BruceCKoneMDFACP, FAHA, FASN

PubMed

• 3 citations
  Physical and functional interaction of Rnf2 with Af9 regulates basal and aldosterone-stimulated transcription of the α-ENaC gene in a renal collecting duct cell line.
  Zhi Yuan Yu, Qun Kong, Bruce C. Kone> ;Bioscience Reports. 2013 Oct 25
• 11 citations
  Epigenetics and the Control of the Collecting Duct Epithelial Sodium Channel
  Bruce C. Kone> ;Seminars in Nephrology. 2013 Jul 1
• 18 citations
  Aldosterone reprograms promoter methylation to regulate αENaC transcription in the collecting cuct
  Zhiyuan Yu, Qun Kong, Bruce C. Kone> ;American Journal of Physiology. Renal Physiology. 2013 Oct 1
• 6 citations
  Sp1 trans-activates and is required for maximal aldosterone induction of the αENaC gene in collecting duct cells.
  Zhiyuan Yu, Qun Kong, Bruce C. Kone> ;American Journal of Physiology. Renal Physiology. 2013 Sep 1
• 4 citations
  Molecular regulation of Trypanosoma congolense-induced nitric oxide production in macrophages.
  Rani Singh, Bruce C. Kone, Abdelilah S. Gounni, Jude E. Uzonna> ;Plos One. 2013 Mar 25
• 17 citations
  An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the αENaC gene.
  Wenzheng Zhang, Zhiyuan Yu, Hongyu Wu, Lihe Chen, Qun Kong, Bruce C. Kone> ;American Journal of Physiology. Renal Physiology. 2013 Feb 15
• 18 citations
  Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide
  Julio D. Duarte, Issam Zineh, Ben Burkley, Yan Gong, Taimour Y. Langaee, Stephen T. Turner, Arlene B. Chapman, Eric Boerwinkle, John G. Gums, Rhonda M. Cooper-DeHoff, ...> ;Journal of Translational Medicine. 2012 Mar 22
• 12 citations
  CREB trans-activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of CTGF transcription in mesangial cells.
  Zhiyuan Yu, Qun Kong, Bruce C. Kone> ;American Journal of Physiology. Renal Physiology. 2010 Jan 6
• 39 citations
  AF17 Competes with AF9 for Binding to Dot1a to Up-regulate Transcription of Epithelial Na+ Channel α
  Mary Rose Reisenauer, Marc Anderson, Le Huang, Zhijing Zhang, Qiaoling Zhou, Bruce C. Kone, Andrew P. Morris, Gene LeSage, Stuart E. Dryer, Wenzheng Zhang> ;The Journal of Biological Chemistry. 2009 Dec 18
• 12 citations
  Intestinal Ischemic Preconditioning After Ischemia/Reperfusion Injury in Rat Intestine: Profiling Global Gene Expression Patterns
  Stacey D. Moore-Olufemi, Shodimu Emmanuel Olufemi, Steven T. Lott, Norio Sato, Rosemary A. Kozar, Frederick A. Moore, Ravi S. Radhakrishnan, Shinil K. Shah, Fernando J...> ;Digestive Diseases and Sciences. 2010 Jul 1
• 60 citations
  Sirtuin 1 Functionally and Physically Interacts with Disruptor of Telomeric Silencing-1 to Regulate α-ENaC Transcription in Collecting Duct
  Dongyu Zhang, Shiyu Li, Pedro E. Cruz, Bruce C. Kone> ;The Journal of Biological Chemistry. 2009 Jul 31
• 9 citations
  Sp1 trans-activates the murine H(+)-K(+)-ATPase alpha(2)-subunit gene.
  Zhiyuan Yu, Mei Li, Dongyu Zhang, William Xu, Bruce C Kone> ;American Journal of Physiology. Renal Physiology. 2009 Jul 1
