BurtonEliotAppelMD,MBA

Pediatric Hematology & Oncology • Hackensack, NJ

Associate Director, Children's Cancer Institute, Joseph M. Sanzari Children's Hospital Director, Fertility Preservation Program, Joseph M. Sanzari Children's Hospital Associate Professor, Hackensack Meridian School of Medicine, Nutley, NJ

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Office
Children's Cancer Institute
30 Prospect Avenue WFAN - PC 120
Hackensack, NJ 07601
Phone+1 551-996-5437

Fax+1 201-487-7340
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Education & Training

University of ChicagoFellowship, Pediatric Hematology/Oncology, 1993 - 1996
University of ChicagoResidency, Pediatrics, 1990 - 1993
University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 1990

Certifications & Licensure

NJ State Medical License 1997 - 2025
NY State Medical License 1996 - 2008
WI State Medical License 2002 - 2005
IL State Medical License 1990 - 1996
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Fellow (FAAP) American Academy of Pediatrics

Clinical Trials

Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma Start of enrollment: 2001 Oct 18
Active, not recruiting
Phase 3
Treating Young Patients With Newly Diagnosed, Low Stage, Lymphocyte Predominant Hodgkin Disease Start of enrollment: 2006 Jan 02
Active, not recruiting
Phase 2
Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET Start of enrollment: 2007 Mar 26
Active, not recruiting
Phase 3
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies Start of enrollment: 2008 Jul 17
Recruiting
Neuropsychological and Behavioral Testing in Younger Patients With Cancer Start of enrollment: 2009 Feb 27
Recruiting
Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer Start of enrollment: 2003 Oct 13
Completed
Study of Kidney Tumors in Younger Patients Start of enrollment: 2006 Feb 27
Recruiting
Collecting and Storing Biological Samples From Patients With Ewing Sarcoma Start of enrollment: 2008 Feb 04
Completed
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Start of enrollment: 2000 Nov 06
Recruiting
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma Start of enrollment: 1999 Mar 15
Completed
Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Start of enrollment: 2004 Feb 16
Completed
Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor Start of enrollment: 2009 Jul 13
Active, not recruiting
Phase 3
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 14
Active, not recruiting
Phase 3
Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Start of enrollment: 2010 May 07
Active, not recruiting
Phase 3
Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2010 Aug 09
Completed
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Start of enrollment: 2010 Aug 09
Active, not recruiting
Phase 3
Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Start of enrollment: 2010 Nov 22
Completed
Phase 2
Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Start of enrollment: 2010 Nov 22
Active, not recruiting
Phase 3
Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2011 Jun 20
Active, not recruiting
Phase 3
A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum Start of enrollment: 2012 Feb 01
Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission Start of enrollment: 2012 Feb 21
Active, not recruiting
Phase 3
Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients Start of enrollment: 2012 Jun 01
Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Start of enrollment: 2013 Feb 12
Completed
Phase 2
Blood Sample Markers of Reproductive Hormones in Assessing Ovarian Reserve in Younger Patients With Newly Diagnosed Lymphomas Start of enrollment: 2013 Jun 17
Active, not recruiting
Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma Start of enrollment: 2013 Nov 13
Active, not recruiting
Phase 2
Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia Start of enrollment: 2020 Apr 06
Active, not recruiting
Phase 1, Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

