BryanAWolfMD

Pathology • Philadelphia, PA

Anatomic Pathology, Clinical Pathology

Professor, Pathology & Laboratory Medicine, Perelman School of Medicine

Join to view full profile

Dr. Wolf is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Wolf's full profile

Already have an account?

Office
3400 Civic Center Blvd
Room 5135
Philadelphia, PA 19104
Phone+1 215-590-2266

Fax+1 215-590-2171
Is this information wrong?

Education & Training

Washington University/B-JH/SLCH ConsortiumResidency, Pathology-Anatomic and Clinical, 1987 - 1990
Necker- Enfants Malades HospClass of 1984

Certifications & Licensure

PA State Medical License 1991 - 2018
NJ State Medical License 2006 - 2009
American Board of Pathology Clinical Pathology

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 2001

Publications & Presentations

PubMed

14 citations
Interactive pediatric emergency checklists to the palm of your hand - How the Pedi Crisis App traveled around the world.
Jorge A. Gálvez, Justin L. Lockman, Laura E. Schleelein, Allan F. Simpao, Luis M. Ahumada, Bryan A. Wolf, Maully J. Shah, Eugenie S. Heitmiller, Mohamed A. Rehman> ;Paediatric Anaesthesia. 2017 Jun 7
147 citations
PEDSnet: a National Pediatric Learning Health System
Christopher B. Forrest, Peter A. Margolis, L. Charles Bailey, Keith Marsolo, Mark A. Del Beccaro, Jonathan A. Finkelstein, Veronica J. Vieland, Bryan A. Wolf, Felician...> ;Journal of the American Medical Informatics Association. 2014 Jul 1
1245 citations
Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
Konrad Talbot, Hoau-Yan Wang, Hala Kazi, Li-Ying Han, Kalindi Bakshi, Andres Stucky, Robert L. Fuino, Krista R. Kawaguchi, Andrew J. Samoyedny, Robert S. Wilson, Zoe A...> ;The Journal of Clinical Investigation. 2012 Apr 2
27 citations
Liver-Specific Overexpression of Pancreatic-Derived Factor (PANDER) Induces Fasting Hyperglycemia in Mice
Camella G. Wilson, Michael Schupp, Brant R. Burkhardt, Jianmei Wu, Robert A. Young, Bryan A. Wolf> ;Endocrinology. 2010 Nov 1
35 citations
Targeted Disruption of Pancreatic-Derived Factor (PANDER, FAM3B) Impairs Pancreatic β-Cell Function
Claudia E. Robert-Cooperman, Jason R. Carnegie, Camella G. Wilson, Jichun Yang, Joshua R. Cook, Jianmei Wu, Robert A. Young, Bryan A. Wolf, Brant R. Burkhardt> ;Diabetes. 2010 Sep 1
17 citations
Characterization of the expression, localization, and secretion of PANDER in α-cells
Jason R. Carnegie, Claudia E. Robert-Cooperman, Jianmei Wu, Robert A. Young, Bryan A. Wolf, Brant R. Burkhardt> ;Molecular and Cellular Endocrinology. 2010 Aug 30
132 citations
Leucine metabolism in regulation of insulin secretion from pancreatic beta cells
Jichun Yang, Yujing Chi, Brant R. Burkhardt, Youfei Guan, Bryan A. Wolf> ;Nutrition Reviews. 2010 May 1
32 citations
PANDER binds to the liver cell membrane and inhibits insulin signaling in HepG2 cells.
Jichun Yang, Chunjiong Wang, Jing Li, Brant R. Burkhardt, Claudia E. Robert-Cooperman, Camella G. Wilson, Zhiyong Gao, Bryan A. Wolf> ;FEBS Letters. 2009 Sep 17
18 citations