• 1 citations
  2009 Southern Society For Clinical Investigation presidential address: opportunity knocks.
  Bruce C. Kone> ;The American Journal of the Medical Sciences. 2009 Jul 1
• 51 citations
  Narrative Review: Evolving Concepts in Potassium Homeostasis and Hypokalemia
  Megan M. Greenlee, Alicia A. McDonough, Jang H. Youn, Bruce C. Kone, Charles S. Wingo> ;Annals of Internal Medicine. 2009 May 5
• A different perspective on admission decisions.
  Bruce C. Kone> ;Academic Medicine. 2009 Mar 1
• 16 citations
  Pretreatment with bone morphogenetic protein-7 (BMP-7) mimics ischemia preconditioning following intestinal ischemia/reperfusion injury in the intestine and liver.
  Ravi S. Radhakrishnan, Geetha L. Radhakrishnan, Hari Radhakrishnan, Hasen Xue, Sasha D. Adams, Stacey D. Moore-Olufemi, Matthew T. Harting, Charles S. Cox, Bruce C. Kone> ;Shock. 2008 Nov 1
• 45 citations
  Epigenetics and the control of epithelial sodium channel expression in collecting duct
  Dongyu Zhang, Zhi Yuan Yu, Pedro E. Cruz, Qun Kong, Shiyu Li, Bruce C. Kone> ;Kidney International. 2009 Feb 1
• 1 citations
  New Mechanisms for Transcriptional Repression of ENaC And iNOS
  Bruce C. Kone, Zhang Wenzhang, yu Zhiyuan> ;Transactions of the American Clinical and Climatological Association. 2007 Jan 1
• Advances in genetic detection of kidney disease.
  Akinsan K Dosekun, John R Foringer, Bruce C. Kone> ;Saudi Journal of Kidney Diseases and Transplantation. 2003 Jul 1
• 120 citations
  Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel α
  Wenzheng Zhang, Xuefeng Xia, Mary Rose Reisenauer, Timo Rieg, Florian Lang, Dietmar Kuhl, Volker Vallon, Bruce C. Kone> ;The Journal of Clinical Investigation. 2007 Mar 1
• 14 citations
  Myelodysplastic Syndrome Manifesting As Sweet’s Syndrome and Brochiolitis Obliterative Organizing Pneumonia
  Rajeev K. Garg, Youssef Soud, Rajiv Lal, Niraj Mehta, Bruce C. Kone> ;The American Journal of Medicine. 2006 Nov 1
• 135 citations
  Dot1a-AF9 Complex Mediates Histone H3 Lys-79 Hypermethylation and Repression of ENaCα in an Aldosterone-sensitive Manner
  Wenzheng Zhang, Xuefeng Xia, Mary Rose Reisenauer, Charles S. Hemenway, Bruce C. Kone> ;The Journal of Biological Chemistry. 2006 Jun 30
• 3 citations
  NO break-ins at water gate.
  Bruce C. Kone> ;Hypertension. 2006 Jul 1
• 53 citations
  Differential induction of PPAR-γ by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel
  Norio Sato, Frederick A. Moore, Bruce C. Kone, Lei Zou, M. A. Smith, M. A. Childs, Stacey D. Moore-Olufemi, Stanley G. Schultz, Rosemary A. Kozar> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2006 Apr 1
• 52 citations
  Aldosterone-sensitive repression of ENaCα transcription by a histone H3 lysine-79 methyltransferase
  Wenzheng Zhang, Xuefeng Xia, Diana I. Jalal, Teresa Kuncewicz, William Xu, Gene LeSage, Bruce C. Kone> ;American Journal of Physiology. Cell Physiology. 2006 Mar 1
• Join now to see all

