BrianCLewisMD

PubMed

• 26 citations
  IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis.
  Mihir Rajurkar, Kyvan Dang, Maite G. Fernandez-Barrena, Xiangfan Liu, Martin E. Fernandez-Zapico, Brian C. Lewis, Junhao Mao> ;Cancer Research. 2017 Jan 15
• 55 citations
  mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
  David R. Driscoll, Saadia A. Karim, Makoto Sano, Wright Jacob, Jun Yu, Yusuke Mizukami, Aarthi Gopinathan, Duncan I. Jodrell, T.R. Jeffry Evans, Nabeel Bardeesy, Micha...> ;Cancer Research. 2016 Dec 1
• 44 citations
  Activation of WNT/β-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61
  Makoto Sano, David R. Driscoll, Wilfredo E. DeJesus-Monge, Brian Quattrochi, Victoria A. Appleman, Jianhong Ou, Lihua Julie Zhu, Nao Yoshida, Shintaro Yamazaki, Tadato...> ;Neoplasia. 2016 Dec 1
• 24 citations
  A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination
  Leanne G. Ahronian, Lihua Julie Zhu, Ya-Wen Chen, Hsiao-Chien Chu, David S. Klimstra, Brian C. Lewis> ;Oncogene. 2016 Sep 1
• 5 citations
  The p53R172H mutant does not enhance hepatocellular carcinoma development and progression.
  Leanne G. Ahronian, David R. Driscoll, David S. Klimstra, Brian C. Lewis> ;Plos One. 2015 Apr 17
• 99 citations
  MicroRNA-378 controls classical brown fat expansion to counteract obesity
  Dongning Pan, Chunxiao Mao, Brian Quattrochi, Randall H. Friedline, Lihua Julie Zhu, Dae Young Jung, Jason K. Kim, Brian C. Lewis, Yong-Xu Wang> ;Nature Communications. 2014 Aug 22
• 31 citations
  Activated Wnt Signaling in Stroma Contributes to Development of Pancreatic Mucinous Cystic Neoplasms
  Makoto Sano, David R. Driscoll, Wilfredo E. De Jesus-Monge, David S. Klimstra, Brian C. Lewis> ;Gastroenterology. 2014 Jan 1
• Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleo-cytoplasmic shuttling.
  Jiao, B.,Taniguchi-Ishigaki, N.,Güngör, C.,Peters, M. A.,Chen, Y. W.,Riethdorf, S.,Drung, A.,Ahronian, L. G.,Shin, J.,Pagnis, R.,Pantel, K.,Tachibana, T.,Lewis, B. C.,...> ;Mol. Biol. Cell. 2013 Oct
• Racial disparities in travel time to radiotherapy facilities in the Atlanta metropolitan area.
  Peipins, L. A.,Graham, S.,Young, R.,Lewis, B.,Flanagan, B.> ;Soc Sci Med. 2013 Jul
• 137 citations
  TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPα function.
  Jiayi Wang, Joo-Seop Park, Yingying Wei, Mihir Rajurkar, Jennifer L. Cotton, Qishi Fan, Brian C. Lewis, Hongkai Ji, Junhao Mao> ;Molecular Cell. 2013 Jul 25
• Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development.
  Huang, H.,Cotton, J. L.,Wang, Y.,Rajurkar, M.,Zhu, L. J.,Lewis, B. C.,Mao, J.> ;J. Biol. Chem.. 2013 Jun 14
• 20 citations
  KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling.
  Victoria A. Appleman, Leanne G. Ahronian, JiuFeng Cai, David S. Klimstra, Brian C. Lewis> ;Molecular Cancer Research. 2012 Sep 1
• 48 citations
  Differential Roles of Insulin-like Growth Factor Receptor- and Insulin Receptor-mediated Signaling in the Phenotypes of Hepatocellular Carcinoma Cells
  Ya-Wen Chen, Victor L. Boyartchuk, Brian C. Lewis> ;Neoplasia. 2009 Sep 1
• 34 citations
  Lentivirus-Mediated Oncogene Introduction into Mammary Cells In Vivo Induces Tumors
  Stefan K. Siwko, Wen Bu, Carolina Gutierrez, Brian C. Lewis, Martin Jechlinger, Brian Schaffhausen, Yi Li> ;Neoplasia. 2008 Jul 1
• 24 citations
  Trp53 Deletion Stimulates the Formation of Metastatic Pancreatic Tumors
  Jennifer P. Morton, David S. Klimstra, Michelle E. Mongeau, Brian C. Lewis> ;The American Journal of Pathology. 2008 Apr 1
• 50 citations
  p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein.
  Ya-Wen Chen, Seema Paliwal, Kyle M. Draheim, Steven R. Grossman, Brian C. Lewis> ;Cancer Research. 2008 Jan 15
• 60 citations
  Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion.
  Yi-Chieh Nancy Du, Brian C. Lewis, Douglas Hanahan, Harold E. Varmus> ;Plos Biology. 2007 Oct 16
• The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor.
  Paliwal, S., Kovi, R.C., Nath, B., Chen, Y., Lewis, B.C., Grossman, S.R.> ;Cancer Res. 2007 Oct 1
• 50 citations
  Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells.
  Ya-Wen Chen, David S. Klimstra, Michelle E. Mongeau, Jessica L. Tatem, Victor L. Boyartchuk, Brian C. Lewis> ;Cancer Research. 2007 Aug 15
• Shh signaling and pancreatic cancer: implications for therapy?
  Morton, J.P., Lewis, B.C.> ;Cell Cycle. 2007 Jul 1
• Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.
  Morton, J.P., Mongeau, M.E., Klimstra, D.S., Morris, J.P., Lee, Y.C., Kawaguchi, Y., Wright, C.E., Hebrok, M., Lewis, B.C.> ;Proc Natl Acad Sci U S A. 2007 Mar 20
• 5 citations
  Development of the Pancreas and Pancreatic Cancer
  Brian C. Lewis> ;Endocrinology and Metabolism Clinics of North America. 2006 Jun 1
• The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma.
  Lewis, B. C.,Klimstra, D. S.,Socci, N. D.,Xu, S.,Koutcher, J. A.,Varmus, H. E.> ;Mol Cell Biol. 2005 Feb
• The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer.
  Lewis, B.C., Klimstra, D.S., Varmus, H.E.> ;Genes Dev. 2003 Dec 15
• 49 citations
  A Novel c-Myc- responsive Gene, JPO1, Participates in Neoplastic Transformation
  Julia E. Prescott, Rebecca C. Osthus, Linda A. Lee, Brian C. Lewis, Hyunsuk Shim, John Barrett, Qingbin Guo, Anita L. Hawkins, Constance A. Griffin, Chi V. Dang> ;The Journal of Biological Chemistry. 2001 Dec 21
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