BrianLucasMD

PubMed

• 26 citations
  An expeditious synthesis of the MDM2-p53 inhibitor AM-8553.
  Brian Lucas, Benjamin Fisher, Lawrence R. McGee, Steven H. Olson, Julio C. Medina, Eugene Cheung> ;Journal of the American Chemical Society. 2012 Jul 16
• 15 citations
  Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit
  Matthew L. Brown, Wade Aaron, Richard J. Austin, Angela Chong, Tom Huang, Ben Jiang, Jacob Kaizerman, Gary Lee, Brian Lucas, Dustin McMinn, Jessica Orf, Minqing Rong, ...> ;Bioorganic & Medicinal Chemistry Letters. 2011 Sep 15
• 13 citations
  Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines
  Jacob Kaizerman, Wade Aaron, Songzhu An, Richard J. Austin, Matthew L. Brown, Angela Chong, Tom Huang, Randall W. Hungate, Ben Jiang, Michael G. Johnson, Gary Lee, Bri...> ;Bioorganic & Medicinal Chemistry Letters. 2010 Aug 1
• 15 citations
  Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists.
  Brian Lucas, Wade Aaron, Songzhu An, Richard J. Austin, Matthew L. Brown, Hon Chan, Angela Chong, Randall W. Hungate, Tom Huang, Ben Jiang, Michael G. Johnson, Jacob K...> ;Bioorganic & Medicinal Chemistry Letters. 2010 Jun 15
• Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors.
  Coburn CA, Rush DM, Williams PD, Homnick C, Lyle EA, Lewis SD, Lucas BJ, Di Muzio-Mower JM, Juliano M, Krueger JA, Vastag K, Chen IW, Vacca JP> ;Bioorg. Med. Chem. Lett.. 2000-05-15
• Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates.
  Sanderson PE, Lyle TA, Cutrona KJ, Dyer DL, Dorsey BD, McDonough CM, Naylor-Olsen AM, Chen IW, Chen Z, Cook JJ, Cooper CM, Gardell SJ, Hare TR, Krueger JA, Lewis SD, L...> ;J. Med. Chem.. 1998-11-05
• L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor.
  Sanderson PE, Cutrona KJ, Dorsey BD, Dyer DL, McDonough CM, Naylor-Olsen AM, Chen IW, Chen Z, Cook JJ, Gardell SJ, Krueger JA, Lewis SD, Lin JH, Lucas BJ, Lyle EA, Lyn...> ;Bioorg. Med. Chem. Lett.. 1998-04-07
• Characterization of the two-step pathway for inhibition of thrombin by alpha-ketoamide transition state analogs.
  Lewis SD, Lucas BJ, Brady SF, Sisko JT, Cutrona KJ, Sanderson PE, Freidinger RM, Mao SS, Gardell SJ, Shafer JA> ;J. Biol. Chem.. 1998-02-27
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