Journal Articles

• Renal H+-K+-ATPase: structure, function, and regulation.  
  Kone, B.C, Miner. Elect. Metab. 22:349-365
• Biosynthesis and homeostatic roles of nitric oxide in the normal kidney.  
  Kone, B.C., and C. Baylis, Am. J. Physiol. 272:F561-578
• Nitric oxide in renal health and disease.  
  Kone, B.C, Am. J. Kid. Dis., 30:311-333
• A “BOLD” new approach to renal oxygen economy.  
  Kone, B.C, Circulation 94:3067-3068
• Molecular approaches to renal physiology and therapeutics.  
  Kone, B.C, Seminars Nephrol. 18:102-121
• Localization and regulation of nitric oxide synthases in the kidney.  
  Kone, B.C, Seminars Nephrol. 19:230-241
• How will gene therapy apply to the kidney in the 21st century?  
  Kone, B.C, Seminars Nephrol. 20:47-59
• Protein-protein interactions important for regulation of nitric oxide synthases.  
  Kone, B.C, Acta Physiol. Scand., 168:27-31
• Postinjury multiple organ failure: the role of the gut.  
  Hassoun, H.T., Kone, B.C., Mercer, D.W., Moody, F.G., Weisbrodt, N.W., and Moore, F.A, Shock. 15:1-10
• Molecular biology of natriuretic peptides and nitric oxide synthases.  
  Kone, B.C, Cardiovasc Res. (Review) 15:429-441
• Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide.  
  Kone, B.C., Kuncewicz, T., Zhang, W., and Yu, Z, Am. J. Physiol. 285:F178-F190
• Advances in genetic detection of kidney disease.  
  Dosekun, A., Foringer, J., and Kone, B.C, Saudi J. Nephrol. Transplant. 14:259-275
• Protein-protein interactions involving inducible nitric oxide synthase.  
  Zhang, W., Kuncewicz, T., Yu, Z., Zou, L., Xu, X., and Kone, B.C, Acta Physiol. Scand. 179:137-42
• Nitric oxide synthesis in the kidney – isoforms, biosynthesis and function in health.  
  Kone, B.C. and Yu, Z, Seminars in Nephrol. 24:299-315
• NO break-ins at water gate.  
  Kone, B.C, Hypertension 48:29-30
• S-Nitrosylation: targets, controls, and outcomes.  
  Kone, B.C, Curr. Gen. 7:301-310
• Epigenetic control of the epithelial sodium channel in collecting duct.  
  Zhang, D., Yu, Z., Cruz, P., Kong, Q., Li, S., and Kone, B.C, Kidney Int. 75:260-267
• Evolving concepts in potassium homeostasis and hypokalemia.  
  Greenlee, M., Wingo, C.S., McDonough, A.A., Youn, J.-H., and Kone, B.C, Ann. Int. Med. (Review), 150:619-625
• 2009 Southern Society for Clinical Investigation presidential address: Opportunity knocks.  
  Kone, B.C, Am. J. Med. Sci. 338:1-2
• Epigenetics and the control of the collecting duct epithelial sodium channel.  
  Kone, B.C, Sem. Nephrol
• Join now to see all

