assessed in healthy subjects.
  Mark Johnson, Roxanne C. Jewell, Amanda Peppercorn, Elizabeth Gould, Jianfeng Xu, Yu Lou, Matt Davies, Sandra J. Baldwin, Allan R Tenorio, Matthew Burke, Jerry Jeffrey...> ;Pharmacology Research & Perspectives. 2018 Jun 5
• 13 citations
  Synthesis and Biological Evaluation of Macrocyclized Betulin Derivatives as a Novel Class of Anti-HIV-1 Maturation Inhibitors.
  Jun Tang, Stacey A. Jones, Jerry L. Jeffery, Sonia R. Miranda, Cristin M. Galardi, David M. Irlbeck, Kevin W. Brown, Charlene B. McDanal, Nianhe Han, Daxin Gao, Yongyo...> ;The Open Medicinal Chemistry Journal. 2014 Sep 3
• 10 citations
  Pyridopyrimidinone inhibitors of HIV-1 RNase H
  Emile Johann Velthuisen, Brian A. Johns, Peter Gerondelis, Yan Chen, Ming Li, Ke Mou, Wenwen Zhang, John W. Seal, Kendra E. Hightower, Sonia R. Miranda, Kevin K. Brown...> ;European Journal of Medicinal Chemistry. 2014 Aug 18
• 34 citations
  Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase
  Andrew Maynard, Renae M. Crosby, Byron Ellis, Robert Hamatake, Zhi Hong, Brian A. Johns, Kirsten M. Kahler, Cecilia S. Koble, Anna L. Leivers, Martin Robert Leivers, A...> ;Journal of Medicinal Chemistry. 2014 Mar 13
• 111 citations
  Carbamoyl Pyridone HIV-1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572)...
  Brian A. Johns, Takashi Kawasuji, Teruhiko Taishi, David Temelkoff, Hiroshi Yoshida, Akiyama Toshiyuki, Yoshiyuki Taoda, Hitoshi Murai, Ryuichi Kiyama, Masahiro Fuji, ...> ;Journal of Medicinal Chemistry. 2013 Jul 11
• 12 citations
  Synthesis and pharmacokinetic profile of highly deuterated brecanavir analogs.
  Emile Johann Velthuisen, Todd M. Baughman, Brian A. Johns, David Temelkoff> ;European Journal of Medicinal Chemistry. 2013 May 1
• 10 citations
  Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.
  Brian A. Johns, Takashi Kawasuji, Eric E. Boros, James B. Thompson, Cecilia S. Koble, Edward P. Garvey, Scott A. Foster, Jerry Jeffrey, Tamio Fujiwara> ;Bioorganic & Medicinal Chemistry Letters. 2013 Jan 15
• 5 citations
  Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors
  Brian A. Johns, Takashi Kawasuji, Eric E. Boros, James B. Thompson, Edward P. Garvey, Scott A. Foster, Jerry Jeffrey, Wayne H. Miller, Noriyuki Kurose, Kenichi Matsumu...> ;Bioorganic & Medicinal Chemistry Letters. 2011 Nov 1
• 32 citations
  1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position.
  Brian A. Johns, Scott H. Allen, James B. Thompson, Edward P. Garvey, Scott A. Foster, Jerry Jeffrey, Wayne H. Miller> ;Bioorganic & Medicinal Chemistry Letters. 2009 Mar 15
• 55 citations
  The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.
  Brian A. Johns, Scott H. Allen, James B. Thompson, Edward P. Garvey, Scott A. Foster, Jerry Jeffrey, Wayne H. Miller> ;Bioorganic & Medicinal Chemistry Letters. 2009 Mar 15
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