BrianJWaingerMDPhD

Headache, Pain Medicine

Assistant Professor in Anesthesiology and Neurology at Harvard Medical School and an attending physician at Massachusetts General Hospital

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Office
55 Fruit St
Boston, MA 02114
Phone+1 617-726-8810

Fax+1 617-726-3441
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Education & Training

Massachusetts General HospitalFellowship, Pain Medicine, 2008 - 2009
Columbia University Vagelos College of Physicians and SurgeonsClass of 2004

Certifications & Licensure

MA State Medical License 2006 - 2025
American Board of Psychiatry and Neurology Neurology
American Board of Psychiatry and Neurology Pain Medicine

Clinical Trials

Clinical Study to Evaluate the Effect of pH on Pain Upon Local Anesthetic Administration. Start of enrollment: 2011 Jan 01
Terminated
Not Applicable
Study of Sulfasalazine in Treating Painful Neuropathy Start of enrollment: 2013 May 01
Terminated
Phase 2

Publications & Presentations

PubMed

Interleukin-1α links peripheral Ca2.2 channel activation to rapid adaptive increases in heat sensitivity in skin.
Anne-Mary N Salib, Meredith J Crane, Sang Hun Lee, Amanda M Jamieson, Diane Lipscombe, Brian J Wainger> ;Scientific Reports. 2024 Apr 20
Neuroma Analysis in Humans: Standardizing Sample Collection and Documentation.
Floris V Raasveld, Wen-Chih Liu, Maximilian Mayrhofer-Schmid, Brian J Wainger, Ian L Valerio, William Renthal, Kyle R Eberlin> ;The Journal of Surgical Research. 2024 Apr 15
Interleukin-1α links peripheral Ca2.2 channel activation to rapid adaptive increases in heat sensitivity in skin.
Anne-Mary N Salib, Meredith J Crane, Sang Hun Lee, Amanda M Jamieson, Diane Lipscombe, Brian J Wainger> ;Biorxiv. 2024 Mar 31
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia.
Christine Marques, Aaron Held, Katherine Dorfman, Joon Sung, Catherine Song, Amey S Kavuturu, Corey Aguilar, Tommaso Russo, Derek H Oakley, Mark W Albers, Bradley T Hy...> ;Acta Neuropathologica. 2024 Mar 13
9 citations
S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.
Liwen Deng, Flavia Costa, Kimbria J Blake, Samantha Choi, Arundhasa Chandrabalan, Muhammad Saad Yousuf, Stephanie Shiers, Daniel Dubreuil, Daniela Vega-Mendoza, Corinn...> ;Cell. 2023 Nov 22
1 citations
Biology and pathophysiology of symptomatic neuromas.
Charles D Hwang, Yannick Albert J Hoftiezer, Floris V Raasveld, Barbara Gomez-Eslava, E P A van der Heijden, Selwyn Jayakar, Bryan James Black, Benjamin R Johnston, Br...> ;Pain. 2024 Mar 1
3 citations
iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons.
Aaron Held, Michelle Adler, Christine Marques, Charles Jourdan Reyes, Amey S Kavuturu, Ana R A A Quadros, I Sandra Ndayambaje, Erika Lara, Michael Ward, Clotilde Lagie...> ;Cell Reports. 2023 Sep 26
1 citations
Multi-target modulation of ion channels underlying the analgesic effects of α-mangostin in dorsal root ganglion neurons.
Sung Eun Kim, Ming Zhe Yin, Jae Won Roh, Hyun Jong Kim, Seong Woo Choi, Brian J Wainger, Woo Kyung Kim, Sung Joon Kim, Joo Hyun Nam> ;Phytomedicine. 2023 Jul 1
20 citations
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration.
Dylan V Neel, Himanish Basu, Georgia Gunner, Matthew D Bergstresser, Richard M Giadone, Haeji Chung, Rui Miao, Vicky Chou, Eliza Brody, Xin Jiang, Edward Lee, Michelle...> ;Neuron. 2023 Apr 19
10 citations
Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke.
Wenlu Li, Emiri T Mandeville, Violeta Durán-Laforet, Norito Fukuda, Zhanyang Yu, Yi Zheng, Aaron Held, Ji-Hyun Park, Takafumi Nakano, Masayoshi Tanaka, Jingfei Shi, El...> ;Nature Communications. 2022 Dec 19
3 citations
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic.
Daniel M DuBreuil, Xiaofan Lai, Kevin Zhu, Gracesenia Chahyadinata, Caroline Perner, Brenda M Chiang, Ashley Battenberg, Caroline L Sokol, Brian J Wainger> ;Molecular Pain. 2022 Dec 16
2 citations
Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models ofdisease.
Melanie Jambeau, Kevin D Meyer, Marian Hruska-Plochan, Ricardos Tabet, Chao-Zong Lee, Ananya Ray-Soni, Corey Aguilar, Kitty Savage, Nibha Mishra, Nicole Cavegn, Petra ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Dec 6