PDX-1 interaction and regulation of the Pancreatic Derived Factor (PANDER, FAM3B) promoter.
Brant R. Burkhardt, Joshua R. Cook, Robert A. Young, Bryan A. Wolf> ;Biochimica Et Biophysica Acta. 2008 Jul 29
18 citations
PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21).
Brant R. Burkhardt, Scott R. Greene, Peter White, Ryan K. Wong, John Brestelli, Jichun Yang, Claudia E. Robert, Todd M. Brusko, Clive Wasserfall, Jianmei Wu, Mark A. A...> ;Gene. 2006 Mar 15
24 citations
Over-expression of CLN3P, the Batten disease protein, inhibits PANDER-induced apoptosis in neuroblastoma cells: further evidence that CLN3P has anti-apoptotic properties.
Srinivas B. Narayan, Dinesh Rakheja, Johanne Pastor, Kevin P. Rosenblatt, Scott R. Greene, Jichun Yang, Bryan A. Wolf, Michael J. Bennett> ;Molecular Genetics and Metabolism. 2006 Jun 1
41 citations
Leucine Regulation of Glucokinase and ATP Synthase Sensitizes Glucose-Induced Insulin Secretion in Pancreatic β-Cells
Jichun Yang, Ryan K. Wong, MieJung Park, Jianmei Wu, Joshua R. Cook, David A. York, Shaoping Deng, James F. Markmann, Ali Naji, Bryan A. Wolf, Zhiyong Gao> ;Diabetes. 2006 Jan 1
49 citations
Mechanisms of Glucose-Induced Secretion of Pancreatic-Derived Factor (PANDER or FAM3B) in Pancreatic β-Cells
Jichun Yang, Claudia E. Robert, Brant R. Burkhardt, Robert A. Young, Jianmei Wu, Zhiyong Gao, Bryan A. Wolf> ;Diabetes. 2005 Nov 1
25 citations
Interferon-γ-induced regulation of the pancreatic derived cytokine FAM3B in islets and insulin-secreting βTC3 cells
Weizhen Xu, Zhiyong Gao, Jianmei Wu, Bryan A. Wolf> ;Molecular and Cellular Endocrinology. 2005 Aug 30
28 citations
Structure−Function Studies of PANDER, an Islet Specific Cytokine Inducing Cell Death of Insulin-Secreting β Cells†
Jichun Yang, Zhiyong Gao, Claudia E. Robert, Brant R. Burkhardt, Helena Gaweska, Amary Wagner, Jianmei Wu, Scott Greene, Robert A. Young, Bryan A. Wolf> ;Biochemistry. 2005 Aug 4
31 citations
Tissue-specific and glucose-responsive expression of the pancreatic derived factor (PANDER) promoter.
Brant R. Burkhardt, Michael C. Yang, Claudia E. Robert, Scott Greene, K. Kelly McFadden, Jichun Yang, Jianmei Wu, Zhiyong Gao, Bryan A. Wolf> ;Biochimica Et Biophysica Acta. 2005 Sep 25
34 citations
Effects of overexpression of pancreatic derived factor (FAM3B) in isolated mouse islets and insulin-secreting βTC3 cells
Xiaopei Cao, Jichun Yang, Brant R. Burkhardt, Zhiyong Gao, Ryan K. Wong, Scott Greene, Jianmei Wu, Bryan A. Wolf> ;American Journal of Physiology. Endocrinology and Metabolism. 2005 May 31
26 citations
Leucine Culture Reveals That ATP Synthase Functions as a Fuel Sensor in Pancreatic β-Cells
Jichun Yang, Ryan K. Wong, Xujing Wang, Jacob Moibi, Martin J. Hessner, Scott Greene, Jianmei Wu, Siam S. Sukumvanich, Bryan A. Wolf, Zhiyong Gao> ;The Journal of Biological Chemistry. 2004 Dec 24
53 citations
Interleukin-1β Upregulates Functional Expression of Neurokinin-1 Receptor (NK-1R) via NF-κB in Astrocytes
Chang-Jiang Guo, Steven D. Douglas, Zhiyong Gao, Bryan A. Wolf, Judith B. Grinspan, Jian-Ping Lai, Eric Riedel, Wen-Zhe Ho> ;Glia. 2004 Nov 15
