CarlBartonShanholtzMD

Pulmonology • Baltimore, MD

Critical Care Medicine

Professor, Medicine, University of Maryland School of Medicine

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Office
110 South Paca St.
2nd Floor
Baltimore, MD 21201
Phone+1 410-328-8141

Fax+1 410-328-0177
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Education & Training

Naval Medical Center (San Diego)Internship, Internal Medicine, 1983 - 1984
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1983

Certifications & Licensure

MD State Medical License 1989 - 2025
PA State Medical License 1984 - 1990
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Critical Care Medicine

Clinical Trials

Assessment of End Expiratory Lung Volumes in Healthy Subjects Using High Flow Oxygen (Vapotherm®) Start of enrollment: 2012 Jul 01
Completed
Not Applicable
Managing Acute Pain in Critically Ill Non-communicative Palliative Care Patients Start of enrollment: 2015 Mar 01
Completed
Not Applicable
Regenerative Medicine for COVID-19 and Flu-Elicited ARDS Using Lomecel-B (RECOVER) Start of enrollment: 2020 Jul 24
Active, not recruiting
Phase 1

Publications & Presentations

PubMed

Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure.
Li Gao, Nicholas Rafaels, Tanda M Dudenkov, Mahendra Damarla, Rachel Damico, James P Maloney, Marc Moss, Greg S Martin, Jonathan Sevransky, Carl Shanholtz, Dan L Herr,...> ;Respiratory Research. 2023 Jul 6
1 citations
Design and rationale of the CHILL phase II trial of hypothermia and neuromuscular blockade for acute respiratory distress syndrome.
Carl B Shanholtz, Michael L Terrin, Thelma Harrington, Caleb Chan, Whittney Warren, Robert Walter, Faith Armstrong, Jeffrey Marshall, Rachel Scheraga, Abjihit Duggal, ...> ;Contemporary Clinical Trials Communications. 2023 Jun 1
Refining the Classification of Mechanical Ventilation Weaning Outcomes: Getting a Second WIND.
Carl Shanholtz> ;Critical Care Medicine. 2023 May 1
2 citations
Clinical outcomes and echocardiographic characteristics between African American and Caucasian patients with acute pulmonary embolism.
Rafael S Cires-Drouet, Jacob Sama, Paul Han, Kevin Jones, Daniel Haase, Taylor Miller, Shahab Toursavadkohi, Khanjan Nagarsheth, Lateaqua Alston, Angela Smedley, Carl ...> ;Phlebology. 2022 Oct 1
15 citations
Neutralizing COVID-19 Convalescent Plasma in Adults Hospitalized With COVID-19: A Blinded, Randomized, Placebo-Controlled Trial.
Wesley H Self, Allison P Wheeler, Thomas G Stewart, Harry Schrager, Jason Mallada, Christopher B Thomas, Vince D Cataldo, Hollis R O'Neal Jr, Nathan I Shapiro, Conor H...> ;Chest. 2022 Nov 1
1 citations
A syndrome by any other name: playing the long-term outcome CARDS.
Andrea R Levine, Carl Shanholtz> ;Thorax. 2022 Mar 1
2 citations
I, DOCTOR: The role of machine learning in phenotyping ARDS.
Andrea R Levine, Carl B Shanholtz> ;Ebiomedicine. 2022 Jan 1
8 citations
Deep dissection of the antiviral immune profile of patients with COVID-19.
Djordje Atanackovic, Stephanie V Avila, Forat Lutfi, Diego de Miguel-Perez, Xiaoxuan Fan, Gabriela Sanchez-Petitto, Erica Vander Mause, Jonathan Siglin, John Baddley, ...> ;Communications Biology. 2021 Dec 16
2 citations
Understanding Patients' Perceived Health After Critical Illness: Analysis of Two Prospective, Longitudinal Studies of ARDS Survivors.
Alison E. Turnbull, Hongkai Ji, Victor D. Dinglas, Albert W. Wu, Pedro A. Mendez-Tellez, Cheryl Dennison Himmelfarb, Carl Shanholtz, Megan M. Hosey, Ramona O. Hopkins,...> ;Chest. 2021 Aug 19
2 citations
Assessment and Impact of Intravenous Medication Fluid Administration in Critically Ill Patients With Acute Respiratory Failure
Jeffrey P. Gonzales, Debbi Child, Thelma Harrington, Peter Kratz, Laura Seiberlich, Giora Netzer, Carl Shanholtz> ;The Annals of Pharmacotherapy. 2022 Jan 1
8 citations
A qualitative assessment of the diagnosis and management of ventilator-associated pneumonia among critical care clinicians exploring opportunities for diagnostic stewa...
Blaine Kenaa, Lyndsay M. O’Hara, Mary Richert, Jessica P. Brown, Carl Shanholtz, Michael J Armahizer, Surbhi Leekha> ;Infection Control and Hospital Epidemiology. 2021 Apr 16
6 citations
Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalize...
Wesley H. Self, Thomas G. Stewart, Allison P. Wheeler, Wissam El Atrouni, Amanda J. Bistran-Hall, Jonathan D Casey, Vince D. Cataldo, James D. Chappell, Claudia S. Coh...> ;Trials. 2021 Mar 20
10 citations
Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalize...
Wesley H. Self, Thomas G. Stewart, Allison P. Wheeler, Wissam El Atrouni, Amanda J. Bistran-Hall, Jonathan D Casey, Vince D. Cataldo, James D. Chappell, Claudia S. Coh...> ;Research Square. 2021 Mar 2
43 citations
Immune effector cell-associated neurotoxicity syndrome after chimeric antigen receptor T-cell therapy for lymphoma: predictive biomarkers and clinical outcomes.
Noa G. Holtzman, Hao Xie, Søren M. Bentzen, Vivek Kesari, Ali Bukhari, Firas El Chaer, Forat Lutfi, Jonathan Siglin, Elizabeth Hutnick, Natalie Gahres, Kathleen Ruehle...> ;Neuro-Oncology. 2021 Jan 30
C-reactive protein: not always a reliable marker of ongoing cytokine release syndrome in CAR-T therapy following IL-6 blockade.
Jonathan Siglin, Ali Bukhari, Forat Lutfi, Noa G. Holtzman, Carl Shanholtz, Jean A. Yared, Nancy M. Hardy, Aaron P. Rapoport, Saurabh Dahiya> ;Leukemia & Lymphoma. 2020 Apr 28
12 citations
Anemia in Critically Ill Patients With Acute Respiratory Distress Syndrome and Posthospitalization Physical Outcomes.
Matthew A. Warner, Daryl J. Kor, Ryan D. Frank, Victor D. Dinglas, Pedro A. Mendez-Tellez, Cheryl Dennison Himmelfarb, Carl Shanholtz, Curtis B. Storlie, Dale M. Needham> ;Journal of Intensive Care Medicine. 2021 May 1
11 citations
A Survey of Academic Intensivists' Use of Neuromuscular Blockade in Subjects With ARDS
Neal Dodia, Mary Richert, Andrew R. Deitchman, Charlene C. Quinn, Ellen T Marciniak, Clayton H. Brown, Michael L. Terrin, Diana E. Amariei, Carl Shanholtz, Jeffrey D. ...> ;Respiratory Care. 2020 Mar 1
13 citations
Ventilator-Associated Pneumonia: Diagnostic Test Stewardship and Relevance of Culturing Practices
Blaine Kenaa, Mary Richert, Kimberly C. Claeys, Andrea G. Shipper, Kaede V. Sullivan, Gregory M. Schrank, Lyndsay M. O’Hara, Daniel J. Morgan, Carl Shanholtz, Surbhi L...> ;Current Infectious Disease Reports. 2019 Nov 21
24 citations
Rapid relapse of large B-cell lymphoma after CD19 directed CAR-T-cell therapy due to CD-19 antigen loss
Ali Bukhari, Firas El Chaer, Rima Koka, Zeba N. Singh, Elizabeth Hutnick, Kathleen Ruehle, Seung Tae Lee, Mehmet H. Kocoglu, Carl Shanholtz, Ashraf Badros, Nancy M. Ha...> ;American Journal of Hematology. 2019 Oct 1
Center Effects in Multicenter Clinical Trials: Mileage May Vary.
Carl Shanholtz> ;Critical Care Medicine. 2019 Jun 1
4 citations
Feasibility, safety, and utility of bronchoscopy in patients with ARDS while in the prone position
Or Kalchiem-Dekel, Carl Shanholtz, Jean Jeudy, Ashutosh Sachdeva, Edward M. Pickering> ;Critical Care. 2018 Mar 2
76 citations
Return to work and lost earnings after acute respiratory distress syndrome: a 5-year prospective, longitudinal study of long-term survivors.
Biren B. Kamdar, Kristin A. Sepulveda, Alexandra Chong, Robert K. Lord, Victor D. Dinglas, Pedro A. Mendez-Tellez, Carl Shanholtz, Elizabeth Colantuoni, Till von Wacht...> ;Thorax. 2018 Feb 1
56 citations
Oxygen Exposure Resulting in Arterial Oxygen Tensions Above the Protocol Goal Was Associated With Worse Clinical Outcomes in Acute Respiratory Distress Syndrome.
Neil R. Aggarwal, Roy G. Brower, David N. Hager, B. Taylor Thompson, Giora Netzer, Carl Shanholtz, Adrian Lagakos, William Checkley> ;Critical Care Medicine. 2017 Dec 1
10 citations
Oncologic Mechanical Emergencies
Umar A. Khan, Carl Shanholtz, Michael T. McCurdy> ;Hematology/oncology Clinics of North America. 2017 Dec 1
6 citations
Family Presence at First Cardiopulmonary Resuscitation and Subsequent Limitations on Care in the Medical Intensive Care Unit.
Rebecca L. Krochmal, John W. Blenko, Majid Afshar, Giora Netzer, Susan C. Roy, Debra L. Wiegand, Carl Shanholtz> ;American Journal of Critical Care. 2017 May 1
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Abstracts/Posters

Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) after CD19-Directed Chimeric Antigen Receptor T-Cell Therapy (CAR-T) for Large B-Cell Lymphoma: Predicti...
Carl Shanholtz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019