BrianMPopkoMD

Emergency Medicine • Pittsburgh, PA

Medical Director, Emergency Department, Canonsburg Hospital, Allegheny Health Network

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Office
3516 Saw Mill Run Blvd
Pittsburgh, PA 15227
Phone+1 412-844-0327

Fax+1 412-367-5083
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Education & Training

The MetroHealth System/Case Western Reserve UniversityResidency, Emergency Medicine, 1999 - 2000
The MetroHealth System/Case Western Reserve UniversityResidency, Emergency Medicine, 1997 - 1999
MCP-Hahnemann College of MedicineClass of 1997

Certifications & Licensure

NC State Medical License 2016 - 2025
FL State Medical License 2021 - 2025
PA State Medical License 2000 - 2024
OH State Medical License 1998 - 2024
MN State Medical License 2021 - 2024
SC State Medical License 2000 - 2000
American Board of Emergency Medicine Emergency Medicine

Publications & Presentations

PubMed

14 citations
Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques.
Nicolas Guehl, Karla M. Ramos-Torres, Clas Linnman, Sung-Hyun Moon, Maeva Dhaynaut, Moses Q. Wilks, Paul Kyu Han, Chao Ma, Ramesh Neelamegam, Yu-Peng Zhou, Brian Popko...> ;Journal of Cerebral Blood Flow and Metabolism. 2021 Jul 1
13 citations
Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment.
Yanan Chen, Rejani B. Kunjamma, Molly Weiner, Jonah R. Chan, Brian Popko> ;Elife. 2021 Mar 23
95 citations
CNS fibroblasts form a fibrotic scar in response to immune cell infiltration
Cayce E. Dorrier, Dvir Aran, Ezekiel A. Haenelt, Ryan N. Sheehy, Kimberly K. Hoi, Lucija Pintarić, Yanan Chen, Carlos Lizama, Kelly M. Cautivo, Geoffrey Weiner, Brian ...> ;Nature Neuroscience. 2021 Feb 1
41 citations
Pre-clinical and Clinical Implications of "Inside-Out" vs. "Outside-In" Paradigms in Multiple Sclerosis Etiopathogenesis.
Haley E. Titus, Yanan Chen, Joseph R. Podojil, Andrew P. Robinson, Roumen Balabanov, Brian Popko, Stephen D. Miller> ;Frontiers in Cellular Neuroscience. 2020 Oct 27
86 citations
m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination.
Huan Xu, Yulia Dzhashiashvili, Ankeeta Shah, Rejani B. Kunjamma, Yi Lan Weng, Benayahu Elbaz, Qili Fei, Joshua S. Jones, Yang I. Li, Xiaoxi Zhuang, Guo Li Ming, Chuan ...> ;Neuron. 2020 Jan 22
203 citations
Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease.
Sebastian Werneburg, Jonathan Jung, Rejani B. Kunjamma, Seung Kwon Ha, Nicholas J. Luciano, Cory M. Willis, Guangping Gao, Natalia P. Biscola, Leif A. Havton, Stephen ...> ;Immunity. 2020 Jan 14
23 citations
The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS.
Yulia Dzhashiashvili, Chase P. Monckton, Harini S. Shah, Rejani B. Kunjamma, Brian Popko> ;Neurobiology of Disease. 2019 Jul 1
144 citations
Molecular Control of Oligodendrocyte Development
Benayahu Elbaz, Brian Popko> ;Trends in Neurosciences. 2019 Apr 1
46 citations
Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis
Yanan Chen, Joseph R. Podojil, Rejani B. Kunjamma, Joshua S. Jones, Molly Weiner, Wensheng Lin, Stephen D. Miller, Brian Popko> ;Brain. 2019 Feb 1
23 citations
Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation
Benayahu Elbaz, Joshua D. Aaker, Sara Isaac, Anna Kolarzyk, Pedro Brugarolas, Amir Eden, Brian Popko> ;Cell Reports. 2018 May 22
6 citations
Cholesterol crystals impede nerve repair
Yanan Chen, Brian Popko> ;Science. 2018 Feb 9
28 citations
Development of a PET radioligand for potassium channels to image CNS demyelination.