26 citations
40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004.
M Veitenhansl, K Stegner, Hierl F-X., C Dieterle, H Feldmeier, B Gutt, R Landgraf, Adam Garrow, Loretta Vileikyte, A Findlow, Christine Waterman, Boulton Ajm., K Shank...> ;Diabetologia. 2004 Aug 1
34 citations
Synthesis and evaluation of fluorine-18 labeled glyburide analogs as β-cell imaging agents
Alexander Schmitz, C-Y. Shiue, Q. Feng, Grace G. Shiue, Shaoping Deng, M. T. Pourdehnad, Ralf Schirrmacher, Marko Z. Vatamaniuk, Nicolai M. Doliba, Franz M. Matschinsk...> ;Nuclear Medicine and Biology. 2004 May 1
256 citations
Structural and Functional Abnormalities in the Islets Isolated From Type 2 Diabetic Subjects
Shaoping Deng, Marko Z. Vatamaniuk, Xiaolun Huang, Nicolai M. Doliba, Moh Moh Lian, Adam M. Frank, Ergun Velidedeoglu, Niraj M. Desai, Brigitte Koeberlein, Bryan A. Wo...> ;Diabetes. 2004 Mar 1
115 citations
Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity?
Niraj M. Desai, John A. Goss, Shaoping Deng, Bryan A. Wolf, Eileen Markmann, Maral Palanjian, Angela P. Shock, S. U. E. Feliciano, F. Charles Brunicardi, Clyde F. Bark...> ;Transplantation. 2003 Dec 15
132 citations
Rapamycin Has a Deleterious Effect on MIN-6 Cells and Rat and Human Islets
Ewan Bell, Xiaopei Cao, Jacob A. Moibi, Scott Greene, Robert J. Young, Matteo Trucco, Zhiyong Gao, Franz M. Matschinsky, Shaoping Deng, James F. Markman, Ali Naji, Bry...> ;Diabetes. 2003 Nov 1
65 citations
Pancreatic-Derived Factor (FAM3B), a Novel Islet Cytokine, Induces Apoptosis of Insulin-Secreting β-Cells
Xiaopei Cao, Zhiyong Gao, Claudia E. Robert, Scott Greene, Gang Xu, Weizhen Xu, Ewan Bell, Donald H. Campbell, Yuan Zhu, Robert J. Young, Matteo Trucco, James F. Markm...> ;Diabetes. 2003 Sep 1
Join now to see all

Press Mentions

Beverly Davidson, PhD, Elected to the National Academy of MedicineOctober 21st, 2019

Grant Support

Radioimmunoassay/Biomarkers CoreNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2011
Short Term Research Training For Medical StudentsNational Institute Of Diabetes And Digestive And Kidney Diseases2002–2011
Core--Radioimmunoassy CoreNational Institute Of Diabetes And Digestive And Kidney Diseases2002
Signal Transduction Of Amyloid Precurser Protein Secretion In NT2N CellsNational Institute On Aging1998–2002
Phospholipid Derived Messengers And Neuron DeathNational Institute On Aging1996–2002
Effect Of Cytokines On Beta Cell FunctionNational Institute Of Diabetes And Digestive And Kidney Diseases1996–2002
Core--RadioimmunoassayNational Institute Of Diabetes And Digestive And Kidney Diseases1997–2001
Phospholipases And Insulin SecretionNational Institute Of Diabetes And Digestive And Kidney Diseases1995–1999
Phospholipases And Insulin SecretionNational Institute Of Diabetes And Digestive And Kidney Diseases1994–1998
Role Of Phospholipases In Insulin SecretionNational Institute Of Diabetes And Digestive And Kidney Diseases1991–1993

Hospital Affiliations

Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania