CarlLeierIIMD

Cardiology • Columbus, OH

Heart Failure & Transplantation

Overstreet Professor of Medicine and Pharmacology

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Office
473 west 12th ave
Davis Heart Lung Research Institude
Columbus, OH 43210
Phone+1 614-293-8963

Fax+1 614-293-5614
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Education & Training

Ohio State University HospitalFellowship, Advanced Heart Failure and Transplant Cardiology, 1974 - 1976
Ohio State University HospitalChief Residency, Internal Medicine/Pediatrics, 1973 - 1974
Ohio State University HospitalResidency, Internal Medicine/Pediatrics, 1971 - 1973
Saint Vincent Hospital1970 - 1971
Ohio State University HospitalInternship, Internal Medicine/Pediatrics, 1969 - 1970
Creighton University School of MedicineClass of 1969, MD, Cum Laude

Certifications & Licensure

OH State Medical License 1971 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012
Excellence in Teaching Award The Ohio State University College of Medicne and public Health, 2010
Posted as one of the 100 entries on The Ohio State University Wall of Fame and Achievement The Ohio State University Student Union, 2010
Cardiovascular Achievement Award American Heart Association, Ohio Affiliate, 2006
The Charles F. Wooley Transmission of Excellence Teaching Award Division of Cardiology, The Ohio State University, 2005
Earl N. Metz Distinguished Physician Award Department of Internal Medicine,The Ohio State University, 2005
Honoree for services to The OSU Heart Transplant Program Unverferth Classic, 2002
Marquis Who’s Who in Science and Engineering (annually) 1997
America’s Top Physicians Consumer Research Council of America (annually), 1997
Cited as one of the top 100 heart specialists in the United States Good Housekeeping journal, 1996
Research Excellence Award Ohio Affiliate, American Heart Association, 1996
Faculty Teaching Award The Ohio State University College of Medicine Alumni Association, 1992
Critical Care Medicine American Board of Internal Medicine, 1991
The first Unverferth Research Award The Ohio State University College of Medicine, 1988
Membership Association of University Cardiologists, 1987
Elected Member The American Society for Clinical Investigation, 1983
Awarded the James W. Overstreet Chair in Cardiovascular Medicine The Ohio State University, 1983
Membership American Society for Clinical Investigation, 1983
Honorary Membership and Research Award The Ohio State University College of Medicine, 1981
Young Investigator Central Ohio Heart Chapter, American Heart Association, 1978
Research Recognition Award Central Ohio Heart Chapter, American Heart Association, 1978
Cardiovascular medicine ABIM, 1977
Golden Apple The Ohio State University College of Medicine, 1973
Roche Scholastic Achievement Award 1969
Upjohn Award 1969
Lange Scholar Award 1969
Alpha Omega Alpha 1968
Whos Who in Medicine and Healthcare Marquis Whos Who
Fellow (FACC) American College of Cardiology
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Publications & Presentations

PubMed

1 citations
An unexpected paradox: wall shear stress in the aorta is less in patients with severe atherosclerosis regardless of obesity.
Shahzeb Qaisar, Leon D. Brodsky, Rolf F. Barth, Carl V. Leier, L M Buja, Vedat O. Yildiz, Xiaokui Mo, Patricia Allenby, Stephen Moore, Iouri Ivanov, Wei Chen, Diana L ...> ;Cardiovascular Pathology. 2021 Mar 1
Ambulatory Inotrope Infusions: The Importance of Historical Perspective.
Carl V. Leier> ;JACC. Heart Failure. 2018 Jul 11
27 citations
The Shortcomings of Clinical Practice Guidelines
Konstantinos Dean Boudoulas, Carl V. Leier, Paraschos Geleris, Harisios Boudoulas> ;Cardiology. 2015 Jan 1
9 citations
Relationship of cardiac magnetic resonance imaging and myocardial biopsy in the evaluation of nonischemic cardiomyopathy.
Jennifer A. Dickerson, Subha V. Raman, Peter M. Baker, Carl V. Leier> ;Congestive Heart Failure. 2013 Jan 1
21 citations
Changes in Plasma Profiles of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of MMPs in Stress-Induced Cardiomyopathy
Essa Essa, Michael R. Zile, Robert E. Stroud, Allison D. Rice, Richard J. Gumina, Carl V. Leier, Francis G. Spinale> ;Journal of Cardiac Failure. 2012 Jun 1
15 citations
Y-box binding protein-1 implicated in translational control of fetal myocardial gene expression after cardiac transplant
Jason J. David, Sukanya V. Subramanian, Aiwen Zhang, William L. Willis, Robert J. Kelm, Carl V. Leier, Arthur R. Strauch> ;Experimental Biology and Medicine. 2012 May 1
86 citations
Management of cardiac toxicity in patients receiving vascular endothelial growth factor signaling pathway inhibitors
Richard M. Steingart, George L. Bakris, Helen X. Chen, Ming-Hui Chen, Thomas Force, S. Percy Ivy, Carl V. Leier, Glenn Liu, Daniel J. Lenihan, JoAnn Lindenfeld, Michae...> ;American Heart Journal. 2012 Feb 1
4 citations
Selecting a mentor: a guide for residents, fellows, and young physicians.
Carl V. Leier, Alex J. Auseon, Philip F. Binkley> ;The American Journal of Medicine. 2011 Oct 1
11 citations
Role of the pulmonary artery catheter in diagnosis and management of heart failure.
Rami Kahwash, Carl V. Leier, Leslie W. Miller> ;Cardiology Clinics. 2011 May 1
A look back at 'the management of heart failure 5 years hence'.
Carl V. Leier, Garrie J. Haas> ;The American Heart Hospital Journal. 2011 Jan 1
Coronary microcirculation remodelling in dilated cardiomyopathy: another brick in the wall.
Carl V. Leier> ;Cardiology. 2011 Jan 1
287 citations
Initial Assessment, Surveillance, and Management of Blood Pressure in Patients Receiving Vascular Endothelial Growth Factor Signaling Pathway Inhibitors
Michael L. Maitland, George L. Bakris, Henry R. Black, Helen X. Chen, Jean-Bernard Durand, William J. Elliott, S. Percy Ivy, Carl V. Leier, JoAnn Lindenfeld, Glenn Liu...> ;Journal of the National Cancer Institute. 2010 May 5
173 citations
Triage after hospitalization with advanced heart failure: the ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) ...
Christopher M. O'Connor, Vic Hasselblad, Rajendra H. Mehta, Gudaye Tasissa, Robert M. Califf, Mona Fiuzat, Joseph G. Rogers, Carl V. Leier, Lynne W. Stevenson> ;Journal of the American College of Cardiology. 2010 Mar 2
1 citations
Examining the Jugular Vein Is Never in Vain
Carl V. Leier> ;Circulation. Heart Failure. 2010 Mar 1
4 citations
Role of the Pulmonary Artery Catheter in Diagnosis and Management of Heart Failure
Rami Kahwash, Carl V. Leier, Leslie W. Miller> ;Heart Failure Clinics. 2009 Apr 1
4 citations
Are hemodynamic parameters predictors of mortality
Garrie J. Haas, Carl V. Leier> ;Heart Failure Clinics. 2009 Apr 1
6 citations
Predictors of Inpatient Outcomes in Hospitalized Patients After Left Heart Catheterization
Yun You Li, Charles A. Bush, Anthony R. Orsini, Zhibao Mi, Carl V. Leier> ;The American Journal of Cardiology. 2009 Feb 15
3 citations
Latent development of occlusive coronary atherosclerosis as a cause of decompensation of non-ischemic dilated cardiomyopathy.
Bryan M. White, Rohit Mehta, Philip F. Binkley, Carl V. Leier> ;Cardiology. 2009 Jan 1
117 citations
Changing preferences for survival after hospitalization with advanced heart failure.
Lynne W. Stevenson, Anne S. Hellkamp, Carl V. Leier, George Sopko, Todd M. Koelling, J. Wayne Warnica, William T. Abraham, Edward K. Kasper, Joseph G. Rogers, Robert M...> ;Journal of the American College of Cardiology. 2008 Nov 18
46 citations
High Mortality Without ESCAPE: The Registry of Heart Failure Patients Receiving Pulmonary Artery Catheters Without Randomization
Larry A. Allen, Joseph G. Rogers, J. Wayne Warnica, Thomas G. DiSalvo, Gudaye Tasissa, Cynthia Binanay, Christopher M. O'Connor, Robert M. Califf, Carl V. Leier, Monic...> ;Journal of Cardiac Failure. 2008 Oct 1
160 citations
Value of Clinician Assessment of Hemodynamics in Advanced Heart Failure The ESCAPE Trial
Mark H. Drazner, Anne S. Hellkamp, Carl V. Leier, Monica R. Shah, Leslie W. Miller, Stuart D. Russell, James B. Young, Robert M. Califf, Anju Nohria> ;Circulation. Heart Failure. 2008 Sep 1
16 citations
Serum response factor neutralizes Purα- and Purβ-mediated repression of the fetal vascular smooth muscle α-actin gene in stressed adult cardiomyocytes
Aiwen Zhang, Jason J. David, Sukanya V. Subramanian, Xiaoying Liu, Matthew D. Fuerst, Xue Zhao, Carl V. Leier, Charles G. Orosz, Robert J. Kelm, Arthur R. Strauch> ;American Journal of Physiology. Cell Physiology. 2008 Mar 1
52 citations
Recovery of normal ventricular function in patients with dilated cardiomyopathy: predictors of an increasingly prevalent clinical event.
Philip F. Binkley, Amanda Lesinski, Jeanette Pohorence Ferguson, Patricia S. Hatton, Laura Yamokoski, Sheetal Hardikar, Glen E. Cooke, Carl V. Leier> ;American Heart Journal. 2008 Jan 1
5 citations
Invasive hemodynamic monitoring the aftermath of the ESCAPE trial.
Carl V. Leier> ;Cardiology Clinics. 2007 Nov 1
18 citations
Low-dose oral enoximone enhances the ability to wean patients with ultra-advanced heart failure from intravenous inotropic support: Results of the oral enoximone in in...
Arthur M. Feldman, Ron M. Oren, William T. Abraham, John P. Boehmer, Peter E. Carson, Eric J. Eichhorn, Edward M. Gilbert, Andrew Kao, Carl V. Leier, Brian D. Lowes, M...> ;American Heart Journal. 2007 Nov 1
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Journal Articles