6 citations
Survival by age in paediatric and adolescent patients with Hodgkin lymphoma: a retrospective pooled analysis of children's oncology group trials.
Justine M Kahn, Qinglin Pei, Debra L Friedman, Joel Kaplan, Frank G Keller, David Hodgson, Yue Wu, Burton E Appel, Tara O Henderson, Cindy L Schwartz, Kara M Kelly, Sh...> ;The Lancet. Haematology. 2022 Jan 1
6 citations
Practice patterns for the management of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL): an international survey by the Global NLPHL One Working Group (GLOW).
Andrea C Lo, Ajay Major, Leanne Super, Burton Appel, Ananth Shankar, Louis S Constine, Lianna J Marks, Kara M Kelly, Monika L Metzger, Ilia N Buhtoiarov, Christine Mau...> ;Leukemia & Lymphoma. 2022 Aug 1
1 citations
Hematopoietic stem cell transplant in two pediatric patients testing positive for SARS-CoV-2: A case report.
Jennifer Krajewski, Jing Chen, Juhi Motiani, Aryeh Baer, Burton Appel, Johannes L Zakrzewski, Melanie Hankewycz, Nancy Durning> ;Pediatric Transplantation. 2021 Oct 27
66 citations
Characterization of COVID-19 disease in pediatric oncology patients: The New York-New Jersey regional experience.
P. Pallavi Madhusoodhan, Joanna Pierro, Jordan Musante, Prachi Kothari, Bradley Gampel, Burton Appel, Adam S. Levy, Adit Tal, Laura Hogan, Archana Sharma, Shari Feinbe...> ;Pediatric Blood & Cancer. 2021 Mar 1
15 citations
Bone Marrow Morphology Associated With Germline RUNX1 Mutations in Patients With Familial Platelet Disorder With Associated Myeloid Malignancy
Karen M. Chisholm, Christopher Denton, Sioban Keel, Amy E. Geddis, Min Xu, Burton Appel, Alan B. Cantor, Mark D. Fleming, Akiko Shimamura> ;Pediatric and Developmental Pathology. 2019 Jan 2
8 citations
Outcomes in intermediate‐risk pediatric lymphocyte‐predominant Hodgkin lymphoma: A report from the Children's Oncology Group
Lianna J. Marks, Qinglin Pei, Rizvan Bush, Allen Buxton, Burton Appel, Kara M. Kelly, Cindy L. Schwartz, Debra L. Friedman> ;Pediatric Blood & Cancer. 2018 Sep 14
4 citations
Patterns of Involved-Field Radiation Therapy Protocol Deviations in Pediatric Versus Adolescent and Young Adults With Hodgkin Lymphoma: A Report From the Children's On...
Aaron S. Parzuchowski, Rizvan Bush, Qinglin Pei, Debra L. Friedman, Thomas J. Fitzgerald, Suzanne L. Wolden, Kavita V. Dharmarajan, Louis S. Constine, Fran Laurie, San...> ;International Journal of Radiation Oncology, Biology, Physics. 2018 Apr 1
1 citations
Surgeon Concordance in the Assessment of Resectability for Stage IA Nodular Lymphocyte Predominant Hodgkin Lymphoma.
Jennifer H. Aldrink, Burton Appel, Joel Kaplan, Robert E. Hutchison, Cindy L. Schwartz, Kara M. Kelly, Kathleen M. McCarten, Peter F. Ehrlich> ;Journal of Pediatric Hematology/oncology. 2018 Apr 1
16 citations
Variant histology, IgD and CD30 expression in low-risk pediatric nodular lymphocyte predominant Hodgkin lymphoma: A report from the Children's Oncology Group.
Ramona Vesna Untanu, Jason Back, Burton Appel, Qinglin Pei, Lu Chen, Allen Buxton, David C. Hodgson, Peter F. Ehrlich, Louis S. Constine, Cindy L. Schwartz, Robert E. ...> ;Pediatric Blood & Cancer. 2018 Jan 1
87 citations
Outcomes of adults and children with primary mediastinal B-cell lymphoma treated with dose-adjusted EPOCH-R
Lisa Giulino-Roth, Tara O'Donohue, Zhengming Chen, Nancy L. Bartlett, Ann S. LaCasce, William Martin-Doyle, Matthew J. Barth, Kimberly Davies, Kristie A. Blum, Beth A....> ;British Journal of Haematology. 2017 Dec 1
40 citations
Minimal Treatment of Low-Risk, Pediatric Lymphocyte-Predominant Hodgkin Lymphoma: A Report From the Children's Oncology Group.
Burton Appel, Lu Chen, Allen Buxton, Robert E. Hutchison, David C. Hodgson, Peter F. Ehrlich, Louis S. Constine, Cindy L. Schwartz> ;Journal of Clinical Oncology. 2016 Sep 27
35 citations
Children's Oncology Group's 2013 blueprint for research: Hodgkin lymphoma.
Kara M. Kelly, David R. W. Hodgson, Burton Appel, Lu Chen, Peter D. Cole, Terzah M. Horton, Frank G. Keller> ;Pediatric Blood & Cancer. 2013 Jun 1
18 citations
Impact of low-dose involved-field radiation therapy on pediatric patients with lymphocyte-predominant Hodgkin lymphoma treated with chemotherapy: a report from the Chi...
Burton Appel, Lu Chen, Allen Buxton, Suzanne L. Wolden, David C. Hodgson, James B. Nachman> ;Pediatric Blood & Cancer. 2012 Dec 15
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