Books/Book Chapters

• The Sodium Pump: Structure, Mechanism, and Regulation. 
  Chapter: A Cell Biologist’s Perspective on Sites of Na, K-ATPase Regulation 
  Page 17 - 30Fambrough, D.M., Wolitzky, B.A., Taormino, J.P., Tamkun, M.M., Takeyasu, K., Sommerville, D., Renaud, K., Lemas, M.V., Lebovitz, R., Kone, B.C., Hamrick, M., Rome, J.,...Editors: J.H. Kaplan and P. DeWeer.The Rockefeller University Press, New York
• Nephrology for the House Officer. 
  Chapter: Disorders of Water Balance 
  Page 87 - 100Kone, B.C., and Wingo, C.SEditors: C.S. Wilcox and C.C. Tisher.Williams and Wilkins, BaltimoreEdition 2,
• Biology of Nitric Oxide, Part 4. 
  Chapter: Molecular Characterization and Localization of Three Nitric Oxide Synthase Isoforms in Rat Kidney 
  Page 137 - 141Mohaupt, M., Madsen, K.M., Wilcox, C.S., and Kone, B.CEditors: S. Moncada, M. Feelisch, R. Busse, and E.A. Higgs.Portland Press, ny
• Nephrology. 
  Chapter: Disorders of Water Balance 
  Page 94 - 107Kone, B.C., and Wingo, C.SEditors: C.S. Wilcox and C.C. Tisher.Williams and Wilkins, BaltimoreEdition 3,
• Acid-Base and Electrolyte Disorders: A Companion to Brenner and Rector’s The Kidney. 
  Chapter: Hypokalemia 
  Page 381 - 394Kone, B.CEditors: L.L. Hamm and T.D. DuBose, Jr.Saunders, Philadelphia
• Contributions to Nephrology, Vol. 141. 
  Chapter: Proteomic Analysis Reveals Novel Protein Targets of S-Nitrosylation In Mesangial Cells 
  Page 221 - 230Kone, B.C., Sheta, E., Goldknopf, I., and Kuncewicz, TEditors: W. Thongboonkerd and J. Klein.Karger
• The Kidney. 
  Chapter: The Metabolic Basis of Solute Transport 
  Page 231 - 260Kone, B.CEditors: B.M. Brenner.Elsevier Science, PhiladelphiaEdition 7,
• Current Topics in Atherosclerosis Research. 
  Chapter: Atherosclerosis in Chronic Kidney Disease 
  Page 103 - 132Jalal, D., and Kone, B.CEditors: Y.-.J Geng.Nova, New York
• Modern Surgical Care: Physiologic Foundations and Clinical Applications. 
  Chapter: Urine Formation: From Normal Physiology to Florid Renal Failure 
  Page 725 - 765Dosekun, A., Foringer, J., and Kone, B.CEditors: T. Miller.Informa Healthcare, New YorkEdition 3,
• Encyclopedic Reference of Molecular Mechanisms of Disease. 
  Chapter: Mesenteric Ischemia 
  Kone, B.CEditors: F. Lang.Springer Verlag, Heidelberg
• The Kidney. 
  Chapter: The Metabolic Basis of Solute Transport 
  Kone, B.CEditors: B.M. Brenner.Elsevier Science, PhiladelphiaEdition 8,
• Pharmacology and Therapeutics: Principles to Practice. 
  Chapter: Fluid and Electrolyte Homeostasis 
  Kone, B.CEditors: S. Waldman and A. Terzic.Elsevier Science, Philadelphia
• Handbook of Nephrology and Hypertension. 
  Chapter: Potassium Disorders 
  Kone, B.C., and Wingo, C.SEditors: C.S. Wilcox and C.C. Tisher.Williams and Wilkins, BaltimoreEdition 6,
• Join now to see all