Editorial Comment Ambulatory Inotrope Infusions: The Importance of Historical Perspective∗
Carl Leier II, MD, ScienceDirect
Electrophysiologic and antiarrhythmic effects of nitroglycerin in man.
Hoelzer M, Schaal SF, Leier CV, J Cardiovasc Pharmacol 3:917-923
Human myocardial mitochondria: Size differences in parts of the cell.
Unverferth DV, Leier CV, Brierly GP, Magorien RD, Baba N, J Exp and Mol Pathol 35:184-188
A preliminary report of the effects of orally administered enoximone on regional hemodynamics in congestive heart failure.
Leier CV, Meiler SEL, Mathews S, Unverferth DV, Am J Cardiol 60:27C-30C
Central and regional hemodynamic effects of intravenous isosorbide dinitrate, nitroglycerin and nitroprusside in patients with congestive heart failure.
Leier CV, Bambach D, Thompson MJ, Cattaneo SM, Goldberg RJ, Unverferth DV, Am J Cardiol 48:1115-1123
Biochemical and histological correlates of ventricular end-diastolic pressure.
Unverferth DV, Magorien RD, Kolibash AJ, Lewis RP, Lykens M, Altschuld R, Baba N, Leier CV, Int J Cardiol 1:133-142
Effects of hydralazine on coronary blood flow and myocardial energetics in congestive heart failure.
Magorien RD, Brown GP, Unverferth DV, Nelson S, Boudoulas H, Bambach D, Leier CV, Circulation 65:528-533
Oral enoximone pharmacokinetics in patients with congestive heart failure.
Lima JJ, Leier CV, Holtz L, Sterechele J, Shields BJ, MacKichan JJ, J Clin Pharmacol 27:654-660
Intravenous pirbuterol.
Leier CV, Nelson S, Huss P, Bianchine JR, Olukotun AY, Taylor CR, Salzburg DS, Clin Pharmacol Ther 31:89-94
Diastolic time in congestive heart failure.
Meiler SEL, Boudoulas H, Unverferth DV, Leier CV, Am Heart J 114:1192-1198
Right ventricular aneurysm: Clinical and laboratory features.
Walker SS, Binkley PF, Neiger D, Fulkerson PK, Bush CA, Unverferth DV, Leier CV, . Cath and Cardiovasc Diagnosis 8:137-143
Neurohumoral profile in congestive heart failure: response to beta-blockade.
Binkley PF, Lewe R, Lima J, Unverferth DV, Leier CV, J Lab Clin Med 111:393-398
Intravenous isosorbide dinitrate in the management of acute hypertension following cardiopulmonary bypass.
Cattaneo SM, Leier CV, Ann Thorac Surg 33:345-353
Dobutamine-induced inhibition of platelet function.
Smith RE, Briggs B, Unverferth DV, Leier CV, Int J Clin Pharmacol Res 2:89-97
Hemodynamic responses to different levels of alpha-adrenergic interruption in congestive heart failure.
Good AP, Unverferth DV, Leier CV, Cardiovasc Drugs and Therapy 1:529-534
The effect of vasodilator therapy on systolic and diastolic time intervals in congestive heart failure.
Leier CV, Magorien RD, Boudoulas H, Lewis RP, Bambach D, Unverferth DV, Chest 81:723-729
Central and regional hemodynamic effects of oral enoximone in congestive heart failure: A double-blind, placebo-controlled study.
Leier CV, Lima JJ, Meiler SEL, Unverferth DV, Am Heart J 115:1051-1059
The effect of vasodilator therapy on systolic and diastolic time intervals in congestive heart failure.
Leier CV, Magorien RD, Boudoulas H, Lewis RP, Bambach D, Unverferth DV, Chest 81:723-729
Effect of afterload on left ventricular performance in experimental animals.
Boudoulas H, Karayannacos PE, Lewis RP, Leier CV, Vasko JS, Journal of Medicine 13:373-385
A-wave" liver.
George DS, Marsh C, Leier CV, Clin Cardiol 11:349-350
Drug-induced conditioning in congestive heart failure.
Leier CV, Huss P, Lewis RP, Unverferth DV, Circulation 65:1382-1387
Cardiac function in Duchenne's muscular dystrophy.
Hunsaker RH, Fulkerson PK, Barry FJ, Lewis RP, Leier CV, Unverferth DV, Am J Med 73:235-238
Preservation of the end-systolic pressure/end-systolic dimension relation following pindolol in congestive heart failure.
Binkley PF, Lewe RF, Unverferth DV, Leier CV, Am Heart J 115:1245-1250
Hemodynamic effects of vasodilator therapy in severe left heart failure combined with large atrial septal defects.
Kolibash AJ, Magorien RD, Robinson JL, Leier CV, Am J Med 73:489-444
Doxorubicin cardiomyopathy.
Unverferth DV, Magorien RD, Leier CV, Balcerzak SP, Cancer Treatment Reviews 9:149-164
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