44 citations
A reference human induced pluripotent stem cell line for large-scale collaborative studies.
Caroline B Pantazis, Andrian Yang, Erika Lara, Justin A McDonough, Cornelis Blauwendraat, Lirong Peng, Hideyuki Oguro, Jitendra Kanaujiya, Jizhong Zou, David Sebesta, ...> ;Cell Stem Cell. 2022 Dec 1
6 citations
Spinal motor neuron transplantation to enhance nerve reconstruction strategies: Towards a cell therapy.
Stanley Bazarek, Benjamin R Johnston, Margaret Sten, Ross Mandeville, Kevin Eggan, Brian J Wainger, Justin M Brown> ;Experimental Neurology. 2022 Jul 1
1 citations
The threshold tracking nerve conduction study technique: Experience of clinical users unfamiliar with a research-grade neuronal excitability system.
C E McIlduff, B J Wainger, R L Freeman, S Samaan, I Yator, H Gutierrez, S Verga, S B Rutkove> ;Clinical Neurophysiology Practice. 2022 Jan 1
55 citations
Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions.
João D. Pereira, Daniel M. DuBreuil, Anna-Claire Devlin, Aaron Held, Yechiam Sapir, Eugene Berezovski, James Hawrot, Katherine Dorfman, Vignesh Chander, Brian J. Wainger> ;Nature Communications. 2021 Aug 6
6 citations
Heat but not mechanical hypersensitivity depends on voltage-gated CaV2.2 calcium channel activity in peripheral axon terminals innervating skin
Daniel M. DuBreuil, Eduardo Javier López Soto, Simon Daste, Remy Meir, Daniel Li, Brian J. Wainger, Alexander Fleischmann, Diane Lipscombe> ;The Journal of Neuroscience. 2021 Aug 5
2 citations
Transcriptomic signature of painful human neurofibromatosis type 2 schwannomas.
Phanidhar Kukutla, Sherif G. Ahmed, Daniel M DuBreuil, Murat Cetinbas, Giulia Fulci, Berent Aldikacti, Anat Stemmer-Rachamimov, Scott R. Plotkin, Brian J. Wainger, Rus...> ;Annals of Clinical and Translational Neurology. 2021 May 30
6 citations
A high-content platform for physiological profiling and unbiased classification of individual neurons.
Daniel M. DuBreuil, Brenda M. Chiang, Kevin Zhu, Xiaofan Lai, Patrick Flynn, Yechiam Sapir, Brian J. Wainger> ;Cell Reports Methods. 2021 May 24
10 citations
Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial
Michael D. Weiss, Eric A. Macklin, Courtney E. McIlduff, Steve Vucic, Brian J. Wainger, Matthew C. Kiernan, Stephen A. Goutman, Namita Goyal, Seward B. Rutkove, Shafee...> ;Muscle & Nerve. 2021 Mar 1
2 citations
Amyotrophic Lateral Sclerosis: Fuel for the Corticofugal Feud
Brian J. Wainger, Robert H. Brown> ;Annals of Neurology. 2020 Aug 2
46 citations
Modeling cell-autonomous motor neuron phenotypes in ALS using iPSCs.
James Hawrot, Sophie Imhof, Brian J. Wainger> ;Neurobiology of Disease. 2020 Feb 1
55 citations
Measurement of axonal excitability: Consensus guidelines.
Matthew C. Kiernan, Hugh Bostock, Susanna B. Park, Ryuji Kaji, Christian Krarup, Arun V. Krishnan, Satoshi Kuwabara, Cindy S.-Y. Lin, Sonoko Misawa, Mihai Moldovan, Ji...> ;Clinical Neurophysiology. 2020 Jan 1
10 citations
Pharmacological Profiling of Purified Human Stem Cell-Derived and Primary Mouse Motor Neurons
Daniel Moakley, Joan Koh, João D. Pereira, Daniel M. DuBreuil, Anna-Claire Devlin, Eugene Berezovski, Kevin Zhu, Brian J. Wainger> ;Scientific Reports. 2019 Jul 25
268 citations
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
Joseph R. Klim, Luis A. Williams, Francesco Limone, Irune Guerra San Juan, Brandi N. Davis-Dusenbery, Daniel A. Mordes, Aaron Burberry, Michael J. Steinbaugh, Kanchana...> ;Nature Neuroscience. 2019 Jan 14
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Journal Articles

Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis
Brian J Wainger, Nicholas J Maragakis, Richard Bedlack, Namita A Goyal, Seward B Rutkove, Michael H Rivner, Stephen A Goutman, Shafeeq S Ladha, Elizabeth A Mauricio, R..., JAMA Neurology

Press Mentions

Mass General Brigham Researchers Launch New Effort to Find Treatments for Chronic Pain and MigraineJanuary 25th, 2023
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical TrialDecember 10th, 2020
QurAlis to Present Data on Two Precision Medicine Programs (Kv7 and TBK1) at MNDA 31st International Symposium on ALS/MNDDecember 2nd, 2020
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