Abstracts/Posters

• CCAAT/enhancer binding protein beta (C/EBPß) regulates nitric oxide synthase 2 (NOS2) gene expression in mTAL cells.
  Gupta, A.K., Higham, S., and Kone, B.C, 29th Annual Meeting of the American Society of Nephrology, New Orleans, LA
• Structural diversity of the colonic H+-K+-ATPase a subunit (HKa2) gene: cloning and intrarenal distribution of alternative forms.
  Kone, B.C, 29th annual meeting of the American Society of Nephrology, New Orleans, LA
• Autocrine regulation of mTAL active sodium reabsorption by tonically expressed inducible nitric oxide synthase (iNOS).
  Kone, B.C., and Higham S, 29th Annual Meeting of the American Society of Nephrology, New Orleans, LA
• Purification and analysis of a putative transcription factor that interacts with a novel cis-element of the inducible nitric oxide synthase (iNOS) gene.
  Gupta, A.K., R. Diaz, and Kone, B.C, 30th Annual Meeting of the American Society of Nephrology, San Antonio, TX
• a-Melanocyte stimulating hormone (a-MSH) inhibits LPS-induction of the inducible, pro-inflammatory transcription factor CCAAT/enhancer binding protein ? (C/EBP?).
  Gupta, A.K., R. Diaz, and Kone, B.C, 30th Annual Meeting of the American Society of Nephrology, San Antonio, TX
• Alternative promoters transcribe mRNAs encoding two N-terminal variants of the rat H-K-ATPase a2 (HKa2) subunit: structural analysis and renal response to chronic hypo...
  Kone, B.C., and Higham, S, 30th Annual Meeting of the American Society of Nephrology, San Antonio, TX
• Interaction with the small GTPase Rac2 promotes intracellular redistribution of inducible nitric oxide synthase (iNOS).
  Kone, B.C., and Kuncewicz, T, 31st Annual Meeting of the American Society of Nephrology, Philadelphia, PA
• The Rho Family GTPase Rac2 physically interacts with and activates inducible nitric oxide synthase (iNOS).
  Kone, B.C., and Kuncewicz, T, 31st Annual Meeting of the American Society of Nephrology, Philadelphia, PA
• Renal adaptive responses of H/K-ATPase a2 gene to chronic changes in dietary potassium.
  Ahn, K.Y., Kim, B.Y., Kim, K.K., Park, S.S., and Kone, B.C, 32nd Annual Meeting of the American Society of Nephrology, Miami Beach, FL
• Interactions of the Rho Family GTPases Rac1 and Rac2 with Nitric Oxide Synthases (NOS).
  Kone, B.C., and Kuncewicz, T, 32nd Annual Meeting of the American Society of Nephrology, Miami Beach, FL
• a-Melanocyte stimulating hormone does not inhibit NF-?B activation in macrophages: role of a novel inducible I?B kinase.
  Kone, B.C., Bender, J., Kuncewicz, T., and Higham, S, 33rd Annual Meeting of the American Society of Nephrology, Toronto, CA
• Molecular cloning and chromosomal localization of the murine H-K-ATPase a2 subunit gene.
  Kone, B.C., and Kuncewicz, T, 33rd Annual Meeting of the American Society of Nephrology, Toronto, CA
• Interaction of Rac2 and inducible nitric oxide synthase (iNOS) augments superoxide and peroxynitrite generation in activated macrophages.
  Kone, B.C., Balakrishnan, P., and Kuncewicz, T, 34th Annual Meeting of the American Society of Nephrology, San Francisco, CA
• Protein targets of nitric oxide in mesangial cells: proteomic approach to analysis of S-nitrosylated proteins.
  Kuncewicz, T., and Kone, B.C, 34th Annual Meeting of the American Society of Nephrology, San Francisco, CA
• Structure, promoter analysis, and chromosomal localization of the murine colonic H,K-ATPase gene.
  Zhang, W., Kuncewicz, T., Higham, S., and Kone, B.C, 34th Annual Meeting of the American Society of Nephrology, San Francisco, CA
• Stat3? inhibits IL-1ß-mediated activation of the inducible nitric oxide synthase gene in murine mesangial cells.
  Yu, Z-Y., and Kone, B.C, 34th Annual Meeting of the American Society of Nephrology, San Francisco, CA
• a-Melanocyte stimulating hormone (a-MSH) reduces intestinal NF-?B and gut I/R injury.
  Hassoun, H.T., Kone, B.C., Kozar, R.A., Snuggs, M., Phan, T., Moore, F.A, Annual Meeting of the Society of University Surgeons
• Proteomic analysis reveals novel protein targets of S-nitrosylated in mesangial cells.
  Kuncewicz, T., Sheta, E., Goldknopf, I, and Kone, B.C, 35th Annual Meeting of the American Society of Nephrology, Chicago, IL
• Stat3 inhibits transcription of the inducible nitric oxide synthase gene by interacting with NF-?B.
  Yu, Z-Y., Zhang, W., and Kone, B.C, 35th Annual Meeting of the American Society of Nephrology, Chicago, IL
• NF-?B inhibits transcription of the H/K-ATPase a2 subunit gene in mIMCD3 cells: role of histone deacetylase-6.
  Zhang, W. and Kone, B.C, 35th Annual Meeting of the American Society of Nephrology, Chicago, IL
• Histone deacetylases augment cytokine induction of the inducible nitric oxide synthase gene.
  Yu, Z-Y., Zhang, W., and Kone, B.C, 35th Annual Meeting of the American Society of Nephrology, Chicago, IL
• USF-1 and –2 trans-repress IL-1ß-induced iNOS transcription in mesangial cells.
  Kone, B.C., and Gupta, A.K, 35th Annual Meeting of the American Society of Nephrology, Chicago, IL
• Insulin-stimulated cyclic GMP production inhibits vascular smooth muscle cell migration by dephosphorylating and inhibiting Ca/calmodulin-dependent protein kinase II.
  Kahn, AM, Kone, B.C., Yang, Y, and Sang, S, 35th Annual Meeting of the American Society of Nephrology, Chicago, IL
• CREB family proteins transactivate the murine H/K-ATPase a2 gene in mIMCD3 cells.
  Xu, X., Zhang, W., and Kone, B.C, 36th Annual Meeting of the American Society of Nephrology, San Diego, CA
• STAT3 DNA-binding and coiled-coil domains physically and functionally interact with NF-?B p65 to regulate iNOS transcription in mesangial cells.
  Yu, Z-Y., and Kone, B.C, 36th Annual Meeting of the American Society of Nephrology, San Diego, CA
• Join now to see all