Pedro Brugarolas, Jorge E. Sánchez-Rodríguez, Hsiu-Ming Tsai, Falguni Basuli, Shih-Hsun Cheng, Xiang Zhang, Andrew V. Caprariello, Jerome J. Lacroix, Richard Freifelde...> ;Scientific Reports. 2018 Jan 12
10 citations
Detecting Demyelination by PET: The Lesion as Imaging Target
Pedro Brugarolas, Daniel S. Reich, Brian Popko> ;Molecular Imaging. 2018 Jan 1
69 citations
Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease
Andrew M. McKenzie, Sarah Moyon, Minghui Wang, Igor Katsyv, Won-Min Song, Xianxiao Zhou, Eric B. Dammer, Duc M. Duong, Joshua D. Aaker, Yongzhong Zhao, Noam D. Beckman...> ;Molecular Neurodegeneration. 2017 Nov 6
19 citations
Activation of the Integrated Stress Response and Metabolic Dysfunction in a Murine Model of Sleep Apnea.
Abdelnaby Khalyfa, Zhuanhong Qiao, Alex Gileles-Hillel, Ahamed A. Khalyfa, Mahzad Akbarpour, Brian Popko, David Gozal> ;American Journal of Respiratory Cell and Molecular Biology. 2017 Sep 29
6 citations
The Integrated Stress Response in Hypoxia Induced Diffuse White Matter Injury
Benjamin L.L. Clayton, Aaron Huang, Rejani B. Kunjamma, Ani Solanki, Brian Popko> ;The Journal of Neuroscience. 2017 Aug 2
16 citations
Integrated stress response activation by sleep fragmentation during late gestation in mice leads to emergence of adverse metabolic phenotype in offspring.
Wojciech Trzepizur, Abdelnaby Khalyfa, Zhuanhong Qiao, Brian Popko, David Gozal> ;Metabolism. 2017 Apr 1
4 citations
Neonatal Hypoxia Results in Peripheral Nerve Abnormalities.
Benjamin L.L. Clayton, Aaron Huang, Danuta Dukala, Betty Soliven, Brian Popko> ;The American Journal of Pathology. 2017 Feb 1
60 citations
Endoplasmic reticulum stress and the unfolded protein response in disorders of myelinating glia
Benjamin L.L. Clayton, Brian Popko> ;Brain Research. 2016 Oct 1
9 citations
Transcriptional Fingerprint of Hypomyelination in Zfp191null and Shiverer (Mbpshi) Mice.
Joshua D. Aaker, Benayahu Elbaz, Yuwen Wu, Timothy J. Looney, Li Zhang, Bruce T. Lahn, Brian Popko> ;ASN Neuro. 2016 Sep 28
73 citations
Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts.
, , , , , , , , , , , , , , , , > ;Molecular Neurodegeneration. 2016 Aug 3
9 citations
Adenomatous polyposis coli regulates radial axonal sorting and myelination in the PNS
Benayahu Elbaz, Maria Traka, Rejani B. Kunjamma, Danuta Dukala, Amanda Brosius Lutz, Eva S. Anton, Ben A. Barres, Betty Soliven, Brian Popko> ;Development. 2016 Jul 1
4 citations
Connexin23 deletion does not affect lens transparency.
Viviana M. Berthoud, Peter J. Minogue, Joseph I. Snabb, Yulia Dzhashiashvili, Layne A. Novak, Rebecca K. Zoltoski, Brian Popko, Eric C. Beyer> ;Experimental Eye Research. 2016 Mar 31
46 citations
Harnessing the integrated stress response for the treatment of multiple sclerosis
Sharon W. Way, Brian Popko> ;The Lancet. Neurology. 2016 Apr 1
128 citations
Oligodendrocyte death results in immune-mediated CNS demyelination
Maria Traka, Joseph R. Podojil, Derrick P. McCarthy, Stephen D. Miller, Brian Popko> ;Nature Neuroscience. 2016 Jan 1
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Press Mentions

InFlectis BioScience Expands Leadership Team with Three Experienced International Appointments: Mark Pykett Is Appointed Chairman, Béatrice Lejeune Is Appointed Chief Regulatory Officer, and Prof. Brian Popko Joins Scientific Advisory BoardOctober 4th, 2021
Protecting Myelin-Producing Cells from Inflammation May Be Key to Treating MSApril 2nd, 2021

Hospital Affiliations

Allegheny General HospitalPittsburgh, Pennsylvania
Washington Health SystemWashington, Pennsylvania