Lectures

• Proteins Regulating Inducible Nitric Oxide Synthase. 
  Thomas Jefferson University Medical School
• Proteins Involved in the Regulation of Inducible Nitric Oxide Synthase. 
  University of Miami School of Medicine
• Regulation and Functional Contributions of Inducible Nitric Oxide Synthase in the Kidney. 
  University of California, San Diego
• Protein-DNA and Protein-Protein Interactions Involved in Regulation of Inducible Nitric Oxide Synthase. 
  University of Florida College of Medicine
• Nitric Oxide in Epithelial Function and Defense. 
  Emory Univ. Medical School, Atlanta, GA
• Autosomal Dominant Polycystic Kidney Disease: Clinical Spectrum and Scientific Advances. 
  University of Texas Medical School at Houston, Houston, TX
• Acute Glomerulonephritis. 
  University of Texas Medical School at Houston, Houston, TX
• Functional Roles and Regulation of Inducible Nitric Oxide Synthase. 
  Vascular Biology Center, Medical College of Georgia
• Structure, Function, and Regulation of Inducible Nitric Oxide Synthase. 
  Texas Tech University Health Science Center, Lubbock, TX
• Acute Renal Failure. 
  University of Texas Medical Branch at Galveston, TX
• New Pathways for Aldosterone Regulation of Renal Sodium Transport. 
  Renal Grand Rounds, Baylor College of Medicine
• Function and Regulation of Nitric Oxide in Renal Health and Diseases. 
  University of Texas Medical Branch at Galveston, TX
• Aldosterone Action Revisited: A New Mechanism for Regulation of ENaC Transcription. 
  Renal Club, Southern Society for Clinical Investigation
• A New Mechanism of Aldosterone Action. 
  The University of Texas Medical School, Houston
• Inducible Nitric Oxide Synthase. 
  West Virginia University
• Aldosterone Action Revisited: A New Mechanism for ENaC Transcriptional Control. 
  Division of Nephrology, Mt. Sinai School of Medicine
• Nephrology Update. 
  Texas Academy of Internal Medicine
• Localization and Regulation of Inducible NOS in the Kidney. 
  Second Annual Meeting of the Consortium of Southeastern Hypertension Centers, Charleston, SC
• Aldosterone-sensitive Repression of ENaC? Transcription by a Histone H3 lysine-79 Methyltransferase. 
  The University of Texas Health Science Center, San Antonio
• Hypokalemia. 
  The University of Texas Medical School, Houston
• Renal Nitric Oxide Synthases. 
  Renal Hemodynamics: Vascular Biology of the Renal Circulation. Saxtons River, VT
• iNOS: Controls and Targets. 
  Vanderbilt University School of Medicine
• Hypokalemic Syndromes. 
  Vanderbilt University School of Medicine
• Molecular Physiology of the Na/K-ATPase Gene Family: Implications for Hypertension. 
  Georgetown University School of Medicine, Washington, D.C
• Transcriptional Regulation of Inducible Nitric Oxide Synthase in Renal Epithelia. 
  Georgetown University School of Medicine, Washington, D.C
• Join now to see all

Other

• Message from the Renal Section ‘Sage’ --- Impact of Katrina on Research and Scientific Education. 
  Kone, B.C, APS Renal Section Newsletter
• Sage thoughts from the Sage, the NIH Roadmap and CTSAs. 
  Kone, B.C, APS Renal Section Newsletter
• A different perspective on admissions decisions. 
  Kone, B.C, Acad. Med. 84:289